{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:20:55Z","timestamp":1790083255838,"version":"4.0.1"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["18K16808"],"award-info":[{"award-number":["18K16808"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"crossref","award":["20K22983"],"award-info":[{"award-number":["20K22983"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science, and Technology, Japan","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>Does the restoration of regulatory T cells (Tregs) suppress the progression of endometriosis?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>Adoptive transfer of Tregs suppresses the progression of endometriosis and reduces the levels of helper T (Th)-cell-related and proinflammatory cytokines in mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>Endometriosis is a chronic inflammatory gynecological disease, which involves multiple immune components. Activated Treg counts decrease in the endometrioma and endometrium of patients with endometriosis, and depletion of Tregs exacerbates endometriosis in mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>We evaluated the effects of adoptive transfer of Tregs on the progression of endometriosis in mice. We used Foxp3tm3Ayr\/J (Foxp3DTR) mice with temporarily ablated Tregs by injecting diphtheria toxin to develop an endometriosis model, which was generated by ovariectomy, estradiol administration and transplantation of uterine fragments from donor mice. Foxp3DTR mice were randomly divided into Treg adoptive transfer (n\u2009=\u200912) and control (n\u2009=\u200911) groups. Tregs were isolated from lymph nodes and spleens of wild-type (WT) mice and were adoptively transferred into mice that were temporarily Treg-depleted. Control mice were injected with vehicle. Treg adoptive transfer was performed on the day of uterine implantation, and a second adoptive transfer was performed after 14\u2009days. Mice were euthanized 28\u2009days after uterine implantation, and blood, peritoneal fluid, spleen, and endometriosis-like lesion samples were collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>Foxp3DTR mice were intravenously injected with Tregs isolated from WT mice. The number, total weight, and total volume of the endometriosis-like lesions were evaluated on Day 28 following implantation of uterine fragments. The proportion of Tregs in endometriosis-like lesions, ascites, and peripheral blood was analyzed by flow cytometry. Inflammation in lesions and serum was examined using real-time PCR and ELISA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>Injection of Tregs increased their total count and decreased the number (P\u2009&amp;lt;\u20090.0001), weight (P\u2009=\u20090.0021), and volume (P\u2009=\u20090.0010) of endometriosis-like lesions in Foxp3DTR Treg-depleted mice. Furthermore, injection of Tregs decreased the mRNA expression of Th 1-, 2-, and 17-related cytokines, including interferon gamma (P\u2009=\u20090.0101), interleukin (IL)-4 (P\u2009=\u20090.0051), and IL-17 (P\u2009=\u20090.0177), as well as the levels of the proinflammatory cytokine IL-6 (P\u2009=\u20090.0002), in endometriosis-like lesions of Foxp3DTR Treg-depleted mice.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LARGE SCALE DATA<\/jats:title>\n                  <jats:p>N\/A.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>Treg-related immune mechanisms in mice may not precisely reflect those in humans.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>Restoration of Tregs may be a useful therapeutic strategy for inhibiting the progression of endometriosis in cases where the decrease in the Treg population is an exacerbating factor.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>This study was partially supported by the Grants-in-Aid for Scientific Research (grant numbers 18K16808 and 20K22983) from the Ministry of Education, Culture, Sports, Science, and Technology, Japan. The sponsor had no role in the study design, collection, analysis and interpretation of data, writing of the report, and decision to submit the article for publication. The authors have no conflicts of interest to disclose.