{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T00:51:16Z","timestamp":1792543876395,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,4,1]]},"DOI":"10.1093\/humrep\/deh711","type":"journal-article","created":{"date-parts":[[2004,12,23]],"date-time":"2004-12-23T21:26:44Z","timestamp":1103837204000},"page":"936-941","source":"Crossref","is-referenced-by-count":103,"title":["A selective estrogen receptor-\u03b2 agonist causes lesion regression in an experimentally induced model of endometriosis"],"prefix":"10.1093","volume":"20","author":[{"given":"Heather A.","family":"Harris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaylon L.","family":"Bruner-Tran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaochun","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Osteen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C. Richard","family":"Lyttle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,4]]},"reference":[{"key":"key\n\t\t\t\t20171012185225_R1","unstructured":"American College of Obstetricians and Gynecologists (2000) Medical management of endometriosis. Int J Gynecol Obstet71, 185\u2013195."},{"key":"key\n\t\t\t\t20171012185225_R2","doi-asserted-by":"crossref","unstructured":"Bruner KL, Matrisian LM, Rodgers WH, Gorstein F and Osteen KG (1997) Suppression of matrix metalloproteinases inhibits establishment of ectopic lesions by human endometrium in nude mice. J Clin Invest99, 2851\u20132857.","DOI":"10.1172\/JCI119478"},{"key":"key\n\t\t\t\t20171012185225_R3","doi-asserted-by":"crossref","unstructured":"Bruner KL, Etsenberg E, Gorstein F and Osteen KG (1999) Progesterone and transforming growth factor-beta coordinately regulate suppression of endometrial matrix metalloproteinases in a model of experimental endometriosis. Steroids64, 648\u2013653.","DOI":"10.1016\/S0039-128X(99)00048-3"},{"key":"key\n\t\t\t\t20171012185225_R4","doi-asserted-by":"crossref","unstructured":"Bruner-Tran K, Eisenberg E, Yeaman G, Anderson T, McBean J and Osteen K (2002) Steroid and cytokine regulation of matrix metalloproteinase expression in endometriosis and the establishment of experimental endometriosis in nude mice. J Clin Endocrinol Metab87, 4782\u20134791.","DOI":"10.1210\/jc.2002-020418"},{"key":"key\n\t\t\t\t20171012185225_R5","doi-asserted-by":"crossref","unstructured":"Cheers C and Waller R (1975) Activated macrophages in congenitally athymic \u201cnude mice\u201d and in lethally irradiate mice. J Immunol115, 844\u2013847.","DOI":"10.4049\/jimmunol.115.3.844"},{"key":"key\n\t\t\t\t20171012185225_R6","doi-asserted-by":"crossref","unstructured":"Couse JF and Korach KS (1999) Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev20, 358\u2013417.","DOI":"10.1210\/edrv.20.3.0370"},{"key":"key\n\t\t\t\t20171012185225_R7","doi-asserted-by":"crossref","unstructured":"Couse JF, Lindzey J, Grandien K, Gustafsson JA and Korach KS (1997) Tissue distribution and quantitative analysis of estrogen receptor-alpha (ERalpha) and estrogen receptor-beta (ERbeta) messenger ribonucleic acid in the wild-type and ERalpha-knockout mouse. Endocrinology138, 4613\u20134621.","DOI":"10.1210\/endo.138.11.5496"},{"key":"key\n\t\t\t\t20171012185225_R8","doi-asserted-by":"crossref","unstructured":"Curran EM, Berghaus L, Vernetti N, Saporita A, Lubahn D and Estes D (2001) Natural killer cells express estrogen receptor-alpha and estrogen receptor-beta and can respond to estrogen via a non-estrogen receptor-alpha-mediated pathway. Cellular Immunol214, 12\u201320.","DOI":"10.1006\/cimm.2002.1886"},{"key":"key\n\t\t\t\t20171012185225_R9","doi-asserted-by":"crossref","unstructured":"Green S, Walter P, Kumar V, Krust A, Bornert J, Argos P and Chambon P (1986) Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A. Nature320, 