{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T16:50:20Z","timestamp":1791996620008,"version":"4.4.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>STUDY QUESTION<\/jats:title>\n                    <jats:p>Do IVF outcomes differ in patients over the age of 40 using donor oocytes?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUMMARY ANSWER<\/jats:title>\n                    <jats:p>Even with the use of donor oocytes, maternal age appears to have an impact on live birth (LB) rate and perinatal outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                    <jats:p>Maternal age has a significant impact on the outcome of IVF, mainly attributed to age-related oocyte chromosomal factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                    <jats:p>This was a retrospective cohort study between 1 January 2015 and 31 December 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                    <jats:p>This study included all patients who had a single embryo transfer cycle using donor oocytes during the study period. The study was conducted at a single university-affiliated fertility center. Data on BMI, paternal age, and type of cycle (natural vs programmed) were evaluated in relation to miscarriages and LBs when comparing age groups of 40\u201344, 45\u201349, and \u226550. Generalized estimating equation (GEE) models with logit functions were used to control for confounding variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                    <jats:p>A total of 1660 single embryo transfer cycles using donor oocytes in patients \u226540\u2009years were performed during the study period. Of these, 969 were in patients aged 40\u201344, 607 in patients 45\u201349, and 84 in patients \u226550\u2009years of age. The presence of an LB was significantly lower in patients 45\u201349 compared to those 40\u201344 (P\u2009=\u20090.023). The LB rate remained lower in patients &amp;gt;50 but was not statistically significant. This relationship persisted after adjusting for BMI, paternal age, cycle type, and type of oocyte donor (fresh vs frozen oocyte donor) (P\u2009=\u20090.016). Moreover, the birthweight was lower in the older age groups (45\u201349 and \u226550) compared to the reference group of patients aged 40\u201344 (P\u2009=\u20090.004).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                    <jats:p>The presence of an LB was lower in patients aged 45\u201349 and \u226550 compared to 40\u201344; however, this finding was not statistically significant for the \u226550 age group, likely due to the smaller sample size compared to the other two age groups. The use of preimplantation genetic testing for aneuploidy (PGT-A) was not included since only a minority of patients using donor oocytes underwent PGT-A. The inclusion of both fresh and frozen donor oocytes may also be deemed a limitation, as some studies have indicated better outcomes from fresh compared to frozen donor oocytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                    <jats:p>Maternal age, beyond its relation to oocyte quality, was shown to affect the achievement of an LB. This is an important finding to include in patient counseling, particularly for those proceeding with donor oocytes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                    <jats:p>No authors report conflicts of interest or disclosures. There was no study funding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                    <jats:p>N\/A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/humrep\/deaf044","type":"journal-article","created":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T15:20:26Z","timestamp":1741188026000},"page":"1325-1331","source":"Crossref","is-referenced-by-count":9,"title":["Pregnancy outcomes with increasing maternal age, greater than 40 years, in donor oocyte cycles"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3768-8406","authenticated-orcid":false,"given":"Riwa","family":"Sabbagh","sequence":"first","affiliation":[{"name":"Boston IVF-IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center , Boston, MA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Meyers","sequence":"additional","affiliation":[{"name":"Boston IVF-IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Korkidakis","sequence":"additional","affiliation":[{"name":"Boston IVF-IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center , Boston, MA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quetrell","family":"Heyward","sequence":"additional","affiliation":[{"name":"Boston IVF-IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center , Boston, MA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Penzias","sequence":"additional","affiliation":[{"name":"Boston IVF-IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center , Boston, MA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9509-6791","authenticated-orcid":false,"given":"Denny","family":"Sakkas","sequence":"additional","affiliation":[{"name":"Boston IVF-IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denis","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Boston IVF-IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center , Boston, MA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Toth","sequence":"additional","affiliation":[{"name":"Boston IVF-IVIRMA Global Research Alliance , Waltham, MA,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Beth Israel Deaconess Medical Center , Boston, MA,","place":["USA"]},{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School , Boston, MA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,20]]},"reference":[{"key":"2025070301515886300_deaf044-B1","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1093\/oxfordjournals.humrep.a138289","article-title":"Age, pregnancy and miscarriage: uterine versus ovarian factors","volume":"8","author":"Abdalla","year":"1993","journal-title":"Hum