{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:15:39Z","timestamp":1791080139764,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004622","name":"Dutch Cancer Society","doi-asserted-by":"crossref","award":["NKI 2006-3631"],"award-info":[{"award-number":["NKI 2006-3631"]}],"id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Department of Obstetrics and Gynecology of Erasmus Medical Center","award":["2011-019"],"award-info":[{"award-number":["2011-019"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>What is the risk of endometrial cancer after long-term follow-up in women treated with ART between 1983 and 2001 compared with women in the general population and subfertile women who did not undergo ART?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>The risk of endometrial cancer is not increased in women who underwent ART in the Netherlands between 1983 and 2001, neither compared with women from the general population nor compared with subfertile women not treated with ART.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>Concerns have been raised that subfertility treatment may be associated with increased risk of endometrial cancer. However, published studies show inconsistent results regarding the effects of ovarian stimulation and specific subfertility diagnoses on endometrial cancer risk.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>A nationwide historic cohort study (the OMEGA-cohort) was conducted to examine the risk of cancer in women after ovarian stimulation for ART. The OMEGA-cohort comprises 30\u00a0625 women who received ovarian stimulation for ART (ART group) in 1983\u20132000 and 9988 subfertile women not treated with ART (non-ART group). After a median follow-up of 24\u2009years, endometrial cancer incidence was ascertained through linkage with the Netherlands Cancer Registry. Endometrial cancer risk in the cohort was compared with that in the general population using person-years analyses, and between the ART group and non-ART group using multivariable Cox regression analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>Detailed ART-treatment data were obtained from the medical records and complete information on parity and age at first birth was obtained through linkage with the Personal Records Database. Information on hysterectomy and endometriosis was collected through linkage with the Dutch Nationwide Pathology Databank (Palga). Data about lifestyle factors, including BMI, were obtained through a self-administered questionnaire.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>After a median follow-up duration of 24\u2009years, 137 endometrial cancers were diagnosed. Endometrial cancer risk after ART was not significantly increased compared with that in the general population (standardized incidence ratio\u2009=\u20091.19; 95% CI\u2009=\u20090.97\u20131.44) nor compared with that in the non-ART group (multivariably adjusted hazard ratio\u2009=\u20091.11; 95% CI\u2009=\u20090.74\u20131.67). Risk of endometrial cancer did not increase with longer follow-up or with more ART cycles, and the risk within the cohort, did not vary by cause of subfertility (male, tubal, unexplained, and other). Irrespective of ART treatment, endometrial cancer risk was increased in obese women and women with endometriosis, but decreased among parous women and women who used oral contraceptives.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>Although the findings of the study are reassuring, the median age of the women at the end of follow-up (median age 56\u2009years) was still rather young. Therefore, there is a need for at least 10\u201315 additional follow-up years to draw definitive conclusions. In addition, other large studies are needed to investigate the risk of endometrial cancer in women who underwent ART.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>The results of this study contribute to knowledge about long-term health after ART treatment, which is valuable to subfertile couples, considering or undergoing fertility treatments, and their healthcare providers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>This study was supported by a grant from the Dutch Cancer Society (NKI 2006-3631) and a departmental grant from the Department of Obstetrics and Gynecology of Erasmus Medical Center, Rotterdam, the Netherlands (2011-019). Ma.S. is Associate Editor of Human Reproduction Open; A.W.vd.B.-D received support for attending meetings and\/or travel from the Dutch Cancer Society; C.B.L. is Editor-in-Chief of Human Reproduction; A.E.P.C. is Associate Editor of Human Reproduction Update, received royalties from Uptodate Hyperthecosis, and participated at the Data Safety Monitoring Board of the DSMB POEM Study; F.B. has received research support from Merck, honoraria or consultation fees from Merck Healthcare KGaA, Bensis Healthcare, CooperSurgical, and participated in an advisory board for Merck and Ferring; J.L. has received research support from Ferring, Merck, and Roche Diagnostics, consulting fees and honoraria from Ferring, participated on a Data Safety Monitoring Board or Advisory Board of the LOCI trial, is President of the AE-PCOS society, and Member of the ASRM Integrity Committee; J.M.J.S. has received honoraria from Ferring and Merck, support for attending meetings and\/or travel from Ferring, Merck, and Good Life, and participated in the advisory board of Merck; L.L.v.L. received support for attending meetings and\/or travel from Olympus Medical Expert training; M.M.v.R. received support for attending meetings and\/or travel from Ferring; M.G. declares departmental research and educational grants from Ferring (location VUmc), unrelated to the presented work. The other authors declare no competing interests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>N\/A.