{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:26:38Z","timestamp":1791894398212,"version":"4.3.4"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T00:00:00Z","timestamp":1740441600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"Abstract<\/jats:title>\n \n STUDY QUESTION<\/jats:title>\n How does two-consecutive single embryo transfer (2xSET) affect reproductive outcomes of IVF and ICSI compared to double embryo transfer (DET)?<\/jats:p>\n <\/jats:sec>\n \n SUMMARY ANSWER<\/jats:title>\n Two-consecutive SET may provide greater or comparable live birth rate (LBR); with lower multiple birth, preterm birth, and pregnancy loss or neonatal death rates compared to DET.<\/jats:p>\n <\/jats:sec>\n \n WHAT IS KNOWN ALREADY<\/jats:title>\n Elective SET in IVF\/ICSI is widely encouraged over DET to minimize the risk of multiple births and associated morbidities. Despite this, multiple birth rates following IVF remain higher than the 10% target across Europe and the USA. Currently, the majority of evidence regarding SET and DET is based on various studies assessing outcomes such as LBR per treatment cycle, as opposed to per oocyte retrieval. As such, the representation of SET is mostly unfavourable. Analysis of cumulative LBR following the transfer of two embryos over consecutive cycles, rather than in one transfer event (DET) is more effective at distinguishing the two methods and will therefore provide more valuable information relevant to clinical practice.<\/jats:p>\n <\/jats:sec>\n \n STUDY DESIGN, SIZE, DURATION<\/jats:title>\n This retrospective cohort study was conducted using Human Fertilisation and Embryology Authority (HFEA) register data, which encompasses national data from all IVF clinics in the UK. All women who underwent their first oocyte retrieval and IVF or ICSI treatment cycle with subsequent SET, DET, or 2xSET between 2010 and 2019 using blastocyst embryos were included (N\u2009=\u200971\u00a0807).<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n The rate of live birth, liveborn baby rate, multiple birth, preterm birth, and pregnancy loss or neonatal death was compared between SET, DET, and 2xSET IVF\/ICSI pregnancies using blastocyst-stage embryos, where data were stratified by maternal age. Data analysis was conducted in RStudio v4.2, alpha equals 0.05.<\/jats:p>\n <\/jats:sec>\n \n MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n Blastocyst-stage 2xSET achieved a greater median LBR of 0.47 (interquartile range [IQR] 0.13) than SET, 0.41 (IQR 0.13), and DET, 0.38 (IQR 0.13) (P\u2009&lt;\u20090.05). Using SET as the reference standard, 2xSET was associated with a significantly lower odds of multiple births compared to DET ((odds ratio [OR] 6.87, 95% CI 6.14\u20137.68) vs 28.20, 95% CI 25.20\u201331.57). The odds of preterm birth were also lower following 2xSET (OR 1.11, 95% CI 1.06\u20131.15) compared to DET (OR 2.80, 95% CI 2.67\u20132.94). Similarly, the odds of pregnancy loss or neonatal death were lower following 2xSET (OR 1.14, 95% CI 1.08\u20131.21) compared to DET (OR 2.11, 95% CI 1.98\u20132.24). LBR was consistently higher following 2xSET than DET and SET in women aged 39\u00a0years and under (P\u2009&lt;\u20090.05). However, results were comparable in women over 39\u2009years (P\u2009&gt;\u20090.05). Across all age groups, DET pregnancies had the highest multiple birth rate (P\u2009&lt;\u20090.05). In women aged 39\u00a0years and under, DET was associated with the highest preterm birth rate (P\u2009&lt;\u20090.05), whereas the rate was comparable across cohorts in women over 39 (P\u2009&gt;\u20090.05). Moreover, pregnancy loss and neonatal death rates were highest following DET in women aged 37\u00a0years and under (P\u2009&lt;\u20090.05), and comparable to SET and 2xSET in women over 37\u2009years (P\u2009&gt;\u20090.05).<\/jats:p>\n <\/jats:sec>\n \n LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n Certain confounders are not recorded within HFEA registry data, including patient BMI, evaluation of embryo quality, and endometrial thickness at embryo transfer. Consequently, while our analysis identifies broad trends in embryo transfer success and morbidity, results may differ within certain patient populations.<\/jats:p>\n <\/jats:sec>\n \n WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n Blastocyst-stage 2xSET may provide greater LBR in women aged 39\u00a0years and under, and comparable LBR in women over 39\u2009years old, with overall lower multiple birth and morbidity than DET. 2xSET should be considered first-line among certain patient cohorts, including women with advanced maternal age to improve reproductive outcomes and reduce the risk of morbidity following ART.