{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,24]],"date-time":"2026-03-24T20:21:40Z","timestamp":1774383700142,"version":"3.50.1"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ZIA CP010197"],"award-info":[{"award-number":["ZIA CP010197"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Institutes of Health, Bethesda, Maryland","award":["HHSN267200603423"],"award-info":[{"award-number":["HHSN267200603423"]}]},{"name":"National Institutes of Health, Bethesda, Maryland","award":["HHSN267200603424"],"award-info":[{"award-number":["HHSN267200603424"]}]},{"name":"National Institutes of Health, Bethesda, Maryland","award":["HHSN267200603426"],"award-info":[{"award-number":["HHSN267200603426"]}]},{"name":"National Institutes of Health, Bethesda, Maryland","award":["HHSN275201300023I"],"award-info":[{"award-number":["HHSN275201300023I"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"Abstract<\/jats:title>\n \n STUDY QUESTION<\/jats:title>\n Are preconception sleep characteristics associated with pregnancy loss and adverse pregnancy outcomes?<\/jats:p>\n <\/jats:sec>\n \n SUMMARY ANSWER<\/jats:title>\n Preconception sleep characteristics were not associated with pregnancy loss, but earlier sleep midpoints were associated with lower risk of adverse pregnancy outcomes, while social jetlag &gt;1\u2009h was associated with greater risk of a composite of adverse pregnancy outcomes.<\/jats:p>\n <\/jats:sec>\n \n WHAT IS KNOWN ALREADY<\/jats:title>\n Short sleep duration in mid-pregnancy has been associated with risk of second-trimester pregnancy loss, preterm birth (PTB), and hypertensive disorders of pregnancy (HDP). The relationships between preconception sleep and pregnancy loss, and adverse pregnancy outcomes have not been well characterized, despite plausible links.<\/jats:p>\n <\/jats:sec>\n \n STUDY DESIGN, SIZE, DURATION<\/jats:title>\n This was a secondary analysis of a randomized controlled trial conducted between 2006 and 2012 that prospectively followed 1228 women who were attempting to become pregnant after a history of pregnancy loss. Women were followed for \u22646 cycles while attempting pregnancy, and throughout pregnancy if they conceived. Over the follow-up, 140 women withdrew from the study.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n This study evaluated baseline, self-reported preconception sleep duration, sleep latency, sleep midpoint, and social jetlag with risk of pregnancy loss and adverse pregnancy outcomes (e.g. PTB, HDP, and gestational diabetes (GDM)) among 1228 women with a history of pregnancy loss in the EAGeR trial. Pregnancy was documented by hCG tests; 797 women became pregnant over the follow-up. Pregnancy losses were defined as any loss after a positive hCG test; there were 188 pregnancy losses. PTB, HDP, and GDM cases were ascertained via medical record abstraction. PTB (n\u2009=\u200953), HDP (n\u2009=\u200962), and GDM (n\u2009=\u200922) were examined as a composite outcome (n\u2009=\u2009118) and PTB and HDP were examined individually in exploratory analyses. GDM was not examined individually due to insufficient numbers. Log-Poisson models were used to estimate relative risks (RR) and 95% CIs for associations between preconception sleep characteristics, and pregnancy loss or adverse pregnancy outcomes with adjustment for age, BMI, lifestyle, and sociodemographic factors. Stabilized inverse probability weights were applied to address potential selection bias from loss to follow-up and from restricting to pregnancy.<\/jats:p>\n <\/jats:sec>\n \n MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n Preconception sleep characteristics were not associated with risk of pregnancy loss. Preconception sleep duration and sleep latency were not associated with risk of the composite adverse pregnancy outcome. Early preconception sleep midpoints were associated with a lower risk of the composite adverse pregnancy outcome (first vs second tertile RR; 0.63, 95% CI: 0.40, 0.98) and preconception social jetlag was associated with a higher risk of the composite adverse pregnancy outcome (&gt;1 vs \u22641\u2009h RR; 1.65, 95% CI: 1.11, 2.44).<\/jats:p>\n <\/jats:sec>\n \n LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n Preconception sleep was restricted to baseline self-report, which may be non-differentially misclassified and may underestimate these associations. The EAGeR study did not measure sleep during pregnancy. There were few adverse pregnancy outcomes and thus limited power to evaluate individual outcomes; the findings could be due to chance.<\/jats:p>\n <\/jats:sec>\n \n WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n These findings suggest that preconception sleep is not associated with pregnancy loss, but preconception sleep timing may be relevant for risk of adverse pregnancy outcomes. Additional studies on preconception sleep and adverse pregnancy outcomes are needed given the potential impact of poor sleep on pregnancy outcomes.