{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T16:22:06Z","timestamp":1787502126908,"version":"build-2736575974"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>STUDY QUESTION<\/jats:title>\n                    <jats:p>Do corifollitropin alfa (CFA) and follitropin beta (FSH-B) have different effects on oocyte yield and live birth rates (LBRs) after IVM in women with polycystic ovaries?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUMMARY ANSWER<\/jats:title>\n                    <jats:p>In patients who underwent IVM, one injection of CFA resulted in lower oocyte retrieval rates, but similar cumulative LBRs compared to three injections of FSH-B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                    <jats:p>IVM involves the maturation of cumulus\u2013oocyte complexes (COCs) from antral follicles and has been offered to women with polycystic ovaries as an alternative for conventional ovarian stimulation (OS). A short course of exogenous FSH is typically administered in IVM cycles to enhance meiotic and developmental competence of immature oocytes in vivo. Previous studies have shown that the number of COCs is associated with pregnancy rates after IVM. Because one injection of CFA yields more oocytes compared to daily FSH-B injections in conventional OS protocols, CFA has the potential to combine patient-friendliness and maximum COC yield in IVM cycles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                    <jats:p>We conducted a randomized controlled superiority trial from November 2017 to December 2022. The primary endpoint was the number of COCs at oocyte retrieval. We randomized 145 patients to either one injection of 100\u2009\u03bcg CFA or three daily injections of 150\u2009IU FSH-B. Laboratory and safety parameters, and pregnancy outcomes after frozen embryo transfer (FET) were analysed on an intention-to-treat (ITT) basis. All cycles were scheduled using oral contraceptive pre-treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS\/MATERIALS, SETTINGS, METHODS<\/jats:title>\n                    <jats:p>Eligible patients were &amp;lt;37\u2009years, had \u226524 antral follicles and an anti-M\u00fcllerian hormone \u22653.25\u2009ng\/ml, and BMI 18\u201330\u2009kg\/m2. We analysed serum oestradiol, progesterone, LH, and FSH on stimulation days 1 and 3, at oocyte retrieval, and at 6\u2009days after oocyte retrieval. No ovulation trigger was given. Oocyte retrieval was performed 5\u00a0days after the start of OS. COCs were incubated in monophasic IVM media for 30\u2009h. After ICSI, an elective freeze-only strategy was performed. Data were analysed using STATA 13.0.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                    <jats:p>After randomization, 70 patients underwent oocyte retrieval after FSH-B and 72 had oocyte retrieval after CFA. According to the ITT analysis, hormone levels at oocyte retrieval were significantly different between FSH-B-treated and CFA-treated patients (FSH 6.4\u2009\u00b1\u20093.1\u2009IU\/l vs 22.6\u2009\u00b1\u20099.8\u2009IU\/l, P\u2009&amp;lt;\u20090.001; LH 3.1\u2009\u00b1\u20092.7\u2009IU\/l vs 1.6\u2009\u00b1\u20091.6\u2009IU\/l, P\u2009=\u20090.002; E2 100.8\u2009\u00b1\u2009144.9\u2009ng\/l vs 536.2\u2009\u00b1\u2009519.0\u2009ng\/l, P\u2009&amp;lt;\u2009001; Prog 0.17\u2009\u00b1\u20090.16\u2009\u03bcg\/l vs 0.26\u2009\u00b1\u20090.21\u2009\u03bcg\/l, P\u2009&amp;lt;\u20090.001, respectively). On average, 37.7\u2009\u00b1\u200924.8 (FSH-B) versus 45.9\u2009\u00b1\u200931.5 (CFA) follicles, all &amp;lt;10\u00a0mm, were punctured during oocyte retrieval (P\u2009=\u20090.06). More COCs per follicle were retrieved after FSH-B (59.8\u2009\u00b1\u200937.2% vs 46.1\u2009\u00b1\u200927.9%, P\u2009=\u20090.02), resulting in more COCs after FSH-B (30.5\u2009\u00b1\u200923.5), compared to CFA (23.1\u2009\u00b1\u200911.9, P\u2009=\u20090.11, difference \u22127.4, 95% CI (\u221213.5 to \u22121.3)). Maturation rates after IVM were similar (48.3\u2009\u00b1\u200916.6% vs 48.3\u2009\u00b1\u200920.0%, P\u2009=\u20090.88). In spite of more mature oocytes after FSH-B (15.5\u2009\u00b1\u200914.6 vs 11.5\u2009\u00b1\u20097.9, P\u2009=\u20090.13), the number of good-quality cryopreserved embryos was similar (3.8\u2009\u00b1\u20092.9 (FSH-B) vs 3.5\u2009\u00b1\u20092.7 (CFA), P\u2009=\u20090.53). LBR after the first FET (25.0% (FSH-B) vs 34.2% (CFA), P\u2009=\u20090.31) and cumulative LBR 6\u00a0months after oocyte retrieval (38.9% (FSH-B) vs 45.2% (CFA), P\u2009=\u20090.44) were comparable. None of the patients developed ovarian hyperstimulation syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                    <jats:p>Results are only valid for patients with high antral follicle count (AFC) who are treated using a monophasic IVM culture system. The sample size was too small to draw significant conclusions for LBR.