{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T02:47:51Z","timestamp":1791859671067,"version":"4.3.4"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program","doi-asserted-by":"publisher","award":["2025YFC2708000"],"award-info":[{"award-number":["2025YFC2708000"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation Grant of China","doi-asserted-by":"crossref","award":["82371647"],"award-info":[{"award-number":["82371647"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Science Foundation for Outstanding Youth of Liaoning Province","award":["2024JH3\/50100023"],"award-info":[{"award-number":["2024JH3\/50100023"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>STUDY QUESTION<\/jats:title>\n                    <jats:p>Does 3\u2032-phosphoadenosine 5\u2032-phosphosulfate synthase 2 (PAPSS2)-mediated sulfation contribute to defective decidualization in patients with recurrent implantation failure (RIF), and what are the underlying mechanisms?<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SUMMARY ANSWER<\/jats:title>\n                    <jats:p>Downregulation of PAPSS2 enhances the interaction between bone morphogenetic protein receptor type 1A (BMPR1A) and bone morphogenetic protein 2 (BMP2), as well as SMAD family member 1\/5\/9 (SMAD1\/5\/9)-dependent autophagic flux, thereby promoting decidualization and increasing the receptivity of endometrial stromal cells to trophoblast invasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                    <jats:p>Decidualization is essential for embryo implantation and pregnancy maintenance, and impaired decidualization is considered a key pathological mechanism underlying RIF. Although protein tyrosine sulfation is a critical post-translational modification, its role in endometrial decidualization remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                    <jats:p>We integrated transcriptomic datasets, performed in vitro decidualization assays in immortalized human endometrial stromal cells (T-HESCs) and primary human endometrial stromal cells (hEnSCs), and established an artificial decidualization mouse model. Functional assays and molecular analyses were conducted between 2023 and 2026.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                    <jats:p>Mid-secretory endometrial tissues were collected from patients with RIF and fertile controls. Decidualization was induced in T-HESCs and primary hEnSCs using dibutyryl-cAMP and progesterone. The effects of PAPSS2 knockdown or overexpression were assessed by RT-qPCR, Western blotting, immunoprecipitation, immunofluorescence, and in vitro implantation assays with BeWo spheroids. In vivo, an ovariectomized mouse model was used to evaluate decidualization under pharmacological modulation of BMP\u2013SMAD signaling and autophagy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                    <jats:p>We found that sulfation levels were elevated in endometrial stromal cells from RIF patients. Transcriptomic analysis revealed that PAPSS2, a known sulfation-related gene, was consistently downregulated during decidualization. Mechanistically, PAPSS2 knockdown in endometrial stromal cells decreased BMPR1A sulfation, enhanced its binding affinity for BMP2, and activated the downstream SMAD1\/5\/9 signaling pathway. Functionally, the activation of this pathway promoted autophagy, thereby enhancing decidualization and increasing stromal cell receptivity to trophoblast invasion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LARGE SCALE DATA<\/jats:title>\n                    <jats:p>Publicly available bulk transcriptomic datasets GSE75425 and GSE17504, together with the single-cell RNA-seq dataset GSE183837, were obtained from the Gene Expression Omnibus (GEO) database.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                    <jats:p>Although our data support dysregulated sulfotyrosine levels and implicate the PAPSS2\u2013BMPR1A sulfation axis in stromal decidualization in RIF, further studies with larger sample sizes are required to confirm their in vivo relevance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                    <jats:p>Our findings reveal a previously unrecognized mechanism in which the PAPSS2\u2013BMPR1A sulfation axis fine-tunes BMP2\/SMAD signaling and autophagy homeostasis to regulate decidualization. This study provides a molecular basis and highlights a potential therapeutic target for uterine factor-related infertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>FUNDING<\/jats:title>\n                    <jats:p>This work was supported by the National Key Research and Development Program (No. 2025YFC2708000), the National Natural Science Foundation of China (No. 82371647), the Science Foundation for Outstanding Youth of Liaoning Province (No. 2024JH3\/50100023), and the Shenyang Young and Middle-aged Science and Technology Innovation Talents Support Program (No. RC210436).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>DISCLOSURES<\/jats:title>\n                    <jats:p>The authors declare no competing interests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                    <jats:p>N\/A.