<\/jats:p>\n <\/jats:sec>\n \n STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n Joshua R. Freeman and this work were supported by the Intramural Research Program Cancer Research Training Award, National Cancer Institute, National Institutes of Health (ZIA CP010197), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland (Contract numbers: HHSN267200603423, HHSN267200603424, HHSN267200603426, HHSN275201300023I). Dr Silver received NIH funding through the listed contracts as site-PI for the original EAGeR trial at the University of Utah. Dr O\u2019Brien reports receiving funding from the Star Legacy Foundation (paid to institution); an advisory board role at the Star Legacy Foundation; and receiving travel support from the Star Legacy Foundation. Dr Dunietz reports a role as Associate Editor at Human Reproduction and a role on the Journal Editorial Board of SLEEP. Dr Purdue-Smithe is an employee of Merck & Co. and has received stock compensation as an employee of Merck & Co. in the past 36\u2009months. The work in this manuscript was completed before Dr Purdue-Smithe\u2019s employment at Merck & Co. and is unrelated to Dr Purdue-Smithe\u2019s work at the company. Dr Silver reports royalties or licenses from BJOG and UpToDate, Inc. in the past 36\u2009months, receiving payment or honoraria for Grand Rounds in the past 36\u2009months, and participating on a Data Safety Monitoring Board or Advisory Board for a National Institutes of Health-funded Apple Trial in the past 36\u2009months. The other authors report there are no competing interests to declare.<\/jats:p>\n <\/jats:sec>\n \n TRIAL REGISTRATION NUMBER<\/jats:title>\n Clinicaltrials.gov NCT00467363<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humrep\/deaf074","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T20:09:21Z","timestamp":1745438961000},"page":"1366-1376","source":"Crossref","is-referenced-by-count":3,"title":["Preconception sleep, pregnancy loss, and adverse pregnancy outcomes among women with a history of pregnancy loss"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7483-7848","authenticated-orcid":false,"given":"Joshua R","family":"Freeman","sequence":"first","affiliation":[{"name":"National Institutes of Health Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, , Bethesda, MD,","place":["USA"]},{"name":"Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst , Amherst, MA,","place":["USA"]},{"name":"Metabolic Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health , Bethesda, MD,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-5823","authenticated-orcid":false,"given":"Brian W","family":"Whitcomb","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst , Amherst, MA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth R","family":"Bertone-Johnson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst , Amherst, MA,","place":["USA"]},{"name":"Department of Health Promotion and Policy, School of Public Health and Health Sciences, University of Massachusetts Amherst , Amherst, MA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7512-9701","authenticated-orcid":false,"given":"Louise M","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine, Department of Neurology, University of Michigan , Ann Arbor, MI,","place":["USA"]},{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Michigan , Ann Arbor, MI,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7240-4923","authenticated-orcid":false,"given":"Galit L","family":"Dunietz","sequence":"additional","affiliation":[{"name":"Division of Sleep Medicine, Department of Neurology, University of Michigan , Ann Arbor, MI,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7356-3651","authenticated-orcid":false,"given":"Alexandra C","family":"Purdue-Smithe","sequence":"additional","affiliation":[{"name":"Division of Women\u2019s Health, Brigham and Women\u2019s Hospital and Harvard Medical School , Boston, MA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keewan","family":"Kim","sequence":"additional","affiliation":[{"name":"National Institutes of Health Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, , Bethesda, MD,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M","family":"Silver","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, University of Utah Health , Salt Lake City, UT,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique F","family":"Schisterman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0133-3176","authenticated-orcid":false,"given":"Sunni L","family":"Mumford","sequence":"additional","affiliation":[{"name":"National Institutes of