{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T03:56:57Z","timestamp":1790049417833,"version":"4.0.1"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,2,1]]},"DOI":"10.1093\/humrep\/deh611","type":"journal-article","created":{"date-parts":[[2004,11,27]],"date-time":"2004-11-27T01:13:38Z","timestamp":1101518018000},"page":"350-358","source":"Crossref","is-referenced-by-count":44,"title":["Nimesulide, a COX-2 inhibitor, does not reduce lesion size or number in a nude mouse model of endometriosis"],"prefix":"10.1093","volume":"20","author":[{"given":"M.L.","family":"Hull","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Prentice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.Y.","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.P.","family":"Butt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.C.","family":"Phillips","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.K.","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.S.","family":"Charnock-Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,2]]},"reference":[{"key":"key\n\t\t\t\t20171012084537_R1","unstructured":"Aoki D, Katsuki Y, Shimizu A, Kakinuma C and Nozawa S (1994) Successful heterotransplantation of human endometrium in SCID mice. Obstet Gynecol83, 220\u2013228."},{"key":"key\n\t\t\t\t20171012084537_R2","doi-asserted-by":"crossref","unstructured":"Ben-Av P, Crofford LJ, Wilder L and Hla T (1995) Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E interleukin-1: a potential mechanism for inflammatory angiogenesis. FEBS Lett372, 83\u201387.","DOI":"10.1016\/0014-5793(95)00956-A"},{"key":"key\n\t\t\t\t20171012084537_R3","doi-asserted-by":"crossref","unstructured":"Brideau C, Kargman S, Liu S, Dallob AL, Ehrich EW, Rodger W and Chan CC (1996) A human whole blood assay for clinical evaluation of biochemical efficacy of cyclooxygenase inhibitors. Inflamm Res45, 68\u201374.","DOI":"10.1007\/BF02265118"},{"key":"key\n\t\t\t\t20171012084537_R4","doi-asserted-by":"crossref","unstructured":"Bruner KL, Matrisian LM, Rodgers WH, Gorstein F and Osteen KG (1997) Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J Clin Invest99, 2851\u20132857.","DOI":"10.1172\/JCI119478"},{"key":"key\n\t\t\t\t20171012084537_R5","doi-asserted-by":"crossref","unstructured":"Bruner-Tran KL, Webster-Clair D and Osteen KG (2002) Experimental endometriosis: the nude mouse as a xenographic host. Ann NY Acad Sci955, 328\u2013339.","DOI":"10.1111\/j.1749-6632.2002.tb02793.x"},{"key":"key\n\t\t\t\t20171012084537_R6","doi-asserted-by":"crossref","unstructured":"Bulun SE, Zeitoun KM, Takayama K and Sasano H (2000) Estrogen biosynthesis in endometriosis: molecular basis and clinical relevance. J Mol Endocrinol25, 35\u201342.","DOI":"10.1677\/jme.0.0250035"},{"key":"key\n\t\t\t\t20171012084537_R7","doi-asserted-by":"crossref","unstructured":"Bulun SE, Yang S, Fang Z, Gurates B, Tamura M and Sebastian S (2002) Estrogen production and metabolism in endometriosis. Ann NY Acad Sci955, 75\u201385.","DOI":"10.1111\/j.1749-6632.2002.tb02767.x"},{"key":"key\n\t\t\t\t20171012084537_R8","doi-asserted-by":"crossref","unstructured":"Chishima F, Hayakawa S, Sugita K, Kinukawa N, Aleemuzzaman S, Nemoto N, Yamamoto T and Honda M (2002) Increased expression of cyclooxygenase-2 in local lesions of endometriosis