{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T12:33:22Z","timestamp":1784637202184,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T00:00:00Z","timestamp":1753747200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82201814"],"award-info":[{"award-number":["82201814"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"publisher","award":["2021A1515110444"],"award-info":[{"award-number":["2021A1515110444"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Foundation of Shenzhen Hospital of Southern Medical University","award":["PY2022YM03"],"award-info":[{"award-number":["PY2022YM03"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>Can harmine mitigate endometriosis by modulating oxidative phosphorylation (OXPHOS) suppression and macrophage polarization?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>Harmine induces apoptosis in endometriotic lesions by inhibiting OXPHOS while also modulating macrophage polarization through the reduction of extracellular adenosine (eADO), a metabolic byproduct of OXPHOS.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>Endometriosis is associated with mitochondrial dysfunction while ectopic endometrial stromal cells (EESCs) exhibit heightened susceptibility to oxidative stress. Macrophages accumulate in the peritoneal cavity and peritoneal fluid, constituting a dominant immune cell population within endometriotic lesions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>A total of 25 patients diagnosed with ovarian endometriosis and 25 healthy donors undergoing surgical treatment at a university-affiliated hospital within 6\u00a0months were included. Primary normal endometrial stromal cells (NESCs) and EESCs were isolated, cultured, and subjected to pharmacological drug intervention, small interfering RNA (siRNA) transfection, OXPHOS analysis, and transcriptomic profiling. Macrophage cell line RAW264.7 was used to study macrophage polarization. The in vivo study involved 24 C57BL\/6 female mice to establish an endometriosis model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>The impact of harmine on cellular viability in vitro was assessed using Cell Counting Kit-8 (CCK-8) clonogenic assays, 5-ethynyl-2\u2032-deoxyuridine (EdU) incorporation, and flow cytometry. OXPHOS inhibition was evaluated through mitochondrial ultrastructural changes observed via transmission electron microscopy and fluorescence staining. Oxidative stress was quantified using JC-1 mitochondrial membrane potential assays and reactive oxygen species (ROS) detection kits. Seahorse oxygen consumption rate assay was conducted to measure OXPHOS activity. Immunohistochemistry was employed to examine key protein expression in endometrial tissues. ATP and eADO levels were quantified using an ATP Assay Kit and Adenosine Assay Kit, respectively. We used RNA sequencing (RNA-seq) to identify enriched biological pathways. Flow cytometry was used to characterize macrophage populations in peritoneal fluid, and CIBERSORTx software was applied to generate immune cell expression profiles. Samples with P-values &amp;lt;0.05 were selected for analysis, with macrophage subtype (M\u03c62\/M\u03c61) alterations statistically evaluated using the Wilcoxon test.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>EESCs exhibited greater susceptibility to harmine treatment compared to NESCs (P\u2009&amp;lt;\u20090.05). RNA-seq analysis revealed that harmine primarily influences pathways related to cell proliferation, oxidative stress, and HIF-1 signaling. Differentially expressed genes were enriched in complexes regulating mitochondrial OXPHOS. Harmine intervention significantly increased mitochondrial fission in EESCs compared to NESCs and markedly suppressed OXPHOS activity in EESCs. Treatment with harmine decreased total ROS levels in cultured EESCs (P\u2009&amp;lt;\u20090.05 vs NESCs). The eADO\/CD73-mediated adenosine pathway was upregulated in endometriotic lesions, accompanied by a predominance of M\u03c62 macrophages in the microenvironment (Wilcoxon test, P\u2009&amp;lt;\u20090.05). In the murine model, harmine treatment decreased eADO production and shifted macrophage polarization toward a pro-inflammatory M\u03c61 phenotype, contributing to endometriotic lesion regression.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LARGE SCALE DATA<\/jats:title>\n                  <jats:p>N\/A.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>The study\u2019s reliance on primary cells was constrained by their limited passage potential and inherent heterogeneity, precluding co-culture investigations. Further mechanistic elucidation requires cell line-based studies. More subtypes should be included in the research, not just models of ovarian endometriosis. Eutopic endometrial cells should be included in the experiment if conditions permit. Additionally, primate models with menstrual cycles, such as rhesus monkeys, should be considered for future in vivo validation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>These findings indicate that harmine may serve as a promising alkaloid-based therapeutic for endometriosis by modulating energy metabolism and immune responses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>This research was supported by the National Natural Science Foundation of China (NSFC No. 82201814), the Guangdong Basic and Applied Basic Research Foundation (2021A1515110444), and the Foundation of Shenzhen Hospital of Southern Medical University (PY2022YM03). The authors declare no conflicts of interest.