Health Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, , Bethesda, MD,","place":["USA"]},{"name":"Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania , Philadelphia, PA,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,23]]},"reference":[{"key":"2025070301515021200_deaf074-B1","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.annepidem.2016.04.011","article-title":"Pregnancy loss history at first parity and selected adverse pregnancy outcomes","volume":"26","author":"Ahrens","year":"2016","journal-title":"Ann Epidemiol"},{"key":"2025070301515021200_deaf074-B2","doi-asserted-by":"crossref","first-page":"e13664","DOI":"10.1111\/obr.13664","article-title":"Social jetlag and obesity: a systematic review and meta-analysis","volume":"25","author":"Arab","year":"2024","journal-title":"Obes Rev"},{"key":"2025070301515021200_deaf074-B3","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.cjca.2020.11.010","article-title":"Missing data in clinical research: a tutorial on multiple imputation","volume":"37","author":"Austin","year":"2021","journal-title":"Can J Cardiol"},{"key":"2025070301515021200_deaf074-B4","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1136\/oemed-2018-105592","article-title":"Night work and miscarriage: a Danish nationwide register-based cohort study","volume":"76","author":"Begtrup","year":"2019","journal-title":"Occup Environ Med"},{"key":"2025070301515021200_deaf074-B5","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s12958-022-00889-3","article-title":"Impact of sleep patterns upon\u202ffemale\u202fneuroendocrinology and reproductive outcomes: a comprehensive review","volume":"20","author":"Beroukhim","year":"2022","journal-title":"Reprod Biol Endocrinol"},{"key":"2025070301515021200_deaf074-B6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/humrep\/dead249","article-title":"Preconception sleep duration, non-daytime work schedules, and incidence of spontaneous abortion: a prospective cohort study","volume":"39","author":"Bond","year":"2024","journal-title":"Hum Reprod"},{"key":"2025070301515021200_deaf074-B7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res"},{"key":"2025070301515021200_deaf074-B8","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsw058","article-title":"Sleep quality and nocturnal sleep duration in pregnancy and risk of gestational diabetes mellitus","volume":"40","author":"Cai","year":"2017","journal-title":"Sleep"},{"key":"2025070301515021200_deaf074-B9","author":"CDC","year":"2024"},{"key":"2025070301515021200_deaf074-B10","author":"CDC","year":"2024"},{"key":"2025070301515021200_deaf074-B11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1093\/aje\/kwv251","article-title":"Comparison of self-reported sleep duration with actigraphy: results from the Hispanic community health study\/study of Latinos Sueno ancillary study","volume":"183","author":"Cespedes","year":"2016","journal-title":"Am J Epidemiol"},{"key":"2025070301515021200_deaf074-B12","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/aje\/kwn164","article-title":"Constructing inverse probability weights for marginal structural models","volume":"168","author":"Cole","year":"2008","journal-title":"Am J Epidemiol"},{"key":"2025070301515021200_deaf074-B13","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12929-022-00884-1","article-title":"Circadian gene Rev-erb\u03b1 influenced by sleep conduces to pregnancy by promoting endometrial decidualization via IL-6-PR-C\/EBP\u03b2 axis","volume":"29","author":"Cui","year":"2022","journal-title":"J Biomed Sci"},{"key":"2025070301515021200_deaf074-B14","doi-asserted-by":"crossref","first-page":"e2240788","DOI":"10.1001\/jamanetworkopen.2022.40788","article-title":"Evaluation of sleep habits and disturbances among US adults, 2017-2020","volume":"5","author":"Di","year":"2022","journal-title":"JAMA Netw Open"},{"key":"2025070301515021200_deaf074-B15","doi-asserted-by":"crossref","first-page":"447.e1","DOI":"10.1016\/j.ajog.2017.05.066","article-title":"Objectively measured short sleep duration and later sleep midpoint in pregnancy are associated with a higher risk of gestational diabetes","volume":"217","author":"Facco","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"2025070301515021200_deaf074-B16","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.5664\/jcsm.7534","article-title":"Association of adverse pregnancy outcomes with self-reported measures of sleep duration and timing in women who are nulliparous","volume":"14","author":"Facco","year":"2018","journal-title":"J Clin Sleep Med"},{"key":"2025070301515021200_deaf074-B17","first-page":"100040","article-title":"Later sleep timing is associated with an increased risk of preterm birth in nulliparous women","volume":"1","author":"Facco","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"2025070301515021200_deaf074-B18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.15585\/mmwr.mm7117a1","article-title":"Hypertensive