patients. Am J Reprod Immunol48, 50\u201356.","DOI":"10.1034\/j.1600-0897.2002.01101.x"},{"key":"key\n\t\t\t\t20171012084537_R9","doi-asserted-by":"crossref","unstructured":"Corbellis L, Razzi S, De Simone S, Sartini A, Fava A, Danero S, Gioffre W, Mazzini M and Petraglia F (2004) The treatment with a COX-2 specific inhibitor is effective in the management of pain related to endometriosis. Eur J Obstet Gynecol Reprod Biol116, 100\u2013102.","DOI":"10.1016\/j.ejogrb.2004.02.007"},{"key":"key\n\t\t\t\t20171012084537_R10","unstructured":"Daniel TO, Liu H, Morrow JD, Crews BC and Marnett LJ (1999) Thromboxane A2 is a mediator of cyclooxygenase-2-dependent endothelial migration and angiogenesis. Cancer Res59, 4574\u20134577."},{"key":"key\n\t\t\t\t20171012084537_R11","doi-asserted-by":"crossref","unstructured":"Dannenberg AJ, Altorki NK, Boyle JO, Dang C, Howe LR, Weksler BB and Subbaramaiah K (2001) Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer. Lancet Oncol2, 544\u2013551.","DOI":"10.1016\/S1470-2045(01)00488-0"},{"key":"key\n\t\t\t\t20171012084537_R12","doi-asserted-by":"crossref","unstructured":"Davis R and Brogden RN (1994) Nimesulide. An update of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs48, 431\u2013454.","DOI":"10.2165\/00003495-199448030-00008"},{"key":"key\n\t\t\t\t20171012084537_R13","doi-asserted-by":"crossref","unstructured":"Deeks JJ, Smith LA and Bradley MD (2002) Efficacy, tolerability, and upper gastrointestinal safety of celecoxib for treatment of osteoarthritis and rheumatoid arthritis: systematic review of randomised controlled trials. Br Med J325, 619.","DOI":"10.1136\/bmj.325.7365.619"},{"key":"key\n\t\t\t\t20171012084537_R14","doi-asserted-by":"crossref","unstructured":"Diaz-Flores L, Gutierrez R, Valladares F, Varela H and Perez M (1994) Intense vascular sprouting from rat femoral vein induced by prostaglandins E1 and E2. Anat Rec238, 68\u201376.","DOI":"10.1002\/ar.1092380109"},{"key":"key\n\t\t\t\t20171012084537_R15","doi-asserted-by":"crossref","unstructured":"Dormond O, Foletti A, Paroz C and Ruegg C (2001) NSAIDs inhibit alpha V beta 3 integrin-mediated and Cdc42\/Rac-dependent endothelial-cell spreading, migration and angiogenesis. Nat Med7, 1041\u20131047.","DOI":"10.1038\/nm0901-1041"},{"key":"key\n\t\t\t\t20171012084537_R16","doi-asserted-by":"crossref","unstructured":"Evett GE, Xie W, Chipman JG, Robertson DL and Simmons DL (1993) Prostaglandin G\/H synthase isoenzyme 2 expression in fibroblasts: regulation by dexamethasone, mitogens, and oncogenes. Arch Biochem Biophys306, 169\u2013177.","DOI":"10.1006\/abbi.1993.1496"},{"key":"key\n\t\t\t\t20171012084537_R17","doi-asserted-by":"crossref","unstructured":"Fagotti A, Ferrandina G, Fanfani F, Legge F, Lauriola L, Gessi M, Castelli P, Barbieri F, Minelli L and Scambia G (2004) Analysis of cyclooxygenase-2 (COX-2) expression in different sites of endometriosis and correlation with clinico-pathological parameters. Hum Reprod19, 393\u2013397.","DOI":"10.1093\/humrep\/deh054"},{"key":"key\n\t\t\t\t20171012084537_R18","doi-asserted-by":"crossref","unstructured":"FitzGerald GA and Patrono C (2001) The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med345, 433\u2013442.","DOI":"10.1056\/NEJM200108093450607"},{"key":"key\n\t\t\t\t20171012084537_R19","doi-asserted-by":"crossref","unstructured":"Form