Reprod"},{"key":"2025070301515886300_deaf044-B2","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1093\/humrep\/12.4.827","article-title":"Age of the uterus does not affect pregnancy or implantation rates; a study of egg donation in women of different ages sharing oocytes from the same donor","volume":"12","author":"Abdalla","year":"1997","journal-title":"Hum Reprod"},{"key":"2025070301515886300_deaf044-B3","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.rbmo.2011.01.009","article-title":"Cross-validation and predictive value of near-infrared spectroscopy algorithms for day-5 blastocyst transfer","volume":"22","author":"Ahlstrom","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"2025070301515886300_deaf044-B4","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.fertnstert.2013.12.032","article-title":"Female age-related fertility decline. Committee Opinion No. 589","volume":"101","author":"American College of Obstetricians and Gynecologists Committee on Gynecologic Practice and Practice Committee","year":"2014","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B5","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1093\/oxfordjournals.humrep.a138410","article-title":"Oocyte donation in humans: a model to study the effect of age on embryo implantation rate","volume":"9","author":"Balmaceda","year":"1994","journal-title":"Hum Reprod"},{"key":"2025070301515886300_deaf044-B6","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1016\/S0015-0282(16)57611-0","article-title":"Success rates with gamete intrafallopian transfer and in vitro fertilization in women of advanced maternal age","volume":"63","author":"Bopp","year":"1995","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B7","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S0015-0282(16)57351-8","article-title":"Pregnancies in postmenopausal women over 50 years old in an oocyte donation program","volume":"63","author":"Borini","year":"1995","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B8","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0015-0282(16)58033-9","article-title":"Oocyte donation program: pregnancy and implantation rates in women of different ages sharing oocytes from single donor","volume":"65","author":"Borini","year":"1996","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B9","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/S0015-0282(16)57797-8","article-title":"Effect of aging on the female reproductive system: evidence for a role of uterine senescence in the decline in female fecundity","volume":"64","author":"Cano","year":"1995","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0015-0282(16)56512-1","article-title":"The use of a shared donor oocyte program to evaluate the effect of uterine senescence","volume":"61","author":"Check","year":"1994","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B11","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1097\/01.AOG.0000158118.75532.51","article-title":"Impact of maternal age on obstetric outcome","volume":"105","author":"Cleary-Goldman","year":"2005","journal-title":"Obstet Gynecol"},{"key":"2025070301515886300_deaf044-B12","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12887-016-0708-5","article-title":"Neonatal outcomes in pregnancies resulting from oocyte donation: a cohort study in Sweden","volume":"16","author":"Elenis","year":"2016","journal-title":"BMC Pediatr"},{"key":"2025070301515886300_deaf044-B13","doi-asserted-by":"crossref","first-page":"e3","DOI":"10.1016\/j.fertnstert.2016.07.002","article-title":"Oocyte or embryo donation to women of advanced reproductive age: an Ethics Committee opinion","volume":"106","author":"Ethics Committee of the American Society for Reproductive Medicine","year":"2016","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B14","doi-asserted-by":"crossref","first-page":"2088","DOI":"10.1093\/oxfordjournals.humrep.a137986","article-title":"Oocyte donation: comparison between recipients from different age groups","volume":"8","author":"Flamigni","year":"1993","journal-title":"Hum Reprod"},{"key":"2025070301515886300_deaf044-B15","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.fertnstert.2013.11.004","article-title":"The nature of aneuploidy with increasing age of the female partner: a review of 15,169 consecutive trophectoderm biopsies evaluated with comprehensive chromosomal screening","volume":"101","author":"Franasiak","year":"2014","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B16","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00001703-199906000-00013","article-title":"Culture and transfer of human blastocysts","volume":"11","author":"Gardner","year":"1999","journal-title":"Curr Opin Obstet Gynecol"},{"key":"2025070301515886300_deaf044-B17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1038\/35066065","article-title":"To err (meiotically) is human: the genesis of human aneuploidy","volume":"2","author":"Hassold","year":"2001","journal-title":"Nat Rev Genet"},{"key":"2025070301515886300_deaf044-B18","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.rbmo.2009.04.002","article-title":"Assisted reproduction in women over 40 years of age: how old is too old?","volume":"19","author":"Hourvitz","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"2025070301515886300_deaf044-B19","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0015-0282(16)58214-4","article-title":"The age-related decline in female fecundity: a quantitative controlled study of implanting capacity and survival of individual embryos after in vitro fertilization","volume":"65","author":"Hull","year":"1996","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B20","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.fertnstert.2016.11.012","article-title":"Morphologic grading of euploid blastocysts influences implantation and ongoing pregnancy