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/deaf054","type":"journal-article","created":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T00:22:50Z","timestamp":1743726170000},"page":"926-937","source":"Crossref","is-referenced-by-count":7,"title":["Adoptive transfer of regulatory T cells inhibits the progression of endometriosis-like lesions in regulatory T-cell-depleted mice"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6654-2097","authenticated-orcid":false,"given":"Eiko","family":"Maeda","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2154-1602","authenticated-orcid":false,"given":"Hiroyuki","family":"Okimura","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7344-4919","authenticated-orcid":false,"given":"Maya","family":"Fujii","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6058-594X","authenticated-orcid":false,"given":"Yosuke","family":"Tarumi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7397-4960","authenticated-orcid":false,"given":"Hisashi","family":"Kataoka","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akemi","family":"Koshiba","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8651-4445","authenticated-orcid":false,"given":"Masahide","family":"Hamaguchi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michiaki","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9792-4132","authenticated-orcid":false,"given":"Taisuke","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4359-959X","authenticated-orcid":false,"given":"Jo","family":"Kitawaki","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,3]]},"reference":[{"key":"2025050201521743900_deaf054-B1","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1080\/01443615.2019.1601167","article-title":"Vitamin C and E supplementation effects on secretory and molecular aspects of vascular endothelial growth factor derived from peritoneal fluids of patients with endometriosis","volume":"39","author":"Ansariniya","year":"2019","journal-title":"J Obstet Gynaecol"},{"key":"2025050201521743900_deaf054-B2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1477-7827-8-116","article-title":"The frequency of CD25+CD4+ and FOXP3+ regulatory T cells in ectopic endometrium and ectopic decidua","volume":"8","author":"Basta","year":"2010","journal-title":"Reprod Biol Endocrinol"},{"key":"2025050201521743900_deaf054-B3","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1159\/000496607","article-title":"Interleukin-15 and interleukin-7 are the major cytokines to maintain endometriosis","volume":"84","author":"Bellelis","year":"2019","journal-title":"Gynecol Obstet Invest"},{"key":"2025050201521743900_deaf054-B4","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1093\/humrep\/deq020","article-title":"The role of Foxp3+ regulatory T-cells in endometriosis: a potential controlling mechanism for a complex, chronic immunological condition","volume":"25","author":"Berbic","year":"2010","journal-title":"Hum Reprod"},{"key":"2025050201521743900_deaf054-B5","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.it.2023.04.005","article-title":"Engineered Treg cells as putative therapeutics against inflammatory diseases and beyond","volume":"44","author":"Bittner","year":"2023","journal-title":"Trends Immunol"},{"key":"2025050201521743900_deaf054-B6","doi-asserted-by":"crossref","first-page":"e2208436119","DOI":"10.1073\/pnas.2208436119","article-title":"Biosensors for inflammation as a strategy to engineer regulatory T cells for cell therapy","volume":"119","author":"Bittner","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025050201521743900_deaf054-B7","doi-asserted-by":"crossref","first-page":"315ra189","DOI":"10.1126\/scitranslmed.aad4134","article-title":"Type 1 diabetes immunotherapy using polyclonal regulatory T cells","volume":"7","author":"Bluestone","year":"2015","journal-title":"Sci Transl Med"},{"key":"2025050201521743900_deaf054-B8","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1182\/blood-2010-07-293795","article-title":"Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics","volume":"117","author":"Brunstein","year":"2011","journal-title":"Blood"},{"key":"2025050201521743900_deaf054-B9","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fimmu.2013.00009","article-title":"Endometriosis, a disease of the macrophage","volume":"4","author":"Capobianco","year":"2013","journal-title":"Front Immunol"},{"key":"2025050201521743900_deaf054-B10","doi-asserted-by":"crossref","first-page":"303","DOI":"10.4103\/0976-500X.119726","article-title":"How to calculate