<\/jats:p>\n <\/jats:sec>\n \n STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n No external funding was used for this study. None of the authors has any conflicts of interest.<\/jats:p>\n <\/jats:sec>\n \n TRIAL REGISTRATION NUMBER<\/jats:title>\n This cohort study did not require registration. Following consultation with the Institutional Review Board at Imperial College London, ethical approval was not deemed necessary.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humrep\/deaf028","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T15:22:40Z","timestamp":1739546560000},"page":"885-894","source":"Crossref","is-referenced-by-count":8,"title":["Effectiveness and safety of consecutive single embryo transfer compared to double embryo transfer: results from the UK HFEA registry"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-1989-039X","authenticated-orcid":false,"given":"Jack","family":"Tighe","sequence":"first","affiliation":[{"name":"Department of Gynaecology, Hammersmith Hospital, Imperial College Healthcare NHS Trust , London,","place":["UK"]},{"name":"Department of Metabolism, Digestion and Reproduction, Institute of Reproductive & Developmental Biology, Imperial College London, Hammersmith Hospital Campus , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Broughton","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Institute of Reproductive & Developmental Biology, Imperial College London, Hammersmith Hospital Campus , London,","place":["UK"]},{"name":"School of Medicine, University of Birmingham , Birmingham,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Roberts","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Hammersmith Hospital, Imperial College Healthcare NHS Trust , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1752-5220","authenticated-orcid":false,"given":"Lorraine S","family":"Kasaven","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Hammersmith Hospital, Imperial College Healthcare NHS Trust , London,","place":["UK"]},{"name":"Centre for Reproductive and Genetic Health , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Cutting","sequence":"additional","affiliation":[{"name":"Human Fertility and Embryology Authority (HFEA) , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elliot","family":"Bridges","sequence":"additional","affiliation":[{"name":"Human Fertility and Embryology Authority (HFEA) , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail","family":"Ng","sequence":"additional","affiliation":[{"name":"Human Fertility and Embryology Authority (HFEA) , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Evans","sequence":"additional","affiliation":[{"name":"Human Fertility and Embryology Authority (HFEA) , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Efstathios","family":"Theodorou","sequence":"additional","affiliation":[{"name":"Centre for Reproductive and Genetic Health , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jara","family":"Ben Nagi","sequence":"additional","affiliation":[{"name":"Centre for Reproductive and Genetic Health , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0391-0443","authenticated-orcid":false,"given":"Benjamin P","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Hammersmith Hospital, Imperial College Healthcare NHS Trust , London,","place":["UK"]},{"name":"Department of Metabolism, Digestion and Reproduction, Institute of Reproductive & Developmental Biology, Imperial College London, Hammersmith Hospital Campus , London,","place":["UK"]},{"name":"The Lister Fertility Clinic, The Lister Hospital , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,25]]},"reference":[{"key":"2025050201521773100_deaf028-B1","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.fertnstert.2020.09.003","article-title":"Why are multiple pregnancy rates and single embryo transfer rates so different globally, and what do we do about it?","volume":"114","author":"Adamson","year":"2020","journal-title":"Fertil Steril"},{"key":"2025050201521773100_deaf028-B2","doi-asserted-by":"crossref","first-page":"2765","DOI":"10.1093\/humrep\/dew261","article-title":"Twins conceived using IVF: a follow-up of the family environment and psychosocial adjustment in adolescence","volume":"31","author":"Anderson","year":"2016","journal-title":"Hum Reprod"},{"key":"2025050201521773100_deaf028-B3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1080\/03630242.2012.662934","article-title":"Mothers of IVF twins: