{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T17:12:52Z","timestamp":1790874772597,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001505","name":"Health Research Council of New Zealand","doi-asserted-by":"publisher","award":["18-027"],"award-info":[{"award-number":["18-027"]}],"id":[{"id":"10.13039\/501100001505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>STUDY QUESTION<\/jats:title>\n                    <jats:p>Does anti-M\u00fcllerian hormone (AMH) influence preantral follicle development within a short range of AMH-secreting antral follicles?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUMMARY ANSWER<\/jats:title>\n                    <jats:p>Immunization of sheep against AMH leads to increased follicle survival, specifically in regions close to small-medium antral follicles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                    <jats:p>Serum AMH is known to inhibit the survival of immature ovarian follicles, but its biological role remains poorly understood. Mammalian ovaries contain many more developing ovarian follicles than are needed for ovulation, but how these systems operate remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                    <jats:p>Cross-sectional\u2013control versus treatment studies examining the effects in the presence or absence of AMH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                    <jats:p>Anti-AMH immunization experiments were conducted in sheep followed by histological 2D and 3D tissue analysis. Microdialysis was conducted on ex vivo human and sheep ovaries. Live-imaging of a fluorogenic enzyme-responsive reagent was conducted on ex vivo mouse ovaries. Organ\/follicle culture was conducted on Amh+\/+ and Amh\u2212\/\u2212 ovary tissues to measure follicle activation and growth rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                    <jats:p>The likely site of action of AMH was shown to be ovarian stroma adjacent to large follicles as microdialysis determined that receptor-activating concentrations of AMH were only observed within a short range of the follicle. The AMH-activating enzymes were also shown to be primarily located in stroma using live-imaging of a fluorogenic enzyme-responsive reagent. Sheep were immunized against AMH protein to inhibit extracellular signalling and the ovaries were examined using 3-dimensional reconstructions of ovarian follicle positions. This showed that inhibition of AMH signalling caused an increase in preantral follicle survival, but almost entirely in proximity to large developing follicles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LARGE SCALE DATA<\/jats:title>\n                    <jats:p>None.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                    <jats:p>Limited studies were conducted on human tissue but the results concur with the sheep experiments. Sheep ovaries provide a useful large-animal model for comparative anatomy with humans but there will be interspecies differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                    <jats:p>These results add to the evidence that small growing follicle survival is influenced by the proximity of large follicles. This has relevance for conditions where large follicles are lacking (e.g. primary ovary insufficiency) or where follicle growth is excessive (e.g. PCOS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                    <jats:p>This research was funded by a Sir Charles Hercus Research Fellowship from the Health Research Council of New Zealand (grant number 18-027). The authors have no conflicts of interest to declare.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                    <jats:p>N\/A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/humrep\/deag022","type":"journal-article","created":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T12:37:23Z","timestamp":1770122243000},"page":"795-808","source":"Crossref","is-referenced-by-count":1,"title":["AMH regulates ovary size by counteracting the positive influence of clustered ovarian follicle growth"],"prefix":"10.1093","volume":"41","author":[{"given":"Carmen","family":"Lim","sequence":"first","affiliation":[{"name":"Department of Anatomy, School of Biomedical Sciences, University of Otago , Dunedin,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn","family":"Yiew","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Biomedical Sciences, University of Otago , Dunedin,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8393-1073","authenticated-orcid":false,"given":"Nicholas J","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Biomedical Sciences, University of Otago , Dunedin,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6376-1139","authenticated-orcid":false,"given":"Peter","family":"Smith","sequence":"additional","affiliation":[{"name":"Reproductive and Developmental Biology, AgResearch Invermay, Puddle Alley , Mosgiel,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Quirke","sequence":"additional","affiliation":[{"name":"Reproductive and Developmental Biology, AgResearch Invermay, Puddle Alley , Mosgiel,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Carne","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, School of Biomedical Sciences, University of Otago , Dunedin,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Urooza","family":"Sarma","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Biomedical