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/deaf018","type":"journal-article","created":{"date-parts":[[2025,1,28]],"date-time":"2025-01-28T20:24:43Z","timestamp":1738095883000},"page":"739-749","source":"Crossref","is-referenced-by-count":2,"title":["Long-term risk of endometrial cancer after assisted reproductive technology"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3872-005X","authenticated-orcid":false,"given":"Mandy","family":"Spaan","sequence":"first","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]},{"name":"Department of Epidemiology and Data Science, Amsterdam UMC location University of Amsterdam , Amsterdam,","place":["The Netherlands"]},{"name":"Amsterdam Reproduction and Development Research Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7860-8839","authenticated-orcid":false,"given":"Alexandra W","family":"van den Belt-Dusebout","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]},{"name":"Division of Molecular Pathology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3947-5129","authenticated-orcid":false,"given":"Cornelis B","family":"Lambalk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Amsterdam UMC location Vrije Universiteit Amsterdam , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hester","family":"van Boven","sequence":"additional","affiliation":[{"name":"Department of Pathology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura L","family":"van Loendersloot","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Amsterdam UMC location Vrije Universiteit Amsterdam , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank J M","family":"Broekmans","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine and Gynecology, University Medical Center Utrecht , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5444-9845","authenticated-orcid":false,"given":"Joop S E","family":"Laven","sequence":"additional","affiliation":[{"name":"Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Erasmus Medical Center , Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evert J P","family":"van Santbrink","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, Reinier de Graaf Hospital , Voorburg,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemiek W","family":"Nap","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Center , Nijmegen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucette A J","family":"van der Westerlaken","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Leiden University Medical Center , Leiden,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1405-7780","authenticated-orcid":false,"given":"Ben J","family":"Cohlen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Isala Clinics , Zwolle,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid E P","family":"Cantineau","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University Medical Center Groningen, University of Groningen , Groningen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper M J","family":"Smeenk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Elisabeth Twee Steden Ziekenhuis , Tilburg,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minouche M","family":"van Rumste","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Catharina Hospital , Eindhoven,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mari\u00ebtte","family":"Goddijn","sequence":"additional","affiliation":[{"name":"Amsterdam Reproduction and Development Research Institute , Amsterdam,","place":["The Netherlands"]},{"name":"Department Obstetrics and Gynecology, Centre for Reproductive Medicine, Amsterdam UMC , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ron J T","family":"van Golde","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Maastricht University Medical Center , Maastricht,","place":["The Netherlands"]},{"name":"GROW Institute for Oncology and Reproduction, Maastricht University , Maastricht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A M","family":"Meeuwissen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Admiraal de Ruyter Hospital , Vlissingen,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6909-5912","authenticated-orcid":false,"given":"Jan P","family":"de Bruin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Jeroen Bosch Ziekenhuis , \u2019s-Hertogenbosch,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabri\u00eble M","family":"Ouwens","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda A","family":"Gerritsma","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4390-7182","authenticated-orcid":false,"given":"Michael","family":"Schaapveld","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Curt W","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Gynecologic Oncology, Erasmus Medical Center , Rotterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5871-1484","authenticated-orcid":false,"given":"Flora E","family":"van Leeuwen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, Netherlands Cancer Institute , Amsterdam,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,7]]},"reference":[{"key":"2025040306372471400_deaf018-B1","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1093\/humrep\/deaa293","article-title":"Fertility treatment and cancers\u2014the eternal conundrum: a systematic review and meta-analysis","volume":"36","author":"Barcroft","year":"2021","journal-title":"Hum Reprod"},{"key":"2025040306372471400_deaf018-B2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1093\/humupd\/dmu012","article-title":"Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis","volume":"20","author":"Barry","year":"2014","journal-title":"Hum Reprod Update"},{"key":"2025040306372471400_deaf018-B3","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0140-6736(00)02677-5","article-title":"Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Comprehensive