{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T10:05:59Z","timestamp":1787997959156,"version":"build-2784847793"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T00:00:00Z","timestamp":1766707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"University-Hospital of Dijon"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>STUDY QUESTION<\/jats:title>\n                    <jats:p>Does extended embryo culture (EEC) associate with an increased risk of obstetrical, perinatal, or children\u2019s health complications?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUMMARY ANSWER<\/jats:title>\n                    <jats:p>After thorough adjustment, EEC was not associated with widespread increased risks, although a moderate excess risk persisted for a few specific outcomes, notably cardiac anomalies, whereas reduced risks were observed for gestational diabetes, small birthweight, and musculoskeletal-limb anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                    <jats:p>EEC is increasingly used in IVF cycles. While blastocyst transfer (day-5\/6) often improves birth rates, concerns remain about its impact on maternal and child health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                    <jats:p>In this nationwide longitudinal cohort study, all live-born singletons conceived through IVF\u2014with or without sperm microinjection\u2014and following fresh embryo transfer between 2014 and 2019 in France were included and followed for up to 8\u2009years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                    <jats:p>Data were obtained from the French National Health System and the National Biomedicine Agency registries. A comparative study was conducted between singletons conceived at either day-2\/3 (cleavage-stage embryos group) or day-5\/6 (EEC group). Data from both registries were cross-linked to identify obstetrical, perinatal, and health outcomes, including major congenital malformations, hospitalizations, and surgical interventions. Multivariable logistic and survival models were used to adjust for maternal, paternal, and treatment-related factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                    <jats:p>A total of 41\u00a0315 singletons were included (25\u00a0816 and 15\u00a0499 from day-2\/3 and day-5\/6 groups, respectively). Most outcomes were similar between groups, notably the incidence of global major congenital malformations. However, EEC was associated with increased risks of placenta praevia (aOR, 1.16; 95% CI, 1.02\u20131.30), admission in neonatal intensive care unit (aOR, 1.16; 95% CI, 1.05\u20131.29), and cardiac anomalies at age 3\u00a0years (aHR, 1.78; 95% CI, 1.21\u20132.60). Conversely, the risk of gestational diabetes (aOR, 0.94; 95% CI, 0.88\u20131.00; P\u2009=\u20090.041) and small birthweight (aOR, 0.94; 95% CI, 0.88\u20131.00, P\u2009=\u20090.039) was lower, as was the risk of musculoskeletal-limb anomalies (aHR, 0.63; 95% CI, 0.42\u20130.97)\u2014a finding that persisted up to age 7. Other health outcomes were largely comparable.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                    <jats:p>One limitation of this study is that the data refer to live-born singletons, with stillbirths and medical terminations excluded from the analyses. Despite extensive adjustments, residual confounding cannot be excluded. Findings for specific pathologies\/malformations should be interpreted with caution because the number of cases was small in some sub-groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                    <jats:p>In this large and unique study, after adjusting for multiple maternal, paternal, and cycle-related variables, our findings provide some reassurance regarding the safety of prolonged in vitro embryo culture. A moderate risk remained for a few maternal and child health conditions following EEC\u2014warranting further investigation\u2014whereas the risk was notably lower compared to short embryo culture, particularly for musculoskeletal-limb anomalies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                    <jats:p>This work was supported by the AOI of University Hospital of Dijon. The authors have no competing interests to disclose.