{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T03:01:43Z","timestamp":1793070103304,"version":"4.5.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Ovarian tissue cryopreservation and transplantation has emerged as a promising fertility preservation technique for individuals facing premature ovarian insufficiency due to various medical conditions or treatments. Xenotransplantation, involving the transplantation of ovarian tissue into animal hosts, has played a pivotal role in refining ovarian tissue cryopreservation and transplantation techniques and addressing key challenges. This review provides a comprehensive overview of the current landscape of ovarian tissue xenotransplantation research, focusing on its applications in investigating ovarian biology, optimizing ovarian tissue cryopreservation and transplantation protocols, and assessing safety concerns. It also explores the utilization of xenografting of human ovarian tissue in mouse models in the last 10 years. Key findings from preclinical studies investigating grafting site optimization, cryopreservation protocol refinement, the development of strategies to mitigate chemotherapy-induced damage, follicle development, tissue revascularization, and the risk of malignant cell reintroduction are summarized. Moreover, the review examines the ethical considerations surrounding the use of animals in ovarian tissue xenotransplantation research and suggests emerging alternative models that aim to minimize animal use while maximizing clinical relevance.<\/jats:p>","DOI":"10.1093\/humrep\/deae291","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T23:28:07Z","timestamp":1734478087000},"page":"410-419","source":"Crossref","is-referenced-by-count":12,"title":["Human ovarian tissue xenotransplantation: advancements, challenges, and future perspectives"],"prefix":"10.1093","volume":"40","author":[{"given":"Paweena","family":"Thuwanut","sequence":"first","affiliation":[{"name":"Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University , Bangkok,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen C R","family":"Leonel","sequence":"additional","affiliation":[{"name":"Animal Molecular and Cellular Biology, Louvain Institute of Biomolecular Science and Technology, Universit\u00e9 catholique de Louvain , Louvain-la-Neuve,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thalles Fernando","family":"Rocha Ruiz","sequence":"additional","affiliation":[{"name":"Department of Structural and Functional Biology, Institute of Biology, State University of Campinas , Campinas, S\u00e3o Paulo,","place":["Brazil"]},{"name":"P\u00f4le de Recherche en Physiopathologie de la Reproduction, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain , Brussels,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Porntip","family":"Sirayapiwat","sequence":"additional","affiliation":[{"name":"Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University , Bangkok,","place":["Thailand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1194-8393","authenticated-orcid":false,"given":"Stine Gry","family":"Kristensen","sequence":"additional","affiliation":[{"name":"Laboratory of Reproductive Biology, The Juliane Marie Centre for Women, Children, and Reproduction, University Hospital of Copenhagen, Rigshospitalet , Copenhagen,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1794-0368","authenticated-orcid":false,"given":"Christiani A","family":"Amorim","sequence":"additional","affiliation":[{"name":"P\u00f4le de Recherche en Physiopathologie de la Reproduction, Institut de Recherche Exp\u00e9rimentale et Clinique, Universit\u00e9 Catholique de Louvain , Brussels,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,1,2]]},"reference":[{"key":"2025030423092045300_deae291-B2","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s10815-011-9672-z","article-title":"Impact of freezing and thawing of human ovarian tissue on follicular growth after long-term xenotransplantation","volume":"28","author":"Amorim","year":"2011","journal-title":"J Assist Reprod Genet"},{"key":"2025030423092045300_deae291-B3","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.fertnstert.2012.07.1109","article-title":"Vitrification and xenografting of human ovarian tissue","volume":"98","author":"Amorim","year":"2012","journal-title":"Fertil Steril"},{"key":"2025030423092045300_deae291-B4","doi-asserted-by":"crossref","first-page":"1179558119884945","DOI":"10.1177\/1179558119884945","article-title":"Techniques of cryopreservation for ovarian tissue and whole 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