{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T09:40:48Z","timestamp":1790329248303,"version":"4.1.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,5,1]]},"DOI":"10.1093\/humrep\/deh745","type":"journal-article","created":{"date-parts":[[2005,1,22]],"date-time":"2005-01-22T01:13:04Z","timestamp":1106356384000},"page":"1248-1255","source":"Crossref","is-referenced-by-count":34,"title":["Mosaic status in lymphocytes of infertile men with or without Klinefelter syndrome"],"prefix":"10.1093","volume":"20","author":[{"given":"P.","family":"Lenz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.M.","family":"Luetjens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Kamischke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"K\u00fchnert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Kennerknecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Nieschlag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2005,5]]},"reference":[{"key":"key\n\t\t\t\t20171011150720_R1","doi-asserted-by":"crossref","unstructured":"Abramsky L and Chapple J (1997) 47,XXY (Klinefelter syndrome) and 47,XYY: estimated rates of an indication for postnatal diagnosis with implications for prenatal counselling. Prenat Diagn17, 363\u2013368.","DOI":"10.1002\/(SICI)1097-0223(199704)17:4<363::AID-PD79>3.0.CO;2-O"},{"key":"key\n\t\t\t\t20171011150720_R2","doi-asserted-by":"crossref","unstructured":"Amory JK, Anawalt BD, Paulsen CA and Bremner WJ (2000) Klinefelter's syndrome. Lancet356, 333\u2013335.","DOI":"10.1016\/S0140-6736(00)02517-4"},{"key":"key\n\t\t\t\t20171011150720_R3","doi-asserted-by":"crossref","unstructured":"Bhat NM, Bieber MM and Teng NN (1993) One-step enrichment of nucleated red blood cells. A potential application in perinatal diagnosis. J Immunol Methods158, 277\u2013280.","DOI":"10.1016\/0022-1759(93)90224-U"},{"key":"key\n\t\t\t\t20171011150720_R4","doi-asserted-by":"crossref","unstructured":"Blanco J, Egozcue J and Vidal F (2001) Meiotic behaviour of the sex chromosomes in three patients with sex chromosome anomalies (47,XXY, mosaic 46,XY\/47,XXY and 47,XYY) assessed by fluorescence in-situ hybridization. Hum Reprod16, 887\u2013892.","DOI":"10.1093\/humrep\/16.5.887"},{"key":"key\n\t\t\t\t20171011150720_R5","doi-asserted-by":"crossref","unstructured":"Bojesen A, Juul S and Hojberg Gravholt C (2003) Prenatal and postnatal prevalence of Klinefelter syndrome: a national registry study. JCEM88, 622\u2013626.","DOI":"10.1210\/jc.2002-021491"},{"key":"key\n\t\t\t\t20171011150720_R6","doi-asserted-by":"crossref","unstructured":"Bortolai A and Melaragno MI (2001) Cell-cycle kinetics of cell lines from patients with chromosomal mosaicism. Ann Genet44, 93\u201397.","DOI":"10.1016\/S0003-3995(01)01070-X"},{"key":"key\n\t\t\t\t20171011150720_R7","doi-asserted-by":"crossref","unstructured":"Cooper TG, Neuwinger J, Bahrs S and Nieschlag E (1992) Internal quality control of semen analysis. Fertil Steril58, 172\u2013178.","DOI":"10.1016\/S0015-0282(16)55156-5"},{"key":"key\n\t\t\t\t20171011150720_R8","doi-asserted-by":"crossref","unstructured":"Cooper TG, Atkinson AD and Nieschlag E (1999) Experience with external quality control in spermatology. Hum Reprod14, 765\u2013769.","DOI":"10.1093\/humrep\/14.3.765"},{"key":"key\n\t\t\t\t20171011150720_R9","doi-asserted-by":"crossref","unstructured":"Critchlow HM, Payne A and Griffin DK (2004) Genes and proteins involved in the control of meiosis. Cytogenet Genome Res105, 4\u201310.","DOI":"10.1159\/000078002"},{"key":"key\n\t\t\t\t20171011150720_R10","doi-asserted-by":"crossref","unstructured":"Damani