the mediating role of employment and social coping resources in maternal stress","volume":"52","author":"Baor","year":"2012","journal-title":"Women Health"},{"key":"2025050201521773100_deaf028-B4","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1093\/humrep\/deac063","article-title":"IVF outcomes of embryos with abnormal PGT-A biopsy previously refused transfer: a prospective cohort study","volume":"37","author":"Barad","year":"2022","journal-title":"Hum Reprod"},{"key":"2025050201521773100_deaf028-B5","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.fertnstert.2008.12.032","article-title":"Female obesity impairs in vitro fertilization outcome without affecting embryo quality","volume":"93","author":"Bellver","year":"2010","journal-title":"Fertil Steril"},{"key":"2025050201521773100_deaf028-B6","doi-asserted-by":"crossref","first-page":"e0228743","DOI":"10.1371\/journal.pone.0228743","article-title":"Impact of diabetes, obesity and hypertension on preterm birth: population-based study","volume":"15","author":"Berger","year":"2020","journal-title":"PLoS One"},{"key":"2025050201521773100_deaf028-B7","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1080\/14767058.2018.1425834","article-title":"Twins and neurodevelopmental outcomes: the effect of IVF, fetal growth restriction, and preterm birth","volume":"32","author":"Briana","year":"2019","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2025050201521773100_deaf028-B8","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/uog.18930","article-title":"Risk of spontaneous preterm birth in singleton pregnancies conceived after IVF\/ICSI treatment: meta-analysis of cohort studies","volume":"51","author":"Cavoretto","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2025050201521773100_deaf028-B9","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1017\/S2040174417000228","article-title":"The health outcomes of human offspring conceived by assisted reproductive technologies (ART)","volume":"8","author":"Chen","year":"2017","journal-title":"J Dev Orig Health Dis"},{"key":"2025050201521773100_deaf028-B10","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1186\/s12884-020-03353-5","article-title":"Live birth rate and neonatal outcomes of different quantities and qualities of frozen transferred blastocyst in patients requiring whole embryo freezing stratified by age","volume":"20","author":"Chen","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"key":"2025050201521773100_deaf028-B11","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.rbmo.2021.02.013","article-title":"Prediction of embryo survival and live birth rates after cryotransfers of vitrified blastocysts","volume":"42","author":"Coello","year":"2021","journal-title":"Reprod Biomed Online"},{"key":"2025050201521773100_deaf028-B12","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.fertnstert.2015.10.032","article-title":"Costs of achieving live birth from assisted reproductive technology: a comparison of sequential single and double embryo transfer approaches","volume":"105","author":"Crawford","year":"2016","journal-title":"Fertil Steril"},{"key":"2025050201521773100_deaf028-B13","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.fertnstert.2020.08.1423","article-title":"Current evidence supporting a goal of singletons: a review of maternal and perinatal outcomes associated with twin versus singleton pregnancies after in vitro fertilization and intracytoplasmic sperm injection","volume":"114","author":"Eapen","year":"2020","journal-title":"Fertil Steril"},{"key":"2025050201521773100_deaf028-B14","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1016\/j.fertnstert.2004.11.053","article-title":"Psychosocial risks associated with multiple births resulting from assisted reproduction","volume":"83","author":"Ellison","year":"2005","journal-title":"Fertil Steril"},{"key":"2025050201521773100_deaf028-B15","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/humrep\/deae010","article-title":"Evidence-based guideline: number of embryos to transfer during IVF\/ICSI","volume":"39","author":"ESHRE Guideline Group on the Number of Embryos to Transfer","year":"2024","journal-title":"Hum Reprod"},{"key":"2025050201521773100_deaf028-B16","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/S0015-0282(00)00518-5","article-title":"Blastocyst score affects implantation and pregnancy outcome: towards a single blastocyst transfer","volume":"73","author":"Gardner","year":"2000","journal-title":"Fertil