{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T11:09:18Z","timestamp":1781089758974,"version":"3.54.1"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES028957"],"award-info":[{"award-number":["ES028957"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD020676"],"award-info":[{"award-number":["HD020676"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ES029280"],"award-info":[{"award-number":["ES029280"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD105734"],"award-info":[{"award-number":["HD105734"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD112559"],"award-info":[{"award-number":["HD112559"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001864","name":"Sosland Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001864","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>How does activation of aryl hydrocarbon receptor (AHR) signaling affect human trophoblast cell development and differentiation?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>AHR activation alters gene expression without impairing the ability of trophoblast cells to maintain a stem cell state or differentiate into essential cell types, such as extravillous trophoblast (EVT) cells or syncytiotrophoblast (ST), while promoting the production of 2-methoxy estradiol (2ME), which may impact placental development.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>The placenta serves both as a nutrient delivery system and a protective barrier against environmental toxins. AHR signaling is known to mediate cellular responses to environmental pollutants, potentially affecting trophoblast cell function, but the specific impacts of AHR activation on these cells were not fully understood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>This study utilized an in vitro model of human trophoblast stem (TS) cells to investigate the downstream effects of AHR activation. The study focused on both undifferentiated TS cells and cells undergoing differentiation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>Human TS cells were used as a model system. Researchers examined the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exposure in TS cells maintained in their stem state and in TS cells induced to differentiate into EVT cells or ST. The study assessed changes in gene expression, particularly focusing on CYP1A1 and CYP1B1, as well as the production of 2ME.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>AHR activation stimulated the expression of CYP1A1 and CYP1B1, key genes associated with AHR signaling, in both undifferentiated and differentiating trophoblast cells. While AHR activation did not impact the ability of the cell to remain in a stem state or differentiate, it increased the production of 2ME, which may influence placentation. These effects were dependent on AHR signaling.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LARGE SCALE DATA<\/jats:title>\n                  <jats:p>n\/a<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>This study was conducted in vitro, which may not fully replicate in vivo conditions. Further research is needed to confirm whether these findings apply to placental development in humans.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>The results suggest that AHR signaling activated by environmental pollutants could have a significant impact on placental development through mechanisms involving AHR activation. These findings may have broader implications for understanding how environmental factors affect fetal development.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>This work was funded by the National Institutes of Health: ES028957, HD020676, ES029280, HD105734, HD112559, and the Sosland Foundation. The authors declare no conflicts of interest.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/deaf075","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T21:13:26Z","timestamp":1745874806000},"page":"1163-1172","source":"Crossref","is-referenced-by-count":5,"title":["Effects of an aryl hydrocarbon receptor ligand on human trophoblast cell development"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6181-269X","authenticated-orcid":false,"given":"Vinay","family":"Shukla","sequence":"first","affiliation":[{"name":"Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center , Kansas City, KS,","place":["USA"]},{"name":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center , Kansas City, KS,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khursheed","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center , Kansas City, KS,","place":["USA"]},{"name":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center , Kansas City, KS,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Okae","sequence":"additional","affiliation":[{"name":"Department of Trophoblast Research, Institute of Molecular Embryology and Genetics, Kumamoto University , Kumamoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Arima","sequence":"additional","affiliation":[{"name":"Department of Informative Genetics, Environment and Genome Research Center, Tohoku University Graduate School of Medicine , Sendai,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7158-1592","authenticated-orcid":false,"given":"Michael J","family":"Soares","sequence":"additional","affiliation":[{"name":"Institute for Reproductive and Developmental Sciences, University of Kansas Medical Center , Kansas City, KS,","place":["USA"]},{"name":"Department of Pathology and Laboratory Medicine, University of Kansas Medical Center , Kansas City, KS,","place":["USA"]},{"name":"Center for Perinatal Research, Children\u2019s Mercy Research Institute, Children\u2019s Mercy , Kansas City, MO,","place":["USA"]},{"name":"Department of Obstetrics and Gynecology, University of Kansas Medical Center , Kansas City, KS,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"2025060201511785800_deaf075-B1","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1210\/edrv-11-1-124","article-title":"Placental steroid hormone biosynthesis in primate pregnancy","volume":"11","author":"Albrecht","year":"1990","journal-title":"Endocr Rev"},{"key":"2025060201511785800_deaf075-B2","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ydbio.2010.12.038","article-title":"FGF4-dependent stem cells derived from rat blastocysts differentiate along the trophoblast lineage","volume":"351","author":"Asanoma","year":"2011","journal-title":"Dev Biol"},{"key":"2025060201511785800_deaf075-B3","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1021\/acs.chemrestox.9b00476","article-title":"The Ah receptor: adaptive metabolism, ligand diversity, and the xenokine model","volume":"33","author":"Avilla","year":"2020","journal-title":"Chem Res Toxicol"},{"key":"2025060201511785800_deaf075-B4","first-page":"1","article-title":"Aryl hydrocarbon receptor ligands: from mechanism of action to potential therapeutic use","volume":"207","author":"Baba","year":"2005","journal-title":"Toxicology"},{"key":"2025060201511785800_deaf075-B5","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1476-069X-11-42","article-title":"Developmental origins of non-communicable disease: implications for research and public health","volume":"11","author":"Barouki","year":"2012","journal-title":"Environ Health"},{"key":"2025060201511785800_deaf075-B6","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1615\/CritRevEukarGeneExpr.v18.i3.20","article-title":"The aryl hydrocarbon receptor complex and the control of gene expression","volume":"18","author":"Beischlag","year":"2008","journal-title":"Crit Rev Eukaryot Gene Expr"},{"key":"2025060201511785800_deaf075-B152","first-page":"139","article-title":"Evidence for the role of the Ah receptor in response to dioxin","volume":"387","author":"Birnbaum","year":"1994","journal-title":"Prog Clin Biol Res"},{"key":"2025060201511785800_deaf075-B7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2014.04.009","article-title":"Homeostatic control of xeno- and endobiotics in the drug-metabolizing enzyme system","volume":"90","author":"Bock","year":"2014","journal-title":"Biochem Pharmacol"},{"key":"2025060201511785800_deaf075-B8","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/j.bcp.2018.07.032","article-title":"From TCDD-mediated toxicity to searches of physiologic AHR functions","volume":"155","author":"Bock","year":"2018","journal-title":"Biochem Pharmacol"},{"key":"2025060201511785800_deaf075-B9","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.reprotox.2007.03.006","article-title":"Effects of some endocrine disruptors on the proliferation and viability of human endometrial endothelial cells in vitro","volume":"23","author":"Bredhult","year":"2007","journal-title":"Reprod Toxicol"},{"key":"2025060201511785800_deaf075-B10","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1152\/physrev.00029.2015","article-title":"Placental origins of chronic disease","volume":"96","author":"Burton","year":"2016","journal-title":"Physiol Rev"},{"key":"2025060201511785800_deaf075-B11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/bdra.20216","article-title":"Understanding dioxin