{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T05:51:09Z","timestamp":1792907469807,"version":"4.5.0"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,1]]},"abstract":"Abstract<\/jats:title>\n \n STUDY QUESTION<\/jats:title>\n What is the impact of male age- and sperm-related factors on embryonic aneuploidy?<\/jats:p>\n <\/jats:sec>\n \n SUMMARY ANSWER<\/jats:title>\n Using a 3-fold analysis framework encompassing patient-level, embryo-level, and matching analysis, we found no clinically significant interactions between male age and sperm quality with embryo ploidy.<\/jats:p>\n <\/jats:sec>\n \n WHAT IS KNOWN ALREADY<\/jats:title>\n While the effect of maternal age on embryo chromosomal aneuploidy is well-established, the impact of male age and sperm quality on ploidy is less well-defined.<\/jats:p>\n <\/jats:sec>\n \n STUDY DESIGN, SIZE, DURATION<\/jats:title>\n This retrospective cohort study analyzed autologous preimplantation genetic testing for aneuploidy (PGT-A) and frozen embryo transfer cycles from December 2014 to June 2021. The study involved 11\u00a0087 cycles from 8484 patients, with a total of 35\u00a0797 embryos.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n The aneuploidy rate, calculated as the ratio of aneuploid blastocysts to the total number of blastocysts biopsied in a single treatment cycle, was evaluated. In the embryo-level analysis, the main outcome measure was the ploidy state of the embryos. The study employed a multifaceted analytical approach that included a patient-level analysis using generalized linear mixed models, an embryo-level analysis focusing on chromosomal ploidy, and a propensity score matching analysis contrasting groups with distinct ploidy rates (0% and 100%). There were no interventions as this was an observational study of PGT-A cycles.<\/jats:p>\n <\/jats:sec>\n \n MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n No clinically relevant factors influencing ploidy rate related to male and sperm quality were revealed. In contrast, female age (coefficient\u2009=\u2009\u22120.053), BMI (coefficient\u2009=\u20090.003), prior ART cycle (coefficient\u2009=\u2009\u22120.066), and number of oocytes retrieved (coefficient\u2009=\u2009\u22120.018) were identified at the patient level. Embryo analysis identified age (coefficient\u2009=\u2009\u22120.1244) and ICSI usage (coefficient\u2009=\u2009\u22120.0129) as significant factors. Despite these, no significant interactions between male and female assessed factors on the ploidy rate emerged. Propensity score matching between maximal (100% vs 0%) euploid rates did not reveal significant differences of influence by male age and sperm quality.<\/jats:p>\n <\/jats:sec>\n \n LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n The focus on patients having blastocyst biopsy for PGT-A may not reflect the broader IVF population. Other semen quality parameters like DNA fragmentation were not included. Exclusion of embryo mosaicism from the analysis could affect aneuploidy rate interpretations. There may also be unmeasured influences like lifestyle or environmental factors.<\/jats:p>\n <\/jats:sec>\n \n WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n Male age and sperm quality parameters were consistent across both maximal and minimal ploidy rate comparisons. No significant clinical characteristics related to the factors assessed for the male-influenced blastocyst ploidy status, confirming the dominancy of the oocyte and female age.<\/jats:p>\n <\/jats:sec>\n \n STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n The study was not funded. There are no competing interests.<\/jats:p>\n <\/jats:sec>\n \n TRIAL REGISTRATION NUMBER<\/jats:title>\n N\/A.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humrep\/deae224","type":"journal-article","created":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T17:51:40Z","timestamp":1727805100000},"page":"2442-2452","source":"Crossref","is-referenced-by-count":14,"title":["Do sperm factors influence embryonic aneuploidy? Long live the oocyte"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8880-8298","authenticated-orcid":false,"given":"Yuval","family":"Fouks","sequence":"first","affiliation":[{"name":"Boston IVF, IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]},{"name":"Reproductive Services, The Royal Women\u2019s Hospital , Parkville, Victoria,","place":["Australia"]},{"name":"The Department of Gynecology and Obstetrics, Faculty of Medical and Health Sciences, Tel Aviv University , Tel Aviv,","place":["Israel"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Boston IVF, IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center , Boston, MA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veda","family":"Sripada","sequence":"additional","affiliation":[{"name":"Harvard T.H. Chan School of Public Health , Cambridge, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S","family":"Penzias","sequence":"additional","affiliation":[{"name":"Boston IVF, IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center , Boston, MA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Bortoletto","sequence":"additional","affiliation":[{"name":"Boston IVF, IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center , Boston, MA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9509-6791","authenticated-orcid":false,"given":"Denny","family":"Sakkas","sequence":"additional","affiliation":[{"name":"Boston