Sciences, University of Otago , Dunedin,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Rose","sequence":"additional","affiliation":[{"name":"School of Biomedicine, Robinson Research Institute, University of Adelaide , Adelaide,","place":["Australia"]},{"name":"Genea Fertility South Australia , Adelaide,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Nicholson","sequence":"additional","affiliation":[{"name":"Awanui Labs , Dunedin,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2945-8301","authenticated-orcid":false,"given":"Christine L","family":"Jasoni","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Biomedical Sciences, University of Otago , Dunedin,","place":["New Zealand"]},{"name":"Centre for Neuroendocrinology, University of Otago , Dunedin,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6350-0657","authenticated-orcid":false,"given":"Ping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Biomedical Sciences, University of Otago , Dunedin,","place":["New Zealand"]},{"name":"Brain Health Research Centre, University of Otago , Dunedin,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Petrich","sequence":"additional","affiliation":[{"name":"Department of Women\u2019s and Children\u2019s Health, Dunedin School of Medicine, University of Otago , Dunedin,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2717-7311","authenticated-orcid":false,"given":"Jenny","family":"Juengel","sequence":"additional","affiliation":[{"name":"Reproductive and Developmental Biology, AgResearch Invermay, Puddle Alley , Mosgiel,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-5742","authenticated-orcid":false,"given":"Michael W","family":"Pankhurst","sequence":"additional","affiliation":[{"name":"Department of Anatomy, School of Biomedical Sciences, University of Otago , Dunedin,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"2026050501524074900_deag022-B1","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/ar.1090940210","article-title":"Estimation of nuclear population from microtome sections","volume":"94","author":"Abercrombie","year":"1946","journal-title":"Anat Rec"},{"key":"2026050501524074900_deag022-B2","doi-asserted-by":"crossref","first-page":"4951","DOI":"10.1210\/endo.136.11.7588229","article-title":"Anti-Mullerian hormone and anti-Mullerian hormone type II receptor messenger ribonucleic acid expression in rat ovaries during postnatal development, the estrous cycle, and gonadotropin-induced follicle growth","volume":"136","author":"Baarends","year":"1995","journal-title":"Endocrinology"},{"key":"2026050501524074900_deag022-B3","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mce.2008.04.006","article-title":"Hormonal regulation of proprotein convertase subtilisin\/kexin type 5 expression during ovarian follicle development in the rat","volume":"289","author":"Bae","year":"2008","journal-title":"Mol Cell Endocrinol"},{"key":"2026050501524074900_deag022-B4","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1093\/molehr\/gaw064","article-title":"A grafted ovarian fragment rescues host fertility after chemotherapy","volume":"22","author":"Batchvarov","year":"2016","journal-title":"Mol Hum Reprod"},{"key":"2026050501524074900_deag022-B5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/0092-8674(94)90251-8","article-title":"Mullerian-inhibiting substance function during mammalian sexual development","volume":"79","author":"Behringer","year":"1994","journal-title":"Cell"},{"key":"2026050501524074900_deag022-B6","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1530\/REP-16-0129","article-title":"Reproductive age-associated fibrosis in the stroma of the mammalian ovary","volume":"152","author":"Briley","year":"2016","journal-title":"Reproduction"},{"key":"2026050501524074900_deag022-B7","volume-title":"Blender Spreadsheet Import v. 0.2.0","author":"Broggi","year":"2022"},{"key":"2026050501524074900_deag022-B8","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1210\/en.2012-1158","article-title":"The role of anti-Mullerian hormone (AMH) during follicle development in a monovulatory species (sheep)","volume":"153","author":"Campbell","year":"2012","journal-title":"Endocrinology"},{"key":"2026050501524074900_deag022-B9","doi-asserted-by":"crossref","first-page":"3376","DOI":"10.1210\/jc.2018-00549","article-title":"Expression of Mullerian-inhibiting substance\/anti-Mullerian hormone type II receptor in the human theca cells","volume":"103","author":"Cheon","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"2026050501524074900_deag022-B10","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.semcdb.2014.01.008","article-title":"Regulation of TGFbeta and related signals by precursor processing","volume":"32","author":"Constam","year":"2014","journal-title":"Semin Cell Dev Biol"},{"key":"2026050501524074900_deag022-B11","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1073\/pnas.0810012106","article-title":"Inferring biological mechanisms from spatial analysis: prediction of a local inhibitor in the ovary","volume":"106","author":"Da Silva-Buttkus","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026050501524074900_deag022-B12","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1210\/endo.143.3.8691","article-title":"Anti-Mullerian hormone inhibits initiation of primordial follicle growth in the mouse