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                    <jats:p>N\/A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/humrep\/deaf245","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T12:36:25Z","timestamp":1765197385000},"page":"443-452","source":"Crossref","is-referenced-by-count":1,"title":["Obstetrical, perinatal, and children\u2019s health outcomes following fresh embryo transfer after extended embryo culture"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9708-1710","authenticated-orcid":false,"given":"Patricia","family":"Fauque","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Paris Cit\u00e9, INSERM 1016 , Paris,","place":["France"]},{"name":"Department of Reproductive Biology-CECOS, Assistance publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8501-3312","authenticated-orcid":false,"given":"Jonathan","family":"Cottenet","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics (DIM), University Hospital, Bourgogne Franche-Comt\u00e9 University , Dijon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8269-7515","authenticated-orcid":false,"given":"Julie","family":"Firmin","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Paris Cit\u00e9, INSERM 1016 , Paris,","place":["France"]},{"name":"Department of Reproductive Biology-CECOS, Assistance publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-4859","authenticated-orcid":false,"given":"Khaled","family":"Pocate-Cheriet","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology-CECOS, Assistance publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4822-9176","authenticated-orcid":false,"given":"Lucile","family":"Ferreux","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology-CECOS, Assistance publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5684-6991","authenticated-orcid":false,"given":"Ahmed","family":"Chargui","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology-CECOS, Assistance publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2892-3715","authenticated-orcid":false,"given":"Sol\u00e8ne","family":"Tapia","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics (DIM), University Hospital, Bourgogne Franche-Comt\u00e9 University , Dijon,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0473-4381","authenticated-orcid":false,"given":"Chlo\u00e9","family":"Maignien","sequence":"additional","affiliation":[{"name":"Department of Gynecology Obstetrics II and Reproductive Medicine, Assistance publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3922-3493","authenticated-orcid":false,"given":"Mathilde","family":"Bourdon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Paris Cit\u00e9, INSERM 1016 , Paris,","place":["France"]},{"name":"Department of Gynecology Obstetrics II and Reproductive Medicine, Assistance publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4985-7326","authenticated-orcid":false,"given":"Pietro","family":"Santulli","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Paris Cit\u00e9, INSERM 1016 , Paris,","place":["France"]},{"name":"Department of Gynecology Obstetrics II and Reproductive Medicine, Assistance publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4885-8885","authenticated-orcid":false,"given":"Catherine","family":"Patrat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Universit\u00e9 de Paris Cit\u00e9, INSERM 1016 , Paris,","place":["France"]},{"name":"Department of Reproductive Biology-CECOS, Assistance publique-H\u00f4pitaux de Paris (AP-HP), H\u00f4pital Universitaire Paris Centre (HUPC), Centre Hospitalier Universitaire (CHU) Cochin , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5134-9411","authenticated-orcid":false,"given":"Catherine","family":"Quantin","sequence":"additional","affiliation":[{"name":"Biostatistics and Bioinformatics (DIM), University Hospital, Bourgogne Franche-Comt\u00e9 University , Dijon,","place":["France"]},{"name":"INSERM, CIC 1432, Clinical Investigation Centre, Dijon University Hospital, Clinical Epidemiology\/Clinical Trials Unit , Dijon,","place":["France"]},{"name":"Biostatistics, Biomathematics, Pharmacoepidemiology and Infectious Diseases (B2PHI), INSERM, UVSQ, Institut Pasteur, Universit\u00e9 Paris-Saclay , Paris,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,26]]},"reference":[{"key":"2026030500514565600_deaf245-B1","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.fertnstert.2025.02.009","article-title":"How many infants have been born with the help of assisted reproductive technology?","volume":"124","author":"Adamson","year":"2025","journal-title":"Fertil Steril"},{"key":"2026030500514565600_deaf245-B2","author":"Agence de la biom\u00e9decine\u2014Du don \u00e0 la vie"},{"key":"2026030500514565600_deaf245-B3","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/uog.18942","article-title":"Influence of cryopreservation on perinatal outcome after blastocyst- vs cleavage-stage embryo transfer: systematic review and meta-analysis","volume":"51","author":"Alviggi","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2026030500514565600_deaf245-B4","doi-asserted-by":"crossref","first-page":"e2314","DOI":"10.1002\/bdr2.2314","article-title":"Updated EUROCAT guidelines for classification of cases with congenital anomalies","volume":"116","author":"Bergman","year":"2024","journal-title":"Birth Defects Res"},{"key":"2026030500514565600_deaf245-B5","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1071\/RD14049","article-title":"Impacts of and interactions between environmental stress and epigenetic programming during early embryo development","volume":"27","author":"Bertoldo","year":"2015","journal-title":"Reprod