Cancer Centres\u2019 ALERT Group. Assessment of liver and endometrial cancer risk following tamoxifen","volume":"356","author":"Bergman","year":"2000","journal-title":"Lancet"},{"key":"2025040306372471400_deaf018-B4","first-page":"1","volume-title":"Statistical Methods in Cancer Research. Volume II\u2014The Design and Analysis of Cohort Studies","author":"Breslow","year":"1987"},{"key":"2025040306372471400_deaf018-B5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/S1472-6483(10)60689-X","article-title":"Long-term effects of ovulation-stimulating drugs on cancer risk","volume":"15","author":"Brinton","year":"2007","journal-title":"Reprod Biomed Online"},{"key":"2025040306372471400_deaf018-B6","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1016\/j.fertnstert.2009.10.012","article-title":"Cancer risk among infertile women with androgen excess or menstrual disorders (including polycystic ovary syndrome)","volume":"94","author":"Brinton","year":"2010","journal-title":"Fertil Steril"},{"key":"2025040306372471400_deaf018-B7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1055\/s-0032-1307421","article-title":"Fertility drugs and the risk of breast and gynecologic cancers","volume":"30","author":"Brinton","year":"2012","journal-title":"Semin Reprod Med"},{"key":"2025040306372471400_deaf018-B8","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1016\/j.fertnstert.2012.12.029","article-title":"In vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services","volume":"99","author":"Brinton","year":"2013","journal-title":"Fertil Steril"},{"key":"2025040306372471400_deaf018-B9","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1093\/humrep\/det323","article-title":"Fertility drugs and endometrial cancer risk: results from an extended follow-up of a large infertility cohort","volume":"28","author":"Brinton","year":"2013","journal-title":"Hum Reprod"},{"key":"2025040306372471400_deaf018-B10","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1016\/S1472-6483(10)60175-7","article-title":"Polycystic ovary syndrome and the risk of gynaecological cancer: a systematic review","volume":"19","author":"Chittenden","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"2025040306372471400_deaf018-B11","author":"ESHRE","year":"2018"},{"key":"2025040306372471400_deaf018-B12","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s10552-020-01372-3","article-title":"Endometrial cancer risk after fertility treatment: a population-based cohort study","volume":"32","author":"Guleria","year":"2021","journal-title":"Cancer Causes Control"},{"key":"2025040306372471400_deaf018-B13","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1158\/1055-9965.EPI-19-0652","article-title":"A cohort study of breast cancer risk after 20 years of follow-up of women treated with fertility drugs","volume":"28","author":"Guleria","year":"2019","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025040306372471400_deaf018-B14","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/bjc.1983.127","article-title":"The epidemiology of endometrial cancer in young women","volume":"47","author":"Henderson","year":"1983","journal-title":"Br J Cancer"},{"key":"2025040306372471400_deaf018-B15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10549-007-9823-1","article-title":"Prognosis of uterine corpus cancer after tamoxifen treatment for breast cancer","volume":"112","author":"Hoogendoorn","year":"2008","journal-title":"Breast Cancer Res Treat"},{"key":"2025040306372471400_deaf018-B16","first-page":"1","volume-title":"Cancer Incidence in Five Continents","author":"IARC","year":"2008"},{"key":"2025040306372471400_deaf018-B17","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1093\/aje\/kwp290","article-title":"Use of fertility drugs and risk of uterine cancer: results from a large Danish population-based cohort study","volume":"170","author":"Jensen","year":"2009","journal-title":"Am J Epidemiol"},{"key":"2025040306372471400_deaf018-B18","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/humupd\/dmaa045","article-title":"Endometriosis and cancer: a systematic review and meta-analysis","volume":"27","author":"Kvaskoff","year":"2021","journal-title":"Hum Reprod Update"},{"key":"2025040306372471400_deaf018-B19","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/ijc.2910530207","article-title":"Long-term impact of reproductive factors on cancer risk","volume":"53","author":"La Vecchia","year":"1993","journal-title":"Int J Cancer"},{"key":"2025040306372471400_deaf018-B20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/s00404-018-4968-1","article-title":"Impact of endometriosis on risk of ovarian, endometrial and cervical cancers: a meta-analysis","volume":"299","author":"Li","year":"2019","journal-title":"Arch Gynecol Obstet"},{"key":"2025040306372471400_deaf018-B21","doi-asserted-by":"crossref","first-page":"e1001356","DOI":"10.1371\/journal.pmed.1001356","article-title":"National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys","volume":"9","author":"Mascarenhas","year":"2012","journal-title":"PLoS Med"},{"key":"2025040306372471400_deaf018-B22","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.ygyno.2016.07.095","article-title":"Endometriosis and risks for ovarian, endometrial and breast cancers: a nationwide cohort study","volume":"143","author":"Mogensen","year":"2016","journal-title":"Gynecol Oncol"},{"key":"2025040306372471400_deaf018-B23","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/CEJ.0b013e32833d9388","article-title":"Use of fertility drugs and risk of endometrial cancer in an Italian case-control study","volume":"19","author":"Parazzini","year":"2010","journal-title":"Eur J Cancer Prev"},{"key":"2025040306372471400_deaf018-B24","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1002\/ijc.31961","article-title":"Risk