ovary","volume":"143","author":"Durlinger","year":"2002","journal-title":"Endocrinology"},{"key":"2026050501524074900_deag022-B13","doi-asserted-by":"crossref","first-page":"4891","DOI":"10.1210\/endo.142.11.8486","article-title":"Anti-Mullerian hormone attenuates the effects of FSH on follicle development in the mouse ovary","volume":"142","author":"Durlinger","year":"2001","journal-title":"Endocrinology"},{"key":"2026050501524074900_deag022-B14","doi-asserted-by":"crossref","first-page":"5789","DOI":"10.1210\/endo.140.12.7204","article-title":"Control of primordial follicle recruitment by anti-Mullerian hormone in the mouse ovary","volume":"140","author":"Durlinger","year":"1999","journal-title":"Endocrinology"},{"key":"2026050501524074900_deag022-B15","first-page":"292","article-title":"Incessant ovulation and ovarian cancer \u2013 a hypothesis re-visited","volume":"5","author":"Fathalla","year":"2013","journal-title":"Facts Views Vis Obgyn"},{"key":"2026050501524074900_deag022-B16","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3758\/BF03193146","article-title":"GPower 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences","volume":"39","author":"Faul","year":"2007","journal-title":"Behav Res Methods"},{"key":"2026050501524074900_deag022-B17","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1002\/mrd.22285","article-title":"Cytokines in ovarian folliculogenesis, oocyte maturation and luteinisation","volume":"81","author":"Field","year":"2014","journal-title":"Mol Reprod Dev"},{"key":"2026050501524074900_deag022-B18","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1477-7827-4-18","article-title":"Regulation of the ovarian follicular vasculature","volume":"4","author":"Fraser","year":"2006","journal-title":"Reprod Biol Endocrinol"},{"key":"2026050501524074900_deag022-B19","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1210\/edrv-17-2-121","article-title":"Regulation of ovarian follicular development in primates: facts and hypotheses","volume":"17","author":"Gougeon","year":"1996","journal-title":"Endocr Rev"},{"key":"2026050501524074900_deag022-B20","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s12020-007-9014-1","article-title":"Testosterone upregulation of tissue type plasminogen activator expression in Sertoli cells: tPA expression in Sertoli cells","volume":"32","author":"Guo","year":"2007","journal-title":"Endocrine"},{"key":"2026050501524074900_deag022-B21","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1093\/biolre\/ioz227","article-title":"Accelerated ovarian reserve depletion in female anti-Mullerian hormone knockout mice has no effect on lifetime fertilitydagger","volume":"102","author":"Guo","year":"2020","journal-title":"Biol Reprod"},{"key":"2026050501524074900_deag022-B22","first-page":"134","article-title":"Onset and heterogeneity of responsiveness to FSH in mouse preantral follicles in culture","volume":"158","author":"Hardy","year":"2017","journal-title":"Endocrinology"},{"key":"2026050501524074900_deag022-B23","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1080\/02841850600885419","article-title":"Magnetic resonance imaging of the ovaries of healthy women: determination of normal values","volume":"47","author":"Hauth","year":"2006","journal-title":"Acta Radiol"},{"key":"2026050501524074900_deag022-B24","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.mce.2016.05.019","article-title":"Intra-cellular mechanism of anti-Mullerian hormone (AMH) in regulation of follicular development","volume":"433","author":"Hayes","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"2026050501524074900_deag022-B25","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1095\/biolreprod58.3.705","article-title":"The ovarian blood follicle barrier is both charge- and size-selective in mice","volume":"58","author":"Hess","year":"1998","journal-title":"Biol Reprod"},{"key":"2026050501524074900_deag022-B26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1093\/molehr\/gat024","article-title":"Which follicles make the most anti-Mullerian hormone in humans? Evidence for an abrupt decline in AMH production at the time of follicle selection","volume":"19","author":"Jeppesen","year":"2013","journal-title":"Mol Hum Reprod"},{"key":"2026050501524074900_deag022-B27","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1093\/humupd\/dmi014","article-title":"AMH and AMH receptor defects in persistent Mullerian duct syndrome","volume":"11","author":"Josso","year":"2005","journal-title":"Hum Reprod Update"},{"key":"2026050501524074900_deag022-B28","doi-asserted-by":"crossref","first-page":"E1688","DOI":"10.1073\/pnas.1620729114","article-title":"AMH\/MIS as a contraceptive that protects the ovarian reserve during chemotherapy","volume":"114","author":"Kano","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026050501524074900_deag022-B29","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/mrd.22828","article-title":"Anti-Mullerian hormone signaling is influenced by Follistatin 288, but not 14 other transforming growth factor beta superfamily regulators","volume":"84","author":"Kawagishi","year":"2017","journal-title":"Mol Reprod Dev"},{"key":"2026050501524074900_deag022-B30","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1095\/biolreprod.109.079947","article-title":"Ovarian furin (proprotein convertase subtilisin\/kexin type3): expression, localization, and potential role