{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T18:49:13Z","timestamp":1762541353254},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,12,1]]},"DOI":"10.1093\/humrep\/deh512","type":"journal-article","created":{"date-parts":[[2004,9,10]],"date-time":"2004-09-10T00:23:57Z","timestamp":1094775837000},"page":"2742-2747","source":"Crossref","is-referenced-by-count":9,"title":["Patterns of hormonal response to the GnRH agonist leuprolide in brothers of women with polycystic ovary syndrome: a pilot study"],"prefix":"10.1093","volume":"19","author":[{"given":"T. Sir","family":"Petermann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Cartes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Maliqueo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Vantman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Toloza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Echibur\u00fa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.E.","family":"Recabarren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2004,12]]},"reference":[{"key":"key\n\t\t\t\t20171011122456_R1","doi-asserted-by":"crossref","unstructured":"Adams J, Polson DW and Franks S (1986) Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J293, 355\u2013359.","DOI":"10.1136\/bmj.293.6543.355"},{"key":"key\n\t\t\t\t20171011122456_R2","doi-asserted-by":"crossref","unstructured":"Barnes RB, Rosenfield RL, Burstein S and Ehrmann D (1989) Pituitary\u2013ovarian responses to nafarelin testing in the polycystic ovary syndrome. N Engl J Med320, 559\u2013565.","DOI":"10.1056\/NEJM198903023200904"},{"key":"key\n\t\t\t\t20171011122456_R3","doi-asserted-by":"crossref","unstructured":"Carey AH, Chan KL, Short F, White D, Williamson R and Franks S (1993) Evidence for a single gene effect causing polycystic ovaries and male pattern baldness. Clin Endocrinol (Oxf)38, 653\u2013658.","DOI":"10.1111\/j.1365-2265.1993.tb02150.x"},{"key":"key\n\t\t\t\t20171011122456_R4","doi-asserted-by":"crossref","unstructured":"Cicognani A, Alessandroni R, Pasini A, Pirazzoli P, Cassio A, Barbieri E and Cacciari E (2002) Low birth weight for gestational age and subsequent male gonadal function. J Pediatr141, 376\u2013379.","DOI":"10.1067\/mpd.2002.126300"},{"key":"key\n\t\t\t\t20171011122456_R5","doi-asserted-by":"crossref","unstructured":"Cohen PN, Givens JR, Wiser WL, Wilroy RS, Summitt RL and Coleman SA (1975) Polycystic ovarian disease, maturation arrest of spermiogenesis, and Klinefelter's syndrome in siblings of a family with familial hirsutism. Fertil Steril26, 1228\u20131238.","DOI":"10.1016\/S0015-0282(16)41539-6"},{"key":"key\n\t\t\t\t20171011122456_R6","doi-asserted-by":"crossref","unstructured":"Cooper H, Spellacy W, Prem K and Cohen W (1968) Hereditary factors in the Stein-Leventhal syndrome. Am J Obstet Gynecol100, 371\u2013387.","DOI":"10.1016\/S0002-9378(15)33704-2"},{"key":"key\n\t\t\t\t20171011122456_R7","doi-asserted-by":"crossref","unstructured":"Crosignani PG and Nicolosi AE (2001) Polycystic ovarian disease: heritability and heterogeneity. Hum Reprod Update7, 3\u20137.","DOI":"10.1093\/humupd\/7.1.3"},{"key":"key\n\t\t\t\t20171011122456_R8","doi-asserted-by":"crossref","unstructured":"Ehrmann DA, Rosenfield RL, Barnes RB, Brigell DF and Sheikh Z (1992) Detection of functional ovarian hyperandrogenism in women with androgen excess. N Engl J Med327, 157\u2013162.","DOI":"10.1056\/NEJM199207163270304"},{"key":"key\n\t\t\t\t20171011122456_R9","doi-asserted-by":"crossref","unstructured":"Ehrmann DA, Barnes RB and Rosenfield RL (1995) Polycystic ovary syndrome as a form of functional ovarian hyperandrogenism due to dysregulation of androgen secretion. Endocr Rev16, 322\u2013353.","DOI":"10.1210\/er.16.3.322"},{"key":"key\n\t\t\t\t20171011122456_R10","doi-asserted-by":"crossref","unstructured":"Ferriman D and Purdie AW (1979) The inheritance of polycystic ovarian disease and a possible relationship to premature balding. Clin Endocrinol (Oxf)11, 291\u2013300.","DOI":"10.1111\/j.1365-2265.1979.tb03077.x"},{"key":"key\n\t\t\t\t20171011122456_R11","doi-asserted-by":"crossref","unstructured":"Francois I, de Zegher F, Spiessens C, D'Hooghe T and Vanderschueren D (1997) Low birth weight and subsequent male subfertility. Pediatr