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>N\/A.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/deaf130","type":"journal-article","created":{"date-parts":[[2025,7,29]],"date-time":"2025-07-29T23:15:28Z","timestamp":1753830928000},"page":"1893-1908","source":"Crossref","is-referenced-by-count":3,"title":["Harmine inhibits oxidative phosphorylation, thus regulating the polarization of macrophages mediated by extracellular adenosine in endometriosis"],"prefix":"10.1093","volume":"40","author":[{"given":"Anwei","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuying","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]},{"name":"The First School of Clinical Medicine, Southern Medical University , Guangzhou, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]},{"name":"The First School of Clinical Medicine, Southern Medical University , Guangzhou, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haijuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengyu","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuye","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojuan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxin","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Clinical Medicine Innovation Center, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-0983-2363","authenticated-orcid":false,"given":"Li","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1351-0635","authenticated-orcid":false,"given":"Minuo","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,7,29]]},"reference":[{"key":"2025100301520562700_deaf130-B1","doi-asserted-by":"crossref","first-page":"599117","DOI":"10.3389\/fimmu.2020.599117","article-title":"Immunological basis of the endometriosis: the complement system as a potential therapeutic target","volume":"11","author":"Agostinis","year":"2020","journal-title":"Front Immunol"},{"key":"2025100301520562700_deaf130-B2","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/s41571-020-0382-2","article-title":"The adenosine pathway in immuno-oncology","volume":"17","author":"Allard","year":"2020","journal-title":"Nat Rev Clin Oncol"},{"key":"2025100301520562700_deaf130-B3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1556\/EuJMI.2.2012.2.3","article-title":"Impact of enzymatic tissue disintegration on the level of surface molecule expression and immune cell function","volume":"2","author":"Autengruber","year":"2012","journal-title":"Eur J Microbiol Immunol (Bp)"},{"key":"2025100301520562700_deaf130-B4","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1111\/1471-0528.15692","article-title":"Influence of race\/ethnicity on prevalence and presentation of endometriosis: a systematic review and meta-analysis","volume":"126","author":"Bougie","year":"2019","journal-title":"BJOG"},{"key":"2025100301520562700_deaf130-B5","doi-asserted-by":"crossref","first-page":"7138","DOI":"10.3390\/ijms22137138","article-title":"Can endometriosis-related oxidative stress pave the way for new treatment targets?","volume":"22","author":"Cacciottola","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2025100301520562700_deaf130-B6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.freeradbiomed.2019.03.027","article-title":"Mitochondria and oxidative stress in ovarian endometriosis","volume":"136","author":"Chen","year":"2019","journal-title":"Free Radic Biol Med"},{"key":"2025100301520562700_deaf130-B7","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.7150\/thno.51777","article-title":"Metabolic regulatory crosstalk between tumor microenvironment and tumor-associated macrophages","volume":"11","author":"Chen","year":"2021","journal-title":"Theranostics"},{"key":"2025100301520562700_deaf130-B8","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0140-6736(10)60490-4","article-title":"Endometriosis and infertility: pathophysiology and management","volume":"376","author":"de Ziegler","year":"2010","journal-title":"Lancet"},{"key":"2025100301520562700_deaf130-B9","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.beem.2018.10.001","article-title":"Assisted reproduction in endometriosis","volume":"33","author":"de Ziegler","year":"2019","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"2025100301520562700_deaf130-B10","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1097\/j.pain.0000000000001832","article-title":"Nonsurgical mouse model of endometriosis-associated pain that responds to clinically active drugs","volume":"161","author":"Fattori","year":"2020","journal-title":"Pain"},{"key":"2025100301520562700_deaf130-B11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/cmi.2016.71","article-title":"IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity","volume":"15","author":"Feng","year":"2018","journal-title":"Cell Mol Immunol"},{"key":"2025100301520562700_deaf130-B12","doi-asserted-by":"crossref","first-page":"417","DOI":"10.4103\/1735-5362.350242","article-title":"Harmine mitigates cisplatin-induced renal injury in male mice through antioxidant, anti-inflammatory, and anti-apoptosis effects","volume":"17","author":"Ghanbari","year":"2022","journal-title":"Res Pharm Sci"},{"key":"2025100301520562700_deaf130-B13","doi-asserted-by":"crossref","first-page":"324","DOI":"10.5653\/cerm.2023.06254","article-title":"Harmine exhibits anti-apoptotic properties and reduces diabetes-induced testicular damage caused by streptozotocin