IVF, IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,10,1]]},"reference":[{"key":"2024110408195389900_deae224-B1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12958-015-0032-1","article-title":"A unique view on male infertility around the globe","volume":"13","author":"Agarwal","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"2024110408195389900_deae224-B2","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1023\/A:1009454114973","article-title":"The effects of age and abnormal sperm count on the nondisjunction of spermatozoa","volume":"17","author":"Asada","year":"2000","journal-title":"J Assist Reprod Genet"},{"key":"2024110408195389900_deae224-B3","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/j.fertnstert.2010.11.044","article-title":"Paternal body mass index is associated with decreased blastocyst development and reduced live birth rates following assisted reproductive technology","volume":"95","author":"Bakos","year":"2011","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B4","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1093\/humrep\/deaa162","article-title":"Chromosomal abnormalities after ICSI in relation to semen parameters: results in 1114 fetuses and 1391 neonates from a single center","volume":"35","author":"Belva","year":"2020","journal-title":"Hum Reprod"},{"key":"2024110408195389900_deae224-B5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1046\/j.1365-2605.2002.00373.x","article-title":"How work-place conditions, environmental toxicants and lifestyle affect male reproductive function","volume":"25","author":"Bonde","year":"2002","journal-title":"Int J Androl"},{"key":"2024110408195389900_deae224-B6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.fertnstert.2022.04.020","article-title":"Relationship between paternal factors and embryonic aneuploidy of paternal origin","volume":"118","author":"Bonus","year":"2022","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10815-011-9537-5","article-title":"The effects of male aging on semen quality, sperm DNA fragmentation and chromosomal abnormalities in an infertile population","volume":"28","author":"Brahem","year":"2011","journal-title":"J Assist Reprod Genet"},{"key":"2024110408195389900_deae224-B8","doi-asserted-by":"crossref","first-page":"572","DOI":"10.4103\/aja202297","article-title":"Decade of WHO 2010: total sperm number temporal trend and role of lifestyle factors","volume":"25","author":"Cargnelutti","year":"2023","journal-title":"Asian J Androl"},{"key":"2024110408195389900_deae224-B9","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1007\/s10815-019-01549-z","article-title":"Advanced paternal age does not affect embryo aneuploidy following blastocyst biopsy in egg donor cycles","volume":"36","author":"Carrasquillo","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"2024110408195389900_deae224-B10","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/01485010290099390","article-title":"Sperm DNA fragmentation is increased in couples with unexplained recurrent pregnancy loss","volume":"49","author":"Carrell","year":"2003","journal-title":"Arch Androl"},{"key":"2024110408195389900_deae224-B11","doi-asserted-by":"crossref","first-page":"e0165125","DOI":"10.1371\/journal.pone.0165125","article-title":"Measuring sperm DNA fragmentation and clinical outcomes of medically assisted reproduction: a systematic review and meta-analysis","volume":"11","author":"Cissen","year":"2016","journal-title":"PLoS One"},{"key":"2024110408195389900_deae224-B12","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1007\/s10815-018-1304-4","article-title":"Paternal factors contributing to embryo quality","volume":"35","author":"Colaco","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"2024110408195389900_deae224-B13","doi-asserted-by":"crossref","first-page":"e14409","DOI":"10.1111\/and.14409","article-title":"The association of impaired semen quality and pregnancy rates in assisted reproduction technology cycles: systematic review and meta-analysis","volume":"54","author":"Del Giudice","year":"2022","journal-title":"Andrologia"},{"key":"2024110408195389900_deae224-B14","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.fertnstert.2020.03.034","article-title":"Is there a correlation between paternal age and aneuploidy rate? An analysis of 3,118 embryos derived from young egg donors","volume":"114","author":"Dviri","year":"2020","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B15","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1007\/s10815-021-02299-7","article-title":"The effect of rapid and delayed insemination on reproductive outcome in conventional insemination and intracytoplasmic sperm injection in vitro fertilization cycles","volume":"38","author":"Esiso","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"2024110408195389900_deae224-B16","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1093\/humrep\/14.4.1039","article-title":"Utility of the sperm chromatin structure assay as a diagnostic and prognostic tool in the human fertility clinic","volume":"14","author":"Evenson","year":"1999","journal-title":"Hum Reprod"},{"key":"2024110408195389900_deae224-B17","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1080\/10503307.2020.1785037","article-title":"Generalized