Steril"},{"key":"2025050201521773100_deaf028-B17","author":"HFEA","year":"2013"},{"key":"2025050201521773100_deaf028-B18","author":"HFEA","year":"2021"},{"key":"2025050201521773100_deaf028-B19","author":"HFEA","year":"2022"},{"key":"2025050201521773100_deaf028-B20","author":"HFEA","year":"2023"},{"key":"2025050201521773100_deaf028-B21","doi-asserted-by":"crossref","first-page":"k2204","DOI":"10.1136\/bmj.k2204","article-title":"The hidden costs of infertility treatment","volume":"361","author":"Howard","year":"2018","journal-title":"BMJ"},{"key":"2025050201521773100_deaf028-B22","author":"Jacklin","year":"2018"},{"key":"2025050201521773100_deaf028-B23","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/01.AOG.0000114989.84822.51","article-title":"Perinatal outcomes in singletons following in vitro fertilization: a meta-analysis","volume":"103","author":"Jackson","year":"2004","journal-title":"Obstet Gynecol"},{"key":"2025050201521773100_deaf028-B24","first-page":"CD003416","article-title":"Number of embryos for transfer following in vitro fertilisation or intra-cytoplasmic sperm injection","volume":"8","author":"Kamath","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"2025050201521773100_deaf028-B25","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.rbmo.2017.02.015","article-title":"Neurodevelopmental and cardiometabolic outcome in 4-year-old twins and singletons born after IVF","volume":"34","author":"Kuiper","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"2025050201521773100_deaf028-B26","first-page":"264","article-title":"Transfers of lower quality embryos based on morphological appearance result in appreciable live birth rates: a Canadian center\u2019s experience","volume":"1","author":"Lai","year":"2020","journal-title":"F S Rep"},{"key":"2025050201521773100_deaf028-B27","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3109\/14647270903586364","article-title":"Attitudes towards single embryo transfer, twin and higher order pregnancies in patients undergoing infertility treatment: a review","volume":"13","author":"Leese","year":"2010","journal-title":"Hum Fertil (Camb)"},{"key":"2025050201521773100_deaf028-B28","doi-asserted-by":"crossref","first-page":"2530","DOI":"10.1002\/sim.7628","article-title":"Targeted maximum likelihood estimation for a binary treatment: a tutorial","volume":"37","author":"Luque-Fernandez","year":"2018","journal-title":"Stat Med"},{"key":"2025050201521773100_deaf028-B29","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s12958-020-00636-6","article-title":"Effect of endometrial thickness and embryo quality on live-birth rate of fresh IVF\/ICSI cycles: a retrospective cohort study","volume":"18","author":"Lv","year":"2020","journal-title":"Reprod Biol Endocrinol"},{"key":"2025050201521773100_deaf028-B30","doi-asserted-by":"crossref","first-page":"c3428","DOI":"10.1136\/bmj.c3428","article-title":"Overweight and obesity in mothers and risk of preterm birth and low birth weight infants: systematic review and meta-analyses","volume":"341","author":"McDonald","year":"2010","journal-title":"BMJ"},{"key":"2025050201521773100_deaf028-B31","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S1701-2163(16)30527-8","article-title":"Perinatel outcomes of singleton pregnancies achieved by in vitro fertilization: a systematic review and meta-analysis","volume":"27","author":"McDonald","year":"2005","journal-title":"J Obstet Gynaecol Can"},{"key":"2025050201521773100_deaf028-B32","first-page":"50","article-title":"Elective transfer of one embryo is associated with a higher cumulative live birth rate and improved perinatal outcomes compared to the transfer of two embryos with in vitro fertilization","volume":"2","author":"Mejia","year":"2021","journal-title":"F S Rep"},{"key":"2025050201521773100_deaf028-B33","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1093\/genetics\/163.3.1153","article-title":"Maximum-likelihood estimation of relatedness","volume":"163","author":"Milligan","year":"2003","journal-title":"Genetics"},{"key":"2025050201521773100_deaf028-B34","author":"NICE","year":"2013"},{"key":"2025050201521773100_deaf028-B35","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.fertnstert.2018.06.005","article-title":"Forty years of IVF","volume":"110","author":"Niederberger","year":"2018","journal-title":"Fertil Steril"},{"key":"2025050201521773100_deaf028-B36","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/humupd\/dms018","article-title":"Obstetric and perinatal outcomes in singleton pregnancies resulting from IVF\/ICSI: a systematic review and meta-analysis","volume":"18","author":"Pandey","year":"2012","journal-title":"Hum