in rats","volume":"51","author":"Ghanbari","year":"2024","journal-title":"Clin Exp Reprod Med"},{"key":"2025100301520562700_deaf130-B14","doi-asserted-by":"crossref","first-page":"1382142","DOI":"10.3389\/fonc.2024.1382142","article-title":"Research progress on the antitumor effects of harmine","volume":"14","author":"Hu","year":"2024","journal-title":"Front Oncol"},{"key":"2025100301520562700_deaf130-B15","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1439-0442.1971.tb00573.x","article-title":"Effect of harmine and harmaline hydrochloride on pregnancy in white rats","volume":"18","author":"Kamel","year":"1971","journal-title":"Zentralbl Veterinarmed A"},{"key":"2025100301520562700_deaf130-B16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1530\/REP-22-0265","article-title":"Oxidative phosphorylation inhibitors inhibit proliferation of endometriosis cells","volume":"165","author":"Kapur","year":"2023","journal-title":"Reproduction"},{"key":"2025100301520562700_deaf130-B17","doi-asserted-by":"crossref","first-page":"e108130","DOI":"10.15252\/embj.2021108130","article-title":"ATP and cancer immunosurveillance","volume":"40","author":"Kepp","year":"2021","journal-title":"EMBO J"},{"key":"2025100301520562700_deaf130-B18","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.fertnstert.2003.07.037","article-title":"Differential macrophage infiltration in early and advanced endometriosis and adjacent peritoneum","volume":"81","author":"Khan","year":"2004","journal-title":"Fertil Steril"},{"key":"2025100301520562700_deaf130-B19","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1080\/09513590.2019.1683821","article-title":"Evaluation of M1 and M2 macrophages in ovarian endometriomas from women affected by endometriosis at different stages of the disease","volume":"36","author":"Lagana","year":"2020","journal-title":"Gynecol Endocrinol"},{"key":"2025100301520562700_deaf130-B20","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40425-018-0360-8","article-title":"Targeting adenosine for cancer immunotherapy","volume":"6","author":"Leone","year":"2018","journal-title":"J Immunother Cancer"},{"key":"2025100301520562700_deaf130-B21","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1093\/humrep\/deaa363","article-title":"Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis","volume":"36","author":"Li","year":"2021","journal-title":"Hum Reprod"},{"key":"2025100301520562700_deaf130-B22","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.pnpbp.2017.06.012","article-title":"Harmine produces antidepressant-like effects via restoration of astrocytic functions","volume":"79","author":"Liu","year":"2017","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2025100301520562700_deaf130-B23","doi-asserted-by":"crossref","first-page":"113554","DOI":"10.1016\/j.ejmech.2021.113554","article-title":"Design, synthesis and biological evaluation of harmine derivatives as potent GSK-3beta\/DYRK1A dual inhibitors for the treatment of Alzheimer\u2019s disease","volume":"222","author":"Liu","year":"2021","journal-title":"Eur J Med Chem"},{"key":"2025100301520562700_deaf130-B24","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.jid.2021.06.010","article-title":"Single-cell RNA-sequencing reveals lineage-specific regulatory changes of fibroblasts and vascular endothelial cells in keloids","volume":"142","author":"Liu","year":"2022","journal-title":"J Invest Dermatol"},{"key":"2025100301520562700_deaf130-B25","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s40425-016-0154-9","article-title":"Adenosine-generating ovarian cancer cells attract myeloid cells which differentiate into adenosine-generating tumor associated macrophages\u2014a self-amplifying, CD39- and CD73-dependent mechanism for tumor immune escape","volume":"4","author":"Montalban Del Barrio","year":"2016","journal-title":"J Immunother Cancer"},{"key":"2025100301520562700_deaf130-B26","doi-asserted-by":"crossref","first-page":"115401","DOI":"10.1016\/j.jpba.2023.115401","article-title":"Lipid class-dependent alterations of Caenorhabditis elegans under harmane exposure","volume":"231","author":"Nguyen","year":"2023","journal-title":"J Pharm Biomed Anal"},{"key":"2025100301520562700_deaf130-B27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.canlet.2021.09.022","article-title":"Plasmacytoid dendritic cells recruited by HIF-1alpha\/eADO\/ADORA1 signaling induce immunosuppression in hepatocellular carcinoma","volume":"522","author":"Pang","year":"2021","journal-title":"Cancer Lett"},{"key":"2025100301520562700_deaf130-B28","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1111\/1471-0528.13920","article-title":"Pregnancy outcomes in women with endometriosis: a national record linkage study","volume":"124","author":"Saraswat","year":"2017","journal-title":"BJOG"},{"key":"2025100301520562700_deaf130-B29","doi-asserted-by":"crossref","first-page":"2807","DOI":"10.1016\/j.cell.2021.04.041","article-title":"Endometriosis: etiology, pathobiology, and therapeutic prospects","volume":"184","author":"Saunders","year":"2021","journal-title":"Cell"},{"key":"2025100301520562700_deaf130-B30","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1177\/0963689719833305","article-title":"The effect of enzymatic digestion on cultured epithelial autografts","volume":"28","author":"Skog","year":"2019","journal-title":"Cell Transplant"},{"key":"2025100301520562700_deaf130-B31","doi-asserted-by":"crossref","first-page":"104384","DOI":"10.1016\/j.jri.2024.104384","article-title":"The