in ovulation in the rat","volume":"83","author":"Kelty","year":"2010","journal-title":"Biol Reprod"},{"key":"2026050501524074900_deag022-B31","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/ng0297-201","article-title":"Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility","volume":"15","author":"Kumar","year":"1997","journal-title":"Nat Genet"},{"key":"2026050501524074900_deag022-B32","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1210\/en.2016-1538","article-title":"Androgen stimulates growth of mouse preantral follicles in vitro: interaction with follicle-stimulating hormone and with growth factors of the TGFbeta superfamily","volume":"158","author":"Laird","year":"2017","journal-title":"Endocrinology"},{"key":"2026050501524074900_deag022-B33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.theriogenology.2019.10.037","article-title":"Anti-Mullerian hormone inhibits luteinizing hormone-induced androstenedione synthesis in porcine theca cells","volume":"142","author":"Li","year":"2020","journal-title":"Theriogenology"},{"key":"2026050501524074900_deag022-B34","doi-asserted-by":"crossref","first-page":"9198","DOI":"10.1073\/pnas.1004702107","article-title":"Unique characteristics of Ca2+ homeostasis of the trans-Golgi compartment","volume":"107","author":"Lissandron","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026050501524074900_deag022-B35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1056\/NEJMra022784","article-title":"Sex determination and differentiation","volume":"350","author":"MacLaughlin","year":"2004","journal-title":"N Engl J Med"},{"key":"2026050501524074900_deag022-B36","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1210\/endo.131.1.1612008","article-title":"Mullerian duct regression and antiproliferative bioactivities of mullerian inhibiting substance reside in its carboxy-terminal domain","volume":"131","author":"MacLaughlin","year":"1992","journal-title":"Endocrinology"},{"key":"2026050501524074900_deag022-B37","first-page":"200","article-title":"Initial and cyclic recruitment of ovarian follicles","volume":"21","author":"McGee","year":"2000","journal-title":"Endocr Rev"},{"key":"2026050501524074900_deag022-B38","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1095\/biolreprod64.1.293","article-title":"Mullerian inhibitory substance induces growth of rat preantral ovarian follicles","volume":"64","author":"McGee","year":"2001","journal-title":"Biol Reprod"},{"key":"2026050501524074900_deag022-B39","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1146\/annurev.bi.55.070186.003311","article-title":"Acidification of the endocytic and exocytic pathways","volume":"55","author":"Mellman","year":"1986","journal-title":"Annu Rev Biochem"},{"key":"2026050501524074900_deag022-B40","doi-asserted-by":"crossref","first-page":"7711","DOI":"10.1073\/pnas.93.15.7711","article-title":"Bioactivation of Mullerian inhibiting substance during gonadal development by a kex2\/subtilisin-like endoprotease","volume":"93","author":"Nachtigal","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026050501524074900_deag022-B41","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1530\/REP-07-0119","article-title":"Actions of anti-Mullerian hormone on the ovarian transcriptome to inhibit primordial to primary follicle transition","volume":"134","author":"Nilsson","year":"2007","journal-title":"Reproduction"},{"key":"2026050501524074900_deag022-B42","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1016\/j.fertnstert.2016.06.010","article-title":"Variation in circulating antiMullerian hormone precursor during the periovulatory and acute postovulatory phases of the human ovarian cycle","volume":"106","author":"Pankhurst","year":"2016","journal-title":"Fertil Steril"},{"key":"2026050501524074900_deag022-B43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1530\/JOE-18-0005","article-title":"Anti-Mullerian hormone overexpression restricts preantral ovarian follicle survival","volume":"237","author":"Pankhurst","year":"2018","journal-title":"J Endocrinol"},{"key":"2026050501524074900_deag022-B44","doi-asserted-by":"crossref","first-page":"1622","DOI":"10.1210\/en.2015-1834","article-title":"The anti-Mullerian hormone precursor (proAMH) is not converted to the receptor-competent form (AMHN, C) in the circulating blood of mice","volume":"157","author":"Pankhurst","year":"2016","journal-title":"Endocrinology"},{"key":"2026050501524074900_deag022-B45","doi-asserted-by":"crossref","first-page":"E1241","DOI":"10.1152\/ajpendo.00395.2013","article-title":"Human blood contains both the uncleaved precursor of anti-Mullerian hormone and a complex of the NH2- and COOH-terminal peptides","volume":"305","author":"Pankhurst","year":"2013","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"2026050501524074900_deag022-B46","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.mce.2015.10.013","article-title":"A specific immunoassay for proAMH, the uncleaved proprotein precursor of anti-Mullerian hormone","volume":"419","author":"Pankhurst","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"2026050501524074900_deag022-B47","doi-asserted-by":"crossref","first-page":"jc20161742","DOI":"10.1210\/jc.2016-1742","article-title":"Most cleaved anti-Mullerian hormone binds its receptor in human follicular fluid but little is competent in