linear mixed-model (GLMM) trees: a flexible decision-tree method for multilevel and longitudinal data","volume":"31","author":"Fokkema","year":"2021","journal-title":"Psychother Res"},{"key":"2024110408195389900_deae224-B18","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.fertnstert.2022.06.008","article-title":"A diagnosis of diminished ovarian reserve does not impact embryo aneuploidy or live birth rates compared to patients with normal ovarian reserve","volume":"118","author":"Fouks","year":"2022","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B19","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.fertnstert.2013.11.004","article-title":"The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening","volume":"101","author":"Franasiak","year":"2014","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B20","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S0889-8529(05)70042-6","article-title":"Declining male fertility and environmental factors","volume":"27","author":"Giwercman","year":"1998","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2024110408195389900_deae224-B21","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1126\/science.aav7321","article-title":"Chromosome errors in human eggs shape natural fertility over reproductive life span","volume":"365","author":"Gruhn","year":"2019","journal-title":"Science"},{"key":"2024110408195389900_deae224-B22","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1093\/humrep\/dev058","article-title":"Total motile sperm count: a better indicator for the severity of male factor infertility than the WHO sperm classification system","volume":"30","author":"Hamilton","year":"2015","journal-title":"Hum Reprod"},{"key":"2024110408195389900_deae224-B23","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1038\/344768a0","article-title":"Pregnancies from biopsied human preimplantation embryos sexed by Y-specific DNA amplification","volume":"344","author":"Handyside","year":"1990","journal-title":"Nature"},{"key":"2024110408195389900_deae224-B24","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/pd.5816","article-title":"Copy number analysis of meiotic and postzygotic mitotic aneuploidies in trophectoderm cells biopsied at the blastocyst stage and arrested embryos","volume":"41","author":"Handyside","year":"2021","journal-title":"Prenat Diagn"},{"key":"2024110408195389900_deae224-B25","first-page":"99","article-title":"Impact of paternal age on embryology and pregnancy outcomes in the setting of a euploid single-embryo transfer with ejaculated sperm: retrospective cohort study","volume":"1","author":"Hanson","year":"2020","journal-title":"F S Rep"},{"key":"2024110408195389900_deae224-B26","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/35066065","article-title":"To err (meiotically) is human: the genesis of human aneuploidy","volume":"2","author":"Hassold","year":"2001","journal-title":"Nat Rev Genet"},{"key":"2024110408195389900_deae224-B27","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1097\/MOP.0b013e328332c6ab","article-title":"Maternal age and chromosomally abnormal pregnancies: what we know and what we wish we knew","volume":"21","author":"Hassold","year":"2009","journal-title":"Curr Opin Pediatr"},{"key":"2024110408195389900_deae224-B28","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/0959-437X(93)90111-2","article-title":"Trisomy in humans: incidence, origin and etiology","volume":"3","author":"Hassold","year":"1993","journal-title":"Curr Opin Genet Dev"},{"key":"2024110408195389900_deae224-B29","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1002\/pd.5910","article-title":"Missed connections: recombination and human aneuploidy","volume":"41","author":"Hassold","year":"2021","journal-title":"Prenat Diagn"},{"key":"2024110408195389900_deae224-B30","doi-asserted-by":"crossref","first-page":"2356","DOI":"10.1093\/humrep\/deaa161","article-title":"Comparison of pregnancy outcomes following preimplantation genetic testing for aneuploidy using a matched propensity score design","volume":"35","author":"Haviland","year":"2020","journal-title":"Hum Reprod"},{"key":"2024110408195389900_deae224-B31","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.fertnstert.2023.04.040","article-title":"A North American study of anthropometric factors and semen quality","volume":"120","author":"Joseph","year":"2023","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B32","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/humrep\/deaa332","article-title":"Association between preconception paternal health and pregnancy loss in the USA: an analysis of US claims data","volume":"36","author":"Kasman","year":"2021","journal-title":"Hum Reprod"},{"key":"2024110408195389900_deae224-B33","doi-asserted-by":"crossref","first-page":"k4372","DOI":"10.1136\/bmj.k4372","article-title":"Association of paternal age with perinatal outcomes between 2007 and 2016 in the United States: population based cohort study","volume":"363","author":"Khandwala","year":"2018","journal-title":"BMJ"},{"key":"2024110408195389900_deae224-B34","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1111\/andr.13362","article-title":"Can a sperm selection technique improve embryo ploidy?","volume":"11","author":"Kocur","year":"2022","journal-title":"Andrology"},{"key":"2024110408195389900_deae224-B35","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.rbmo.2018.11.023","article-title":"Incidence