{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T02:01:52Z","timestamp":1779156112795,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705500"],"award-info":[{"award-number":["2023YFC2705500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705501"],"award-info":[{"award-number":["2023YFC2705501"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2705505"],"award-info":[{"award-number":["2023YFC2705505"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0802604"],"award-info":[{"award-number":["2019YFA0802604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130046"],"award-info":[{"award-number":["82130046"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82320108009"],"award-info":[{"award-number":["82320108009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371660"],"award-info":[{"award-number":["82371660"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32300710"],"award-info":[{"award-number":["32300710"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>Do obstetric and perinatal complications vary according to different blastocyst developmental parameters after frozen-thawed single-blastocyst transfer (SBT) cycles?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>Pregnancies following the transfer of a blastocyst with a grade C trophectoderm (TE) were associated with an increased risk of placenta previa compared to those with a blastocyst of grade A TE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>Existing studies investigating the effect of blastocyst morphology grades on birth outcomes have mostly focused on fetal growth and have produced conflicting results, while the risk of obstetric complications has rarely been reported. Additionally, growing evidence has suggested that the appearance of TE cells could serve as the most important parameter for predicting implantation and live birth. Given that the TE ultimately develops into the placenta, it is plausible that this independent predictor may also impact placentation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>This retrospective cohort study at a tertiary-care academic medical center included 6018 singleton deliveries after frozen-thawed SBT cycles between January 2017 and December 2021.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>Singleton pregnancies were grouped into two groups according to blastocyst developmental stage (Days 5 and 6), four groups according to embryo expansion (Stages 3, 4, 5, and 6), three groups according to inner cell mass (ICM) quality (A, B, and C), and three groups according to TE quality (A, B, and C). The main outcomes included pregnancy-induced hypertension, preeclampsia, gestational diabetes mellitus, preterm premature rupture of membrane, placenta previa, placental abruption, placenta accreta, postpartum hemorrhage, preterm birth, low birth weight, small for gestational age, and birth defects. Multivariate logistic regressions were performed to evaluate the effect of blastocyst developmental stage, embryo expansion stage, ICM grade, and TE grade on measured outcomes adjusting for potential confounders.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>No association was found between blastocyst developmental stage and obstetric or perinatal outcomes both before and after adjusting for potential confounders, and similar results were found with regard to embryo expansion stage and ICM grade. Meanwhile, the incidence of placenta previa derived from a blastocyst with TE of grade C was higher compared with those derived from a blastocyst with TE of grade A (1.7%, 2.4%, and 4.0% for A, B, and C, respectively, P\u2009=\u20090.001 for all comparisons). After adjusting for potential covariates, TE grade C blastocysts had 2.81 times the likelihood of resulting in placenta previa compared to TE grade A blastocysts (adjusted odds ratio 2.81, 95% CI 1.11\u20137.09). No statistically significant differences were detected between any other measured outcomes and TE grades both before or after adjustment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>The study is limited by its retrospective, single-center design. Additionally, although the sample size was relatively large for the study group, the sample size for certain subgroups was relatively small and lacked adequate power, particularly the ICM grade C group. Therefore, these results should be interpreted with caution.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>The study extends our knowledge of the potential downstream effect of TE grade on placental abnormalities.