MN, Mittal R and Oates RD (2001) Testicular tissue extraction in a young male with 47,XXY Klinefelter's syndrome: potential strategy for preservation of fertility. Fertil Steril76, 1054\u20131056.","DOI":"10.1016\/S0015-0282(01)02837-0"},{"key":"key\n\t\t\t\t20171011150720_R11","doi-asserted-by":"crossref","unstructured":"De Braekeleer M and Dao TN (1991) Cytogenetic studies in male infertility: a review. Hum Reprod6, 245\u2013250.","DOI":"10.1093\/oxfordjournals.humrep.a137315"},{"key":"key\n\t\t\t\t20171011150720_R12","doi-asserted-by":"crossref","unstructured":"Eskenazi B, Wyrobek AJ, Kidd SA, Lowe X, Moore D 2nd, Weisiger K and Aylstock M (2002) Can biological or clinical parameters predict testicular sperm recovery in 47,XXY Klinefelter's syndrome patients? Hum Reprod17, 576\u2013583.","DOI":"10.1093\/humrep\/17.3.576"},{"key":"key\n\t\t\t\t20171011150720_R13","doi-asserted-by":"crossref","unstructured":"Gazvani MR, Wilson EDA, Richmond DH, Howard PJ, Kingsland CR and Lewis-Jones DI (2000) Evaluation of the role of mitotic instability in karyotypically normal men with oligozoospermia. Fertil Steril73, 51\u201355.","DOI":"10.1016\/S0015-0282(99)00467-7"},{"key":"key\n\t\t\t\t20171011150720_R15","doi-asserted-by":"crossref","unstructured":"Kamischke A, Baumgardt A, Horst J and Nieschlag E (2003) Clinical and diagnostic features of patients with suspected Klinefelter syndrome. J Androl24, 41\u201348.","DOI":"10.1002\/j.1939-4640.2003.tb02638.x"},{"key":"key\n\t\t\t\t20171011150720_R16","doi-asserted-by":"crossref","unstructured":"Klinefelter HF, Reifenstein EC and Albright F (1942) Syndrome characterized by gynecomastia, aspermatogenesis without Leydigism, increased excretion of follicle stimulating hormone. J Clin Endocrinol2, 615\u2013627.","DOI":"10.1210\/jcem-2-11-615"},{"key":"key\n\t\t\t\t20171011150720_R17","unstructured":"Kurkov\u00e1 S, Zemanova Z, Hana V, Mayerova K, Pacovska K, Musilova J, Stepan J and Michalova K (1999) Molecular cytogenetic diagnosis of Klinefelter's syndrome in men more frequently detects sex chromosome mosaicism than classical cytogenetic methods. Cas Lek Cesk138, 235\u2013238."},{"key":"key\n\t\t\t\t20171011150720_R18","doi-asserted-by":"crossref","unstructured":"Lanfranco F, Kamischke A, Zitzmann M and Nieschlag E (2004) Klinefelter's syndrome. Lancet364, 273\u2013283.","DOI":"10.1016\/S0140-6736(04)16678-6"},{"key":"key\n\t\t\t\t20171011150720_R19","doi-asserted-by":"crossref","unstructured":"Luetjens CM, Rolf C, Gassner P, Werny JE and Nieschlag E (2002) Sperm aneuploidy rates in younger and older men. Hum Reprod17, 1826\u20131832.","DOI":"10.1093\/humrep\/17.7.1826"},{"key":"key\n\t\t\t\t20171011150720_R20","doi-asserted-by":"crossref","unstructured":"Mark HF, Bai H, Sotomayor E, Mark S, Zolnierz K, Airall E and Sigman M (1999) A variant Klinefelter syndrome patient with an XXY\/XX\/XY karyotype studied by GTG-banding and fluorescence in situ hybridization. Exp Mol Pathol67, 50\u201356.","DOI":"10.1006\/exmp.1999.2244"},{"key":"key\n\t\t\t\t20171011150720_R21","doi-asserted-by":"crossref","unstructured":"Meschede D, Lemcke B, Exeler JR, De Geyter C, Behre HM, Nieschlag E and Horst J (1998) Chromosome abnormalities in 447 couples undergoing intracytoplasmic sperm injection: prevalence, types, sex distribution and reproductive relevance. Hum Reprod13, 576\u2013582.","DOI":"10.1093\/humrep\/13.3.576"},{"key":"key\n\t\t\t\t20171011150720_R22","doi-asserted-by":"crossref","unstructured":"Nielsen