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                    <jats:p>While follicle priming for IVM using one injection of CFA in subfertile patients with high AFC results in a trend towards lower oocyte retrieval rates compared to daily injections of FSH-B, the use of CFA in IVM cycles is safe, convenient, and as efficacious as priming with FSH-B.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                    <jats:p>Supported in part by a research grant from the Investigator Initiated Studies Program of Organon. The opinions expressed in this abstract are those of the authors and do not necessarily represent those of Organon. M.D.V. declares honoraria for lecturing from Cooper Surgical, Ferring, Gedeon Richter, and IBSA in the past 2\u00a0years. He also declares support from Ferring for attending ESHRE 2024 and ASRM 2024. He is also a member of the Scientific Advisory Board of Gameto Inc. and is a past chair of the IVM SIG of ASRM. C.B. declares honoraria from Abbott, IBSA, Organon, Gedeon Richter, Merck A\/S, and Ferring. C.B. has also received grants from Gedeon Richter and Ferring which were paid to his institution. P.D. has received payment from Ferring Pharmaceuticals, Merck A\/S, and Organon for lectures\/presentations. S.M. Declares consulting fees from Oxolife and payment or honoraria from IBSA, Ferring, and Gedeon-Richter. J.S. has received royalties or licenses from Lavima Fertility and is an unpaid treasurer for ISIVF. J.S. also holds stock for Lavima Fertility. The other authors declare no conflict of interest related to this study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                    <jats:p>EudraCT 2017-002571-25.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTER DATE<\/jats:title>\n                    <jats:p>16th June 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DATE OF FIRST PATIENT\u2019S ENROLMENT<\/jats:title>\n                    <jats:p>1st November 2017.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/humrep\/deaf053","type":"journal-article","created":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T00:22:15Z","timestamp":1742343735000},"page":"1127-1137","source":"Crossref","is-referenced-by-count":3,"title":["Randomized controlled trial to evaluate the impact of follicle priming on IVM outcomes in women with polycystic ovaries: CFA versus FSH-B"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5019-5924","authenticated-orcid":false,"given":"Michel","family":"De Vos","sequence":"first","affiliation":[{"name":"Brussels IVF, Universitair Ziekenhuis Brussel , Brussels,","place":["Belgium"]},{"name":"Follicle Biology Laboratory, Vrije Universiteit Brussel , Brussels,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linde","family":"Mostinckx","sequence":"additional","affiliation":[{"name":"Brussels IVF, Universitair Ziekenhuis Brussel , Brussels,","place":["Belgium"]},{"name":"Follicle Biology Laboratory, Vrije Universiteit Brussel , Brussels,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-785X","authenticated-orcid":false,"given":"Panagiotis","family":"Drakopoulos","sequence":"additional","affiliation":[{"name":"Brussels IVF, Universitair Ziekenhuis Brussel , Brussels,","place":["Belgium"]},{"name":"Institute of Life, IVF Clinic , Athens,","place":["Greece"]},{"name":"School of Medicine, European University Cyprus , Nicosia,","place":["Cyprus"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Anckaert","sequence":"additional","affiliation":[{"name":"Follicle Biology Laboratory, Vrije Universiteit Brussel , Brussels,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan","family":"Smitz","sequence":"additional","affiliation":[{"name":"Follicle Biology Laboratory, Vrije Universiteit Brussel , Brussels,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shari","family":"Mackens","sequence":"additional","affiliation":[{"name":"Brussels IVF, Universitair Ziekenhuis Brussel , Brussels,","place":["Belgium"]},{"name":"Follicle Biology Laboratory, Vrije Universiteit Brussel , Brussels,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-5158","authenticated-orcid":false,"given":"Christophe","family":"Blockeel","sequence":"additional","affiliation":[{"name":"Brussels IVF, Universitair Ziekenhuis Brussel , Brussels,","place":["Belgium"]},{"name":"Follicle Biology Laboratory, Vrije Universiteit Brussel , Brussels,","place":["Belgium"]},{"name":"Department of Obstetrics and Gynaecology, School of Medicine, University of Zagreb , Zagreb,","place":["Croatia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Segers","sequence":"additional","affiliation":[{"name":"Brussels