sample size in animal studies?","volume":"4","author":"Charan","year":"2013","journal-title":"J Pharmacol Pharmacother"},{"key":"2025050201521743900_deaf054-B11","doi-asserted-by":"crossref","first-page":"1134663","DOI":"10.3389\/fimmu.2023.1134663","article-title":"Peritoneal immune microenvironment of endometriosis: role and therapeutic perspectives","volume":"14","author":"Chen","year":"2023","journal-title":"Front Immunol"},{"key":"2025050201521743900_deaf054-B12","doi-asserted-by":"crossref","first-page":"5844","DOI":"10.3390\/cancers15245877","article-title":"Promises and pitfalls of next-generation Treg adoptive immunotherapy","volume":"15","author":"Christofi","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2025050201521743900_deaf054-B13","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0890-6238(95)00004-T","article-title":"Induction of endometriosis in mice: a new model sensitive to estrogen","volume":"9","author":"Cummings","year":"1995","journal-title":"Reprod Toxicol"},{"key":"2025050201521743900_deaf054-B14","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/art.40737","article-title":"Adoptive Treg cell therapy in a patient with systemic lupus erythematosus","volume":"71","author":"Dall'Era","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"2025050201521743900_deaf054-B15","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1182\/blood-2010-10-311894","article-title":"Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation","volume":"117","author":"Di Ianni","year":"2011","journal-title":"Blood"},{"key":"2025050201521743900_deaf054-B16","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1007\/s10875-009-9345-1","article-title":"Foxp3+ regulatory T cells, Th17 effector cells, and cytokine environment in inflammatory bowel disease","volume":"30","author":"Eastaff-Leung","year":"2010","journal-title":"J Clin Immunol"},{"key":"2025050201521743900_deaf054-B17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1084\/jem.20040165","article-title":"Compromised function of regulatory T cells in rheumatoid arthritis and reversal by anti-TNF\u03b1 therapy","volume":"200","author":"Ehrenstein","year":"2004","journal-title":"J Exp Med"},{"key":"2025050201521743900_deaf054-B18","doi-asserted-by":"crossref","first-page":"1721","DOI":"10.1053\/j.gastro.2009.01.049","article-title":"Amelioration of colitis by genetically engineered murine regulatory T cells redirected by antigen-specific chimeric receptor","volume":"136","author":"Elinav","year":"2009","journal-title":"Gastroenterology"},{"key":"2025050201521743900_deaf054-B19","doi-asserted-by":"crossref","first-page":"103825","DOI":"10.1016\/j.jri.2023.103825","article-title":"Decrease in activated regulatory T cell populations in the endometrium during ovulation in endometriosis","volume":"156","author":"Fujii","year":"2023","journal-title":"J Reprod Immunol"},{"key":"2025050201521743900_deaf054-B20","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"2025050201521743900_deaf054-B21","doi-asserted-by":"crossref","first-page":"852","DOI":"10.7326\/L20-0681","article-title":"Regulatory T cells for treating patients with COVID-19 and acute respiratory distress syndrome: two case reports","volume":"173","author":"Gladstone","year":"2020","journal-title":"Ann Intern Med"},{"key":"2025050201521743900_deaf054-B22","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.3892\/mmr.2014.2294","article-title":"T regulatory lymphocytes in patients with endometriosis","volume":"10","author":"Gogacz","year":"2014","journal-title":"Mol Med Rep"},{"key":"2025050201521743900_deaf054-B23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jri.2016.04.289","article-title":"Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis","volume":"117","author":"Gogacz","year":"2016","journal-title":"J Reprod Immunol"},{"key":"2025050201521743900_deaf054-B24","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.fertnstert.2012.06.021","article-title":"Nuclear factor-kappaB: a main regulator of inflammation and cell survival in endometriosis pathophysiology","volume":"98","author":"Gonz\u00e1lez-Ramos","year":"2012","journal-title":"Fertil Steril"},{"key":"2025050201521743900_deaf054-B25","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/molehr\/gam033","article-title":"Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis","volume":"13","author":"Gonzalez-Ramos","year":"2007","journal-title":"Mol