disorders in pregnancy and mortality at delivery hospitalization\u2014United States, 2017-2019","volume":"71","author":"Ford","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025070301515021200_deaf074-B19","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1002\/j.2040-4603.2021.tb00168.x","article-title":"Uterine vascular control preconception and during pregnancy","volume":"11","author":"Fournier","year":"2021","journal-title":"Compr Physiol"},{"key":"2025070301515021200_deaf074-B20","doi-asserted-by":"crossref","first-page":"S886","DOI":"10.1016\/j.ajog.2020.09.039","article-title":"Decidualization resistance in the origin of preeclampsia","volume":"226","author":"Garrido-G\u00f3mez","year":"2022","journal-title":"Am J Obstet Gynecol"},{"key":"2025070301515021200_deaf074-B21","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.5664\/jcsm.10078","article-title":"Later sleep timing and social jetlag are related to increased inflammation in a population with a high proportion of OSA: findings from the Cleveland Family Study","volume":"18","author":"Girtman","year":"2022","journal-title":"J Clin Sleep Med"},{"key":"2025070301515021200_deaf074-B22","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/s41390-023-02789-7","article-title":"Childhood growth outcomes 2 years after hypertensive versus normotensive pregnancy: a P4 study","volume":"95","author":"Gow","year":"2024","journal-title":"Pediatr Res"},{"key":"2025070301515021200_deaf074-B23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1479-8425.2006.00207.x","article-title":"Criterion validity of the Pittsburgh Sleep Quality Index: investigation in a non-clinical sample","volume":"4","author":"Grandner","year":"2006","journal-title":"Sleep Biol Rhythms"},{"key":"2025070301515021200_deaf074-B24","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s41586-023-06298-9","article-title":"A spatially resolved timeline of the human maternal-fetal interface","volume":"619","author":"Greenbaum","year":"2023","journal-title":"Nature"},{"key":"2025070301515021200_deaf074-B25","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1210\/jc.2004-2033","article-title":"Brief wake episodes modulate sleep-inhibited luteinizing hormone secretion in the early follicular phase","volume":"90","author":"Hall","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"2025070301515021200_deaf074-B26","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1042\/CS20150702","article-title":"The role of inflammation in the pathology of preeclampsia","volume":"130","author":"Harmon","year":"2016","journal-title":"Clin Sci (Lond)"},{"key":"2025070301515021200_deaf074-B27","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1080\/07420528.2022.2090372","article-title":"Association of social jetlag with gestational diabetes: Qazvin Maternal and Neonatal Metabolic Study","volume":"39","author":"Hashemipour","year":"2022","journal-title":"Chronobiol Int"},{"key":"2025070301515021200_deaf074-B28","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/clc.22887","article-title":"Adverse pregnancy outcomes and future maternal cardiovascular disease","volume":"41","author":"Hauspurg","year":"2018","journal-title":"Clin Cardiol"},{"key":"2025070301515021200_deaf074-B29","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/01.ede.0000135174.63482.43","article-title":"A structural approach to selection bias","volume":"15","author":"Hernan","year":"2004","journal-title":"Epidemiology"},{"key":"2025070301515021200_deaf074-B30","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00001648-199301000-00013","article-title":"Pregnancy loss and work schedule during pregnancy","volume":"4","author":"Infante-Rivard","year":"1993","journal-title":"Epidemiology"},{"key":"2025070301515021200_deaf074-B31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/npp.2016.148","article-title":"Sleep health: reciprocal regulation of sleep and innate immunity","volume":"42","author":"Irwin","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"2025070301515021200_deaf074-B32","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsz246","article-title":"Concordance between self-reported and actigraphy-assessed sleep duration among African-American adults: findings from the Jackson Heart Sleep Study","volume":"43","author":"Jackson","year":"2020","journal-title":"Sleep"},{"key":"2025070301515021200_deaf074-B33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.placenta.2012.01.020","article-title":"Human placentation from nidation to 5 weeks of gestation. Part I: what do we know about formative placental development following