IVF, Universitair Ziekenhuis Brussel , Brussels,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"2025060201521386400_deaf053-B1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1530\/jrf.0.1050237","article-title":"Maintenance of meiotic arrest by increasing [cAMP]i may have physiological relevance in bovine oocytes","volume":"105","author":"Aktas","year":"1995","journal-title":"J Reprod Fertil"},{"key":"2025060201521386400_deaf053-B2","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/humrep\/der037","article-title":"The Istanbul consensus workshop on embryo assessment: proceedings of an expert meeting","volume":"26","author":"Alpha Scientists in Reproductive Medicine and ESHRE Special Interest Group of Embryology","year":"2011","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B3","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1056\/NEJM199911183412118","article-title":"Priming with human chorionic gonadotropin before retrieval of immature oocytes in women with infertility due to the polycystic ovary syndrome","volume":"341","author":"Chian","year":"1999","journal-title":"N Engl J Med"},{"key":"2025060201521386400_deaf053-B4","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.rbmo.2010.03.019","article-title":"Corifollitropin alfa for ovarian stimulation in IVF: a randomized trial in lower-body-weight women","volume":"21","author":"Corifollitropin Alfa Ensure Study Group","year":"2010","journal-title":"Reprod Biomed Online"},{"key":"2025060201521386400_deaf053-B5","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.fertnstert.2024.05.164","article-title":"Clinical procedures for in vitro maturation (IVM) treatment","volume":"122","author":"De Vos","year":"2024","journal-title":"Fertil Steril"},{"key":"2025060201521386400_deaf053-B6","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1093\/humrep\/dew208","article-title":"The definition of IVM is clear-variations need defining","volume":"31","author":"De Vos","year":"2016","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B7","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1093\/humrep\/dep291","article-title":"A double-blind, non-inferiority RCT comparing corifollitropin alfa and recombinant FSH during the first seven days of ovarian stimulation using a GnRH antagonist protocol","volume":"24","author":"Devroey","year":"2009","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B8","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1016\/S0140-6736(65)92903-X","article-title":"Maturation in vitro of human ovarian oocytes","volume":"2","author":"Edwards","year":"1965","journal-title":"Lancet"},{"key":"2025060201521386400_deaf053-B10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1530\/jrf.0.0950119","article-title":"Developmental capacity of mouse oocytes matured in vitro: effects of gonadotrophic stimulation, follicular origin and oocyte size","volume":"95","author":"Eppig","year":"1992","journal-title":"J Reprod Fertil"},{"key":"2025060201521386400_deaf053-B11","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/S1472-6483(10)60168-X","article-title":"Effect of different gonadotrophin priming on IVM of oocytes from women with normal ovaries: a prospective randomized study","volume":"19","author":"Fadini","year":"2009","journal-title":"Reprod Bio Med Online"},{"key":"2025060201521386400_deaf053-B12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.rbmo.2010.06.032","article-title":"Pharmacokinetics and follicular dynamics of corifollitropin alfa versus recombinant FSH during ovarian stimulation for IVF","volume":"21","author":"Fauser","year":"2010","journal-title":"Reprod Biomed Online"},{"key":"2025060201521386400_deaf053-B13","doi-asserted-by":"crossref","first-page":"46222","DOI":"10.1038\/srep46222","article-title":"A novel action of follicle-stimulating hormone in the ovary promotes estradiol production without inducing excessive follicular growth before puberty","volume":"7","author":"Fran\u00e7ois","year":"2017","journal-title":"Sci Rep"},{"key":"2025060201521386400_deaf053-B14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/humupd\/dmad023","article-title":"A fresh start for IVM: capacitating the oocyte for development using pre-IVM","volume":"30","author":"Gilchrist","year":"2024","journal-title":"Hum Reprod Update"},{"key":"2025060201521386400_deaf053-B15","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1095\/biolreprod56.1.238","article-title":"Maturation, fertilization, and development of marmoset monkey oocytes in vitro","volume":"56","author":"Gilchrist","year":"1997","journal-title":"Biol