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>This study was supported by the National Key Research and Development Program of China (2023YFC2705500, 2023YFC2705501, 2023YFC2705505, 2019YFA0802604); National Natural Science Foundation of China (82130046, 82320108009, 82371660, 32300710); Shanghai leading talent program, Innovative research team of high-level local universities in Shanghai (SHSMU-ZLCX20210201, SHSMU-ZLCX20210200, SHSMU-ZLCX20180401), Shanghai Jiaotong University School of Medicine Affiliated Renji Hospital Clinical Research Innovation Cultivation Fund Program (RJPY-DZX-003), Science and Technology Commission of Shanghai Municipality (23Y11901400), Shanghai\u2019s Top Priority Research Center Construction Project (2023ZZ02002), and Three-Year Action Plan for Strengthening the Construction of the Public Health System in Shanghai (GWVI-11.1-36). The authors have no conflicts of interest to declare.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>N\/A.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/deae172","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T01:04:56Z","timestamp":1724893496000},"page":"2249-2258","source":"Crossref","is-referenced-by-count":4,"title":["Trophectoderm grade is associated with the risk of placenta previa in frozen-thawed single-blastocyst transfer cycles"],"prefix":"10.1093","volume":"39","author":[{"given":"Jiaan","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaqiong","family":"He","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinyu","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven R","family":"Lindheim","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai,","place":["China"]},{"name":"Department of Obstetrics and Gynecology, Baylor Scott & White , Temple, TX,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9073-8142","authenticated-orcid":false,"given":"Yun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai,","place":["China"]},{"name":"Shanghai Key Laboratory for Assisted Reproduction and Reproductive Genetics , Shanghai,","place":["China"]},{"name":"Shanghai Immune Therapy Institute, Shanghai Jiao Tong University School of Medicine-Affiliated Renji Hospital , Shanghai,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,8,28]]},"reference":[{"key":"2024100305522170800_deae172-B1","doi-asserted-by":"crossref","first-page":"3289","DOI":"10.1093\/humrep\/der325","article-title":"Trophectoderm morphology: an important parameter for predicting live birth after single blastocyst transfer","volume":"26","author":"Ahlstr\u00f6m","year":"2011","journal-title":"Hum Reprod"},{"key":"2024100305522170800_deae172-B2","doi-asserted-by":"crossref","first-page":"110784","DOI":"10.1016\/j.celrep.2022.110784","article-title":"Aberrant H3K4me3 modification of epiblast genes of extraembryonic tissue causes placental defects and implantation failure in mouse IVF embryos","volume":"39","author":"Bai","year":"2022","journal-title":"Cell Rep"},{"key":"2024100305522170800_deae172-B3","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1007\/s10815-019-01580-0","article-title":"Association between blastocyst morphology and pregnancy and perinatal outcomes following fresh and cryopreserved embryo transfer","volume":"36","author":"Bakkensen","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"2024100305522170800_deae172-B4","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1093\/humrep\/deaa149","article-title":"High-quality human preimplantation embryos stimulate endometrial stromal cell migration via secretion of microRNA hsa-miR-320a","volume":"35","author":"Berkhout","year":"2020","journal-title":"Hum Reprod"},{"key":"2024100305522170800_deae172-B5","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s10815-017-1107-z","article-title":"High-quality human preimplantation embryos actively influence endometrial stromal cell migration","volume":"35","author":"Berkhout","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"2024100305522170800_deae172-B6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/humrep\/deab242","article-title":"Developmental stage and morphology of the competent blastocyst are associated with sex of the child but not with other obstetric outcomes: a multicenter cohort study","volume":"37","author":"Borgstrom","year":"2021","journal-title":"Hum Reprod"},{"key":"2024100305522170800_deae172-B7","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.fertnstert.2022.08.013","article-title":"A unique placenta previa risk factor profile for pregnancies conceived with assisted reproductive technology","volume":"118","author":"Carusi","year":"2022","journal-title":"Fertil Steril"},{"key":"2024100305522170800_deae172-B8","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1007\/s10815-014-0317-x","article-title":"Trophectoderm morphology predicts outcomes of pregnancy in vitrified-warmed single-blastocyst transfer cycle in a Chinese population","volume":"31","author":"Chen","year":"2014","journal-title":"J