Fertil Dev"},{"key":"2026030500514565600_deaf245-B6","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/pds.4233","article-title":"The national healthcare system claims databases in France, SNIIRAM and EGB: powerful tools for pharmacoepidemiology","volume":"26","author":"Bezin","year":"2017","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2026030500514565600_deaf245-B7","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.healthplace.2011.06.002","article-title":"Out-of-hospital births and the supply of maternity units in France","volume":"17","author":"Blondel","year":"2011","journal-title":"Health Place"},{"key":"2026030500514565600_deaf245-B8","author":"Born too soon: decade of action on preterm birth"},{"key":"2026030500514565600_deaf245-B9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/humupd\/dmu001","article-title":"Neonatal outcomes among singleton births after blastocyst versus cleavage stage embryo transfer: a systematic review and meta-analysis","volume":"20","author":"Dar","year":"2014","journal-title":"Hum Reprod Update"},{"key":"2026030500514565600_deaf245-B10","volume-title":"Reference Module in Biomedical Sciences","author":"Ducreux","year":"2024"},{"key":"2026030500514565600_deaf245-B11","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jgyn.2015.08.009","article-title":"Courbes de croissance in utero ajust\u00e9es et non ajust\u00e9es adapt\u00e9es \u00e0 la population fran\u00e7aise. I\u2014M\u00e9thodes de construction","volume":"45","author":"Ego","year":"2016","journal-title":"J Gyn\u00e9col Obst\u00e9t Biol Reprod"},{"key":"2026030500514565600_deaf245-B12","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1007\/s00404-020-05593-4","article-title":"Neonatal outcomes in singleton pregnancies conceived by fresh or frozen embryo transfer compared to spontaneous conceptions: a systematic review and meta-analysis","volume":"302","author":"Elias","year":"2020","journal-title":"Arch Gynecol Obstet"},{"key":"2026030500514565600_deaf245-B13","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.fertnstert.2025.06.029","article-title":"The influence of male age and sperm parameters on blastulation and euploidy rates","volume":"124","author":"Elkhatib","year":"2025","journal-title":"Fertil Steril"},{"key":"2026030500514565600_deaf245-B14","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1093\/humrep\/dead197","article-title":"ART in Europe, 2019: results generated from European registries by ESHRE\u2020","volume":"38","author":"European IVF Monitoring Consortium (EIM) for the European Society of Human Reproduction and Embryology (ESHRE)","year":"2023","journal-title":"Hum Reprod"},{"key":"2026030500514565600_deaf245-B15","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1093\/humrep\/deaa323","article-title":"Do in vitro fertilization, intrauterine insemination or female infertility impact the risk of congenital anomalies in singletons? A longitudinal national French study","volume":"36","author":"Fauque","year":"2021","journal-title":"Hum Reprod"},{"key":"2026030500514565600_deaf245-B16","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1471-0528.2010.02531.x","article-title":"Termination of pregnancy for fetal anomaly after 23 weeks of gestation: a European register-based study","volume":"117","author":"Garne","year":"2010","journal-title":"BJOG"},{"key":"2026030500514565600_deaf245-B17","doi-asserted-by":"crossref","first-page":"378.e1","DOI":"10.1016\/j.ajog.2015.12.040","article-title":"Neonatal and maternal outcome after blastocyst transfer: a population-based registry study","volume":"214","author":"Ginstr\u00f6m Ernstad","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"2026030500514565600_deaf245-B18","doi-asserted-by":"crossref","first-page":"e035218","DOI":"10.1136\/bmjopen-2019-035218","article-title":"Validation study: evaluation of the metrological quality of French hospital data for perinatal algorithms","volume":"10","author":"Goueslard","year":"2020","journal-title":"BMJ Open"},{"key":"2026030500514565600_deaf245-B19","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.fertnstert.2023.07.003","article-title":"Risk of congenital malformations in live-born singletons conceived after intracytoplasmic sperm injection: a Nordic study from the CoNARTaS group","volume":"120","author":"Henningsen","year":"2023","journal-title":"Fertil Steril"},{"key":"2026030500514565600_deaf245-B20","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/01.ede.0000135174.63482.43","article-title":"A structural approach to selection bias","volume":"15","author":"Hern\u00e1n","year":"2004","journal-title":"Epidemiology"},{"key":"2026030500514565600_deaf245-B21","volume-title":"Human Fertilisation & Embryology Authority (HFEA)","author":"HFEA: UK fertility regulator"},{"key":"2026030500514565600_deaf245-B22","volume-title":"EUROCAT Guide 