DW and Auerbach R (1983) PGE2 and angiogenesis. Proc Soc Exp Biol Med172, 214\u2013218.","DOI":"10.3181\/00379727-172-41548"},{"key":"key\n\t\t\t\t20171012084537_R20","doi-asserted-by":"crossref","unstructured":"Gallo O, Masini E, Bianchi B, Bruschini L, Paglierani M and Franchi A (2002) Prognostic significance of cyclooxygenase-2 pathway and angiogenesis in head and neck squamous cell carcinoma. Hum Pathol33, 708\u2013714.","DOI":"10.1053\/hupa.2002.125376"},{"key":"key\n\t\t\t\t20171012084537_R21","doi-asserted-by":"crossref","unstructured":"Gasparini G, Longo R, Sarmiento R and Morabito A (2003) Inhibitors of cyclo-oxygenase 2: a new class of anticancer agents? Lancet Oncol4, 605\u2013615.","DOI":"10.1016\/S1470-2045(03)01220-8"},{"key":"key\n\t\t\t\t20171012084537_R22","doi-asserted-by":"crossref","unstructured":"Gilroy DW, Tomlinson A and Willoughby DA (1998) Differential effects of inhibitors of cyclooxygenase (cyclooxygenase 1 and cyclooxygenase 2) in acute inflammation. Eur J Pharmacol355, 211\u2013217.","DOI":"10.1016\/S0014-2999(98)00508-1"},{"key":"key\n\t\t\t\t20171012084537_R23","doi-asserted-by":"crossref","unstructured":"Gupta SK, Bhardwaj RK, Tyagi P, Sengupta S and Velpandian T (1999) Anti-inflammatory activity and pharmacokinetic profile of a new parenteral formulation of nimesulide. Pharmacol Res39, 137\u2013141.","DOI":"10.1006\/phrs.1998.0417"},{"key":"key\n\t\t\t\t20171012084537_R24","doi-asserted-by":"crossref","unstructured":"Haney AF and Weinberg JB (1988) Reduction of the intraperitoneal inflammation associated with endometriosis by treatment with medroxyprogesterone acetate. Am J Obstet Gynecol159, 450\u2013454.","DOI":"10.1016\/S0002-9378(88)80106-6"},{"key":"key\n\t\t\t\t20171012084537_R25","doi-asserted-by":"crossref","unstructured":"Hull ML, Charnock-Jones DS, Chan CL, Bruner-Tran KL, Osteen KG, Tom BD, Fan TP and Smith SK (2003) Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab88, 2889\u20132899.","DOI":"10.1210\/jc.2002-021912"},{"key":"key\n\t\t\t\t20171012084537_R26","doi-asserted-by":"crossref","unstructured":"Jabbour HN and Boddy SC (2003) Prostaglandin E2 induces proliferation of glandular epithelial cells of the human endometrium via extracellular regulated kinase 1\/2-mediated pathway. J Clin Endocrinol Metab88, 4481\u20134487.","DOI":"10.1210\/jc.2003-030297"},{"key":"key\n\t\t\t\t20171012084537_R27","doi-asserted-by":"crossref","unstructured":"Jabbour HN, Milne SA, Williams AR, Anderson RA and Boddy SC (2001) Expression of COX-2 and PGE synthase and synthesis of PGE2 in endometrial adenocarcinoma: a possible autocrine\/paracrine regulation of neoplastic cell function via EP2\/EP4 receptors. Br J Cancer85, 1023\u20131031.","DOI":"10.1054\/bjoc.2001.2033"},{"key":"key\n\t\t\t\t20171012084537_R28","doi-asserted-by":"crossref","unstructured":"Jones RK, Searle RF and Bulmer JN (1998) Apoptosis and bcl-2 expression in normal human endometrium, endometriosis and adenomyosis. Hum Reprod13, 3498\u20133502.","DOI":"10.1093\/humrep\/13.12.3496"},{"key":"key\n\t\t\t\t20171012084537_R29","doi-asserted-by":"crossref","unstructured":"Karck U, Reister F, Schafer W, Zahradnik HP and Breckwoldt M (1996) PGE2 and PGF2 alpha release by human peritoneal macrophages in endometriosis. Prostaglandins51, 