{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:32:13Z","timestamp":1791135133513,"version":"4.1.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,3,1]]},"DOI":"10.1093\/humrep\/deh657","type":"journal-article","created":{"date-parts":[[2005,2,17]],"date-time":"2005-02-17T22:52:48Z","timestamp":1108680768000},"page":"761-767","source":"Crossref","is-referenced-by-count":123,"title":["Human sperm chemotaxis: both the oocyte and its surrounding cumulus cells secrete sperm chemoattractants"],"prefix":"10.1093","volume":"20","author":[{"given":"Fei","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anat","family":"Bahat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Gakamsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eliezer","family":"Girsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura C.","family":"Giojalas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilan","family":"Tur-Kaspa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Eisenbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,3]]},"reference":[{"key":"key\n\t\t\t\t20171011134141_R1","doi-asserted-by":"crossref","unstructured":"Adler J (1969) Chemoreceptors in bacteria. Science166, 1588\u20131597.","DOI":"10.1126\/science.166.3913.1588"},{"key":"key\n\t\t\t\t20171011134141_R2","doi-asserted-by":"crossref","unstructured":"Adler J (1973) A method for measuring chemotaxis and use of the method to determine optimum conditions for chemotaxis by Escherichia coli. J Gen Microbiol74, 77\u201391.","DOI":"10.1099\/00221287-74-1-77"},{"key":"key\n\t\t\t\t20171011134141_R3","doi-asserted-by":"crossref","unstructured":"Bahat A, Tur-Kaspa I, Gakamsky A, Giojalas LC, Breitbart H and Eisenbach M (2003) Thermotaxis of mammalian sperm cells: a potential navigation mechanism in the female genital tract. Nature Med9, 149\u2013150.","DOI":"10.1038\/nm0203-149"},{"key":"key\n\t\t\t\t20171011134141_R4","unstructured":"Bedford JM (1982) Fertilization. In Austin CR and Short RV (eds) Germ Cells and Fertilization. Cambridge University Press, Cambridge, UK, Vol 1. pp. 128\u2013163."},{"key":"key\n\t\t\t\t20171011134141_R5","doi-asserted-by":"crossref","unstructured":"Bedford JM and Kim HH (1993) Cumulus oophorus as a sperm sequestering device, in vivo. J Exp Zool265, 321\u2013328.","DOI":"10.1002\/jez.1402650314"},{"key":"key\n\t\t\t\t20171011134141_R6","unstructured":"Biggers JD, Whitten WK and Whittingham DG (1971) The culture of mouse embryos in vitro. In Daniel JD (ed.) Methods in Mammalian Embryology. Freeman, San Francisco, pp. 86\u2013116."},{"key":"key\n\t\t\t\t20171011134141_R7","doi-asserted-by":"crossref","unstructured":"Bronson R and Hamada Y (1977) Gamete interactions in vitro. Fertil Steril28, 570\u2013576.","DOI":"10.1016\/S0015-0282(16)42559-8"},{"key":"key\n\t\t\t\t20171011134141_R8","unstructured":"Brussow K-P, Ratky J, Schneider F, Torner H, Kanitz W and Solti L (1998) Does follicular fluid have any importance in the transfer of porcine oocytes into the oviduct. Theriogenology49, 340."},{"key":"key\n\t\t\t\t20171011134141_R9","doi-asserted-by":"crossref","unstructured":"Cohen-Dayag A, Ralt D, Tur-Kaspa I, Manor M, Makler A, Dor J, Mashiach S and Eisenbach M (1994) Sequential acquisition of chemotactic responsiveness by human spermatozoa. Biol Reprod50, 786\u2013790.","DOI":"10.1095\/biolreprod50.4.786"},{"key":"key\n\t\t\t\t20171011134141_R10","doi-asserted-by":"crossref","unstructured":"Cohen-Dayag A, Tur-Kaspa I, Dor J, Mashiach S and Eisenbach M (1995) Sperm capacitation in humans is transient and correlates with chemotactic responsiveness to follicular factors. Proc Natl Acad Sci USA92, 