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/humrep\/deag103","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:31:52Z","timestamp":1783575112000},"page":"1552-1569","source":"Crossref","is-referenced-by-count":1,"title":["PAPSS2-mediated BMPR1A sulfation in stromal cells regulating endometrial decidualization via autophagy"],"prefix":"10.1093","volume":"41","author":[{"given":"Duo","family":"Zi","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centre of Reproductive Medicine, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centre of Reproductive Medicine, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoli","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centre of Reproductive Medicine, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centre of Reproductive Medicine, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junzhi","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centre of Reproductive Medicine, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centre of Reproductive Medicine, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhe","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centre of Reproductive Medicine, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centre of Reproductive Medicine, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centre of Reproductive Medicine, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Fujian Science & Technology Innovation Laboratory for Optoelectronic Information of China, Fuzhou University , Fuzhou,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4895-1185","authenticated-orcid":false,"given":"Da","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Centre of Reproductive Medicine, Shengjing Hospital of China Medical University , Shenyang,","place":["China"]},{"name":"NHC Key Laboratory of Advanced Reproductive Medicine and Fertility (China Medical University), National Health Commission , Shenyang,","place":["China"]},{"name":"Key Laboratory of Reproductive Dysfunction Diseases and Fertility Remodeling of Liaoning Province, China Medical University , Shenyang,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,9]]},"reference":[{"key":"2026090801520984400_deag103-B1","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1210\/en.2009-0923","article-title":"The protein kinase A pathway-regulated transcriptome of endometrial stromal fibroblasts reveals compromised differentiation and persistent proliferative potential in endometriosis","volume":"151","author":"Aghajanova","year":"2010","journal-title":"Endocrinology"},{"key":"2026090801520984400_deag103-B2","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1177\/1933719116657894","article-title":"Decidualization differentially regulates microRNA expression in eutopic and ectopic endometrial stromal cells","volume":"24","author":"Aoyagi","year":"2017","journal-title":"Reprod Sci"},{"key":"2026090801520984400_deag103-B3","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1083\/jcb.105.6.2655","article-title":"Tyrosine sulfation is a trans-Golgi-specific protein modification","volume":"105","author":"Baeuerle","year":"1987","journal-title":"J Cell Biol"},{"key":"2026090801520984400_deag103-B4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.actbio.2025.11.026","article-title":"Unexplained infertility and impaired decidualization: a case for studying endometrial mechanics and microstructure","volume":"209","author":"Bastias","year":"2026","journal-title":"Acta Biomater"},{"key":"2026090801520984400_deag103-B5","doi-asserted-by":"crossref","first-page":"104134","DOI":"10.1016\/j.ebiom.2022.104134","article-title":"Miscarriage syndrome: linking early pregnancy loss to obstetric and age-related disorders","volume":"81","author":"Bortoletto","year":"2022","journal-title":"EBioMedicine"},{"key":"2026090801520984400_deag103-B6","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat Med"},{"key":"2026090801520984400_deag103-B7","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.rbmo.2013.08.011","article-title":"Recurrent implantation failure: definition and management","volume":"28","author":"Coughlan","year":"2014","journal-title":"Reprod Biomed Online"},{"key":"2026090801520984400_deag103-B8","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1080\/15548627.2020.1752548","article-title":"Autophagy in the physiological endometrium and cancer","volume":"17","author":"Devis-Jauregui","year":"2021","journal-title":"Autophagy"},{"key":"2026090801520984400_deag103-B9","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1210\/er.2014-1045","article-title":"Cyclic decidualization of the human endometrium in reproductive health and failure","volume":"35","author":"Gellersen","year":"2014","journal-title":"Endocr Rev"},{"key":"2026090801520984400_deag103-B10","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1093\/humrep\/dep468","article-title":"Invasiveness of human endometrial stromal cells is promoted by decidualization and by trophoblast-derived signals","volume":"25","author":"Gellersen","year":"2010","journal-title":"Hum Reprod"},{"key":"2026090801520984400_deag103-B11","doi-asserted-by":"crossref","first-page":"2102307","DOI":"10.1183\/13993003.02307-2021","article-title":"Bone morphogenetic protein 4 inhibits pulmonary fibrosis by modulating cellular senescence and mitophagy in lung fibroblasts","volume":"60","author":"Guan","year":"2022","journal-title":"Eur Respir J"},{"key":"2026090801520984400_deag103-B12","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.3390\/ijms25063451","article-title":"Establishment