serum","volume":"101","author":"Pierre","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"2026050501524074900_deag022-B48","doi-asserted-by":"crossref","first-page":"e00172","DOI":"10.1002\/edm2.172","article-title":"Interactions between serum FSH, inhibin B and antral follicle count in the decline of serum AMH during the menstrual cycle in late reproductive age","volume":"4","author":"Robertson","year":"2021","journal-title":"Endocrinol Diabetes Metab"},{"key":"2026050501524074900_deag022-B49","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1095\/biolreprod.109.082941","article-title":"Formation of the ovarian follicular antrum and follicular fluid","volume":"82","author":"Rodgers","year":"2010","journal-title":"Biol Reprod"},{"key":"2026050501524074900_deag022-B50","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1186\/s12859-017-1934-z","article-title":"ImageJ2: ImageJ for the next generation of scientific image data","volume":"18","author":"Rueden","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"2026050501524074900_deag022-B51","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"key":"2026050501524074900_deag022-B52","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.fertnstert.2010.10.011","article-title":"Age-specific serum anti-Mullerian hormone values for 17,120 women presenting to fertility centers within the United States","volume":"95","author":"Seifer","year":"2011","journal-title":"Fertil Steril"},{"key":"2026050501524074900_deag022-B53","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1007\/s10815-018-1180-y","article-title":"Biomechanics and mechanical signaling in the ovary: a systematic review","volume":"35","author":"Shah","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"2026050501524074900_deag022-B54","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1095\/biolreprod35.2.447","article-title":"The ontogeny of Mullerian inhibiting substance in granulosa cells of the bovine ovarian follicle","volume":"35","author":"Takahashi","year":"1986","journal-title":"Biol Reprod"},{"key":"2026050501524074900_deag022-B55","doi-asserted-by":"crossref","first-page":"2622","DOI":"10.1172\/JCI2081","article-title":"Androgens stimulate early stages of follicular growth in the primate ovary","volume":"101","author":"Vendola","year":"1998","journal-title":"J Clin Invest"},{"key":"2026050501524074900_deag022-B56","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1210\/en.2006-1265","article-title":"Increased oocyte degeneration and follicular atresia during the estrous cycle in anti-Mullerian hormone null mice","volume":"148","author":"Visser","year":"2007","journal-title":"Endocrinology"},{"key":"2026050501524074900_deag022-B57","first-page":"936","article-title":"The serine\/threonine transmembrane receptor ALK2 mediates Mullerian inhibiting substance signaling","volume":"15","author":"Visser","year":"2001","journal-title":"Mol Endocrinol"},{"key":"2026050501524074900_deag022-B58","doi-asserted-by":"crossref","first-page":"e8772","DOI":"10.1371\/journal.pone.0008772","article-title":"Human ovarian reserve from conception to the menopause","volume":"5","author":"Wallace","year":"2010","journal-title":"PLoS One"},{"key":"2026050501524074900_deag022-B59","first-page":"161","article-title":"Stage-dependent actions of antiMullerian hormone in regulating granulosa cell proliferation and follicular function in the primate ovary","volume":"1","author":"Xu","year":"2020","journal-title":"F S Sci"},{"key":"2026050501524074900_deag022-B60","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1093\/humrep\/dew100","article-title":"Anti-Mullerian hormone promotes pre-antral follicle growth, but inhibits antral follicle maturation and dominant follicle selection in primates","volume":"31","author":"Xu","year":"2016","journal-title":"Hum Reprod"},{"key":"2026050501524074900_deag022-B61","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1093\/biolre\/iox181","article-title":"Anti-Mullerian hormone is a survival factor and promotes the growth of rhesus macaque preantral follicles during matrix-free culture","volume":"98","author":"Xu","year":"2018","journal-title":"Biol Reprod"},{"key":"2026050501524074900_deag022-B62","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1095\/biolreprod.106.051813","article-title":"Testosterone stimulates the primary to secondary follicle transition in bovine follicles in vitro","volume":"75","author":"Yang","year":"2006","journal-title":"Biol Reprod"},{"key":"2026050501524074900_deag022-B63","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1093\/humrep\/deac204","article-title":"Anti-Mullerian hormone-mediated preantral follicle atresia is a key determinant of antral follicle count in mice","volume":"37","author":"Zhou","year":"2022","journal-title":"Hum Reprod"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/41\/5\/795\/67124399\/deag022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/41\/5\/795\/67124399\/deag022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T05:53:11Z","timestamp":1777960391000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/41\/5\/795\/8498885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":63,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,2,26]]},"published-print":{"date-parts":[[2026,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deag022","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,5]]},"published":{"date-parts":[[2026,2,26]]}}}