{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:51:52Z","timestamp":1777974712409,"version":"3.51.4"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T00:00:00Z","timestamp":1762128000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,1]]},"abstract":"Abstract<\/jats:title>\n \n STUDY QUESTION<\/jats:title>\n Can network modelling of single-cell transcriptomic data identify cellular developmental trajectories of fallopian tube (FT) epithelium and reveal functional and pathological divergence from the endometrium?<\/jats:p>\n <\/jats:sec>\n \n SUMMARY ANSWER<\/jats:title>\n A bidirectional differentiation trajectory originating from a novel OVGP1+ progenitor population of FT epithelial cells was uncovered, and causal network modelling of whole-transcriptome activity in the FT and endometrium revealed functional divergence between their secretory epithelial cells, with implications for ectopic pregnancy candidate genes.<\/jats:p>\n <\/jats:sec>\n \n WHAT IS KNOWN ALREADY<\/jats:title>\n The FT forms the in vivo peri-conceptual environment, which has a significant impact on programming offspring health. The FT epithelium establishes this environment; however, the epithelial cell types are poorly characterized in health and disease.<\/jats:p>\n <\/jats:sec>\n \n STUDY DESIGN, SIZE, DURATION<\/jats:title>\n Publicly available, benign FT single-cell RNA sequencing (scRNA-seq) samples from 13 women across three previous studies were combined. Endometrial scRNA-seq samples from 13 women from one study were used to demonstrate transcriptomic differences between the epithelia of the two tissues. Network models of transcriptomic action were constructed with hypergraphs.<\/jats:p>\n <\/jats:sec>\n \n PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n A meta-analysis of FT scRNA-seq samples was performed to identify epithelial populations. Differential gene expression assessed differences between FT and endometrial epithelial scRNA-seq data. Functional differences between secretory cells in the tissues were characterized using hypergraph models. To identify associations with ectopic pregnancy, expression quantitative trait loci (eQTLs) from a recent GWAS were mapped onto the network models.<\/jats:p>\n <\/jats:sec>\n \n MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n Epithelial cells (n\u2009=\u200914\u00a0360) were clustered into eight secretory and ciliated epithelial populations in the meta-analysis of three scRNA-seq datasets. A novel OVGP1+ epithelial progenitor cell was also identified, and its bidirectional differentiation to mature secretory or mature ciliated populations was mapped by RNA velocity analysis. This progenitor exhibited a high velocity magnitude (12.47) and low confidence (0.69): a combination strongly indicative of multipotent progenitor status. Comparing FT epithelial cells with endometrial epithelial cells revealed 5.3-fold fewer shared genes between FT and endometrial glandular secretory cells than between FT and endometrial ciliated cells, suggesting functional divergence of secretory cells along the reproductive tract. Hypergraphs were used to identify highly coordinated regions of the transcriptome robustly associated with functional gene networks. In the FT secretory cells, these networks were enriched for lipid-related (false discovery rate (FDR)\u2009&lt;\u20090.002) and immune-related (FDR\u2009&lt;\u20090.00007) pathways. We mapped eQTLs from a GWAS meta-analysis of 7070 women with ectopic pregnancy over a range of significance (P\u2009=\u20091.68 \u00d7 10\u221221\u20135.8 \u00d7 10\u22124) to the hypergraphs of FT and endometrium. Of the 22 genes present in the hypergraphs, 13 of these clustered as highly coordinated genes. This demonstrated the functional importance of MUC1 in the FT and endometrium (GWAS Study P\u2009=\u20095.32\u2009\u00d7\u200910\u22129) and identified additional genes (SLC7A2, CLDN1, GLS, PEX6, PLXNA4, NR2F1, CLGN, PGGHG, and ANKRD36) implicated in ectopic pregnancy and eutopic pregnancy.<\/jats:p>\n <\/jats:sec>\n \n LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n The sample size of reproductive age women was limited in previous studies, and though causal network modelling was used and previous mechanistic data supports candidate gene involvement, no in vitro or in vivo validation of candidate was performed.