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While clinical cases using this groundbreaking strategy have now been reported for the two principal MRT methods\u2014pronuclear transfer and maternal spindle transfer\u2014recent data continues to raise questions about the reliability of these approaches for disease prevention.<\/jats:p>","DOI":"10.1093\/humrep\/deag020","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:44:03Z","timestamp":1769777043000},"page":"479-482","source":"Crossref","is-referenced-by-count":3,"title":["Revisiting the promise and pitfalls of mitochondrial replacement therapies"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2073-7515","authenticated-orcid":false,"given":"Nuno","family":"Costa-Borges","sequence":"first","affiliation":[{"name":"Embryotools SL , Science Park of Barcelona , 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