rates","volume":"107","author":"Irani","year":"2017","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B21","doi-asserted-by":"crossref","first-page":"2433","DOI":"10.1093\/humrep\/15.11.2433","article-title":"The risks associated with pregnancy in women aged 35 years or older","volume":"15","author":"Jolly","year":"2000","journal-title":"Hum Reprod"},{"key":"2025070301515886300_deaf044-B22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0015-0282(00)01679-4","article-title":"Effects of male age on semen quality and fertility: a review of the literature","volume":"75","author":"Kidd","year":"2001","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.fertnstert.2005.02.020","article-title":"One last chance for pregnancy: a review of 2,705 in vitro fertilization cycles initiated in women age 40 years and above","volume":"84","author":"Klipstein","year":"2005","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.fertnstert.2007.06.014","article-title":"Obstetric outcomes in donor oocyte pregnancies compared with advanced maternal age in in vitro fertilization pregnancies","volume":"90","author":"Krieg","year":"2008","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B25","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1093\/humrep\/der469","article-title":"Association between oocyte donation and maternal and perinatal outcomes in women aged 43 years or older","volume":"27","author":"Le Ray","year":"2012","journal-title":"Hum Reprod"},{"key":"2025070301515886300_deaf044-B26","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/0002-9378(95)90091-8","article-title":"Recipient\u2019s age does not adversely affect pregnancy outcome after oocyte donation","volume":"172","author":"Legro","year":"1995","journal-title":"Am J Obstet Gynecol"},{"key":"2025070301515886300_deaf044-B27","first-page":"245","article-title":"Effect of advanced paternal age on reproductive outcomes in IVF cycles of non-male-factor infertility: a retrospective cohort study","volume":"25","author":"Lu","year":"2023","journal-title":"Asian J Androl"},{"key":"2025070301515886300_deaf044-B28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S1472-6483(10)61988-8","article-title":"Chromosome abnormalities in 1255 cleavage-stage human embryos","volume":"1","author":"Marquez","year":"2000","journal-title":"Reprod Biomed Online"},{"key":"2025070301515886300_deaf044-B29","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.fertnstert.2018.09.021","article-title":"Oocyte donation: insights gleaned and future challenges","volume":"110","author":"Melnick","year":"2018","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B30","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0015-0282(16)56459-0","article-title":"Age-related decline in female fertility is not due to diminished capacity of the uterus to sustain embryo implantation","volume":"61","author":"Navot","year":"1994","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1080\/09513590310001651849","article-title":"Results of in vitro fertilization cycles in women aged 43-45 years","volume":"18","author":"Orvieto","year":"2004","journal-title":"Gynecol Endocrinol"},{"key":"2025070301515886300_deaf044-B32","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/s10815-020-01739-0","article-title":"The impact of age beyond ploidy: outcome data from 8175 euploid single embryo transfers","volume":"37","author":"Reig","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"2025070301515886300_deaf044-B33","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0378-5122(98)00077-2","article-title":"The impact of age on reproductive potential: lessons learned from oocyte donation","volume":"30","author":"Sauer","year":"1998","journal-title":"Maturitas"},{"key":"2025070301515886300_deaf044-B34","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/j.fertnstert.2018.06.015","article-title":"How much does the uterus matter? Perinatal outcomes are improved when donor oocyte embryos are transferred to gestational carriers compared to intended parent recipients","volume":"110","author":"Segal","year":"2018","journal-title":"Fertil Steril"},{"key":"2025070301515886300_deaf044-B35","doi-asserted-by":"crossref","first-page":"2087","DOI":"10.1093\/humrep\/det242","article-title":"How does vitrification affect oocyte viability in oocyte donation cycles? A prospective study to compare outcomes achieved with fresh versus vitrified sibling oocytes","volume":"28","author":"Sole","year":"2013","journal-title":"Hum Reprod"},{"key":"2025070301515886300_deaf044-B36","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41467-017-00308-x","article-title":"Decidualisation and placentation defects are a major cause of age-related reproductive decline","volume":"8","author":"Woods","year":"2017","journal-title":"Nat Commun"},{"key":"2025070301515886300_deaf044-B37","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/humrep\/13.7.1819","article-title":"Oocyte donation in Israel: a study of 1001 initiated treatment cycles","volume":"13","author":"Yaron","year":"1998","journal-title":"Hum Reprod"},{"key":"2025070301515886300_deaf044-B38","doi-asserted-by":"crossref","first-page":"2460","DOI":"10.18632\/aging.204555","article-title":"Relationship between advanced maternal age and decline of endometrial receptivity: a systematic review and meta-analysis","volume":"15","author":"Zhao","year":"2023","journal-title":"Aging (Albany NY)"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/7\/1325\/62495422\/deaf044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/7\/1325\/62495422\/deaf044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T01:52:14Z","timestamp":1751507534000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/40\/7\/1325\/8088399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,20]]},"references-count":38,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,3,20]]},"published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaf044","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,3,20]]}}}