11039\u201311043.","DOI":"10.1073\/pnas.92.24.11039"},{"key":"key\n\t\t\t\t20171011134141_R11","doi-asserted-by":"crossref","unstructured":"Davis RO and Siemers RJ (1995) Derivation and reliability of kinematic measures of sperm motion. Reprod Fertil Dev7, 857\u2013869.","DOI":"10.1071\/RD9950857"},{"key":"key\n\t\t\t\t20171011134141_R12","doi-asserted-by":"crossref","unstructured":"Eisenbach M (1995) Sperm changes enabling fertilization in mammals. Curr Opin Endocrinol Diabetes2, 468\u2013475.","DOI":"10.1097\/00060793-199512000-00002"},{"key":"key\n\t\t\t\t20171011134141_R13","doi-asserted-by":"crossref","unstructured":"Eisenbach M (1999) Sperm chemotaxis. Rev Reprod4, 56\u201366.","DOI":"10.1530\/ror.0.0040056"},{"key":"key\n\t\t\t\t20171011134141_R14","doi-asserted-by":"crossref","unstructured":"Eisenbach M (2004) Chemotaxis. Imperial College Press, London.","DOI":"10.1142\/p303"},{"key":"key\n\t\t\t\t20171011134141_R15","doi-asserted-by":"crossref","unstructured":"Eisenbach M and Tur-Kaspa I (1999) Do human eggs attract spermatozoa? BioEssays21, 203\u2013210.","DOI":"10.1002\/(SICI)1521-1878(199903)21:3<203::AID-BIES4>3.0.CO;2-T"},{"key":"key\n\t\t\t\t20171011134141_R16","doi-asserted-by":"crossref","unstructured":"Fabro G, Rovasio RA, Civalero S, Frenkel A, Caplan SR, Eisenbach M and Giojalas LC (2002) Chemotaxis of capacitated rabbit spermatozoa to follicular fluid revealed by a novel directionality-based assay. Biol Reprod67, 1565\u20131571.","DOI":"10.1095\/biolreprod.102.006395"},{"key":"key\n\t\t\t\t20171011134141_R17","doi-asserted-by":"crossref","unstructured":"Fetterolf PM, Jurisicova A, Tyson JE and Casper RF (1994) Conditioned medium from cumulus oophorus cells stimulates human sperm velocity. Biol Reprod51, 184\u2013192.","DOI":"10.1095\/biolreprod51.2.184"},{"key":"key\n\t\t\t\t20171011134141_R18","doi-asserted-by":"crossref","unstructured":"Hansen C, Srikandakumar A and Downey BR (1991) Presence of follicular fluid in the porcine oviduct and its contribution to the acrosome reaction. Mol Reprod Dev30, 148\u2013153.","DOI":"10.1002\/mrd.1080300211"},{"key":"key\n\t\t\t\t20171011134141_R19","unstructured":"Harper MJK (1982) Sperm and egg transport. In Austin CR and Short RV (eds) Germ Cells and Fertilization. Cambridge University Press, Cambridge, UK, Vol 1. pp. 102\u2013127."},{"key":"key\n\t\t\t\t20171011134141_R20","doi-asserted-by":"crossref","unstructured":"Hauser R, Homonnai ZT, Paz GF, Yavetz H, Amit A, Lessing JB, Peyser MR and Yogev L (1992) Migration sedimentation technique as a predictive test for the fertilizing capacity of spermatozoa in an in vitro fertilization programme. Int J Androl15, 498\u2013503.","DOI":"10.1111\/j.1365-2605.1992.tb01143.x"},{"key":"key\n\t\t\t\t20171011134141_R21","doi-asserted-by":"crossref","unstructured":"Hunter RHF, Petersen HH and Greve T (1999) Ovarian follicular fluid, progesterone and Ca2+ ion influences on sperm release from the Fallopian tube reservoir. Mol Reprod Dev54, 283\u2013291.","DOI":"10.1002\/(SICI)1098-2795(199911)54:3<283::AID-MRD9>3.0.CO;2-T"},{"key":"key\n\t\t\t\t20171011134141_R22","doi-asserted-by":"crossref","unstructured":"Jaiswal BS and Eisenbach M (2002) Capacitation. In Hardy DM (ed.) Fertilization. Academic Press, San Diego, pp. 57\u2013117.","DOI":"10.1016\/B978-012311629-1\/50005-X"},{"key":"key\n\t\t\t\t20171011134141_R23","doi-asserted-by":"crossref","unstructured":"Jaiswal BS, Tur-Kaspa I, Dor J, Mashiach S and Eisenbach M (1999) Human sperm chemotaxis: is progesterone a chemoattractant? Biol Reprod60, 1314\u20131319.","DOI":"10.1095\/biolreprod60.6.1314"},{"key":"key\n\t\t\t\t20171011134141_R24","doi-asserted-by":"crossref","unstructured":"Mortimer ST (1997) A critical review of the physiological importance and analysis of sperm movement in mammals. Hum Reprod Update3, 403\u2013439.","DOI":"10.1093\/humupd\/3.5.403"},{"key":"key\n\t\t\t\t20171011134141_R25","doi-asserted-by":"crossref","unstructured":"Oliveira RG, Tomasi L, Rovasio RA and Giojalas LC (1999) Increased velocity and induction of chemotactic response in mouse spermatozoa by follicular and oviductal fluids. J Reprod Fertil115, 23\u201327.","DOI":"10.1530\/jrf.0.1150023"},{"key":"key\n\t\t\t\t20171011134141_R26","doi-asserted-by":"crossref","unstructured":"Ralt D, Goldenberg M, Fetterolf P, Thompson D, Dor J, Mashiach S, Garbers DL and Eisenbach M (1991) Sperm attraction to a follicular factor(s) correlates with human egg fertilizability. Proc Natl Acad Sci USA88, 2840\u20132844.","DOI":"10.1073\/pnas.88.7.2840"},{"key":"key\n\t\t\t\t20171011134141_R27","doi-asserted-by":"crossref","unstructured":"Ralt D, Manor M, Cohen-Dayag A, Tur-Kaspa I, Makler A, Yuli I, Dor J, Blumberg S, Mashiach S and Eisenbach M (1994) Chemotaxis and chemokinesis of human spermatozoa to follicular factors. Biol Reprod50, 774\u2013785.","DOI":"10.1095\/biolreprod50.4.774"},{"key":"key\n\t\t\t\t20171011134141_R28","doi-asserted-by":"crossref","unstructured":"Spehr M, Gisselmann G, Poplawski A, Riffell JA, Wetzel CH, Zimmer RK and Hatt H (2003) Identification of a testicular odorant receptor mediating human sperm chemotaxis. Science299, 2054\u20132058.","DOI":"10.1126\/science.1080376"},{"key":"key\n\t\t\t\t20171011134141_R29","doi-asserted-by":"crossref","unstructured":"Sun F, Giojalas LC, Rovasio RA, Tur-Kaspa I, Sanchez R and Eisenbach M (2003) Lack of species-specificity in mammalian sperm chemotaxis. Dev Biol255, 423\u2013427.","DOI":"10.1016\/S0012-1606(02)00090-8"},{"key":"key\n\t\t\t\t20171011134141_R30","doi-asserted-by":"crossref","unstructured":"Tanghe S, Van Soom A, Mehrzad J, Maes D, Duchateau L and de Kruif A (2003) Cumulus contributions during bovine fertilization in vitro. Theriogenology60, 135\u2013149.","DOI":"10.1016\/S0093-691X(02)01360-2"},{"key":"key\n\t\t\t\t20171011134141_R31","doi-asserted-by":"crossref","unstructured":"Tesarik J, Oltras CM and Testart J (1990) Effect of the human cumulus oophorus on movement characteristics of human capacitated spermatozoa. J Reprod Fertil88, 665\u2013675.","DOI":"10.1530\/jrf.0.0880665"},{"key":"key\n\t\t\t\t20171011134141_R32","unstructured":"Winer BJ, Brown DR and Michels KM (1991) Statistical Principles in Experimental Design. McGraw-Hill, Boston."},{"key":"key\n\t\t\t\t20171011134141_R33","unstructured":"World Health Organization (1993) WHO Laboratory Manual for the Examination of Human Semen and Semen\u2013Cervical Mucus Interaction. Cambridge University Press, New York."},{"key":"key\n\t\t\t\t20171011134141_R34","doi-asserted-by":"crossref","unstructured":"Zigmond SH (1977) Ability of polymorphonuclear leukocytes to orient in gradients of chemotactic factors. J Cell Biol75, 606\u2013616.","DOI":"10.1083\/jcb.75.2.606"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/20\/3\/761\/6952931\/deh657.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,5]],"date-time":"2020-04-05T20:40:55Z","timestamp":1586119255000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humrep\/article\/20\/3\/761\/2356534\/Human-sperm-chemotaxis-both-the-oocyte-and-its"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3,1]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2005,3]]},"published-print":{"date-parts":[[2005,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deh657","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,3]]},"published":{"date-parts":[[2005,3,1]]}}}