<\/jats:p>\n <\/jats:sec>\n \n WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n These findings consolidate the existing single-cell transcriptomic datasets of the FT to provide a comprehensive understanding of epithelial populations and define functionally distinct secretory cells that contribute to the peri-conceptual environment of the FT. This study further implicates the role of MUC1 and secretory cells in ectopic pregnancy and suggests future targets for investigating embryo implantation in the FT and endometrium.<\/jats:p>\n <\/jats:sec>\n \n STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n No funding was received for this study. The authors do not disclose any competing interests.<\/jats:p>\n <\/jats:sec>\n \n TRIAL REGISTRATION NUMBER<\/jats:title>\n N\/A.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humrep\/deaf200","type":"journal-article","created":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T11:56:31Z","timestamp":1759492591000},"page":"2369-2381","source":"Crossref","is-referenced-by-count":1,"title":["Identification of novel differentiation trajectories and gene network associations with ectopic pregnancy in fallopian tube epithelium"],"prefix":"10.1093","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-8915-4744","authenticated-orcid":false,"given":"Lily I","family":"Wright","sequence":"first","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5168-6263","authenticated-orcid":false,"given":"Ivan","family":"Wangsaputra","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3962-9730","authenticated-orcid":false,"given":"Terence","family":"Garner","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-8246","authenticated-orcid":false,"given":"Megan C","family":"Sharps","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4423-5058","authenticated-orcid":false,"given":"Roger","family":"Sturmey","sequence":"additional","affiliation":[{"name":"Biomedical Institute for Multimorbidity, Hull York Medical School, University of Hull , Hull,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1476-1666","authenticated-orcid":false,"given":"Peter T","family":"Ruane","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1950-7325","authenticated-orcid":false,"given":"Adam","family":"Stevens","sequence":"additional","affiliation":[{"name":"Maternal and Fetal Health Research Centre, Division of Developmental Biology and Medicine, School of Medical Sciences, Faculty of Biology, Medicine, and Health, University of Manchester , Manchester,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"2025120400520086100_deaf200-B1","doi-asserted-by":"crossref","first-page":"S18","DOI":"10.1016\/j.ijgo.2013.09.008","article-title":"Anatomical causes of female infertility and their management","volume":"123","author":"Abrao","year":"2013","journal-title":"Int J Gynaecol Obstet"},{"key":"2025120400520086100_deaf200-B2","doi-asserted-by":"crossref","first-page":"2582","DOI":"10.1093\/humrep\/dep233","article-title":"The expression of MUC1 in human Fallopian tube during the menstrual cycle and in ectopic pregnancy","volume":"24","author":"Al-Azemi","year":"2009","journal-title":"Hum Reprod"},{"key":"2025120400520086100_deaf200-B3","doi-asserted-by":"crossref","first-page":"32556","DOI":"10.1038\/srep32556","article-title":"The C-terminal region of OVGP1 remodels the zona pellucida and modifies fertility parameters","volume":"6","author":"Algarra","year":"2016","journal-title":"Sci Rep"},{"key":"2025120400520086100_deaf200-B4","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1530\/REP-17-0054","article-title":"Oviduct extracellular vesicles protein content and their role during oviduct-embryo cross-talk","volume":"154","author":"Alminana","year":"2017","journal-title":"Reproduction"},{"key":"2025120400520086100_deaf200-B5","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1477-7827-7-152","article-title":"Plexin-B1, glycodelin and MMP7 expression in the human fallopian tube and in the endometrium","volume":"7","author":"Amir","year":"2009","journal-title":"Reprod Biol Endocrinol"},{"key":"2025120400520086100_deaf200-B6","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1093\/oxfordjournals.humrep.a138628","article-title":"Comparative immunohistochemical study of oestrogen and progesterone receptors in the fallopian tube and uterus at different stages of the menstrual cycle and the menopause","volume":"9","author":"Amso","year":"1994","journal-title":"Hum