1.5","author":"Kinsner-Ovaskainen","year":"2025"},{"key":"2026030500514565600_deaf245-B23","doi-asserted-by":"crossref","first-page":"e1004536","DOI":"10.1371\/journal.pmed.1004536","article-title":"Risk of placenta previa in assisted reproductive technology: a Nordic population study with sibling analyses","volume":"22","author":"Landsverk","year":"2025","journal-title":"PLoS Med"},{"key":"2026030500514565600_deaf245-B24","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/humupd\/dmab042","article-title":"Obstetric and perinatal outcomes of singleton pregnancies after blastocyst-stage embryo transfer compared with those after cleavage-stage embryo transfer: a systematic review and cumulative meta-analysis","volume":"28","author":"Marconi","year":"2022","journal-title":"Hum Reprod Update"},{"key":"2026030500514565600_deaf245-B25","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1093\/humrep\/dez133","article-title":"Perinatal outcomes in singleton live births after fresh blastocyst-stage embryo transfer: a retrospective analysis of 67\u2009147 IVF\/ICSI cycles","volume":"34","author":"Marconi","year":"2019","journal-title":"Hum Reprod"},{"key":"2026030500514565600_deaf245-B26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.gyobfe.2011.10.010","article-title":"[Single pregnancy outcome after blastocyst transfer: comparison with cleavage stage embryo transfers]","volume":"40","author":"Martin","year":"2012","journal-title":"Gynecol Obstet Fertil"},{"key":"2026030500514565600_deaf245-B27","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1093\/humrep\/dew244","article-title":"Obstetrical and perinatal outcomes following blastocyst transfer compared to cleavage transfer: a systematic review and meta-analysis","volume":"31","author":"Martins","year":"2016","journal-title":"Hum Reprod"},{"key":"2026030500514565600_deaf245-B28","doi-asserted-by":"crossref","first-page":"hoad003","DOI":"10.1093\/hropen\/hoad003","article-title":"A comparison of perinatal outcomes following fresh blastocyst or cleavage stage embryo transfer in singletons and twins and between singleton siblings","volume":"2023","author":"Raja","year":"2023","journal-title":"Hum Reprod Open"},{"key":"2026030500514565600_deaf245-B29","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1093\/eurheartj\/ehae572","article-title":"Congenital heart defects in children born after assisted reproductive technology: a CoNARTaS study","volume":"45","author":"Sargisian","year":"2024","journal-title":"Eur Heart J"},{"key":"2026030500514565600_deaf245-B30","author":"SART Outcome Tables"},{"key":"2026030500514565600_deaf245-B31","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/uog.26019","article-title":"Congenital anomaly and perinatal outcome following blastocyst- vs cleavage-stage embryo transfer: systematic review and network meta-analysis","volume":"61","author":"Siristatidis","year":"2023","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2026030500514565600_deaf245-B32","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1093\/humrep\/deaa032","article-title":"Obstetric and perinatal risks in 4601 singletons and 884 twins conceived after fresh blastocyst transfers: a Nordic study from the CoNARTaS group","volume":"35","author":"Spangmose","year":"2020","journal-title":"Hum Reprod"},{"key":"2026030500514565600_deaf245-B33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7104a1","article-title":"Assisted Reproductive Technology Surveillance\u2014United States, 2018","volume":"71","author":"Sunderam","year":"2022","journal-title":"MMWR Surveill Summ"},{"key":"2026030500514565600_deaf245-B34","author":"The Developing Human","year":"2019"},{"key":"2026030500514565600_deaf245-B35","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.fertnstert.2020.06.017","article-title":"Effect of embryo stage at transfer on placental histopathology features in singleton live births resulting from fresh embryo transfers","volume":"115","author":"Volodarsky-Perel","year":"2021","journal-title":"Fertil Steril"},{"key":"2026030500514565600_deaf245-B36","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s12958-017-0255-4","article-title":"Comparative neonatal outcomes in singleton births from blastocyst transfers or cleavage-stage embryo transfers: a systematic review and meta-analysis","volume":"15","author":"Wang","year":"2017","journal-title":"Reprod Biol Endocrinol"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/41\/3\/443\/66134543\/deaf245.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/41\/3\/443\/66134543\/deaf245.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:51:56Z","timestamp":1772689916000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/41\/3\/443\/8405515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,26]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,12,26]]},"published-print":{"date-parts":[[2026,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deaf245","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2025,12,26]]}}}