Reprod"},{"key":"2025060201521386400_deaf053-B16","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.rbmo.2016.04.005","article-title":"Corifollitropin alfa versus recombinant follicle-stimulating hormone: an individual patient data meta-analysis","volume":"33","author":"Griesinger","year":"2016","journal-title":"Reprod Biomed Online"},{"key":"2025060201521386400_deaf053-B17","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1093\/humrep\/det034","article-title":"A prediction model to select PCOS patients suitable for IVM treatment based on anti-M\u00fcllerian hormone and antral follicle count","volume":"28","author":"Guzman","year":"2013","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B118","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jfma.2017.05.009","article-title":"Feasibility of corifollitropin alfa\/GnRH antagonist protocol combined with GnRH agonist triggering and freeze-all strategy in polycystic ovary syndrome patients","volume":"117","year":"2018","journal-title":"J Formos Med Assoc"},{"issue":"Suppl 1","key":"2025060201521386400_deaf053-B18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1093\/humrep\/13.suppl_1.76","article-title":"Intracytoplasmic sperm injection: laboratory set-up and injection procedure","volume":"13","author":"Joris","year":"1998","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B19","doi-asserted-by":"crossref","first-page":"e37835","DOI":"10.1371\/journal.pone.0037835","article-title":"FSH modulates PKAI and GPR3 activities in mouse oocyte of COC in a gap junctional communication (GJC)-dependent manner to initiate meiotic resumption","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One"},{"key":"2025060201521386400_deaf053-B20","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1095\/biolreprod.103.020644","article-title":"Role of intracellular cyclic adenosine 3\u2032,5\u2032-monophosphate concentration and oocyte-cumulus cells communications on the acquisition of the developmental competence during in vitro maturation of bovine oocytes","volume":"70","author":"Luciano","year":"2004","journal-title":"Biol Reprod"},{"key":"2025060201521386400_deaf053-B21","first-page":"E229","article-title":"Donor side effects experienced under minimal controlled ovarian stimulation (COS) with in vitro maturation (IVM) versus conventional COS for in vitro fertilization (IVF) treatment","volume":"122","author":"Marchante","year":"2024","journal-title":"FS Sci"},{"key":"2025060201521386400_deaf053-B22","first-page":"315","article-title":"Corifollitropin alpha, clomiphene citrate and dydrogesterone without daily gonadotrophin: a new option of a friendly protocol for high-responder oocyte donors","volume":"26","author":"Melo","year":"2022","journal-title":"JBRA Assist Reprod"},{"key":"2025060201521386400_deaf053-B23","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1530\/rep.0.1220587","article-title":"Beneft of FSH priming of women with PCOS to the in vitro maturation procedure and the outcome: a randomized prospective study","volume":"122","author":"Mikkelsen","year":"2001","journal-title":"Reproduction"},{"key":"2025060201521386400_deaf053-B24","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/humrep\/14.7.1847","article-title":"In-vitro maturation of human oocytes from regularly menstruating women may be successful without follicle stimulating hormone priming","volume":"14","author":"Mikkelsen","year":"1999","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B26","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/humrep\/dead205","article-title":"Human-induced pluripotent stem cell-derived ovarian support cell co-culture improves oocyte maturation invitro after abbreviated gonadotropin stimulation","volume":"38","author":"Piechota","year":"2023","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B27","first-page":"CD008720","article-title":"Human chorionic gonadotrophin priming for fertility treatment with in vitro maturation","volume":"11","author":"Reavey","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"2025060201521386400_deaf053-B28","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.rbmo.2012.11.015","article-title":"Evaluation of the degree of satisfaction in oocyte donors using sustained-release FSH corifollitropin \u03b1","volume":"26","author":"Requena","year":"2013","journal-title":"Reprod Biomed Online"},{"key":"2025060201521386400_deaf053-B29","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1007\/s10815-020-01742-5","article-title":"A prospective randomized trial comparing corifollitropin-\u03b1 late-start (day 4) versus standard administration (day 2) in expected poor, normal, and high responders undergoing controlled ovarian stimulation for