and origin of meiotic whole and segmental chromosomal aneuploidies detected by karyomapping","volume":"38","author":"Kubicek","year":"2019","journal-title":"Reprod Biomed Online"},{"key":"2024110408195389900_deae224-B36","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10815-006-9022-8","article-title":"The effects of sperm quality on embryo development after intracytoplasmic sperm injection","volume":"23","author":"Loutradi","year":"2006","journal-title":"J Assist Reprod Genet"},{"key":"2024110408195389900_deae224-B37","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.3390\/ijms24021446","article-title":"Sperm DNA damage and its relevance in fertility treatment: a review of recent literature and current practice guidelines","volume":"24","author":"Marinaro","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2024110408195389900_deae224-B38","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.annepidem.2018.12.001","article-title":"Parental age and stillbirth: a population-based cohort of nearly 10 million California deliveries from 1991 to 2011","volume":"31","author":"Mayo","year":"2019","journal-title":"Ann Epidemiol"},{"key":"2024110408195389900_deae224-B39","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.fertnstert.2023.08.952","article-title":"Genetic causes of sporadic and recurrent miscarriage","volume":"120","author":"Melo","year":"2023","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B40","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1016\/j.fertnstert.2019.07.1346","article-title":"Preimplantation genetic testing for aneuploidy versus morphology as selection criteria for single frozen-thawed embryo transfer in good-prognosis patients: a multicenter randomized clinical trial","volume":"112","author":"Munne","year":"2019","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B41","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/humrep\/dey346","article-title":"To test or not to test? A framework for counselling patients on preimplantation genetic testing for aneuploidy (PGT-A)","volume":"34","author":"Murphy","year":"2019","journal-title":"Hum Reprod"},{"key":"2024110408195389900_deae224-B42","doi-asserted-by":"crossref","first-page":"100103","DOI":"10.1016\/j.xagr.2022.100103","article-title":"Application of machine learning to predict aneuploidy and mosaicism in embryos from in vitro fertilization cycles","volume":"2","author":"Ortiz","year":"2022","journal-title":"AJOG Glob Rep"},{"key":"2024110408195389900_deae224-B43","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3109\/14647273.2010.531883","article-title":"Environmental and lifestyle factors associated with sperm DNA damage","volume":"13","author":"Pacey","year":"2010","journal-title":"Hum Fertil (Camb)"},{"key":"2024110408195389900_deae224-B44","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.fertnstert.2023.04.020","article-title":"Compared with conventional insemination, intracytoplasmic sperm injection provides no benefit in cases of nonmale factor infertility as evidenced by comparable euploidy rate","volume":"120","author":"Patel","year":"2023","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B45","first-page":"89","article-title":"How general semen quality influences the blastocyst formation rate: analysis of 4205 IVF cycles","volume":"22","author":"Piccolomini","year":"2018","journal-title":"JBRA Assist Reprod"},{"key":"2024110408195389900_deae224-B46","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.fertnstert.2023.02.014","article-title":"Recurrent implantation failure: reality or a statistical mirage?: consensus statement from the July 1, 2022 Lugano Workshop on recurrent implantation failure","volume":"120","author":"Pirtea","year":"2023","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B47","first-page":"18","article-title":"Causes of male infertility: a 9-year prospective monocentre study on 1737 patients with reduced total sperm counts","volume":"32","author":"Punab","year":"2017","journal-title":"Hum Reprod"},{"key":"2024110408195389900_deae224-B48","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ajhg.2023.03.003","article-title":"Identifying parental and cell-division origins of aneuploidy in the human blastocyst","volume":"110","author":"Rana","year":"2023","journal-title":"Am J Hum Genet"},{"key":"2024110408195389900_deae224-B49","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.fertnstert.2022.06.021","article-title":"We know to err (meiotically) is human, but do paternal factors impact paternal aneuploidy?","volume":"118","author":"Reig","year":"2022","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B50","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1093\/biolre\/ioz125","article-title":"Sperm chromosomal abnormalities and their contribution to human embryo aneuploidy","volume":"101","author":"Rodrigo","year":"2019","journal-title":"Biol Reprod"},{"key":"2024110408195389900_deae224-B51","doi-asserted-by":"crossref","first-page":"859","DOI":"10.3109\/09513590.2013.808327","article-title":"Endometriosis and IVF: are agonists really better? Analysis of 1180 cycles with the propensity score matching","volume":"29","author":"Rodriguez-Purata","year":"2013","journal-title":"Gynecol