role and potential treatment of macrophages in patients with infertility and endometriosis","volume":"166","author":"Song","year":"2024","journal-title":"J Reprod Immunol"},{"key":"2025100301520562700_deaf130-B32","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/s41573-021-00339-6","article-title":"Targeting cancer metabolism in the era of precision oncology","volume":"21","author":"Stine","year":"2022","journal-title":"Nat Rev Drug Discov"},{"key":"2025100301520562700_deaf130-B33","doi-asserted-by":"crossref","first-page":"837230","DOI":"10.3389\/fimmu.2022.837230","article-title":"Adenosine-A2A receptor pathway in cancer immunotherapy","volume":"13","author":"Sun","year":"2022","journal-title":"Front Immunol"},{"key":"2025100301520562700_deaf130-B34","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/aji.12331","article-title":"Subpopulations of macrophages within eutopic endometrium of endometriosis patients","volume":"73","author":"Takebayashi","year":"2015","journal-title":"Am J Reprod Immunol"},{"key":"2025100301520562700_deaf130-B35","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12935-018-0574-3","article-title":"Harmine, a dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) inhibitor induces caspase-mediated apoptosis in neuroblastoma","volume":"18","author":"Uhl","year":"2018","journal-title":"Cancer Cell Int"},{"key":"2025100301520562700_deaf130-B36","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1093\/humupd\/dmz018","article-title":"The endometrial immune environment of women with endometriosis","volume":"25","author":"Vallve-Juanico","year":"2019","journal-title":"Hum Reprod Update"},{"key":"2025100301520562700_deaf130-B37","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1038\/nrc.2017.86","article-title":"Targeting immunosuppressive adenosine in cancer","volume":"17","author":"Vijayan","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"2025100301520562700_deaf130-B38","doi-asserted-by":"crossref","first-page":"4284","DOI":"10.1038\/s41467-021-24426-9","article-title":"Global kinome profiling reveals DYRK1A as critical activator of the human mitochondrial import machinery","volume":"12","author":"Walter","year":"2021","journal-title":"Nat Commun"},{"key":"2025100301520562700_deaf130-B39","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1080\/07391102.2018.1552197","article-title":"Insight into binding mechanisms of EGFR allosteric inhibitors using molecular dynamics simulations and free energy calculations","volume":"37","author":"Wan","year":"2019","journal-title":"J Biomol Struct Dyn"},{"key":"2025100301520562700_deaf130-B40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/nm.3820","article-title":"A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication","volume":"21","author":"Wang","year":"2015","journal-title":"Nat Med"},{"key":"2025100301520562700_deaf130-B41","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s12943-023-01733-x","article-title":"CD39\/CD73\/A2AR pathway and cancer immunotherapy","volume":"22","author":"Xia","year":"2023","journal-title":"Mol Cancer"},{"key":"2025100301520562700_deaf130-B42","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.fertnstert.2021.01.027","article-title":"Target identification and drug discovery by data-driven hypothesis and experimental validation in ovarian endometriosis","volume":"116","author":"Yin","year":"2021","journal-title":"Fertil Steril"},{"key":"2025100301520562700_deaf130-B43","doi-asserted-by":"crossref","first-page":"e12637","DOI":"10.1002\/rmb2.12637","article-title":"The physiological role of macrophages in reproductive organs","volume":"24","author":"Yoshino","year":"2025","journal-title":"Reprod Med Biol"},{"key":"2025100301520562700_deaf130-B44","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13046-023-02832-9","article-title":"Functional polarization of tumor-associated macrophages dictated by metabolic reprogramming","volume":"42","author":"Zeng","year":"2023","journal-title":"J Exp Clin Canc Res"},{"key":"2025100301520562700_deaf130-B45","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1007\/s12272-020-01283-6","article-title":"Pharmacological effects of harmine and its derivatives: a review","volume":"43","author":"Zhang","year":"2020","journal-title":"Arch Pharm Res"},{"key":"2025100301520562700_deaf130-B46","doi-asserted-by":"crossref","first-page":"271ra9","DOI":"10.1126\/scitranslmed.3010626","article-title":"Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis","volume":"7","author":"Zhao","year":"2015","journal-title":"Sci Transl Med"},{"key":"2025100301520562700_deaf130-B47","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1056\/NEJMra1810764","article-title":"Endometriosis","volume":"382","author":"Zondervan","year":"2020","journal-title":"N Engl J Med"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/10\/1893\/63883006\/deaf130.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/10\/1893\/63883006\/deaf130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T05:52:20Z","timestamp":1759470740000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/40\/10\/1893\/8217637"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,29]]},"references-count":47,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2025,7,29]]},"published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaf130","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,7,29]]}}}