Reprod"},{"key":"2025120400520086100_deaf200-B7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1056\/NEJMcp0810384","article-title":"Ectopic pregnancy","volume":"361","author":"Barnhart","year":"2009","journal-title":"N Engl J Med"},{"key":"2025120400520086100_deaf200-B8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/REP-16-0651","article-title":"Embryo culture in presence of oviductal fluid induces DNA methylation changes in bovine blastocysts","volume":"154","author":"Barrera","year":"2017","journal-title":"Reproduction"},{"key":"2025120400520086100_deaf200-B9","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1111\/ahe.12010","article-title":"Expression of DNA methyltransferase genes in four-cell bovine embryos cultured in the presence of oviductal fluid","volume":"42","author":"Barrera","year":"2013","journal-title":"Anat Histol Embryol"},{"key":"2025120400520086100_deaf200-B10","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41567-021-01371-4","article-title":"The physics of higher-order interactions in complex systems","volume":"17","author":"Battiston","year":"2021","journal-title":"Nat Phys"},{"key":"2025120400520086100_deaf200-B11","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1038\/s41587-020-0591-3","article-title":"Generalizing RNA velocity to transient cell states through dynamical modeling","volume":"38","author":"Bergen","year":"2020","journal-title":"Nat Biotechnol"},{"key":"2025120400520086100_deaf200-B12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/PAI.0000000000000233","article-title":"MUC1 (VPM654 and EPR1023) expression in mucosa of fallopian tubes with ectopic pregnancy is altered","volume":"24","author":"Brito","year":"2016","journal-title":"Appl Immunohistochem Mol Morphol"},{"key":"2025120400520086100_deaf200-B13","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1038\/s41588-018-0248-z","article-title":"An atlas of genetic associations in UK Biobank","volume":"50","author":"Canela-Xandri","year":"2018","journal-title":"Nat Genet"},{"key":"2025120400520086100_deaf200-B14","doi-asserted-by":"crossref","first-page":"jkaa056","DOI":"10.1093\/g3journal\/jkaa056","article-title":"Revisiting the genome-wide significance threshold for common variant GWAS","volume":"11","author":"Chen","year":"2021","journal-title":"G3 GenesGenomesGenetics"},{"key":"2025120400520086100_deaf200-B15","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1093\/oxfordjournals.humrep.a138428","article-title":"Morphology and ultrastructure of fallopian tube epithelium at different stages of the menstrual cycle and menopause","volume":"9","author":"Crow","year":"1994","journal-title":"Hum Reprod"},{"key":"2025120400520086100_deaf200-B16","doi-asserted-by":"crossref","first-page":"S11","DOI":"10.33549\/physiolres.934954","article-title":"From a passive conduit to highly dynamic organ. What are the roles of uterine tube epithelium in reproduction?","volume":"71","author":"Csobonyeiova","year":"2022","journal-title":"Physiol Res"},{"key":"2025120400520086100_deaf200-B17","doi-asserted-by":"crossref","first-page":"bbae667","DOI":"10.1093\/bib\/bbae667","article-title":"Higher order interaction analysis quantifies coordination in the epigenome revealing novel biological relationships in Kabuki syndrome","volume":"26","author":"Cuvertino","year":"2024","journal-title":"Brief Bioinform"},{"key":"2025120400520086100_deaf200-B18","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1582-4934.2011.01280.x","article-title":"Syntaxin 11 marks a distinct intracellular compartment recruited to the immunological synapse of NK cells to colocalize with cytotoxic granules","volume":"16","author":"Dabrazhynetskaya","year":"2012","journal-title":"J Cell Mol Med"},{"key":"2025120400520086100_deaf200-B19","doi-asserted-by":"crossref","first-page":"108978","DOI":"10.1016\/j.celrep.2021.108978","article-title":"Single-cell transcriptomics identifies gene expression networks driving differentiation and tumorigenesis in the human fallopian tube","volume":"35","author":"Dinh","year":"2021","journal-title":"Cell Rep"},{"key":"2025120400520086100_deaf200-B20","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1093\/molehr\/gaq055","article-title":"Expression of the repulsive SLIT\/ROBO pathway in the human endometrium and Fallopian tube","volume":"16","author":"Duncan","year":"2010","journal-title":"Mol