developmental toxicity using the zebrafish model","volume":"76","author":"Carney","year":"2006","journal-title":"Birth Defects Res A Clin Mol Teratol"},{"key":"2025060201511785800_deaf075-B13","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1002\/tera.1420420606","article-title":"A critical review of the developmental toxicity and teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin: recent advances toward understanding the mechanism","volume":"42","author":"Couture","year":"1990","journal-title":"Teratology"},{"key":"2025060201511785800_deaf075-B14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1146\/annurev.pharmtox.43.100901.135828","article-title":"Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals","volume":"43","author":"Denison","year":"2003","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2025060201511785800_deaf075-B15","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1172\/JCI27987","article-title":"Estrogen receptors and human disease","volume":"116","author":"Deroo","year":"2006","journal-title":"J Clin Invest"},{"key":"2025060201511785800_deaf075-B17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.reprotox.2019.03.003","article-title":"Differential effects of ambient PAH mixtures on cellular and steroidogenic properties of placental JEG-3 and BeWo cells","volume":"86","author":"Drwal","year":"2019","journal-title":"Reprod Toxicol"},{"key":"2025060201511785800_deaf075-B18","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1177\/1933719112468946","article-title":"Bioinformatic analysis of benzo-\u03b1-pyrene-induced damage to the human placental insulin-like growth factor-1 gene","volume":"20","author":"Fadiel","year":"2013","journal-title":"Reprod Sci"},{"key":"2025060201511785800_deaf075-B19","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.tem.2020.03.003","article-title":"Placenta disrupted: endocrine disrupting chemicals and pregnancy","volume":"31","author":"Gingrich","year":"2020","journal-title":"Trends Endocrinol Metab"},{"key":"2025060201511785800_deaf075-B21","doi-asserted-by":"crossref","first-page":"R55","DOI":"10.1530\/JME-15-0254","article-title":"What\u2019s new in estrogen receptor action in the female reproductive tract","volume":"56","author":"Hewitt","year":"2016","journal-title":"J Mol Endocrinol"},{"key":"2025060201511785800_deaf075-B22","doi-asserted-by":"crossref","first-page":"117001","DOI":"10.1289\/EHP9256","article-title":"Evaluation of placentation and the role of the aryl hydrocarbon receptor pathway in a rat model of dioxin exposure","volume":"129","author":"Iqbal","year":"2021","journal-title":"Environ Health Perspect"},{"key":"2025060201511785800_deaf075-B23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S1043-2760(02)00567-2","article-title":"Mechanisms in tissue-specific regulation of estrogen biosynthesis in humans","volume":"13","author":"Kamat","year":"2002","journal-title":"Trends Endocrinol Metab"},{"key":"2025060201511785800_deaf075-B24","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1038\/nature06951","article-title":"Deficiency in catechol-O-methyltransferase and 2-methoxyestradiol is associated with pre-eclampsia","volume":"453","author":"Kanasaki","year":"2008","journal-title":"Nature"},{"key":"2025060201511785800_deaf075-B25","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1007\/s00018-019-03104-6","article-title":"Human placenta and trophoblast development: key molecular mechanisms and model systems","volume":"76","author":"Kn\u00f6fler","year":"2019","journal-title":"Cell Mol Life Sci"},{"key":"2025060201511785800_deaf075-B26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.taap.2010.02.007","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin increases reactive oxygen species production in human endothelial cells via induction of cytochrome P4501A1","volume":"245","author":"Kopf","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"key":"2025060201511785800_deaf075-B27","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.steroids.2016.03.017","article-title":"Recent advances in chemistry and pharmacology of 2-methoxyestradiol: an anticancer investigational drug","volume":"110","author":"Kumar","year":"2016","journal-title":"Steroids"},{"key":"2025060201511785800_deaf075-B28","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.stemcr.2016.01.006","article-title":"What is trophoblast? A combination of criteria define human first-trimester trophoblast","volume":"6","author":"Lee","year":"2016","journal-title":"Stem Cell