implantation?","volume":"33","author":"James","year":"2012","journal-title":"Placenta"},{"key":"2025070301515021200_deaf074-B34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/0748730415597520","article-title":"Comparing the Morningness-Eveningness Questionnaire and Munich ChronoType Questionnaire to the dim light melatonin Onset","volume":"30","author":"Kantermann","year":"2015","journal-title":"J Biol Rhythms"},{"key":"2025070301515021200_deaf074-B35","doi-asserted-by":"crossref","first-page":"845","DOI":"10.3109\/07420528.2014.914035","article-title":"Validity of the Japanese version of the Munich ChronoType Questionnaire","volume":"31","author":"Kitamura","year":"2014","journal-title":"Chronobiol Int"},{"key":"2025070301515021200_deaf074-B36","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1038\/s41366-020-0609-4","article-title":"Relationship of prenatal maternal obesity and diabetes to offspring neurodevelopmental and psychiatric disorders: a narrative review","volume":"44","author":"Kong","year":"2020","journal-title":"Int J Obes (Lond)"},{"key":"2025070301515021200_deaf074-B37","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/1741-7015-11-154","article-title":"New insights into mechanisms behind miscarriage","volume":"11","author":"Larsen","year":"2013","journal-title":"BMC Med"},{"key":"2025070301515021200_deaf074-B38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5334\/jcr.190","article-title":"Sleep and reproductive health","volume":"18","author":"Lateef","year":"2020","journal-title":"J Circadian Rhythms"},{"key":"2025070301515021200_deaf074-B39","doi-asserted-by":"crossref","first-page":"e119","DOI":"10.1016\/j.fertnstert.2007.12.043","article-title":"Periconception window: advising the pregnancy-planning couple","volume":"89","author":"Louis","year":"2008","journal-title":"Fertil Steril"},{"key":"2025070301515021200_deaf074-B40","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1007\/s11325-024-03071-8","article-title":"Sleep conditions and sleep hygiene behaviors in early pregnancy are associated with gestational diabetes mellitus: a propensity-score matched study","volume":"28","author":"Ma","year":"2024","journal-title":"Sleep Breath"},{"key":"2025070301515021200_deaf074-B41","doi-asserted-by":"crossref","first-page":"l869","DOI":"10.1136\/bmj.l869","article-title":"Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study","volume":"364","author":"Magnus","year":"2019","journal-title":"BMJ"},{"key":"2025070301515021200_deaf074-B42","doi-asserted-by":"crossref","first-page":"16","DOI":"10.15585\/mmwr.mm7201a4","article-title":"QuickStats: percentage of mothers with gestational diabetes, by maternal age\u2014National Vital Statistics System, United States, 2016 and 2021","volume":"72","author":"Martin","year":"2023","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2025070301515021200_deaf074-B43","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1097\/EDE.0000000000000864","article-title":"Web site and R package for computing E-values","volume":"29","author":"Mathur","year":"2018","journal-title":"Epidemiology"},{"key":"2025070301515021200_deaf074-B44","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.sleep.2014.12.006","article-title":"Sleep patterns and sleep disturbances across pregnancy","volume":"16","author":"Mindell","year":"2015","journal-title":"Sleep Med"},{"key":"2025070301515021200_deaf074-B45","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/humrep\/deaa355","article-title":"Cannabis use while trying to conceive: a prospective cohort study evaluating associations with fecundability, live birth and pregnancy loss","volume":"36","author":"Mumford","year":"2021","journal-title":"Hum Reprod"},{"key":"2025070301515021200_deaf074-B46","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/humrep\/dev329","article-title":"Expanded findings from a randomized controlled trial of preconception low-dose aspirin and pregnancy loss","volume":"31","author":"Mumford","year":"2016","journal-title":"Hum Reprod"},{"key":"2025070301515021200_deaf074-B47","doi-asserted-by":"crossref","first-page":"11084","DOI":"10.1038\/s41598-020-67852-3","article-title":"Association of maternal sleep before and during pregnancy with preterm birth and early infant sleep and temperament","volume":"10","author":"Nakahara","year":"2020","journal-title":"Sci Rep"},{"key":"2025070301515021200_deaf074-B48","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1477-7827-1-122","article-title":"Immunology of term and preterm labor","volume":"1","author":"Peltier","year":"2003","journal-title":"Reprod Biol Endocrinol"},{"key":"2025070301515021200_deaf074-B49","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1203\/PDR.0b013e3182055ede","article-title":"Obesity in pregnancy: implications for the mother and lifelong health of the child. a consensus statement","volume":"69","author":"Poston","year":"2011","journal-title":"Pediatr