Hum Reprod"},{"key":"2025050201521743900_deaf054-B26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s12958-018-0325-2","article-title":"Suppressive regulatory T cells and latent transforming growth factor-\u03b2-expressing macrophages are altered in the peritoneal fluid of patients with endometriosis","volume":"16","author":"Hanada","year":"2018","journal-title":"Reprod Biol Endocrinol"},{"key":"2025050201521743900_deaf054-B27","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1210\/en.2007-0749","article-title":"Interleukin (IL)-17A stimulates IL-8 secretion, cyclooxygensase-2 expression, and cell proliferation of endometriotic stromal cells","volume":"149","author":"Hirata","year":"2008","journal-title":"Endocrinology"},{"key":"2025050201521743900_deaf054-B28","doi-asserted-by":"crossref","first-page":"5468","DOI":"10.1210\/en.2010-0398","article-title":"Recruitment of CCR6-expressing Th17 cells by CCL 20 secreted from IL-1\u03b2-, TNF-\u03b1-, and IL-17A-stimulated endometriotic stromal cells","volume":"151","author":"Hirata","year":"2010","journal-title":"Endocrinology"},{"key":"2025050201521743900_deaf054-B29","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1038\/mi.2012.67","article-title":"Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn\u2019s disease","volume":"6","author":"Ishikawa","year":"2013","journal-title":"Mucosal Immunol"},{"key":"2025050201521743900_deaf054-B30","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.it.2016.08.012","article-title":"Induced regulatory T cells: their development, stability, and applications","volume":"37","author":"Kanamori","year":"2016","journal-title":"Trends Immunol"},{"key":"2025050201521743900_deaf054-B31","doi-asserted-by":"crossref","first-page":"11700","DOI":"10.3390\/ijms222111700","article-title":"Pathogenesis of endometriosis: new insights into prospective therapies","volume":"22","author":"Kapoor","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025050201521743900_deaf054-B32","doi-asserted-by":"crossref","first-page":"4715","DOI":"10.1210\/jc.2019-00350","article-title":"Differential levels of regulatory T cells and T-helper-17 cells in women with early and advanced endometriosis","volume":"104","author":"Khan","year":"2019","journal-title":"J Clin Endocrinol Metab"},{"key":"2025050201521743900_deaf054-B33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ni1428","article-title":"Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice","volume":"8","author":"Kim","year":"2007","journal-title":"Nat Immunol"},{"key":"2025050201521743900_deaf054-B34","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/j.1600-0897.2009.00722.x","article-title":"Effects of peritoneal fluid from endometriosis patients on interferon-gamma-induced protein-10 (CXCL10) and interleukin-8 (CXCL8) released by neutrophils and CD4+ T cells","volume":"62","author":"Kim","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"2025050201521743900_deaf054-B35","first-page":"deae103","article-title":"The role of regulatory T-cells in the development of endometriosis","volume":"16","author":"Knez","year":"2024","journal-title":"Hum Reprod"},{"key":"2025050201521743900_deaf054-B36","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1056\/NEJMoa1108188","article-title":"Interleukin-2 and regulatory T cells in graft-versus-host disease","volume":"365","author":"Koreth","year":"2011","journal-title":"N Engl J Med"},{"key":"2025050201521743900_deaf054-B37","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1210\/endrev\/bnaa028","article-title":"Progress in translational regulatory T cell therapies for type 1 diabetes and islet transplantation","volume":"42","author":"Marfil-Garza","year":"2021","journal-title":"Endocr Rev"},{"key":"2025050201521743900_deaf054-B38","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.immuni.2009.03.019","article-title":"Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor","volume":"30","author":"Miyara","year":"2009","journal-title":"Immunity"},{"key":"2025050201521743900_deaf054-B39","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.fertnstert.2015.11.047","article-title":"Surgical removal of endometriotic lesions alters local and systemic proinflammatory cytokines in endometriosis patients","volume":"105","author":"Monsanto","year":"2016","journal-title":"Fertil