Endocrinol"},{"key":"2024110408195389900_deae224-B52","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1016\/j.fertnstert.2023.08.972","article-title":"From oocytes to a live birth: are we improving the biological efficiency?","volume":"120","author":"Sabbagh","year":"2023","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B53","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/humrep\/14.1.4","article-title":"The use of blastocyst culture to avoid inheritance of an abnormal paternal genome after ICSI","volume":"14","author":"Sakkas","year":"1999","journal-title":"Hum Reprod"},{"key":"2024110408195389900_deae224-B54","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.fertnstert.2003.12.039","article-title":"Extent of nuclear DNA damage in ejaculated spermatozoa impacts on blastocyst development after in vitro fertilization","volume":"82","author":"Seli","year":"2004","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B55","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1093\/humrep\/13.6.1632","article-title":"Blastocyst development from supernumerary embryos after intracytoplasmic sperm injection: a paternal influence?","volume":"13","author":"Shoukir","year":"1998","journal-title":"Hum Reprod"},{"key":"2024110408195389900_deae224-B56","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.procs.2016.05.103","article-title":"Bootstrapping with R to make generalized inference for regression model","volume":"86","author":"Sillabutra","year":"2016","journal-title":"Procedia Comput Sci"},{"key":"2024110408195389900_deae224-B57","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13039-014-0068-5","article-title":"Determining parental origin of embryo aneuploidy: analysis of genetic error observed in 305 embryos derived from anonymous donor oocyte IVF cycles","volume":"7","author":"Sills","year":"2014","journal-title":"Mol Cytogenet"},{"key":"2024110408195389900_deae224-B58","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12958-023-01054-0","article-title":"Lifestyle-, environmental-, and additional health factors associated with an increased sperm DNA fragmentation: a systematic review and meta-analysis","volume":"21","author":"Szab\u00f3","year":"2023","journal-title":"Reprod Biol Endocrinol"},{"key":"2024110408195389900_deae224-B59","doi-asserted-by":"crossref","first-page":"gaab042","DOI":"10.1093\/molehr\/gaab042","article-title":"The paternal toolbox for embryo development and health","volume":"27","author":"Tarozzi","year":"2021","journal-title":"Mol Hum Reprod"},{"key":"2024110408195389900_deae224-B60","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3109\/10408449609012525","article-title":"Occupational hazards for the male reproductive system","volume":"26","author":"Tas","year":"1996","journal-title":"Crit Rev Toxicol"},{"key":"2024110408195389900_deae224-B61","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/humupd\/dmu016","article-title":"The origin, mechanisms, incidence and clinical consequences of chromosomal mosaicism in humans","volume":"20","author":"Taylor","year":"2014","journal-title":"Hum Reprod Update"},{"key":"2024110408195389900_deae224-B62","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1001\/jama.2019.21558","article-title":"Using propensity score methods to create target populations in observational clinical research","volume":"323","author":"Thomas","year":"2020","journal-title":"JAMA"},{"key":"2024110408195389900_deae224-B63","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.fertnstert.2016.10.037","article-title":"How many oocytes are optimal to achieve multiple live births with one stimulation cycle? The one-and-done approach","volume":"107","author":"Vaughan","year":"2017","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B64","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.fertnstert.2023.02.036","article-title":"Does maternal age affect assisted reproduction technology success rates after euploid embryo transfer? A systematic review and meta-analysis","volume":"120","author":"Vitagliano","year":"2023","journal-title":"Fertil Steril"},{"key":"2024110408195389900_deae224-B65","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"WHO","year":"2021"},{"key":"2024110408195389900_deae224-B66","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.1056\/NEJMoa2103613","article-title":"Live birth with or without preimplantation genetic testing for aneuploidy","volume":"385","author":"Yan","year":"2021","journal-title":"N Engl J Med"},{"key":"2024110408195389900_deae224-B67","doi-asserted-by":"crossref","first-page":"1072176","DOI":"10.3389\/fendo.2022.1072176","article-title":"Correlation study of male semen parameters and embryo aneuploidy in preimplantation genetic testing for aneuploidy","volume":"13","author":"Yang","year":"2022","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/39\/11\/2442\/60241820\/deae224.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/39\/11\/2442\/60241820\/deae224.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T08:21:09Z","timestamp":1730708469000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/39\/11\/2442\/7802446"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,1]]},"references-count":67,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,10,1]]},"published-print":{"date-parts":[[2024,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deae224","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,10,1]]}}}