Assist Reprod Genet"},{"key":"2024100305522170800_deae172-B9","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.rbmo.2021.02.013","article-title":"Prediction of embryo survival and live birth rates after cryotransfers of vitrified blastocysts","volume":"42","author":"Coello","year":"2021","journal-title":"Reprod Biomed Online"},{"key":"2024100305522170800_deae172-B10","first-page":"6975","article-title":"The cumulative effect of assisted reproduction procedures on placental development and epigenetic perturbations in a mouse model","volume":"24","author":"de Waal","year":"2015","journal-title":"Hum Mol Genet"},{"key":"2024100305522170800_deae172-B11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s10815-015-0609-9","article-title":"Quantitative and qualitative trophectoderm grading allows for prediction of live birth and gender","volume":"33","author":"Ebner","year":"2016","journal-title":"J Assist Reprod Genet"},{"key":"2024100305522170800_deae172-B12","doi-asserted-by":"crossref","first-page":"e0170194","DOI":"10.1371\/journal.pone.0170194","article-title":"The incidence of postpartum hemorrhage in pregnant women with placenta previa: a systematic review and meta-analysis","volume":"12","author":"Fan","year":"2017","journal-title":"PLoS One"},{"key":"2024100305522170800_deae172-B13","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1093\/humrep\/dead045","article-title":"Does embryo quality at transfer affect obstetric outcomes and placental findings?","volume":"38","author":"Ganer Herman","year":"2023","journal-title":"Hum Reprod"},{"key":"2024100305522170800_deae172-B14","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.fertnstert.2003.07.023","article-title":"Single blastocyst transfer: a prospective randomized trial","volume":"81","author":"Gardner","year":"2004","journal-title":"Fertil Steril"},{"key":"2024100305522170800_deae172-B15","first-page":"2282","article-title":"Perinatal and maternal outcome after vitrification of blastocysts: a Nordic study in singletons from the CoNARTaS group","volume":"34","author":"Ginstrom Ernstad","year":"2019","journal-title":"Hum Reprod"},{"key":"2024100305522170800_deae172-B16","first-page":"CD002118","article-title":"Cleavage stage versus blastocyst stage embryo transfer in assisted reproductive technology","volume":"5","author":"Glujovsky","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2024100305522170800_deae172-B17","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.fertnstert.2012.12.003","article-title":"Trophectoderm grade predicts outcomes of single-blastocyst transfers","volume":"99","author":"Hill","year":"2013","journal-title":"Fertil Steril"},{"key":"2024100305522170800_deae172-B18","doi-asserted-by":"crossref","first-page":"hoab036","DOI":"10.1093\/hropen\/hoab036","article-title":"Blastocyst quality and perinatal outcomes in women undergoing single blastocyst transfer in frozen cycles","volume":"2021","author":"Hu","year":"2021","journal-title":"Hum Reprod Open"},{"key":"2024100305522170800_deae172-B19","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3389\/fphys.2020.00415","article-title":"Poor embryo quality is associated with a higher risk of low birthweight in vitrified-warmed single embryo transfer cycles","volume":"11","author":"Huang","year":"2020","journal-title":"Front Physiol"},{"key":"2024100305522170800_deae172-B20","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/j.jogc.2019.07.019","article-title":"Guideline No. 402: diagnosis and management of placenta previa","volume":"42","author":"Jain","year":"2020","journal-title":"J Obstet Gynaecol Can"},{"key":"2024100305522170800_deae172-B21","doi-asserted-by":"crossref","first-page":"2393","DOI":"10.1093\/humrep\/deu223","article-title":"Controlled ovarian hyperstimulation leads to high progesterone and estradiol levels during early pregnancy","volume":"29","author":"Jarvela","year":"2014","journal-title":"Hum Reprod"},{"key":"2024100305522170800_deae172-B22","doi-asserted-by":"crossref","first-page":"1010453","DOI":"10.3389\/fendo.2022.1010453","article-title":"Blastocyst quality and perinatal outcomes of frozen-thawed single blastocyst transfer cycles","volume":"13","author":"Jia","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2024100305522170800_deae172-B23","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1016\/j.fertnstert.2015.01.021","article-title":"Cryopreserved embryo transfer is an independent risk factor for placenta accreta","volume":"103","author":"Kaser","year":"2015","journal-title":"Fertil Steril"},{"key":"2024100305522170800_deae172-B24","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.fertnstert.2014.10.039","article-title":"Birth weight is associated