49\u201360.","DOI":"10.1016\/0090-6980(95)00159-X"},{"key":"key\n\t\t\t\t20171012084537_R30","doi-asserted-by":"crossref","unstructured":"Keenan JA, Chen TT, Chadwell NL, Torry DS and Caudle MR (1995) IL-1 beta, TNF-alpha, and IL-2 in peritoneal fluid and macrophage-conditioned media of women with endometriosis. Am J Reprod Immunol34, 381\u2013385.","DOI":"10.1111\/j.1600-0897.1995.tb00968.x"},{"key":"key\n\t\t\t\t20171012084537_R31","doi-asserted-by":"crossref","unstructured":"Lee SH, Soyoola E, Chanmugam P, Hart S, Sun W, Zhong H, Liou S, Simmons D and Hwang D (1992) Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem267, 25934\u201325938.","DOI":"10.1016\/S0021-9258(18)35698-9"},{"key":"key\n\t\t\t\t20171012084537_R32","doi-asserted-by":"crossref","unstructured":"Magni E (1993) The effect of nimesulide on prostaniod formation. Drugs46, 10\u201314.","DOI":"10.2165\/00003495-199300461-00004"},{"key":"key\n\t\t\t\t20171012084537_R33","doi-asserted-by":"crossref","unstructured":"Mahutte NG and Arici A (2003) Medical management of endometriosis-associated pain. Obstet Gynecol Clin North Am30, 133\u2013150.","DOI":"10.1016\/S0889-8545(02)00057-8"},{"key":"key\n\t\t\t\t20171012084537_R34","unstructured":"Masferrer JL, Leahy KM, Koki AT, Zweifel BS, Settle SL, Woerner BW, Edwards DA, Flickinger AG, Moore RJ and Seibert K (2000) Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors. Cancer Res60, 1306\u20131311."},{"key":"key\n\t\t\t\t20171012084537_R35","doi-asserted-by":"crossref","unstructured":"Matsumoto H, Ma WG, Daikoku T, Zhao X, Paria BC, Das SK, Trzaskos JM and Dey SK (2002) Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice. J Biol Chem277, 29260\u201329267.","DOI":"10.1074\/jbc.M203996200"},{"key":"key\n\t\t\t\t20171012084537_R36","doi-asserted-by":"crossref","unstructured":"Meresman GF, Vighi S, Buquet RA, Contreras-Ortiz O, Tesone M and Rumi LS (2000) Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis. Fertil Steril74, 760\u2013766.","DOI":"10.1016\/S0015-0282(00)01522-3"},{"key":"key\n\t\t\t\t20171012084537_R37","doi-asserted-by":"crossref","unstructured":"Milne SA and Jabbour HN (2003) Prostaglandin-F2 alpha receptor expression and signalling in human endometrium: role of PGF2 alpha in epithelial cell proliferation. J Clin Endocrinol Metab88, 1825\u20131832.","DOI":"10.1210\/jc.2002-021368"},{"key":"key\n\t\t\t\t20171012084537_R38","doi-asserted-by":"crossref","unstructured":"Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC, Mahler JF, Kluckman KD, Ledford A, Lee CA et al. (1995) Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell83, 473\u2013482.","DOI":"10.1016\/0092-8674(95)90125-6"},{"key":"key\n\t\t\t\t20171012084537_R39","doi-asserted-by":"crossref","unstructured":"Mori H, Sawairi M, Nakagawa M, Itoh N, Wada K and Tamaya T (1991) Peritoneal fluid interleukin-1 beta and tumor necrosis factor in patients with benign gynecologic disease. Am J Reprod Immunol26, 62\u201367.","DOI":"10.1111\/j.1600-0897.1991.tb00972.x"},{"key":"key\n\t\t\t\t20171012084537_R40","doi-asserted-by":"crossref","unstructured":"Nie D, Lamberti M, Zacharek A, Li L, Szekeres K, Tang K, Chen Y and Honn KV (2000) Thromboxane A2 regulation of endothelial cell migration, angiogenesis, and tumor metastasis. Biochem Biophys Res Commun267, 245\u2013251.","DOI":"10.1006\/bbrc.1999.1840"},{"key":"key\n\t\t\t\t20171012084537_R41","unstructured":"Noble LS, Simpson ER, Johns A and Bulun SE (1996) Aromatase expression in endometriosis. J Clin Endocrinol Metab81, 174\u2013179."