of murine pregnancy requires the promyelocytic leukemia zinc finger transcription factor","volume":"25","author":"Hai","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026090801520984400_deag103-B13","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/HEP.0000000000000783","article-title":"Enhanced SLC35B2\/SAV1 sulfation axis promotes tumor growth by inhibiting Hippo signaling in HCC","volume":"81","author":"He","year":"2025","journal-title":"Hepatology"},{"key":"2026090801520984400_deag103-B14","doi-asserted-by":"crossref","first-page":"140065","DOI":"10.1098\/rsob.140065","article-title":"USP15 targets ALK3\/BMPR1A for deubiquitylation to enhance bone morphogenetic protein signalling","volume":"4","author":"Herhaus","year":"2014","journal-title":"Open Biol"},{"key":"2026090801520984400_deag103-B15","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1093\/humupd\/dmae007","article-title":"TGFbeta signalling: a nexus between inflammation, placental health and preeclampsia throughout pregnancy","volume":"30","author":"Horvat Mercnik","year":"2024","journal-title":"Hum Reprod Update"},{"key":"2026090801520984400_deag103-B16","doi-asserted-by":"crossref","first-page":"130046","DOI":"10.1016\/j.bbagen.2021.130046","article-title":"Expression of GALNT8 and O-glycosylation of BMP receptor 1A suppress breast cancer cell proliferation by upregulating ERalpha levels","volume":"1866","author":"Huang","year":"2022","journal-title":"Biochim Biophys Acta Gen Subj"},{"key":"2026090801520984400_deag103-B17","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/ncb2528","article-title":"c-Abl promotes osteoblast expansion by differentially regulating canonical and non-canonical BMP pathways and p16INK4a expression","volume":"14","author":"Kua","year":"2012","journal-title":"Nat Cell Biol"},{"key":"2026090801520984400_deag103-B18","doi-asserted-by":"crossref","first-page":"6527","DOI":"10.7150\/thno.74053","article-title":"Single-cell transcriptome profiling of the human endometrium of patients with recurrent implantation failure","volume":"12","author":"Lai","year":"2022","journal-title":"Theranostics"},{"key":"2026090801520984400_deag103-B19","doi-asserted-by":"crossref","first-page":"5468","DOI":"10.1128\/MCB.00342-07","article-title":"Bmp2 is critical for the murine uterine decidual response","volume":"27","author":"Lee","year":"2007","journal-title":"Mol Cell Biol"},{"key":"2026090801520984400_deag103-B20","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.it.2024.12.007","article-title":"Decidual stromal cells: fibroblasts specialized in immunoregulation during pregnancy","volume":"46","author":"Llorca","year":"2025","journal-title":"Trends Immunol"},{"key":"2026090801520984400_deag103-B21","doi-asserted-by":"crossref","first-page":"2688","DOI":"10.1021\/acs.accounts.3c00388","article-title":"Exploiting chemical protein synthesis to study the role of tyrosine sulfation on anticoagulants from hematophagous organisms","volume":"56","author":"Maxwell","year":"2023","journal-title":"Acc Chem Res"},{"key":"2026090801520984400_deag103-B22","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1093\/bioinformatics\/18.5.769","article-title":"The Sulfinator: predicting tyrosine sulfation sites in protein sequences","volume":"18","author":"Monigatti","year":"2002","journal-title":"Bioinformatics"},{"key":"2026090801520984400_deag103-B23","doi-asserted-by":"crossref","first-page":"E387","DOI":"10.1073\/pnas.1523758113","article-title":"Uterine ALK3 is essential during the window of implantation","volume":"113","author":"Monsivais","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026090801520984400_deag103-B24","doi-asserted-by":"crossref","first-page":"eadv1988","DOI":"10.1126\/sciadv.adv1988","article-title":"Stalling of the endometrial decidual reaction determines the recurrence risk of miscarriage","volume":"11","author":"Muter","year":"2025","journal-title":"Sci Adv"},{"key":"2026090801520984400_deag103-B25","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12958-017-0303-0","article-title":"TGFbeta superfamily signaling and uterine decidualization","volume":"15","author":"Ni","year":"2017","journal-title":"Reprod Biol Endocrinol"},{"key":"2026090801520984400_deag103-B26","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.7150\/ijbs.68335","article-title":"Insight of autophagy in spontaneous miscarriage","volume":"18","author":"Qin","year":"2022","journal-title":"Int J Biol Sci"},{"key":"2026090801520984400_deag103-B27","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/humrep\/dew048","article-title":"Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy","volume":"31","author":"Rhee","year":"2016","journal-title":"Hum Reprod"},{"key":"2026090801520984400_deag103-B28","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.1038\/ncomms2593","article-title":"Crystal structure of human tyrosylprotein sulfotransferase-2 reveals the mechanism of protein tyrosine sulfation reaction","volume":"4","author":"Teramoto","year":"2013","journal-title":"Nat Commun"},{"key":"2026090801520984400_deag103-B29","doi-asserted-by":"crossref","first-page":"25688","DOI":"10.1073\/pnas.1912671116","article-title":"Palmitoylation of BMPR1a regulates neural stem cell