Res"},{"key":"2025070301515021200_deaf074-B50","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1038\/s41467-021-23083-2","article-title":"The role of maternal preconception vitamin D status in human offspring sex ratio","volume":"12","author":"Purdue-Smithe","year":"2021","journal-title":"Nat Commun"},{"key":"2025070301515021200_deaf074-B51","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1071\/RD09243","article-title":"Clock gene expression in gravid uterus and extra-embryonic tissues during late gestation in the mouse","volume":"22","author":"Ratajczak","year":"2010","journal-title":"Reprod Fertil Dev"},{"key":"2025070301515021200_deaf074-B52","doi-asserted-by":"crossref","first-page":"R1038","DOI":"10.1016\/j.cub.2004.11.039","article-title":"A marker for the end of adolescence","volume":"14","author":"Roenneberg","year":"2004","journal-title":"Curr Biol"},{"key":"2025070301515021200_deaf074-B53","doi-asserted-by":"publisher","DOI":"10.3390\/biology8030054","article-title":"Chronotype and social jetlag: a (self-)critical review","volume":"8","author":"Roenneberg","year":"2019","journal-title":"Biology (Basel)"},{"key":"2025070301515021200_deaf074-B54","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1177\/0748730402239679","article-title":"Life between clocks: daily temporal patterns of human chronotypes","volume":"18","author":"Roenneberg","year":"2003","journal-title":"J Biol Rhythms"},{"key":"2025070301515021200_deaf074-B55","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1111\/j.1479-828X.2010.01190.x","article-title":"Maternal sleep deprivation, sedentary lifestyle and cooking smoke: risk factors for miscarriage: a case control study","volume":"50","author":"Samaraweera","year":"2010","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"2025070301515021200_deaf074-B56","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1093\/abbs\/gmz146","article-title":"Regulatory mechanisms of endometrial decidualization and pregnancy-related diseases","volume":"52","author":"Sang","year":"2020","journal-title":"Acta Biochim Biophys Sin"},{"key":"2025070301515021200_deaf074-B57","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1093\/humupd\/dmw004","article-title":"The role of decidual cells in uterine hemostasis, menstruation, inflammation, adverse pregnancy outcomes and abnormal uterine bleeding","volume":"22","author":"Schatz","year":"2016","journal-title":"Hum Reprod Update"},{"key":"2025070301515021200_deaf074-B58","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(14)60157-4","article-title":"Preconception low-dose aspirin and pregnancy outcomes: results from the EAGeR randomised trial","volume":"384","author":"Schisterman","year":"2014","journal-title":"Lancet"},{"key":"2025070301515021200_deaf074-B59","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/ppe.12088","article-title":"A randomised trial to evaluate the effects of low-dose aspirin in gestation and reproduction: design and baseline characteristics","volume":"27","author":"Schisterman","year":"2013","journal-title":"Paediatr Perinat Epidemiol"},{"key":"2025070301515021200_deaf074-B60","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1097\/AOG.0000000000000736","article-title":"Low-dose aspirin and preterm birth: a randomized controlled trial","volume":"125","author":"Silver","year":"2015","journal-title":"Obstet Gynecol"},{"key":"2025070301515021200_deaf074-B61","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.5664\/jcsm.7888","article-title":"Information on bedtimes and wake times improves the relation between self-reported and objective assessments of sleep in adults","volume":"15","author":"St-Onge","year":"2019","journal-title":"J Clin Sleep Med"},{"key":"2025070301515021200_deaf074-B62","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1016\/S0140-6736(18)30311-8","article-title":"Before the beginning: nutrition and lifestyle in the preconception period and its importance for future health","volume":"391","author":"Stephenson","year":"2018","journal-title":"Lancet"},{"key":"2025070301515021200_deaf074-B63","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0140-6736(98)07130-X","article-title":"Brain structure and neurocognitive and behavioural function in adolescents who were born very preterm","volume":"353","author":"Stewart","year":"1999","journal-title":"Lancet"},{"key":"2025070301515021200_deaf074-B64","doi-asserted-by":"crossref","first-page":"268","DOI":"10.7326\/M16-2607","article-title":"Sensitivity analysis in observational research: introducing the e-value","volume":"167","author":"VanderWeele","year":"2017","journal-title":"Ann Intern Med"},{"key":"2025070301515021200_deaf074-B65","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12884-020-2814-5","article-title":"Association