},{"key":"key\n\t\t\t\t20171012084537_R42","doi-asserted-by":"crossref","unstructured":"Noble LS, Takayama K, Zeitoun KM, Putman JM, Johns DA, Hinshelwood MM, Agarwal VR, Zhao Y, Carr BR and Bulun SE (1997) Prostaglandin E2 stimulates aromatase expression in endometriosis-derived stromal cells. J Clin Endocrinol Metab82, 600\u2013606.","DOI":"10.1210\/jc.82.2.600"},{"key":"key\n\t\t\t\t20171012084537_R43","doi-asserted-by":"crossref","unstructured":"Noyes RW, Hertig AT and Roc KJ (1950) Dating the endometrial biopsy. Fertil Steril1, 3\u201325.","DOI":"10.1016\/S0015-0282(16)30062-0"},{"key":"key\n\t\t\t\t20171012084537_R44","doi-asserted-by":"crossref","unstructured":"Ota H, Igarashi S, Sasaki M and Tanaka T (2001) Distribution of cyclooxygenase-2 in eutopic and ectopic endometrium in endometriosis and adenomyosis. Hum Reprod16, 561\u2013566.","DOI":"10.1093\/humrep\/16.3.561"},{"key":"key\n\t\t\t\t20171012084537_R45","doi-asserted-by":"crossref","unstructured":"Pulkkinen M (1993) Nimesulide in dysmenorrhoea. Drugs46 (Suppl 1), 129\u2013133.","DOI":"10.2165\/00003495-199300461-00028"},{"key":"key\n\t\t\t\t20171012084537_R46","doi-asserted-by":"crossref","unstructured":"Raiter-Tenenbaum A, Baranao RI, Etchepareborda JJ, Meresman GF and Rumi LS (1998) Functional and phenotypic alterations in peritoneal macrophages from patients with early and advanced endometriosis. Arch Gynecol Obstet261, 147\u2013157.","DOI":"10.1007\/s004040050214"},{"key":"key\n\t\t\t\t20171012084537_R47","doi-asserted-by":"crossref","unstructured":"Sakamoto Y, Harada T, Horie S, Iba Y, Taniguchi F, Yoshida S, Iwabe T and Terakawa N (2003) Tumor necrosis factor-alpha-induced interleukin-8 (IL-8) expression in endometriotic stromal cells, probably through nuclear factor-kappa B activation: gonadotropin-releasing hormone agonist treatment reduced IL-8 expression. J Clin Endocrinol Metab88, 730\u2013735.","DOI":"10.1210\/jc.2002-020666"},{"key":"key\n\t\t\t\t20171012084537_R48","doi-asserted-by":"crossref","unstructured":"Schreinemachers DM and Everson RB (1994) Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology5, 138\u2013146.","DOI":"10.1097\/00001648-199403000-00003"},{"key":"key\n\t\t\t\t20171012084537_R49","doi-asserted-by":"crossref","unstructured":"Sheng H, Shao J, Kirkland SC, Isakson P, Coffey RJ, Morrow J, Beauchamp RD and DuBois RN (1997) Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest99, 2254\u20132259.","DOI":"10.1172\/JCI119400"},{"key":"key\n\t\t\t\t20171012084537_R50","doi-asserted-by":"crossref","unstructured":"Smith WL, Garavito RM and DeWitt DL (1996) Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem271, 33157\u201333160.","DOI":"10.1074\/jbc.271.52.33157"},{"key":"key\n\t\t\t\t20171012084537_R51","doi-asserted-by":"crossref","unstructured":"Strathy JH, Molgaard CA, Coulam CB and Melton LJ, 3rd (1982) Endometriosis and infertility: a laparoscopic study of endometriosis among fertile and infertile women. Fertil Steril38, 667\u2013672.","DOI":"10.1016\/S0015-0282(16)46691-4"},{"key":"key\n\t\t\t\t20171012084537_R52","doi-asserted-by":"crossref","unstructured":"Tamura