Hum Reprod"},{"key":"2025120400520086100_deaf200-B21","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1016\/S0140-6736(18)30312-X","article-title":"Origins of lifetime health around the time of conception: causes and consequences","volume":"391","author":"Fleming","year":"2018","journal-title":"Lancet"},{"key":"2025120400520086100_deaf200-B22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1745-6150-4-17","article-title":"Chaotic expression dynamics implies pluripotency: when theory and experiment meet","volume":"4","author":"Furusawa","year":"2009","journal-title":"Biol Direct"},{"key":"2025120400520086100_deaf200-B23","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1038\/s41588-021-00972-2","article-title":"Mapping the temporal and spatial dynamics of the human endometrium in vivo and in vitro","volume":"53","author":"Garcia-Alonso","year":"2021","journal-title":"Nat Genet"},{"key":"2025120400520086100_deaf200-B24","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12916-018-1203-7","article-title":"The growth of assisted reproductive treatment-conceived children from birth to 5 years: a national cohort study","volume":"16","author":"Hann","year":"2018","journal-title":"BMC Med"},{"key":"2025120400520086100_deaf200-B25","doi-asserted-by":"crossref","first-page":"2554","DOI":"10.1091\/mbc.e04-12-1077","article-title":"The aftiphilin\/p200\/gamma-synergin complex","volume":"16","author":"Hirst","year":"2005","journal-title":"Mol Biol Cell"},{"key":"2025120400520086100_deaf200-B26","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.ccell.2020.01.003","article-title":"The repertoire of serous ovarian cancer non-genetic heterogeneity revealed by single-cell sequencing of normal fallopian tube epithelial cells","volume":"37","author":"Hu","year":"2020","journal-title":"Cancer Cell"},{"key":"2025120400520086100_deaf200-B27","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1186\/1471-2164-9-488","article-title":"BioVenn\u2014a web application for the comparison and visualization of biological lists using area-proportional Venn diagrams","volume":"9","author":"Hulsen","year":"2008","journal-title":"BMC Genomics"},{"key":"2025120400520086100_deaf200-B28","doi-asserted-by":"crossref","first-page":"e35618","DOI":"10.1371\/journal.pone.0035618","article-title":"Exploring the transcriptome of ciliated cells using in silico dissection of human tissues","volume":"7","author":"Ivliev","year":"2012","journal-title":"PLoS One"},{"key":"2025120400520086100_deaf200-B29","volume-title":"Hypernetworks in the Science of Complex Systems","author":"Johnson","year":"2011"},{"key":"2025120400520086100_deaf200-B30","doi-asserted-by":"crossref","first-page":"1365602","DOI":"10.3389\/fendo.2024.1365602","article-title":"Overview of the expression patterns and roles of Lipocalin 2 in the reproductive system","volume":"15","author":"Krizanac","year":"2024","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2025120400520086100_deaf200-B31","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/humrep\/deh200","article-title":"A study of HLA-DR and -DQ alleles in 588 patients and 562 controls confirms that HLA-DRB103 is associated with recurrent miscarriage","volume":"19","author":"Kruse","year":"2004","journal-title":"Hum Reprod"},{"key":"2025120400520086100_deaf200-B32","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/s41586-018-0414-6","article-title":"RNA velocity of single cells","volume":"560","author":"La Manno","year":"2018","journal-title":"Nature"},{"key":"2025120400520086100_deaf200-B33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1071\/RD07153","article-title":"Female reproductive tract fluids: composition, mechanism of formation and potential role in the developmental origins of health and disease","volume":"20","author":"Leese","year":"2008","journal-title":"Reprod Fertil Dev"},{"key":"2025120400520086100_deaf200-B34","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1530\/rep.0.1210339","article-title":"Formation of Fallopian tubal fluid: role of a neglected epithelium","volume":"121","author":"Leese","year":"2001","journal-title":"Reproduction"},{"key":"2025120400520086100_deaf200-B35","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/JOE-16-0302","article-title":"Oviduct: roles in fertilization and early embryo development","volume":"232","author":"Li","year":"2017","journal-title":"J