Steril"},{"key":"2025050201521743900_deaf054-B40","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1002\/rmb2.12285","article-title":"Local estrogen formation and its regulation in endometriosis","volume":"18","author":"Mori","year":"2019","journal-title":"Reprod Med Biol"},{"key":"2025050201521743900_deaf054-B41","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/humrep\/del077","article-title":"Effects of peritoneal fluid from endometriosis patients on the release of vascular endothelial growth factor by neutrophils and monocytes","volume":"21","author":"Na","year":"2006","journal-title":"Hum Reprod"},{"key":"2025050201521743900_deaf054-B42","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1182\/blood-2006-08-044529","article-title":"In vivo dynamics of regulatory T-cell trafficking and survival predict effective strategies to control graft-versus-host disease following allogeneic transplantation","volume":"109","author":"Nguyen","year":"2007","journal-title":"Blood"},{"key":"2025050201521743900_deaf054-B43","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.immuni.2013.03.002","article-title":"Development and maintenance of regulatory T cells","volume":"38","author":"Ohkura","year":"2013","journal-title":"Immunity"},{"key":"2025050201521743900_deaf054-B44","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1002\/eji.201344280","article-title":"Regulatory T cells in systemic lupus erythematosus","volume":"45","author":"Ohl","year":"2015","journal-title":"Eur J Immunol"},{"key":"2025050201521743900_deaf054-B45","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1093\/humrep\/des346","article-title":"CD4+ CD25+ FOXP3+ regulatory T cells in peripheral blood and peritoneal fluid of patients with endometriosis","volume":"28","author":"Olkowska-Truchanowicz","year":"2013","journal-title":"Hum Reprod"},{"key":"2025050201521743900_deaf054-B46","first-page":"206","article-title":"Immunosuppressive activity of peritoneal fluid in women with endometriosis","volume":"82","author":"Oosterlynck","year":"1993","journal-title":"Obstet Gynecol"},{"key":"2025050201521743900_deaf054-B47","doi-asserted-by":"crossref","first-page":"108858","DOI":"10.1016\/j.intimp.2022.108858","article-title":"Emerging therapeutic potential of regulatory T (Treg) cells for rheumatoid arthritis: new insights and challenges","volume":"108","author":"Rezaei Kahmini","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"2025050201521743900_deaf054-B48","doi-asserted-by":"crossref","first-page":"83ra42","DOI":"10.1126\/scitranslmed.3002076","article-title":"Human regulatory T cells with alloantigen specificity are more potent inhibitors of alloimmune skin graft damage than polyclonal regulatory T cells","volume":"3","author":"Sagoo","year":"2011","journal-title":"Sci Transl Med"},{"key":"2025050201521743900_deaf054-B49","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/j.cell.2008.05.009","article-title":"Regulatory T cells and immune tolerance","volume":"133","author":"Sakaguchi","year":"2008","journal-title":"Cell"},{"key":"2025050201521743900_deaf054-B50","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1093\/humrep\/dep071","article-title":"Dendritic cell populations in the eutopic and ectopic endometrium of women with endometriosis","volume":"24","author":"Schulke","year":"2009","journal-title":"Hum Reprod"},{"key":"2025050201521743900_deaf054-B51","doi-asserted-by":"crossref","first-page":"661875","DOI":"10.3389\/fimmu.2021.661875","article-title":"Antigen-specific regulatory T cell therapy in autoimmune diseases and transplantation","volume":"12","author":"Selck","year":"2021","journal-title":"Front Immunol"},{"key":"2025050201521743900_deaf054-B52","doi-asserted-by":"crossref","first-page":"12163","DOI":"10.18632\/oncotarget.7512","article-title":"Human na\u00efve regulatory T-cells feature high steady-state turnover and are maintained by IL-7","volume":"7","author":"Silva","year":"2016","journal-title":"Oncotarget"},{"key":"2025050201521743900_deaf054-B53","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1210\/jc.2017-00052","article-title":"Exacerbation of endometriosis due to regulatory T-cell dysfunction","volume":"102","author":"Tanaka","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"2025050201521743900_deaf054-B54","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.immuni.2008.03.016","article-title":"Central