Rep"},{"key":"2025060201511785800_deaf075-B29","doi-asserted-by":"crossref","first-page":"710","DOI":"10.2353\/ajpath.2010.090513","article-title":"Preeclampsia: 2-methoxyestradiol induces cytotrophoblast invasion and vascular development specifically under hypoxic conditions","volume":"176","author":"Lee","year":"2010","journal-title":"Am J Pathol"},{"key":"2025060201511785800_deaf075-B30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cbi.2013.12.004","article-title":"Differentiation of human placental BeWo cells by the environmental contaminant benzo(a)pyrene","volume":"210","author":"Le Vee","year":"2014","journal-title":"Chem Biol Interact"},{"key":"2025060201511785800_deaf075-B31","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.tox.2015.08.003","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin differentially suppresses angiogenic responses in human placental vein and artery endothelial cells","volume":"336","author":"Li","year":"2015","journal-title":"Toxicology"},{"key":"2025060201511785800_deaf075-B33","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2174\/1389200013338603","article-title":"Induction of CYP1A1. The AhR\/DRE paradigm: transcription, receptor regulation, and expanding biological roles","volume":"2","author":"Ma","year":"2001","journal-title":"Curr Drug Metab"},{"key":"2025060201511785800_deaf075-B34","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S1535-6108(03)00077-1","article-title":"2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF","volume":"3","author":"Mabjeesh","year":"2003","journal-title":"Cancer Cell"},{"key":"2025060201511785800_deaf075-B35","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s00360-005-0483-3","article-title":"Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology","volume":"175","author":"Mandal","year":"2005","journal-title":"J Comp Physiol B"},{"key":"2025060201511785800_deaf075-B36","first-page":"36","article-title":"Placental epigenetics in children\u2019s environmental health","volume":"34","author":"Marsit","year":"2016","journal-title":"Semin Reprod Med"},{"key":"2025060201511785800_deaf075-B37","doi-asserted-by":"crossref","first-page":"6827","DOI":"10.1038\/s41598-020-63602-7","article-title":"Establishment of macaque trophoblast stem cell lines derived from cynomolgus monkey blastocysts","volume":"10","author":"Matsumoto","year":"2020","journal-title":"Sci Rep"},{"key":"2025060201511785800_deaf075-B38","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/MOP.0b013e32833779bf","article-title":"Environmental exposures and development","volume":"22","author":"Mattison","year":"2010","journal-title":"Curr Opin Pediatr"},{"key":"2025060201511785800_deaf075-B39","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1146\/annurev-physiol-021909-135922","article-title":"Mammalian Per-Arnt-Sim proteins in environmental adaptation","volume":"72","author":"McIntosh","year":"2010","journal-title":"Annu Rev Physiol"},{"key":"2025060201511785800_deaf075-B40","doi-asserted-by":"crossref","first-page":"9614","DOI":"10.3390\/ijms21249614","article-title":"How Ah receptor ligand specificity became important in understanding its physiological function","volume":"21","author":"Murray","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025060201511785800_deaf075-B41","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1021\/tx7001965","article-title":"The search for endogenous activators of the aryl hydrocarbon receptor","volume":"21","author":"Nguyen","year":"2008","journal-title":"Chem Res Toxicol"},{"key":"2025060201511785800_deaf075-B42","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.stem.2017.11.004","article-title":"Derivation of human trophoblast stem cells","volume":"22","author":"Okae","year":"2018","journal-title":"Cell Stem Cell"},{"key":"2025060201511785800_deaf075-B43","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1177\/1933719113477483","article-title":"Metabolic pathways involved in 2-methoxyestradiol synthesis and their role in preeclampsia","volume":"20","author":"Perez-Sepulveda","year":"2013","journal-title":"Reprod Sci"},{"key":"2025060201511785800_deaf075-B44","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1007\/s12672-014-0181-2","article-title":"2-Methoxyestradiol and disorders of female reproductive tissues","volume":"5","author":"Pinto","year":"2014","journal-title":"Horm Cancer"},{"key":"2025060201511785800_deaf075-B45","doi-asserted-by":"crossref","first-page":"19159","DOI":"10.1038\/s41598-020-76313-w","article-title":"Placenta-derived macaque trophoblast stem cells: differentiation to syncytiotrophoblasts