Res42, 899\u2013901.","DOI":"10.1203\/00006450-199712000-00029"},{"key":"key\n\t\t\t\t20171011122456_R12","doi-asserted-by":"crossref","unstructured":"Franks S (1995) Polycystic ovary syndrome. N Engl J Med333, 853\u2013861.","DOI":"10.1056\/NEJM199509283331307"},{"key":"key\n\t\t\t\t20171011122456_R13","doi-asserted-by":"crossref","unstructured":"Franks S, Gharani N, Waterworth D, Batty S, White D, Williamson R and McCarthy M (1997) The genetic basis of polycystic ovary syndrome. Hum Reprod12, 2641\u20132648.","DOI":"10.1093\/humrep\/12.12.2641"},{"key":"key\n\t\t\t\t20171011122456_R14","unstructured":"Ghai K and Rosenfield RL (1994) Maturation of the normal pituitary-testicular axis, as assessed by gonadotropin-releasing hormone agonist challenge. J Clin Endocrinol Metab78, 1336\u20131340."},{"key":"key\n\t\t\t\t20171011122456_R15","doi-asserted-by":"crossref","unstructured":"Govind A, Obhrai MS and Clayton RN (1999) Polycystic ovaries are inherited as an autosomal dominant trait: analysis of 29 polycystic ovary syndrome and 10 control families. J Clin Endocrinol Metab84, 38\u201343.","DOI":"10.1210\/jcem.84.1.5382"},{"key":"key\n\t\t\t\t20171011122456_R16","doi-asserted-by":"crossref","unstructured":"Hamilton JB (1951) Patterned loss of hair in man: types and incidence. Ann NY Acad Sci53, 708\u2013728.","DOI":"10.1111\/j.1749-6632.1951.tb31971.x"},{"key":"key\n\t\t\t\t20171011122456_R17","doi-asserted-by":"crossref","unstructured":"Hull MG (1987) Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. Gynecol Endocrinol1, 235\u2013245.","DOI":"10.3109\/09513598709023610"},{"key":"key\n\t\t\t\t20171011122456_R18","doi-asserted-by":"crossref","unstructured":"Iba\u00f1ez L, Potau N, Virdis R, Zampolli M, Terzi C, Gussinye M, Carrascosa A and Vicens-Calvet E (1993) Postpubertal outcome in girls diagnosed of premature pubarche during childhood: increased frequency of functional ovarian hyperandrogenism. J Clin Endocrinol Metab76, 1599\u20131603.","DOI":"10.1210\/jcem.76.6.8501168"},{"key":"key\n\t\t\t\t20171011122456_R19","doi-asserted-by":"crossref","unstructured":"Iba\u00f1ez L, Potau N, Zampolli M, Virdis R, Gussinye M, Carrascosa A, Saenger P and Vicens-Calvet E (1994) Use of leuprolide acetate response patterns in the early diagnosis of pubertal disorders: comparison with the gonadotropin-releasing hormone test. J Clin Endocrinol Metab78, 30\u201335.","DOI":"10.1210\/jcem.78.1.7507123"},{"key":"key\n\t\t\t\t20171011122456_R20","doi-asserted-by":"crossref","unstructured":"Iba\u00f1ez L, Hall JE, Potau N, Carrascosa A, Prat N and Taylor AE (1996) Ovarian 17-hydroxyprogesterone hyperresponsiveness to gonadotropin-releasing hormone (GnRH) agonist challenge in women with polycystic ovary syndrome is not mediated by luteinizing hormone hypersecretion: evidence from GnRH agonist and human chorionic gonadotropin stimulation testing. J Clin Endocrinol Metab81, 4103\u20134117.","DOI":"10.1210\/jcem.81.11.8923867"},{"key":"key\n\t\t\t\t20171011122456_R21","doi-asserted-by":"crossref","unstructured":"Jahanfar S, Eden JA, Warren P, Seppala M and Nguyen TV (1995) A twin study of polycystic ovary syndrome. Fertil Steril63, 478\u2013486.","DOI":"10.1016\/S0015-0282(16)57412-3"},{"key":"key\n\t\t\t\t20171011122456_R22","doi-asserted-by":"crossref","unstructured":"Knochenhauer ES, Key TJ, Kahsar-Miller M, Waggoner W, Boots LR and Azziz R (1998) Prevalence of the polycystic ovary syndrome in unselected black and white women of the southeastern United States: a prospective study. J Clin Endocrinol Metab83, 3078\u20133082.","DOI":"10.1210\/jc.83.9.3078"},{"key":"key\n\t\t\t\t20171011122456_R23","doi-asserted-by":"crossref","unstructured":"Lander ES and Schork NJ (1994) Genetic dissection of complex traits. Science265, 2037\u20132048.","DOI":"10.1126\/science.8091226"},{"key":"key\n\t\t\t\t20171011122456_R24","unstructured":"Legro RS, Spielman R, Urbanek M, Driscoll D, Strauss JF 3rd and Dunaif A (1998a) Phenotype and genotype in polycystic ovary syndrome. Recent. Prog Horm Res53, 217\u2013256."