J and Wohlert M (1991) Chromosome anomalies found among 34910 newborn children: results from 13-year incidence study in Arhus, Denmark. Hum Genet87, 81\u201383.","DOI":"10.1007\/BF01213097"},{"key":"key\n\t\t\t\t20171011150720_R23","doi-asserted-by":"crossref","unstructured":"Nielsen J, Pelsen B and Sorensen K (1988) Follow-up of 30 Klinefelter males treated with testosterone. Clin Genet33, 262\u2013269.","DOI":"10.1111\/j.1399-0004.1988.tb03447.x"},{"key":"key\n\t\t\t\t20171011150720_R24","unstructured":"Nieschlag E, Behre HM, Meschede D and Kamischke A (2000) Disorders at the testicular level. In Nieschlag E, Behre HM, and Nieschlag S (eds) Andrology. Male Reproductive Health and Dysfunction, 2nd edn. Springer, Berlin, pp. 143\u2013176."},{"key":"key\n\t\t\t\t20171011150720_R25","doi-asserted-by":"crossref","unstructured":"Ohashi Y, Miharu N, Honda H, Samura O and Ohama K (2001) High frequency of XY disomy in spermatozoa of severe oligozoospermic men. Hum Reprod16, 703\u2013708.","DOI":"10.1093\/humrep\/16.4.703"},{"key":"key\n\t\t\t\t20171011150720_R26","doi-asserted-by":"crossref","unstructured":"Okada H, Fujioka H, Tatsumi N, Kanzaki M, Okuda Y, Fujisawa M, Hazama M, Matsumoto O, Gohji K, Arakawa S and Kamidono S (1999) Klinefelter's syndrome in the male infertility clinic. Hum Reprod14, 946\u2013952.","DOI":"10.1093\/humrep\/14.4.946"},{"key":"key\n\t\t\t\t20171011150720_R27","doi-asserted-by":"crossref","unstructured":"Okada H, Dobashi M, Yamazaki T, Fujisawa M, Arakawa S and Kamidono S (2001) Fluorescence in situ hybridization analysis of sex-chromosome mosaicism in azoospermic men. J Androl22, 970\u2013972.","DOI":"10.1002\/j.1939-4640.2001.tb03437.x"},{"key":"key\n\t\t\t\t20171011150720_R28","doi-asserted-by":"crossref","unstructured":"Pang MG, Hoegerman SF, Cuticchia AJ, Moon SY, Doncel GF, Acosta AA and Kearns WG (1999) Detection of aneuploidy for chromosomes 4, 6, 7, 8, 9, 10, 11, 12, 13, 17, 18, 21, X and Y by fluorescence in-situ hybridization in spermatozoa from nine patients with oligoasthenoteratozoospermia undergoing intracytoplasmic sperm injection. Hum Reprod14, 1266\u20131273.","DOI":"10.1093\/humrep\/14.5.1266"},{"key":"key\n\t\t\t\t20171011150720_R29","doi-asserted-by":"crossref","unstructured":"Pettenati MJ, Berry MN, Hart PS, Rao PN, Lantz P and Rosnes J (1999) Prenatal interphase detection by FISH of a sex chromosome mosaicism when cytogenetics reports a pseudomosaicism. Prenat Diagn19, 25\u201328.","DOI":"10.1002\/(SICI)1097-0223(199901)19:1<25::AID-PD451>3.0.CO;2-J"},{"key":"key\n\t\t\t\t20171011150720_R30","doi-asserted-by":"crossref","unstructured":"Rives N, Mazurier S, Bellet D, Joly G and Mace B (1998) Assessment of autosome and gonosome disomy in human sperm nuclei by chromosome painting. Hum Genet102, 616\u2013623.","DOI":"10.1007\/s004390050751"},{"key":"key\n\t\t\t\t20171011150720_R31","doi-asserted-by":"crossref","unstructured":"Rubes J, Vozdova M, Robbins WA, Rezacova O, Perreault SD and Wyrobek AJ (2002) Stable variants of sperm aneuploidy among healthy men show associations between germinal and somatic aneuploidy. Am J Hum Genet70, 1507\u20131519.","DOI":"10.1086\/340791"},{"key":"key\n\t\t\t\t20171011150720_R32","doi-asserted-by":"crossref","unstructured":"Schmid TE, Kamischke A, Bollwein H, Nieschlag E and Brinkworth MH (2003) Genetic damage in oligozoospermic patients detected by fluorescence in-situ hybridization, inverse restriction site mutation assay, sperm chromatin structure assay and the Comet assay. Hum Reprod18, 