Endocrinol"},{"key":"2025120400520086100_deaf200-B36","doi-asserted-by":"crossref","first-page":"W199","DOI":"10.1093\/nar\/gkz401","article-title":"WebGestalt 2019: gene set analysis toolkit with revamped UIs and APIs","volume":"47","author":"Liao","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2025120400520086100_deaf200-B37","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1093\/humrep\/deaa177","article-title":"Fallopian tube epithelial cells express androgen receptor and have a distinct hormonal responsiveness when compared with endometrial epithelium","volume":"35","author":"Maclean","year":"2020","journal-title":"Hum Reprod"},{"key":"2025120400520086100_deaf200-B38","doi-asserted-by":"crossref","first-page":"5320","DOI":"10.1210\/jc.2010-0603","article-title":"MUC1 as a discriminator between endometrium from fertile and infertile patients with PCOS and endometriosis","volume":"95","author":"Margarit","year":"2010","journal-title":"J Clin Endocrinol Metab"},{"key":"2025120400520086100_deaf200-B39","doi-asserted-by":"crossref","first-page":"S300","DOI":"10.1016\/j.fertnstert.2007.07.1012","article-title":"Apoproteins and cholesterol trafficking in human ovarian follicular fluid","volume":"88","author":"Monisova","year":"2007","journal-title":"Fertil Steril"},{"key":"2025120400520086100_deaf200-B40","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1159\/000364935","article-title":"Molecular genetics of Mullerian duct formation, regression and differentiation","volume":"8","author":"Mullen","year":"2014","journal-title":"Sex Dev"},{"key":"2025120400520086100_deaf200-B41","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1093\/humrep\/dead217","article-title":"Genome-wide association study meta-analysis supports association between MUC1 and ectopic pregnancy","volume":"38","author":"Pujol Gualdo","year":"2023","journal-title":"Hum Reprod"},{"key":"2025120400520086100_deaf200-B42","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.fertnstert.2012.02.035","article-title":"Why does the fallopian tube fail in ectopic pregnancy? The role of activins, inducible nitric oxide synthase, and MUC1 in ectopic implantation","volume":"97","author":"Refaat","year":"2012","journal-title":"Fertil Steril"},{"key":"2025120400520086100_deaf200-B43","doi-asserted-by":"crossref","first-page":"165954","DOI":"10.1016\/j.scitotenv.2023.165954","article-title":"Warming during embryogenesis induces a lasting transcriptomic signature in fishes","volume":"902","author":"Ripley","year":"2023","journal-title":"Sci Total Environ"},{"key":"2025120400520086100_deaf200-B44","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1093\/humrep\/deac008","article-title":"Trophectoderm differentiation to invasive syncytiotrophoblast is promoted by endometrial epithelial cells during human embryo implantation","volume":"37","author":"Ruane","year":"2022","journal-title":"Hum Reprod"},{"key":"2025120400520086100_deaf200-B45","doi-asserted-by":"crossref","first-page":"792","DOI":"10.15252\/msb.20145549","article-title":"Cell dynamics and gene expression control in tissue homeostasis and development","volume":"11","author":"Rue","year":"2015","journal-title":"Mol Syst Biol"},{"key":"2025120400520086100_deaf200-B46","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1111\/j.1447-0756.2010.01272.x","article-title":"Development of the genital ducts and external genitalia in the early human embryo","volume":"36","author":"Sajjad","year":"2010","journal-title":"J Obstet Gynaecol Res"},{"key":"2025120400520086100_deaf200-B47","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.ejogrb.2014.06.001","article-title":"MUC1 expression in Fallopian tubes of women with hydrosalpinx","volume":"180","author":"Silva","year":"2014","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2025120400520086100_deaf200-B48","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1093\/humrep\/dey083","article-title":"Does human endometrial LGR5 gene expression suggest the existence of another hormonally regulated epithelial stem cell niche?","volume":"33","author":"Tempest","year":"2018","journal-title":"Hum Reprod"},{"key":"2025120400520086100_deaf200-B49","doi-asserted-by":"crossref","first-page":"103308","DOI":"10.1016\/j.jri.2021.103308","article-title":"HLA-DRB1 polymorphism in recurrent pregnancy loss: new evidence for an association