role of defective interleukin-2 production in the triggering of islet autoimmune destruction","volume":"28","author":"Tang","year":"2008","journal-title":"Immunity"},{"key":"2025050201521743900_deaf054-B55","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1084\/jem.20040139","article-title":"In vitro-expanded antigen-specific regulatory T cells suppress autoimmune diabetes","volume":"199","author":"Tang","year":"2004","journal-title":"J Exp Med"},{"key":"2025050201521743900_deaf054-B56","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/nm1652","article-title":"Deacetylase inhibition promotes the generation and function of regulatory T cells","volume":"13","author":"Tao","year":"2007","journal-title":"Nat Med"},{"key":"2025050201521743900_deaf054-B57","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1111\/aji.12408","article-title":"Natural killer cells: key players in endometriosis","volume":"74","author":"Thiruchelvam","year":"2015","journal-title":"Am J Reprod Immunol"},{"key":"2025050201521743900_deaf054-B58","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.3324\/haematol.2011.041483","article-title":"Stability of human rapamycin-expanded CD4+CD25+ T regulatory cells","volume":"96","author":"Tresoldi","year":"2011","journal-title":"Haematologica"},{"key":"2025050201521743900_deaf054-B59","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/imr.13254","article-title":"Eras of designer Tregs: harnessing synthetic biology for immune suppression","volume":"320","author":"Tuomela","year":"2023","journal-title":"Immunol Rev"},{"key":"2025050201521743900_deaf054-B60","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1093\/humrep\/deu288","article-title":"Inhibitor of apoptosis proteins (IAPs) may be effective therapeutic targets for treating endometriosis","volume":"30","author":"Uegaki","year":"2015","journal-title":"Hum Reprod"},{"key":"2025050201521743900_deaf054-B61","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/humupd\/dmz018","article-title":"The endometrial immune environment of women with endometriosis","volume":"25","author":"Vallve-Juanico","year":"2019","journal-title":"Hum Reprod Update"},{"key":"2025050201521743900_deaf054-B62","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/j.1365-2567.2007.02690.x","article-title":"Compromised CD4+ CD25(high) regulatory T-cell function in patients with relapsing-remitting multiple sclerosis is correlated with a reduced frequency of FOXP3-positive cells and reduced FOXP3 expression at the single-cell level","volume":"123","author":"Venken","year":"2008","journal-title":"Immunology"},{"key":"2025050201521743900_deaf054-B63","doi-asserted-by":"crossref","first-page":"6725","DOI":"10.4049\/jimmunol.178.11.6725","article-title":"Cutting edge: regulatory T cells induce CD4+CD25-Foxp3- T cells or are self-induced to become Th17 cells in the absence of exogenous TGF-\u03b2","volume":"178","author":"Xu","year":"2007","journal-title":"J Immunol"},{"key":"2025050201521743900_deaf054-B64","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.2337\/db11-1306","article-title":"Adoptive transfer with in vitro expanded human regulatory T cells protects against porcine islet xenograft rejection via interleukin-10 in humanized mice","volume":"61","author":"Yi","year":"2012","journal-title":"Diabetes"},{"key":"2025050201521743900_deaf054-B65","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.4049\/jimmunol.1203547","article-title":"IL-7 modulates in vitro and in vivo human memory T regulatory cell functions through the CD39\/ATP axis","volume":"191","author":"Younas","year":"2013","journal-title":"J Immunol"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/5\/926\/62857638\/deaf054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/5\/926\/62857638\/deaf054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,2]],"date-time":"2025-05-02T05:52:50Z","timestamp":1746165170000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/40\/5\/926\/8105714"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,3]]},"references-count":65,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2025,4,3]]},"published-print":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaf054","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,5]]},"published":{"date-parts":[[2025,4,3]]}}}