{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T02:43:00Z","timestamp":1789872180323,"version":"4.0.1"},"reference-count":110,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T00:00:00Z","timestamp":1747353600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R00ES030403"],"award-info":[{"award-number":["R00ES030403"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Polycystic ovarian syndrome (PCOS) is a common female endocrinologic condition that affects both the metabolic and reproductive systems and is the most frequent cause of anovulatory infertility. It is also associated with a range of psychiatric outcomes in individuals, including bulimia nervosa, schizophrenia, bipolar disorder, depression, anxiety, and personality disorders. At the same time, evidence suggests that hyperandrogenism, the characteristic trait of PCOS, may impair fetal neurodevelopment. Epidemiological studies have linked maternal PCOS with a variety of behavioral and psychiatric conditions in offspring including autism spectrum disorder and attention deficit hyperactivity disorder. In this review, we explore evidence for potential underlying biological mechanisms that might explain these observed associations, discuss the complex interplay between genetics and various environmental factors across generations, and highlight avenues for future research.<\/jats:p>","DOI":"10.1093\/humrep\/deaf079","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T04:36:11Z","timestamp":1747456571000},"page":"1257-1265","source":"Crossref","is-referenced-by-count":5,"title":["Maternal polycystic ovarian syndrome and offspring psychopathology and neurodevelopment"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6512-6160","authenticated-orcid":false,"given":"Linda G","family":"Kahn","sequence":"first","affiliation":[{"name":"Department of Pediatrics, New York University Grossman School of Medicine , New York, NY,","place":["USA"]},{"name":"Department of Population Health, New York University Grossman School of Medicine , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7179-1151","authenticated-orcid":false,"given":"Alison E","family":"Hipwell","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, University of Pittsburgh , Pittsburgh, PA,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9918-3617","authenticated-orcid":false,"given":"Mia","family":"Charifson","sequence":"additional","affiliation":[{"name":"Department of Population Health, New York University Grossman School of Medicine , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Ling","sequence":"additional","affiliation":[{"name":"Department of Population Health, New York University Grossman School of Medicine , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim N","family":"Cajachagua-Torres","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University Grossman School of Medicine , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9551-4706","authenticated-orcid":false,"given":"Akhgar","family":"Ghassabian","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, New York University Grossman School of Medicine , New York, NY,","place":["USA"]},{"name":"Department of Population Health, New York University Grossman School of Medicine , New York, NY,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,5,16]]},"reference":[{"key":"2025070301520098700_deaf079-B1","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/13625187.2022.2040983","article-title":"Maternal polycystic ovary syndrome and the potential risk of 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