134\u2013139.","DOI":"10.1038\/320134a0"},{"key":"key\n\t\t\t\t20171012185225_R10","doi-asserted-by":"crossref","unstructured":"Grummer R, Schwarzer F, Bainczyk K, Hess-Stumpp H, Regidor P, Schindler A and Winterhager E (2001) Peritoneal endometriosis: validation of an in vivo model. Hum Reprod16, 1736\u20131743.","DOI":"10.1093\/humrep\/16.8.1736"},{"key":"key\n\t\t\t\t20171012185225_R11","doi-asserted-by":"crossref","unstructured":"Harris HA, Albert LM, Leathurby Y, Malamas MS, Mewshaw RE, Miller CP, Kharode YP, Marzolf J, Komm BS, Winneker RC et al. (2003) Evaluation of an estrogen receptor-\u03b2 agonist in animal models of human disease. Endocrinology144, 4241\u20134249.","DOI":"10.1210\/en.2003-0550"},{"key":"key\n\t\t\t\t20171012185225_R12","doi-asserted-by":"crossref","unstructured":"Hasui M, Saikawa Y, Miura M, Takano N, Ueno Y, Yachie A, Miyawaki T and Taniguchi N (1989) Effector and precursor phenotypes of lymphokine-activated killer cells in mice with severe combined immunodeficiency (scid) and athymic (nude) mice. Cellular Immunol120, 230\u2013239.","DOI":"10.1016\/0008-8749(89)90190-1"},{"key":"key\n\t\t\t\t20171012185225_R13","doi-asserted-by":"crossref","unstructured":"Henderson TA, Saunders PTK, Moffett-King A, Groome NP and Critchley HOD (2003) Steroid receptor expression in uterine natural killer cells. J Clin Endocrinol Metab88, 440\u2013449.","DOI":"10.1210\/jc.2002-021174"},{"key":"key\n\t\t\t\t20171012185225_R14","doi-asserted-by":"crossref","unstructured":"Hull ML, Charnock-Jones DS, Chan CLK, Bruner-Tran KL, Osteen KG, Tom BDM, Fan TPD and Smith SK (2003) Antiangiogenic agents are effective inhibitors of endometriosis. J Clin Endocrinol Metab88, 2889\u20132899.","DOI":"10.1210\/jc.2002-021912"},{"key":"key\n\t\t\t\t20171012185225_R15","doi-asserted-by":"crossref","unstructured":"Jelinsky SA, Harris HA, Brown EL, Flanagan K, Zhang XC, Tunkey C, Lai KD, Lane MV, Simcoe DK and Evans MJ (2003) Global transcription profiling of estrogen activity: estrogen receptor a regulates gene expression in the kidney. Endocrinology144, 701\u2013710.","DOI":"10.1210\/en.2002-220728"},{"key":"key\n\t\t\t\t20171012185225_R16","doi-asserted-by":"crossref","unstructured":"Kuiper GGJM, Enmark E, Pelto-Huikko M, Nilsson S and Gustafsson J-A (1996) Cloning of a novel estrogen receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA93, 5925\u20135930.","DOI":"10.1073\/pnas.93.12.5925"},{"key":"key\n\t\t\t\t20171012185225_R17","unstructured":"Kuiper GGJM, Carlsson B, Grandian K, Enmark E, Haggblad J, Nilsson S and Gustafsson JA (1997) Comparison of the ligand binding specificity and transcript tissue distribution of estrogen receptor alpha and beta. Endocrinology138, 863\u2013870."},{"key":"key\n\t\t\t\t20171012185225_R18","doi-asserted-by":"crossref","unstructured":"Lebovic DI, Mueller MD and Taylor RN (2001) Immunobiology of endometriosis. Fertil Steril75, 1\u201310.","DOI":"10.1016\/S0015-0282(00)01630-7"},{"key":"key\n\t\t\t\t20171012185225_R19","unstructured":"Lecce G, Meduri G, Ancelin M, Bergeron C and Perrot-Applanat M (2001) Presence of estrogen receptor beta in the human endometrium through the cycle: expression in glandular, stromal, and vascular cells. J Clin Endocrinol Metab86, 1379\u20131386."},{"key":"key\n\t\t\t\t20171012185225_R20","doi-asserted-by":"crossref","unstructured":"Malamas MS, Manas ES, McDevitt RE, Gunawan I, Zhang XB, Collini MD, Miller CP, Dinh T, Henderson RA, Keith JC, Jr et al. (2004) Design and synthesis of aryl di-phenolic azoles as potent and selective estrogen receptor-\u03b2 ligands. J Med Chem47, 5021\u20135040.","DOI":"10.1021\/jm049719y"},{"key":"key\n\t\t\t\t20171012185225_R21","doi-asserted-by":"crossref","unstructured":"Matsuzaki S, Fukaya T, Suzuki T, Murakami T, Sasano H and Yajima A (1999) Oestrogen receptor alpha and beta mRNA expression in human endometrium throughout the menstrual cycle. Mol Hum Reprod5, 559\u2013564.","DOI":"10.1093\/molehr\/5.6.559"},{"key":"key\n\t\t\t\t20171012185225_R22","unstructured":"Moore J, Kennedy S and Prentice A (2004) Modern combined oral contraceptives for pain associated with endometriosis. Cochrane Database of Systematic Reviews 4."