IVF","volume":"37","author":"Revelli","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"2025060201521386400_deaf053-B30","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.fertnstert.2016.12.026","article-title":"Time-lapse imaging reveals differences in growth dynamics of embryos after in-vitro maturation compared with conventional stimulation","volume":"107","author":"Roesner","year":"2017","journal-title":"Fertil Steril"},{"key":"2025060201521386400_deaf053-B31","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/s10815-014-0334-9","article-title":"Approaches to oocyte retrieval for advanced reproductive technology cycles planning to utilize in vitro maturation: a review of the many choices to be made","volume":"31","author":"Rose","year":"2014","journal-title":"J Assist Reprod Genet"},{"key":"2025060201521386400_deaf053-B32","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1093\/humrep\/dex262","article-title":"An improved IVM method for cumulus-oocyte complexes from small follicles in polycystic ovary syndrome patients enhances oocyte competence and embryo yield","volume":"32","author":"S\u00e1nchez","year":"2017","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B33","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1093\/humrep\/deaa175","article-title":"Live births following fertility preservation using in-vitro maturation of ovarian tissue oocytes","volume":"35","author":"Segers","year":"2020","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B34","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0093-691X(99)00019-9","article-title":"The time interval between FSH administration and ovarian aspiration influences the development of cattle oocytes","volume":"51","author":"Sirard","year":"1999","journal-title":"Theriogenology"},{"key":"2025060201521386400_deaf053-B35","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S1472-6483(10)61438-1","article-title":"Effect of gonadotrophin priming on in-vitro maturation of oocytes collected from women at risk of OHSS","volume":"13","author":"Son","year":"2006","journal-title":"Reprod Biomed Online"},{"issue":"Suppl 3","key":"2025060201521386400_deaf053-B36","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1093\/humrep\/13.suppl_3.52","article-title":"Oocyte maturation","volume":"13","author":"Trounson","year":"1998","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B37","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.fertnstert.2024.09.010","article-title":"Hormone-free versus FSH-primed infertility treatment of women with polycystic ovary syndrome using biphasic in vitro maturation: a randomised clinical trial","volume":"123","author":"Vuong","year":"2025","journal-title":"Fertil Steril"},{"key":"2025060201521386400_deaf053-B38","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1093\/humrep\/deaa240","article-title":"In-vitro maturation of oocytes versus conventional IVF in women with infertility and a high antral follicle count: a randomized non-inferiority controlled trial","volume":"35","author":"Vuong","year":"2020","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B39","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1093\/humrep\/dev125","article-title":"In vitro maturation is associated with increased early embryo arrest without impairing morphokinetic development of useable embryos progressing to blastocysts","volume":"30","author":"Walls","year":"2015","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B40","doi-asserted-by":"crossref","first-page":"3132","DOI":"10.1093\/humrep\/13.11.3132","article-title":"Pretreatment with follicle stimulating hormone promotes the numbers of human oocytes reaching metaphase II by in-vitro maturation","volume":"13","author":"Wynn","year":"1998","journal-title":"Hum Reprod"},{"key":"2025060201521386400_deaf053-B41","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1093\/humrep\/deab243","article-title":"In vitro maturation without gonadotropins versus in vitro fertilization with hyperstimulation in women with polycystic ovary syndrome: a non-inferiority randomized controlled trial","volume":"37","author":"Zheng","year":"2022","journal-title":"Hum Reprod"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/6\/1127\/62885858\/deaf053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/6\/1127\/62885858\/deaf053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T01:52:24Z","timestamp":1748829144000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/40\/6\/1127\/8107877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,7]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,4,7]]},"published-print":{"date-parts":[[2025,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaf053","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,4,7]]}}}