M, Sebastian S, Yang S, Gurates B, Fang Z and Bulun SE (2002) Interleukin-1\u03b2 elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2. J Clin Endocrinol Metab87, 3263\u20133273.","DOI":"10.1210\/jcem.87.7.8594"},{"key":"key\n\t\t\t\t20171012084537_R53","doi-asserted-by":"crossref","unstructured":"Tamura M, Sebastian S, Yang S, Gurates B, Ferrer K, Sasano H, Okamura K and Bulun SE (2002) Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa B. J Biol Chem277, 26208\u201326216.","DOI":"10.1074\/jbc.M201347200"},{"key":"key\n\t\t\t\t20171012084537_R54","doi-asserted-by":"crossref","unstructured":"Thun MJ, Namboodiri MM and Heath CW Jr (1991) Aspirin use and reduced risk of fatal cancer. N Engl J Med325, 1593\u20131596.","DOI":"10.1056\/NEJM199112053252301"},{"key":"key\n\t\t\t\t20171012084537_R55","doi-asserted-by":"crossref","unstructured":"Tong BJ, Tan J, Tajeda L, Das SK, Chapman JA, DuBois RN and Dey SK (2000) Heightened expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-delta in human endometrial adenocarcinoma. Neoplasia2, 483\u2013490.","DOI":"10.1038\/sj.neo.7900119"},{"key":"key\n\t\t\t\t20171012084537_R56","doi-asserted-by":"crossref","unstructured":"Tsujii M and DuBois RN (1995) Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell83, 493\u2013501.","DOI":"10.1016\/0092-8674(95)90127-2"},{"key":"key\n\t\t\t\t20171012084537_R57","doi-asserted-by":"crossref","unstructured":"Tsujii M, Kawano S, Tsuji S, Sawaoka H, Hori M and DuBois RN (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell93, 705\u2013716.","DOI":"10.1016\/S0092-8674(00)81433-6"},{"key":"key\n\t\t\t\t20171012084537_R58","doi-asserted-by":"crossref","unstructured":"Vane JR, Mitchell JA, Appleton I, Tomlinson A, Bishop-Bailey D, Croxtall J and Willoughby DA (1994) Inducible isoforms of cyclooxygenase and nitric-oxide synthase in inflammation. Proc Natl Acad Sci USA91, 2046\u20132050.","DOI":"10.1073\/pnas.91.6.2046"},{"key":"key\n\t\t\t\t20171012084537_R59","doi-asserted-by":"crossref","unstructured":"Williams CS, Sheng H, Brockman JA, Armandla R, Shao J, Washington MK, Elkahloun AG and DuBois RN (2001) A cyclooxygenase-2 inhibitor (SC-58125) blocks growth of established human colon cancer xenografts. Neoplasia3, 428\u2013436.","DOI":"10.1038\/sj.neo.7900177"},{"key":"key\n\t\t\t\t20171012084537_R60","doi-asserted-by":"crossref","unstructured":"Wu MH, Sun HS, Lin CC, Hsiao KY, Chuang PC, Pan HA and Tsai SJ (2002) Distinct mechanisms regulate cyclooxygenase-1 and -2 in peritoneal macrophages of women with and without endometriosis. Mol Hum Reprod8, 1103\u20131110.","DOI":"10.1093\/molehr\/8.12.1103"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/20\/2\/350\/1649796\/deh611.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T20:36:25Z","timestamp":1624998985000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humrep\/article\/20\/2\/350\/603269\/Nimesulide-a-COX2-inhibitor-does-not-reduce-lesion"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,1]]},"references-count":60,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2005,2]]},"published-print":{"date-parts":[[2005,2,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deh611","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,2]]},"published":{"date-parts":[[2005,2,1]]}}}