with inner cell mass grade of blastocysts","volume":"103","author":"Licciardi","year":"2015","journal-title":"Fertil Steril"},{"key":"2024100305522170800_deae172-B25","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.fertnstert.2020.05.021","article-title":"Effect of pretreatment oral contraceptives on fresh and cumulative live birth in vitro fertilization outcomes in ovulatory women","volume":"114","author":"Lu","year":"2020","journal-title":"Fertil Steril"},{"key":"2024100305522170800_deae172-B26","doi-asserted-by":"crossref","first-page":"350.e1","DOI":"10.1016\/j.ajog.2019.10.003","article-title":"In vitro fertilization and risk for hypertensive disorders of pregnancy: associations with treatment parameters","volume":"222","author":"Luke","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"2024100305522170800_deae172-B27","doi-asserted-by":"crossref","first-page":"327.e1","DOI":"10.1016\/j.ajog.2017.04.006","article-title":"Pregnancy, birth, and infant outcomes by maternal fertility status: the Massachusetts Outcomes Study of Assisted Reproductive Technology","volume":"217","author":"Luke","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"2024100305522170800_deae172-B28","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1093\/humupd\/dmx031","article-title":"Is frozen embryo transfer better for mothers and babies? Can cumulative meta-analysis provide a definitive answer?","volume":"24","author":"Maheshwari","year":"2018","journal-title":"Hum Reprod Update"},{"key":"2024100305522170800_deae172-B29","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.fertnstert.2017.01.024","article-title":"Perinatal outcomes among singletons after assisted reproductive technology with single-embryo or double-embryo transfer versus no assisted reproductive technology","volume":"107","author":"Martin","year":"2017","journal-title":"Fertil Steril"},{"key":"2024100305522170800_deae172-B30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humrep\/deh028","article-title":"What is the most relevant standard of success in assisted reproduction? The singleton, term gestation, live birth rate per cycle initiated: the BESST endpoint for assisted reproduction","volume":"19","author":"Min","year":"2004","journal-title":"Hum Reprod"},{"key":"2024100305522170800_deae172-B31","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ejogrb.2011.07.008","article-title":"Maternal morbidity associated with placenta praevia among women who had elective caesarean section","volume":"159","author":"Onwere","year":"2011","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2024100305522170800_deae172-B32","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/humupd\/dms018","article-title":"Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF\/ICSI: a systematic review and meta-analysis","volume":"18","author":"Pandey","year":"2012","journal-title":"Hum Reprod Update"},{"key":"2024100305522170800_deae172-B33","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humupd\/dms044","article-title":"Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis","volume":"19","author":"Pinborg","year":"2013","journal-title":"Hum Reprod Update"},{"key":"2024100305522170800_deae172-B9002431","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.1093\/humrep\/deu240","article-title":"Risk of placenta praevia is linked to endometrial thickness in a retrospective cohort study of 4537 singleton assisted reproduction technology births","volume":"29","author":"Rombauts","year":"2014","journal-title":"Hum Reprod"},{"key":"2024100305522170800_deae172-B34","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.1093\/humrep\/del153","article-title":"Increased risk of placenta previa in pregnancies following IVF\/ICSI; a comparison of ART and non-ART pregnancies in the same mother","volume":"21","author":"Romundstad","year":"2006","journal-title":"Hum Reprod"},{"key":"2024100305522170800_deae172-B35","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s00404-010-1598-7","article-title":"Critical analysis of risk factors and outcome of placenta previa","volume":"284","author":"Rosenberg","year":"2011","journal-title":"Arch Gynecol Obstet"},{"key":"2024100305522170800_deae172-B36","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.fertnstert.2016.04.023","article-title":"Are intracytoplasmic sperm injection and high serum estradiol compounding risk factors for adverse obstetric outcomes in assisted reproductive technology?","volume":"106","author":"Royster","year":"2016","journal-title":"Fertil Steril"},{"key":"2024100305522170800_deae172-B37","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.fertnstert.2017.10.019","article-title":"Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis","volume":"109","author":"Sha","year":"2018","journal-title":"Fertil