factors for endometrial cancer: an umbrella review of the literature","volume":"145","author":"Raglan","year":"2019","journal-title":"Int J Cancer"},{"key":"2025040306372471400_deaf018-B25","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1158\/1055-9965.EPI-16-0809","article-title":"Cancer risk in women treated with fertility drugs according to parity status-a registry-based cohort study","volume":"26","author":"Reigstad","year":"2017","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"2025040306372471400_deaf018-B26","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/humrep\/deh098","article-title":"Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)","volume":"19","author":"Rotterdam","year":"2004","journal-title":"Hum Reprod"},{"key":"2025040306372471400_deaf018-B27","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/AOG.0000000000002624","article-title":"Risk of gynecologic cancer according to the type of endometriosis","volume":"131","author":"Saavalainen","year":"2018","journal-title":"Obstet Gynecol"},{"key":"2025040306372471400_deaf018-B28","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1038\/sj.bjc.6605086","article-title":"Ovulation-stimulation drugs and cancer risks: a long-term follow-up of a British cohort","volume":"100","author":"Silva Idos","year":"2009","journal-title":"Br J Cancer"},{"key":"2025040306372471400_deaf018-B29","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/humupd\/dms051","article-title":"Controlled ovarian hyperstimulation for IVF: impact on ovarian, endometrial and cervical cancer\u2014a systematic review and meta-analysis","volume":"19","author":"Siristatidis","year":"2013","journal-title":"Hum Reprod Update"},{"key":"2025040306372471400_deaf018-B30","first-page":"CD010931","article-title":"Risk of endometrial cancer in women treated with ovary-stimulating drugs for subfertility","volume":"3","author":"Skalkidou","year":"2017","journal-title":"Cochrane Database Syst Rev"},{"key":"2025040306372471400_deaf018-B31","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1093\/jnci\/djaa163","article-title":"Long-term risk of ovarian cancer and borderline tumors after assisted reproductive technology","volume":"113","author":"Spaan","year":"2021","journal-title":"J Natl Cancer Inst"},{"key":"2025040306372471400_deaf018-B32","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1093\/humrep\/dev023","article-title":"Melanoma risk after ovarian stimulation for in vitro fertilization","volume":"30","author":"Spaan","year":"2015","journal-title":"Hum Reprod"},{"key":"2025040306372471400_deaf018-B33","volume-title":"Stata Statistical Software: Release 15","author":"StataCorp","year":"2017"},{"key":"2025040306372471400_deaf018-B34","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fertnstert.2018.05.004","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"110","author":"Teede","year":"2018","journal-title":"Fertil Steril"},{"key":"2025040306372471400_deaf018-B35","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1001\/jama.2016.9389","article-title":"Ovarian stimulation for in vitro fertilization and long-term risk of breast cancer","volume":"316","author":"van den Belt-Dusebout","year":"2016","journal-title":"JAMA"},{"key":"2025040306372471400_deaf018-B36","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1093\/ije\/19.3.553","article-title":"Development of a record linkage protocol for use in the Dutch Cancer Registry for Epidemiological Research","volume":"19","author":"Van den Brandt","year":"1990","journal-title":"Int J Epidemiol"},{"key":"2025040306372471400_deaf018-B37","doi-asserted-by":"crossref","first-page":"3456","DOI":"10.1093\/humrep\/der322","article-title":"Risk of borderline and invasive ovarian tumours after ovarian stimulation for in vitro fertilization in a large Dutch cohort","volume":"26","author":"van Leeuwen","year":"2011","journal-title":"Hum Reprod"},{"key":"2025040306372471400_deaf018-B38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1006\/gyno.2001.6209","article-title":"Characteristics of ovarian and uterine cancers in a cohort of in vitro fertilization patients","volume":"82","author":"Venn","year":"2001","journal-title":"Gynecol Oncol"},{"key":"2025040306372471400_deaf018-B39","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1093\/oxfordjournals.aje.a116427","article-title":"Characteristics relating to ovarian cancer risk: collaborative analysis of 12 US case-control studies. II. Invasive epithelial ovarian cancers in white women. Collaborative Ovarian Cancer Group","volume":"136","author":"Whittemore","year":"1992","journal-title":"Am J Epidemiol"},{"key":"2025040306372471400_deaf018-B40","volume-title":"Classification of Tumours Editorial Board ed. World Health Organization Classification of Tumours. Female Genital Tumours","author":"WHO","year":"2020"},{"key":"2025040306372471400_deaf018-B41","doi-asserted-by":"crossref","first-page":"k2644","DOI":"10.1136\/bmj.k2644","article-title":"Risks of ovarian, breast, and corpus uteri cancer in women treated with assisted reproductive technology in Great Britain, 1991-2010: data linkage study including 2.2 million person years of observation","volume":"362","author":"Williams","year":"2018","journal-title":"BMJ"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/4\/739\/61793448\/deaf018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/4\/739\/61793448\/deaf018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T06:53:10Z","timestamp":1743663190000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/40\/4\/739\/8005322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2025,2,7]]},"published-print":{"date-parts":[[2025,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaf018","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,2,7]]}}}