and extravillous trophoblasts reveals phenotypic reprogramming","volume":"10","author":"Schmidt","year":"2020","journal-title":"Sci Rep"},{"key":"2025060201511785800_deaf075-B46","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1530\/JOE-18-0459","article-title":"Inhibition of TPPP3 attenuates \u03b2-catenin\/NF-\u03baB\/COX-2 signalling in endometrial stromal cells and impairs decidualization","volume":"240","author":"Shukla","year":"2019","journal-title":"J Endocrinol"},{"key":"2025060201511785800_deaf075-B47","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.3390\/ijms23062947","article-title":"Modeling trophoblast cell-guided uterine spiral artery transformation in the rat","volume":"23","author":"Shukla","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2025060201511785800_deaf075-B48","doi-asserted-by":"crossref","first-page":"e2403003121","DOI":"10.1073\/pnas.2403003121","article-title":"NOTUM-mediated WNT silencing drives extravillous trophoblast cell lineage development","volume":"121","author":"Shukla","year":"2024","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2025060201511785800_deaf075-B49","first-page":"185","article-title":"Aromatase expression in health and disease","volume":"52","author":"Simpson","year":"1997","journal-title":"Recent Prog Horm Res"},{"key":"2025060201511785800_deaf075-B50","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/biolre\/ioy049","article-title":"Hemochorial placentation: development, function, and adaptations","volume":"99","author":"Soares","year":"2018","journal-title":"Biol Reprod"},{"key":"2025060201511785800_deaf075-B51","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2174\/138920111795470994","article-title":"The function of cytochrome P450 1A1 enzyme (CYP1A1) and aryl hydrocarbon receptor (AhR) in the placenta","volume":"12","author":"Stejskalova","year":"2011","journal-title":"Curr Pharm Biotechnol"},{"key":"2025060201511785800_deaf075-B52","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.toxlet.2013.09.014","article-title":"Dexamethasone accelerates degradation of aryl hydrocarbon receptor (AHR) and suppresses CYP1A1 induction in placental JEG-3 cell line","volume":"223","author":"Stejskalova","year":"2013","journal-title":"Toxicol Lett"},{"key":"2025060201511785800_deaf075-B53","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/toxsci\/kfr150","article-title":"Aryl hydrocarbon receptor and aryl hydrocarbon nuclear translocator expression in human and rat placentas and transcription activity in human trophoblast cultures","volume":"123","author":"Stejskalova","year":"2011","journal-title":"Toxicol Sci"},{"key":"2025060201511785800_deaf075-B54","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1126\/science.282.5396.2072","article-title":"Promotion of trophoblast stem cell proliferation by FGF4","volume":"282","author":"Tanaka","year":"1998","journal-title":"Science"},{"key":"2025060201511785800_deaf075-B55","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1080\/17425255.2019.1569627","article-title":"Chemical activation of estrogen and aryl hydrocarbon receptor signalling pathways and their interaction in toxicology and metabolism","volume":"15","author":"Tarnow","year":"2019","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"2025060201511785800_deaf075-B56","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jsbmb.2012.12.014","article-title":"The structural biology of oestrogen metabolism","volume":"137","author":"Thomas","year":"2013","journal-title":"J Steroid Biochem Mol Biol"},{"key":"2025060201511785800_deaf075-B57","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.reprotox.2011.11.002","article-title":"2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) suppresses spheroids attachment on endometrial epithelial cells through the down-regulation of the Wnt-signalling pathway","volume":"33","author":"Tsang","year":"2012","journal-title":"Reprod Toxicol"},{"key":"2025060201511785800_deaf075-B58","doi-asserted-by":"crossref","first-page":"4826","DOI":"10.1038\/s41467-023-40424-5","article-title":"Extravillous trophoblast cell lineage development is associated with active remodeling of the chromatin landscape","volume":"14","author":"Varberg","year":"2023","journal-title":"Nat Commun"},{"key":"2025060201511785800_deaf075-B59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.toxrep.2021.11.017","article-title":"The aryl hydrocarbon receptor as a model PAS sensor","volume":"9","author":"Vazquez-Rivera","year":"2022","journal-title":"Toxicol