{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:08:31Z","timestamp":1788847711726,"version":"build-2803163510"},"reference-count":101,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T00:00:00Z","timestamp":1784851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic pelvic pain (CPP) is a prevalent, disabling syndrome encompassing overlapping disorders such as endometriosis\/adenomyosis, bladder pain syndrome\/interstitial cystitis, irritable bowel syndrome, vulvodynia, and myofascial pain syndrome. Despite distinct clinical phenotypes, these conditions converge on shared biological axes\u2014immune dysregulation, endocrine imbalance, and central sensitization\u2014that sustain chronic pain. Increasing evidence implicates the human microbiome as a potential upstream regulator of these pathways. Dysbiosis across the gut, vaginal, urinary, and endometrial microbial ecosystems may promote local and systemic inflammation, compromise epithelial barrier integrity, alter estrogen recirculation through the estrobolome, and engage aberrant neuroimmune signalling along gut\u2013brain and hypothalamic\u2013pituitary\u2013ovarian circuits. Recent multi-site profiling suggests that microbial alterations often co-occur across pelvic compartments but remain anatomically distinct, with shifts in anaerobic taxa and paired cervicovaginal immune signatures supporting microbiome\u2013immune interactions in CPP pathophysiology. This narrative review synthesizes observational, multi-omics, and mechanistic evidence linking microbial dysbiosis to CPP, highlights microbial metabolites as key functional mediators, and evaluates causal data from experimental models. Finally, it discusses translational opportunities and limitations, including microbiome-targeted interventions (dietary modulation, probiotics\/psychobiotics, postbiotics, and microbiota transfer approaches) and the need for harmonized, longitudinal and biomarker-embedded trials to enable mechanism-based stratification and rational therapeutic development.<\/jats:p>","DOI":"10.1093\/humrep\/deag110","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:35:01Z","timestamp":1784921701000},"page":"1482-1496","source":"Crossref","is-referenced-by-count":0,"title":["Microbiome and chronic pelvic pain in women: a mini-review"],"prefix":"10.1093","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2449-7734","authenticated-orcid":false,"given":"Jonas","family":"Vibert","sequence":"first","affiliation":[{"name":"Reproductive Medicine Unit (UMR), Service of Gynecology, Department Woman-Mother-Child, Lausanne University Hospital (CHUV) and University of Lausanne , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5166-5841","authenticated-orcid":false,"given":"Milos","family":"Stojanov","sequence":"additional","affiliation":[{"name":"Materno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Da Silva","sequence":"additional","affiliation":[{"name":"Materno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9914-6496","authenticated-orcid":false,"given":"David","family":"Baud","sequence":"additional","affiliation":[{"name":"Materno-Fetal and Obstetrics Research Unit, Department Woman-Mother-Child, Lausanne University Hospital and University of Lausanne , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7475-9082","authenticated-orcid":false,"given":"Nicola","family":"Pluchino","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Unit (UMR), Service of Gynecology, Department Woman-Mother-Child, Lausanne University Hospital (CHUV) and University of Lausanne , Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,24]]},"reference":[{"key":"2026090801514759600_deag110-B1","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.3390\/nu16233988","article-title":"Dietary and nutritional interventions for the management of 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