between maternal sleep duration and quality, and the risk of preterm birth: a systematic review and meta-analysis of observational studies","volume":"20","author":"Wang","year":"2020","journal-title":"BMC Pregnancy Childbirth"},{"key":"2025070301515021200_deaf074-B66","first-page":"843","article-title":"Recommended amount of sleep for a healthy adult: a joint consensus statement of the American Academy of Sleep Medicine and Sleep Research Society","volume":"38","author":"Watson","year":"2015","journal-title":"Sleep"},{"key":"2025070301515021200_deaf074-B67","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1097\/00001648-199201000-00005","article-title":"Efficiency and bias in studies of early pregnancy loss","volume":"3","author":"Weinberg","year":"1992","journal-title":"Epidemiology"},{"key":"2025070301515021200_deaf074-B68","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1056\/NEJM199906103402304","article-title":"Time of implantation of the conceptus and loss of pregnancy","volume":"340","author":"Wilcox","year":"1999","journal-title":"N Engl J Med"},{"key":"2025070301515021200_deaf074-B69","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1056\/NEJM198807283190401","article-title":"Incidence of early loss of pregnancy","volume":"319","author":"Wilcox","year":"1988","journal-title":"N Engl J Med"},{"key":"2025070301515021200_deaf074-B70","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1093\/sleep\/33.10.1363","article-title":"Associations of early pregnancy sleep duration with trimester-specific blood pressures and hypertensive disorders in pregnancy","volume":"33","author":"Williams","year":"2010","journal-title":"Sleep"},{"key":"2025070301515021200_deaf074-B71","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1080\/07420520500545979","article-title":"Social jetlag: misalignment of biological and social time","volume":"23","author":"Wittmann","year":"2006","journal-title":"Chronobiol Int"},{"key":"2025070301515021200_deaf074-B72","doi-asserted-by":"crossref","first-page":"593","DOI":"10.5664\/jcsm.4760","article-title":"Sleeping for two: the great paradox of sleep in pregnancy","volume":"11","author":"Won","year":"2015","journal-title":"J Clin Sleep Med"},{"key":"2025070301515021200_deaf074-B73","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.sleep.2018.07.021","article-title":"Association between sleep duration during pregnancy and gestational diabetes mellitus: a meta-analysis","volume":"52","author":"Xu","year":"2018","journal-title":"Sleep Med"},{"key":"2025070301515021200_deaf074-B74","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1089\/jwh.2021.0328","article-title":"Sleep self-report and actigraphy measures in healthy midlife women: validity of the Pittsburgh Sleep Quality Index","volume":"31","author":"Zak","year":"2022","journal-title":"J Womens Health (Larchmt)"},{"key":"2025070301515021200_deaf074-B75","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/s44294-024-00020-4","article-title":"Endometrial decidualization status modulates endometrial microvascular complexity and trophoblast outgrowth in gelatin methacryloyl hydrogels","volume":"2","author":"Zambuto","year":"2024","journal-title":"NPJ Women's Health"},{"key":"2025070301515021200_deaf074-B76","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.sleep.2020.05.014","article-title":"The effect of sleep impairment on gestational diabetes mellitus: a systematic review and meta-analysis of cohort studies","volume":"74","author":"Zhang","year":"2020","journal-title":"Sleep Med"},{"key":"2025070301515021200_deaf074-B77","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1097\/01.jom.0000145168.21614.21","article-title":"Shift work, job stress, and late fetal loss: the national birth cohort in Denmark","volume":"46","author":"Zhu","year":"2004","journal-title":"J Occup Environ Med"},{"key":"2025070301515021200_deaf074-B78","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0015-0282(16)58144-8","article-title":"Estimates of human fertility and pregnancy loss","volume":"65","author":"Zinaman","year":"1996","journal-title":"Fertil Steril"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/7\/1366\/62995000\/deaf074.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/7\/1366\/62995000\/deaf074.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T05:52:08Z","timestamp":1751521928000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/40\/7\/1366\/8118776"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,23]]},"references-count":78,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2025,4,23]]},"published-print":{"date-parts":[[2025,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaf074","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,7]]},"published":{"date-parts":[[2025,4,23]]}}}