{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T13:11:17Z","timestamp":1781615477242,"version":"3.54.5"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2025,5,18]],"date-time":"2025-05-18T00:00:00Z","timestamp":1747526400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"Abstract<\/jats:title>\n \n STUDY QUESTION<\/jats:title>\n What is the validity of published administrative health data case definitions of polycystic ovary syndrome (PCOS) compared with reference standards?<\/jats:p>\n <\/jats:sec>\n \n SUMMARY ANSWER<\/jats:title>\n Due to the limited number of eligible studies, drawing definitive conclusions is challenging; however, this review highlights significant gaps and variability in current PCOS case definitions, underscoring the need for standardized case definitions in future research.<\/jats:p>\n <\/jats:sec>\n \n WHAT IS KNOWN ALREADY<\/jats:title>\n Administrative health data offer the opportunity to evaluate health outcomes and disease epidemiology at a population-level. Currently, the validity of existing administrative health data case definitions for PCOS is unknown.<\/jats:p>\n <\/jats:sec>\n \n STUDY DESIGN, SIZE, DURATION<\/jats:title>\n A systematic review of the literature was conducted on full-text English-language articles up to July 2023, using the MEDLINE and EMBASE databases.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n Two reviewers independently screened titles, abstracts and full texts, extracted data, assessed study quality and graded validity. A random effects meta-analysis was conducted to pool reported validity measures and heterogeneity was examined.<\/jats:p>\n <\/jats:sec>\n \n MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n The review included four eligible articles consisting of three cross-sectional studies and one retrospective cohort study. Two studies defined PCOS using the Rotterdam Criteria, one study used self-report, and one used a clinical gold standard. All case definitions included the International Classification of Diseases (ICD)-9 code 256.4 for \u2018polycystic ovaries\u2019 and three studies used E28.2 for \u2018polycystic ovarian syndrome\u2019. Three studies reported positive predictive value (PPV), which ranged from 30 to 96%. One study reported both PPV (96%) and sensitivity (50%) for one case definition. The pooled PPV estimate for the ICD code-based case definitions was 88% (95% confidence interval 82-95%; I2\u2009=\u2009100%). One study reported fair agreement (percent agreement= 90.3, \u03ba\u2009=\u20090.27, percent agreement bias adjusted \u03ba\u2009=\u20090.81). Overall, the risk of bias of the included studies was low.<\/jats:p>\n <\/jats:sec>\n \n LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n There were limited number of validations and precision indices of validations.<\/jats:p>\n <\/jats:sec>\n \n WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n Further validation of these case definitions in other administrative health datasets, and development of novel coding algorithms is required to inform future population-based studies in PCOS.<\/jats:p>\n <\/jats:sec>\n \n STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n No external funding was used and there are no disclosures.<\/jats:p>\n <\/jats:sec>\n \n REGISTRATION NUMBER<\/jats:title>\n PROSPERO CRD42023385617<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humrep\/deaf094","type":"journal-article","created":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T20:09:30Z","timestamp":1747512570000},"page":"1579-1586","source":"Crossref","is-referenced-by-count":2,"title":["Validity of administrative health data case definitions for identifying polycystic ovary syndrome: a systematic review and meta-analysis"],"prefix":"10.1093","volume":"40","author":[{"given":"Sophie","family":"Hu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, University of Manitoba , Winnipeg, MB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophie","family":"Lalonde-Bester","sequence":"additional","affiliation":[{"name":"Faculty of Medicine & Dentistry, University of Alberta , Edmonton, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenna","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary , Calgary, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheffinea","family":"Koshy","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary , Calgary, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7816-3422","authenticated-orcid":false,"given":"Donna","family":"Vine","sequence":"additional","affiliation":[{"name":"Faculty of Medicine & Dentistry, University of Alberta , Edmonton, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyrone G","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary , Calgary, AB,","place":["Canada"]},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary , Calgary, AB,","place":["Canada"]},{"name":"O\u2019Brien Institute for Public Health and Libin Cardiovascular Institute, University of Calgary , Calgary, AB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer M","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, University of Manitoba , Winnipeg, MB,","place":["Canada"]},{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary , Calgary, AB,","place":["Canada"]},{"name":"Children\u2019s Hospital Research Institute of Manitoba, Children's Hospital Foundation of Manitoba , Winnipeg, MB,","place":["Canada"]},{"name":"Department of Community Health Sciences, University of Manitoba , Winnipeg, MB,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2233-4613","authenticated-orcid":false,"given":"Jamie L","family":"Benham","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary , Calgary, AB,","place":["Canada"]},{"name":"Department of Community Health Sciences, Cumming School of Medicine, University of Calgary , Calgary, 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