to HLA-DRB107","volume":"145","author":"Thomsen","year":"2021","journal-title":"J Reprod Immunol"},{"key":"2025120400520086100_deaf200-B50","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/j.devcel.2022.02.017","article-title":"Cellular heterogeneity of human fallopian tubes in normal and hydrosalpinx disease states identified using scRNA-seq","volume":"57","author":"Ulrich","year":"2022","journal-title":"Dev Cell"},{"key":"2025120400520086100_deaf200-B51","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1080\/15548627.2023.2247747","article-title":"The presence of blastocyst within the uteri facilitates lumenal epithelium transformation for implantation via upregulating lysosome proteostasis activity","volume":"20","author":"Wang","year":"2024","journal-title":"Autophagy"},{"key":"2025120400520086100_deaf200-B52","doi-asserted-by":"crossref","first-page":"109382","DOI":"10.1016\/j.celrep.2021.109382","article-title":"In vivo dynamic 3D imaging of oocytes and embryos in the mouse oviduct","volume":"36","author":"Wang","year":"2021","journal-title":"Cell Rep"},{"key":"2025120400520086100_deaf200-B53","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1530\/REP-22-0250","article-title":"Dynamics of gametes and embryos in the oviduct: what can in vivo imaging reveal?","volume":"165","author":"Wang","year":"2023","journal-title":"Reproduction"},{"key":"2025120400520086100_deaf200-B54","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/s41467-024-55440-2","article-title":"A cell atlas of the human fallopian tube throughout the menstrual cycle and menopause","volume":"16","author":"Weigert","year":"2025","journal-title":"Nat Commun"},{"key":"2025120400520086100_deaf200-B55","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/B978-0-12-801238-3.64401-X","volume-title":"Encyclopedia of Reproduction","author":"Winuthayanon","year":"2018"},{"key":"2025120400520086100_deaf200-B56","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol"},{"key":"2025120400520086100_deaf200-B57","doi-asserted-by":"crossref","first-page":"bqac134","DOI":"10.1210\/endocr\/bqac134","article-title":"RhoB promotes endometrial stromal cells decidualization via semaphorin3A\/plexinA4 signaling in early pregnancy","volume":"163","author":"Xu","year":"2022","journal-title":"Endocrinology"},{"key":"2025120400520086100_deaf200-B58","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/path.4649","article-title":"In vitro and in vivo correlates of physiological and neoplastic human Fallopian tube stem cells","volume":"238","author":"Yamamoto","year":"2016","journal-title":"J Pathol"},{"key":"2025120400520086100_deaf200-B59","doi-asserted-by":"crossref","first-page":"104085","DOI":"10.1016\/j.isci.2022.104085","article-title":"The vesicular transporter STX11 governs ATGL-mediated hepatic lipolysis and lipophagy","volume":"25","author":"Zhang","year":"2022","journal-title":"iScience"},{"key":"2025120400520086100_deaf200-B60","doi-asserted-by":"crossref","first-page":"lqaa078","DOI":"10.1093\/nargab\/lqaa078","article-title":"ComBat-seq: batch effect adjustment for RNA-seq count data","volume":"2","author":"Zhang","year":"2020","journal-title":"NAR Genom Bioinform"},{"key":"2025120400520086100_deaf200-B61","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s00418-021-02065-x","article-title":"The role of oviduct-specific glycoprotein (OVGP1) in modulating biological functions of gametes and embryos","volume":"157","author":"Zhao","year":"2022","journal-title":"Histochem Cell Biol"},{"key":"2025120400520086100_deaf200-B62","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1038\/nrg1475","article-title":"The nature of stem cells: state rather than entity","volume":"5","author":"Zipori","year":"2004","journal-title":"Nat Rev Genet"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/12\/2369\/65133447\/deaf200.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/40\/12\/2369\/65133447\/deaf200.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T05:52:13Z","timestamp":1764827533000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/40\/12\/2369\/8313665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":62,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2025,11,3]]},"published-print":{"date-parts":[[2025,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaf200","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,11,3]]}}}