Steril"},{"key":"2024100305522170800_deae172-B38","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0140-6736(78)92957-4","article-title":"Birth after the reimplantation of a human embryo","volume":"2","author":"Steptoe","year":"1978","journal-title":"Lancet"},{"key":"2024100305522170800_deae172-B39","doi-asserted-by":"crossref","first-page":"646220","DOI":"10.3389\/fmed.2021.646220","article-title":"Risks of placenta previa and hypertensive disorders of pregnancy are associated with endometrial preparation methods in frozen-thawed embryo transfers","volume":"8","author":"Tao","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"2024100305522170800_deae172-B40","doi-asserted-by":"crossref","first-page":"e10258","DOI":"10.1371\/journal.pone.0010258","article-title":"Natural selection of human embryos: decidualizing endometrial stromal cells serve as sensors of embryo quality upon implantation","volume":"5","author":"Teklenburg","year":"2010","journal-title":"PLoS One"},{"key":"2024100305522170800_deae172-B41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1111\/1471-0528.15227","article-title":"Are singleton pregnancies after assisted reproduction technology (ART) associated with a higher risk of placental anomalies compared with non-ART singleton pregnancies? A systematic review and meta-analysis","volume":"126","author":"Vermey","year":"2019","journal-title":"BJOG"},{"key":"2024100305522170800_deae172-B42","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/S0140-6736(14)60932-6","article-title":"International standards for newborn weight, length, and head circumference by gestational age and sex: the Newborn Cross-Sectional Study of the INTERGROWTH-21st Project","volume":"384","author":"Villar","year":"2014","journal-title":"Lancet"},{"key":"2024100305522170800_deae172-B43","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.fertnstert.2022.09.030","article-title":"The impact of blastocyst freezing and biopsy on the association of blastocyst morphological parameters with live birth and singleton birthweight","volume":"119","author":"Wang","year":"2023","journal-title":"Fertil Steril"},{"key":"2024100305522170800_deae172-B44","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1016\/S0140-6736(18)32843-5","article-title":"Frozen versus fresh single blastocyst transfer in ovulatory women: a multicentre, randomised controlled trial","volume":"393","author":"Wei","year":"2019","journal-title":"Lancet"},{"key":"2024100305522170800_deae172-B45","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/AOG.0b013e318269baac","article-title":"Natural history of placenta previa in twins","volume":"120","author":"Weis","year":"2012","journal-title":"Obstet Gynecol"},{"key":"2024100305522170800_deae172-B46","doi-asserted-by":"crossref","first-page":"2111","DOI":"10.1093\/humrep\/deab088","article-title":"Advanced trophectoderm quality increases the risk of a large for gestational age baby in single frozen-thawed blastocyst transfer cycles","volume":"36","author":"Xie","year":"2021","journal-title":"Hum Reprod"},{"key":"2024100305522170800_deae172-B47","doi-asserted-by":"crossref","first-page":"107181","DOI":"10.1016\/j.envint.2022.107181","article-title":"Ambient air pollution on fecundity and live birth in women undergoing assisted reproductive technology in the Yangtze River Delta of China","volume":"162","author":"Zhang","year":"2022","journal-title":"Environ Int"},{"key":"2024100305522170800_deae172-B48","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/j.rbmo.2022.06.025","article-title":"Poor morphology of inner cell mass increases birth weight and large for gestational age","volume":"45","author":"Zhu","year":"2022","journal-title":"Reprod Biomed Online"},{"key":"2024100305522170800_deae172-B49","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1080\/14767050701530163","article-title":"Placenta previa and the risk of preterm delivery","volume":"20","author":"Zlatnik","year":"2007","journal-title":"J Matern Fetal Neonatal Med"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/39\/10\/2249\/59401546\/deae172.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/39\/10\/2249\/59401546\/deae172.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T05:53:10Z","timestamp":1727934790000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/39\/10\/2249\/7743370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8,28]]},"references-count":50,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,8,28]]},"published-print":{"date-parts":[[2024,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deae172","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,10]]},"published":{"date-parts":[[2024,8,28]]}}}