},{"key":"key\n\t\t\t\t20171012185225_R23","doi-asserted-by":"crossref","unstructured":"Nothnick WB (2001) Treating endometriosis as an autoimmune disease. Fertil Steril76, 223\u2013231.","DOI":"10.1016\/S0015-0282(01)01878-7"},{"key":"key\n\t\t\t\t20171012185225_R24","doi-asserted-by":"crossref","unstructured":"Nothnick WB and D'Hooghe TM (2003) Medical management of endometriosis: novel targets and approaches towards the development of future treatment regimes. Gynecol Obstet Invest55, 189\u2013198.","DOI":"10.1159\/000072073"},{"key":"key\n\t\t\t\t20171012185225_R25","doi-asserted-by":"crossref","unstructured":"Oosterlynck D, Cornillie F, Waer M, Vandeputte M and Koninckx P (1991) Women with endometriosis show a defect in natural killer activity resulting in a decreased cytoxicity to autologous endometrium. Fertil Steril56, 45\u201351.","DOI":"10.1016\/S0015-0282(16)54414-8"},{"key":"key\n\t\t\t\t20171012185225_R26","doi-asserted-by":"crossref","unstructured":"Osteen KG, Yeaman GR and Bruner-Tran KL (2003) Matrix metalloproteinases and endometriosis. Semin Reprod Med21, 155\u2013163.","DOI":"10.1055\/s-2003-41322"},{"key":"key\n\t\t\t\t20171012185225_R27","unstructured":"Pelletier G and El-Alfy M (2000) Immunocytochemical localization of estrogen receptors alpha and beta in the human reproductive organs. J Clin Endocrinol Metab85, 4835\u20134840."},{"key":"key\n\t\t\t\t20171012185225_R28","doi-asserted-by":"crossref","unstructured":"Sampson JA (1927) Peritoneal endometriosis due to menstrual dissemination of endometrial tissue into the peritoneal cavity. Am J Obstet Gynecol14, 422\u2013469.","DOI":"10.1016\/S0002-9378(15)30003-X"},{"key":"key\n\t\t\t\t20171012185225_R29","doi-asserted-by":"crossref","unstructured":"Stygar D, Wang H, Vladic YS, Ekman G, Eriksson H and Sahlin L (2001) Co-localization of oestrogen receptor beta and leukocyte markers in the human cervix. Mol Hum Reprod7, 881\u2013886.","DOI":"10.1093\/molehr\/7.9.881"},{"key":"key\n\t\t\t\t20171012185225_R30","doi-asserted-by":"crossref","unstructured":"Taylor AH and Al-Azzawi F (2000) Immunolocalisation of oestrogen receptor beta in human tissues. J Mol Endocrinol24, 145\u2013155.","DOI":"10.1677\/jme.0.0240145"},{"key":"key\n\t\t\t\t20171012185225_R31","doi-asserted-by":"crossref","unstructured":"Vegeto E, Bonincontro C, Pollio G, Sala A, Viappiani S, Nardi F, Brusadelli A, Viviani B, Ciana P and Maggi A (2001) Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia. J Neurosci21, 1809\u20131818.","DOI":"10.1523\/JNEUROSCI.21-06-01809.2001"},{"key":"key\n\t\t\t\t20171012185225_R32","doi-asserted-by":"crossref","unstructured":"Witz CA (2002) Pathogenesis of endometriosis. Gynecol Obstet Invest53, 52\u201360.","DOI":"10.1159\/000049425"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/20\/4\/936\/2065611\/deh711.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T22:42:57Z","timestamp":1682894577000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humrep\/article\/20\/4\/936\/701197\/A-selective-estrogen-receptor\u03b2-agonist-causes"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,4,1]]},"references-count":32,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2005,4]]},"published-print":{"date-parts":[[2005,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deh711","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.724924485.793514478","asserted-by":"object"}]},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,4]]},"published":{"date-parts":[[2005,4,1]]}}}