fate","volume":"116","author":"Wegleiter","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026090801520984400_deag103-B30","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/humupd\/dmad031","article-title":"Roles of bone morphogenetic proteins in endometrial remodeling during the human menstrual cycle and pregnancy","volume":"30","author":"Wei","year":"2024","journal-title":"Hum Reprod Update"},{"key":"2026090801520984400_deag103-B31","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.rbmo.2013.10.004","article-title":"Reprint of: in-vitro model systems for the study of human embryo-endometrium interactions","volume":"27","author":"Weimar","year":"2013","journal-title":"Reprod Biomed Online"},{"key":"2026090801520984400_deag103-B32","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1021\/acsptsci.4c00021","article-title":"Bone morphogenetic protein signaling agonist SB4 (BMPSB4) inhibits corticotroph pituitary neuroendocrine tumors by activation of autophagy via a BMP4\/SMADs-dependent pathway","volume":"7","author":"Xu","year":"2024","journal-title":"ACS Pharmacol Transl Sci"},{"key":"2026090801520984400_deag103-B33","doi-asserted-by":"crossref","first-page":"108540","DOI":"10.1016\/j.pharmthera.2023.108540","article-title":"Sulfoconjugation of protein peptides and glycoproteins in physiology and diseases","volume":"251","author":"Xu","year":"2023","journal-title":"Pharmacol Ther"},{"key":"2026090801520984400_deag103-B34","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1053\/j.gastro.2021.12.260","article-title":"Inhibition of p53 sulfoconjugation prevents oxidative hepatotoxicity and acute liver failure","volume":"162","author":"Xu","year":"2022","journal-title":"Gastroenterology"},{"key":"2026090801520984400_deag103-B35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1053\/j.gastro.2021.03.048","article-title":"Intestinal sulfation is essential to protect against colitis and colonic carcinogenesis","volume":"161","author":"Xu","year":"2021","journal-title":"Gastroenterology"},{"key":"2026090801520984400_deag103-B36","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1080\/15548627.2019.1586248","article-title":"SIGMAR1\/Sigma-1 receptor ablation impairs autophagosome clearance","volume":"15","author":"Yang","year":"2019","journal-title":"Autophagy"},{"key":"2026090801520984400_deag103-B37","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.7150\/ijbs.91925","article-title":"GALNT12 suppresses the bone-specific prostate cancer metastasis by activating BMP pathway via the O-glycosylation of BMPR1A","volume":"20","author":"Yang","year":"2024","journal-title":"Int J Biol Sci"},{"key":"2026090801520984400_deag103-B38","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/nm.1888","article-title":"BMP type I receptor inhibition reduces heterotopic [corrected] ossification","volume":"14","author":"Yu","year":"2008","journal-title":"Nat Med"},{"key":"2026090801520984400_deag103-B39","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/s41589-023-01267-9","article-title":"Histone tyrosine sulfation by SULT1B1 regulates H4R3me2a and gene transcription","volume":"19","author":"Yu","year":"2023","journal-title":"Nat Chem Biol"},{"key":"2026090801520984400_deag103-B40","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12974-019-1673-3","article-title":"HMGB1\/RAGE axis mediates stress-induced RVLM neuroinflammation in mice via impairing mitophagy flux in microglia","volume":"17","author":"Zhang","year":"2020","journal-title":"J Neuroinflammation"},{"key":"2026090801520984400_deag103-B41","first-page":"e64278","article-title":"Generation of a mouse artificial decidualization model with ovariectomy for endometrial decidualization research","volume":"185","author":"Zhang","year":"2022","journal-title":"J Vis Exp"},{"key":"2026090801520984400_deag103-B42","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41418-018-0147-y","article-title":"Enhanced PAPSS2\/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis","volume":"26","author":"Zhang","year":"2019","journal-title":"Cell Death Differ"},{"key":"2026090801520984400_deag103-B43","doi-asserted-by":"crossref","first-page":"eadg3983","DOI":"10.1126\/scitranslmed.adg3983","article-title":"Targeting sulfation-dependent mechanoreciprocity between matrix and osteoblasts to mitigate bone loss","volume":"15","author":"Zheng","year":"2023","journal-title":"Sci Transl Med"},{"key":"2026090801520984400_deag103-B44","doi-asserted-by":"crossref","first-page":"2148","DOI":"10.1093\/humrep\/deaf174","article-title":"Increased AIF-1-mediated p38 MAPK phosphorylation in the mid-secretory endometrium impairs endometrial receptivity in women with recurrent implantation failure","volume":"40","author":"Zhou","year":"2025","journal-title":"Hum Reprod"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/41\/9\/1552\/68734224\/deag103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humrep\/article-pdf\/41\/9\/1552\/68734224\/deag103.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T05:52:25Z","timestamp":1788846745000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/41\/9\/1552\/8728936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,9]]},"references-count":44,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2026,7,9]]},"published-print":{"date-parts":[[2026,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deag103","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,7,9]]}}}