Reprod Update"},{"key":"2025050201521773100_deaf028-B37","doi-asserted-by":"crossref","first-page":"920973","DOI":"10.3389\/fendo.2022.920973","article-title":"Effectiveness and safety of two consecutive cycles of single embryo transfer compared with one cycle of double embryo transfer: a systematic review and meta-analysis","volume":"13","author":"Peng","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2025050201521773100_deaf028-B38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.fertnstert.2015.09.007","article-title":"Assisted reproductive technology and the risk of pregnancy-related complications and adverse pregnancy outcomes in singleton pregnancies: a meta-analysis of cohort studies","volume":"105","author":"Qin","year":"2016","journal-title":"Fertil Steril"},{"key":"2025050201521773100_deaf028-B39","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1111\/j.1471-0528.2011.02966.x","article-title":"Minimising twins in in vitro fertilisation: a modelling study assessing the costs, consequences and cost-utility of elective single versus double embryo transfer over a 20-year time horizon","volume":"118","author":"Scotland","year":"2011","journal-title":"BJOG"},{"key":"2025050201521773100_deaf028-B40","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/humrep\/dead197","article-title":"2019: results generated from European registries by ESHRE","volume":"38","author":"Smeenk","year":"2023","journal-title":"Hum Reprod"},{"key":"2025050201521773100_deaf028-B41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.rbms.2018.10.017","article-title":"Effects of patient education on desire for twins and use of elective single embryo transfer procedures during ART treatment: a systematic review","volume":"6","author":"Sunderam","year":"2018","journal-title":"Reprod Biomed Soc Online"},{"key":"2025050201521773100_deaf028-B42","doi-asserted-by":"crossref","first-page":"265.e1","DOI":"10.1016\/j.ajog.2019.09.037","article-title":"The impact of maternal prepregnancy impaired fasting glucose on preterm birth and large for gestational age: a large population-based cohort study","volume":"222","author":"Tang","year":"2020","journal-title":"Am J Obstet Gynecol"},{"key":"2025050201521773100_deaf028-B43","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1097\/AOG.0000000000000017","article-title":"Obstetric complications, neonatal morbidity, and indications for cesarean delivery by maternal age","volume":"122","author":"Timofeev","year":"2013","journal-title":"Obstet Gynecol"},{"key":"2025050201521773100_deaf028-B44","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1007\/s00404-020-05507-4","article-title":"Impact of embryo quality and endometrial thickness on implantation in natural cycle IVF","volume":"301","author":"Tomic","year":"2020","journal-title":"Arch Gynecol Obstet"},{"key":"2025050201521773100_deaf028-B45","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3109\/14767050903042561","article-title":"Maternal BMI and preterm birth: a systematic review of the literature with meta-analysis","volume":"22","author":"Torloni","year":"2009","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2025050201521773100_deaf028-B46","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1007\/s11427-012-4357-0","article-title":"Effect of maternal age on the outcomes of in vitro fertilization and embryo transfer (IVF-ET)","volume":"55","author":"Yan","year":"2012","journal-title":"Sci China Life Sci"},{"key":"2025050201521773100_deaf028-B47","first-page":"CD011184","article-title":"Fresh versus frozen embryo transfers in assisted reproduction","volume":"2","author":"Zaat","year":"2021","journal-title":"Cochrane Database Syst Rev"},{"key":"2025050201521773100_deaf028-B48","doi-asserted-by":"crossref","first-page":"709648","DOI":"10.3389\/fendo.2021.709648","article-title":"Prolonged cryopreservation negatively affects embryo transfer outcomes following the elective freeze-all strategy: a multicenter retrospective study","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/5\/885\/62169827\/deaf028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/5\/885\/62169827\/deaf028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T01:52:46Z","timestamp":1746150766000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/40\/5\/885\/8042547"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,25]]},"references-count":48,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,2,25]]},"published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaf028","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,2,25]]}}}