},{"key":"key\n\t\t\t\t20171011122456_R25","doi-asserted-by":"crossref","unstructured":"Legro RS, Driscoll D, Strauss JF 3rd, Fox J and Dunaif A (1998b) Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome. Proc Natl Acad Sci USA95, 14956\u201314960.","DOI":"10.1073\/pnas.95.25.14956"},{"key":"key\n\t\t\t\t20171011122456_R26","doi-asserted-by":"crossref","unstructured":"Legro RS, Kunselman RA, Demers L, Wang SC, Bentley-Lewis R and Dunaif A (2002) Elevated dehydroepiandrosterone sulfate levels as the reproductive phenotype in the brothers of women with polycystic ovary syndrome. J Clin Endocrinol Metab87, 2134\u20132138.","DOI":"10.1210\/jcem.87.5.8387"},{"key":"key\n\t\t\t\t20171011122456_R27","doi-asserted-by":"crossref","unstructured":"Lunde O, Magnus P, Sandvik L and Hoglo S (1989) Familial clustering in the polycystic ovarian syndrome. Gynecol Obstet Invest28, 23\u201330.","DOI":"10.1159\/000293493"},{"key":"key\n\t\t\t\t20171011122456_R28","doi-asserted-by":"crossref","unstructured":"Matsuda M and DeFronzo RA (1999) Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp. Diabetes Care22, 1462\u20131470.","DOI":"10.2337\/diacare.22.9.1462"},{"key":"key\n\t\t\t\t20171011122456_R29","doi-asserted-by":"crossref","unstructured":"Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF and Turner RC (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia28, 412\u2013419.","DOI":"10.1007\/BF00280883"},{"key":"key\n\t\t\t\t20171011122456_R30","unstructured":"Nestler JE and Jakubowicz DJ (1997) Lean women with polycystic ovary syndrome respond to insulin reduction with decreases in ovarian P450c17 alpha activity and serum androgens. J Clin Endocrinol Metab82, 4075\u20134079."},{"key":"key\n\t\t\t\t20171011122456_R31","doi-asserted-by":"crossref","unstructured":"Rosenfield RL, Barnes RB, Cara JF and Lucky AW (1990) Dysregulation of cytochrome P450c 17 alpha as the cause of polycystic ovarian syndrome. Fertil Steril53, 785\u2013791.","DOI":"10.1016\/S0015-0282(16)53510-9"},{"key":"key\n\t\t\t\t20171011122456_R32","unstructured":"Rosenfield RL, Perovic N, Ehrmann DA and Barnes RB (1996) Acute hormonal responses to the gonadotropin releasing hormone agonist leuprolide: dose-response studies and comparison to nafarelin\u2014a clinical research center study. J Clin Endocrinol Metab81, 3408\u20133411."},{"key":"key\n\t\t\t\t20171011122456_R33","doi-asserted-by":"crossref","unstructured":"Rotterdam ESHRE\/ASRM-sponsored PCOS consensus workshop group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod19, 41\u201347.","DOI":"10.1093\/humrep\/deh098"},{"key":"key\n\t\t\t\t20171011122456_R34","doi-asserted-by":"crossref","unstructured":"Sir-Petermann T, Maliqueo M, Angel B, Lara HE, Perez-Bravo F and Recabarren SE (2002) Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization. Hum Reprod17, 2573\u20132579.","DOI":"10.1093\/humrep\/17.10.2573"},{"key":"key\n\t\t\t\t20171011122456_R35","unstructured":"Sir-Petermann T, Codner E, Maliqueo M, Hitschfeld C, Echibur\u00fa B and Cassorla F (2004) Low androgen concentrations during infancy in sons of women with polycystic ovary syndrome (PCOS) [Abstract P1-553]. Proc 86th Annual Meeting of The Endocrine Society, 293."},{"key":"key\n\t\t\t\t20171011122456_R36","doi-asserted-by":"crossref","unstructured":"Yildiz BO, Yarali H, Oguz H and Bayraktar M (2003) Glucose intolerance, insulin resistance, and hyperandrogenemia in first degree relatives of women with polycystic ovary syndrome. J Clin Endocrinol Metab88, 2031\u20132036.","DOI":"10.1210\/jc.2002-021499"},{"key":"key\n\t\t\t\t20171011122456_R37","unstructured":"Zawadzky JK and Dunaif A (1992) Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In Hershmann JM (ed.) Current Issue in Endocrinology and Metabolism. Blackwell, Boston, pp. 377\u2013384."}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/19\/12\/2742\/6951978\/deh512.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T03:55:54Z","timestamp":1585886154000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humrep\/article\/19\/12\/2742\/2356287\/Patterns-of-hormonal-response-to-the-GnRH-agonist"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,1]]},"references-count":37,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2004,12]]},"published-print":{"date-parts":[[2004,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deh512","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,12]]},"published":{"date-parts":[[2004,12,1]]}}}