Rep"},{"key":"2025060201511785800_deaf075-B60","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.fertnstert.2016.08.016","article-title":"Morphologic and molecular changes in the placenta: what we can learn from environmental exposures","volume":"106","author":"Vrooman","year":"2016","journal-title":"Fertil Steril"},{"key":"2025060201511785800_deaf075-B61","doi-asserted-by":"crossref","first-page":"3762","DOI":"10.3390\/ijms19123762","article-title":"Expression, localization, and activity of the aryl hydrocarbon receptor in the human placenta","volume":"19","author":"Wakx","year":"2018","journal-title":"Int J Mol Sci"},{"key":"2025060201511785800_deaf075-B63","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1146\/annurev.pharmtox.39.1.103","article-title":"Induction of cytochrome P4501A1","volume":"39","author":"Whitlock","year":"1999","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"2025060201511785800_deaf075-B64","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1177\/019262339802600510","article-title":"Mechanisms of ligand-induced aryl hydrocarbon receptor-mediated biochemical and toxic responses","volume":"26","author":"Wilson","year":"1998","journal-title":"Toxicol Pathol"},{"key":"2025060201511785800_deaf075-B151","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.reprotox.2015.11.005","article-title":"Potential involvement of placental AhR in unexplained recurrent spontaneous abortion","volume":"59","author":"Wu","year":"2016","journal-title":"Reprod Toxicol"},{"key":"2025060201511785800_deaf075-B67","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s10735-024-10331-0","article-title":"Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the immune system maternal-fetal interface during palatal development","volume":"56","author":"Yongkai","year":"2024","journal-title":"J Mol Histol"},{"key":"2025060201511785800_deaf075-B68","doi-asserted-by":"crossref","first-page":"617","DOI":"10.3390\/ijms20030617","article-title":"Mechanisms of developmental toxicity of dioxins and related compounds","volume":"20","author":"Yoshioka","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2025060201511785800_deaf075-B69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/toxsci\/kfab050","article-title":"Converging roles of the aryl hydrocarbon receptor in early embryonic development, maintenance of stemness, and tissue repair","volume":"182","author":"Zablon","year":"2021","journal-title":"Toxicol Sci"},{"key":"2025060201511785800_deaf075-B70","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/0006-2952(95)00253-V","article-title":"Modulation by benzo[a]pyrene of epidermal growth factor receptors, cell proliferation, and secretion of human chorionic gonadotropin in human placental cell lines","volume":"50","author":"Zhang","year":"1995","journal-title":"Biochem Pharmacol"},{"key":"2025060201511785800_deaf075-B71","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1006\/bbrc.1997.6053","article-title":"Benzo(a)pyrene, but not 2,3,7,8-tetrachlorodibenzo-p-dioxin, alters cell proliferation and c-myc and growth factor expression in human placental choriocarcinoma JEG-3 cells","volume":"231","author":"Zhang","year":"1997","journal-title":"Biochem Biophys Res Commun"},{"key":"2025060201511785800_deaf075-B72","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0143-4004(98)80014-3","article-title":"Differential effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin and benzo(a)pyrene on proliferation and growth factor gene expression in human choriocarcinoma BeWo cells","volume":"19","author":"Zhang","year":"1998","journal-title":"Placenta"},{"key":"2025060201511785800_deaf075-B73","doi-asserted-by":"crossref","first-page":"123847","DOI":"10.1016\/j.envpol.2024.123847","article-title":"Environmental copper exposure, placental cuproptosis, and miscarriage","volume":"348","author":"Zhao","year":"2024","journal-title":"Environ Pollut"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/6\/1163\/63024248\/deaf075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/6\/1163\/63024248\/deaf075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,2]],"date-time":"2025-06-02T05:51:35Z","timestamp":1748843495000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/40\/6\/1163\/8121380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":68,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2025,4,28]]},"published-print":{"date-parts":[[2025,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaf075","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,6]]},"published":{"date-parts":[[2025,4,28]]}}}