1474\u20131480.","DOI":"10.1093\/humrep\/deg259"},{"key":"key\n\t\t\t\t20171011150720_R33","doi-asserted-by":"crossref","unstructured":"Smyth CM and Bremner WJ (1998) Klinefelter syndrome. Arch Intern Med158, 1309\u20131314.","DOI":"10.1001\/archinte.158.12.1309"},{"key":"key\n\t\t\t\t20171011150720_R34","doi-asserted-by":"crossref","unstructured":"Therman E, Denniston C, Sarto GE and Ulber M (1980) X chromosome constitution and the human female phenotype. Hum Genet54, 133\u2013143.","DOI":"10.1007\/BF00278961"},{"key":"key\n\t\t\t\t20171011150720_R35","doi-asserted-by":"crossref","unstructured":"Vernaeve V, Staessen C, Verheyen G, Van Steirteghem A, Devroey P and Tournaye H (2004) Can biological or clinical parameters predict testicular sperm recovery in 47,XXY Klinefelter's syndrome patients? Hum Reprod19, 1135\u20131139.","DOI":"10.1093\/humrep\/deh253"},{"key":"key\n\t\t\t\t20171011150720_R36","doi-asserted-by":"crossref","unstructured":"Westlander G, Ekerhovd E, Granberg S, Hanson L, Hanson C and Bergh C (2001) Testicular ultrasonography and extended chromosome analysis in men with nonmosaic Klinefelter syndrome: a prospective study of possible predictive factors for successful sperm recovery. Fertil Steril75, 1102\u20131105.","DOI":"10.1016\/S0015-0282(01)01793-9"},{"key":"key\n\t\t\t\t20171011150720_R37","doi-asserted-by":"crossref","unstructured":"Wilkes AJ (2000) Klinefelter's syndrome. Lancet356, 1528.","DOI":"10.1016\/S0140-6736(05)73281-5"},{"key":"key\n\t\t\t\t20171011150720_R38","doi-asserted-by":"crossref","unstructured":"Wolgemuth DJ (2003) Insights into regulation of the mammalian cell cycle from studies on spermatogenesis using genetic approaches in animal models. Cytogenet Genome Res103, 256\u2013266.","DOI":"10.1159\/000076811"},{"key":"key\n\t\t\t\t20171011150720_R39","unstructured":"World Health Organization (1999) WHO Laboratory Manual for the Examination of Human Semen and Sperm\u2013Cervical Mucus Interaction. Cambridge University Press, Cambridge."},{"key":"key\n\t\t\t\t20171011150720_R40","doi-asserted-by":"crossref","unstructured":"Yan J, Guilbault E, Mass\u00e9 J, Bronsard M, DeGrandpr\u00e9 P, Forest J-C and Drouin R (2000) Optimization of the fluorescence in situ hybridization (FISH) technique for high detection efficiency of very small proportions of target interphase nuclei. Clin Genet58, 309\u2013318.","DOI":"10.1034\/j.1399-0004.2000.580409.x"},{"key":"key\n\t\t\t\t20171011150720_R41","unstructured":"Yoshida A, Miura K and Shirai M (1996) Chromosome abnormalities and male infertility. Assist Reprod Rev6, 93\u201399."},{"key":"key\n\t\t\t\t20171011150720_R42","doi-asserted-by":"crossref","unstructured":"Zang KD (1984) Genetics and cytogenetics of Klinefelter's syndrome. In Bandmann HJ and Breit R (eds) Klinefelter's Syndrome. Springer, Heidelberg, pp. 12\u201323.","DOI":"10.1007\/978-3-642-69644-2_3"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/20\/5\/1248\/6953402\/deh745.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T01:26:18Z","timestamp":1705800378000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humrep\/article\/20\/5\/1248\/2356659\/Mosaic-status-in-lymphocytes-of-infertile-men-with"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,1]]},"references-count":41,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2005,5]]},"published-print":{"date-parts":[[2005,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deh745","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,5]]},"published":{"date-parts":[[2005,5,1]]}}}