{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:49:22Z","timestamp":1767833362052,"version":"3.49.0"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,6,1]]},"DOI":"10.1093\/humrep\/deh842","type":"journal-article","created":{"date-parts":[[2005,3,11]],"date-time":"2005-03-11T02:45:35Z","timestamp":1110509135000},"page":"1456-1465","source":"Crossref","is-referenced-by-count":21,"title":["Comparative effects of heparin-binding epidermal growth factor-like growth factor on the growth of cultured human uterine leiomyoma cells and myometrial cells"],"prefix":"10.1093","volume":"20","author":[{"given":"Jiayin","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Ohara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Takekida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Maruo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,6]]},"reference":[{"key":"key\n\t\t\t\t20171010144108_R1","doi-asserted-by":"crossref","unstructured":"Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem72, 248\u2013254.","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"key\n\t\t\t\t20171010144108_R2","doi-asserted-by":"crossref","unstructured":"Chobotova K, Muchmore M-E, Carver J, Yoo H-J, Manek S, Gullick WJ, Barlow DH and Mardon HJ (2002) The mitogenic potential of heparin-binding epidermal growth factor in the human endometrium is mediated by the epidermal growth factor receptor and is modulated by tumor necrosis factor-\u03b1. J Clin Endocrinol Metab87, 5769\u20135777.","DOI":"10.1210\/jc.2002-020069"},{"key":"key\n\t\t\t\t20171010144108_R3","doi-asserted-by":"crossref","unstructured":"Das SK, Wang X-N, Paria BC, Damm D, Abraham JA, Klagsbrun M, Andrews GK and Dey SK (1994) Heparin-binding EGF-like growth factor gene is induced in the mouse uterus temporally by the blastocyst solely at the site of its apposition: a possible ligand for interaction with blastocyst EGF-receptor in implantation. Development120, 1071\u20137083.","DOI":"10.1242\/dev.120.5.1071"},{"key":"key\n\t\t\t\t20171010144108_R4","doi-asserted-by":"crossref","unstructured":"Dixon D, He H and Haseman K (2000) Immunohistochemical localization of growth factors and their receptors in uterine leiomyomas and matched myometrium. Environ Health Perspect108, 795\u2013802.","DOI":"10.1289\/ehp.00108s5795"},{"key":"key\n\t\t\t\t20171010144108_R5","doi-asserted-by":"crossref","unstructured":"Elenius K, Paul S, Allison G, Sun J and Klagsbrun M (1997) Activation of HER4 by heparin-binding epidermal growth factor stimulates chemotaxis but not proliferation. EMBO J16, 1268\u20131278.","DOI":"10.1093\/emboj\/16.6.1268"},{"key":"key\n\t\t\t\t20171010144108_R6","doi-asserted-by":"crossref","unstructured":"Fang L, Li G, Liu G, Lee SW and Aaronson SA (2001) p53 induction of heparin-binding EGF-like growth factor counteracts p53 growth suppression through activation of MAPK and PI3K\/Akt signaling cascades. EMBO J20, 1931\u20131939.","DOI":"10.1093\/emboj\/20.8.1931"},{"key":"key\n\t\t\t\t20171010144108_R7","doi-asserted-by":"crossref","unstructured":"Farkas LM and Krieglstein K (2002) Heparin-binding epidermal growth factor-like growth factor (HB-EGF) regulates survival of midbrain dopaminergic neurons. J Neural Transm100, 267\u2013277.","DOI":"10.1007\/s007020200022"},{"key":"key\n\t\t\t\t20171010144108_R8","unstructured":"Fayed YM, Tsibris JC, Langenberg PW and Robertson AL, Jr (1989) Human uterine leiomyoma cells: binding and growth responses to epidermal growth factor, platelet-derived growth factor, and insulin. Lab Invest60, 30\u201337."},{"key":"key\n\t\t\t\t20171010144108_R9","doi-asserted-by":"crossref","unstructured":"Fukuda K, Kawata S, Inui Y, Higashiyama S, Matsuda Y, Igura T, Tamura S, Taniguchi N and Matsuzawa Y (1997) High concentration of glucose increases mitogenic responsiveness to heparin-binding epidermal growth factor-like growth factor in rat vascular smooth muscle cells. Arterioscler Thromb Vasc Biol17, 1962\u20131968.","DOI":"10.1161\/01.ATV.17.10.1962"},{"key":"key\n\t\t\t\t20171010144108_R10","doi-asserted-by":"crossref","unstructured":"Goishi K, Higashiyama S, Klagsbrun M, Nakano N, Umata T, Ishikawa M, Mekada E and Taniguchi N (1995) Phorbol ester induces the rapid processing of cell surface heparin-binding EGF-like growth factor: conversion from juxtacrine to paracrine growth factor activity. Mol Biol Cell6, 967\u2013980.","DOI":"10.1091\/mbc.6.8.967"},{"key":"key\n\t\t\t\t20171010144108_R11","doi-asserted-by":"crossref","unstructured":"Higashiyama S, Abraham JA, Miller J, Fiddes JC and Klagsbrun M (1991) A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF. Science251, 936\u2013939.","DOI":"10.1126\/science.1840698"},{"key":"key\n\t\t\t\t20171010144108_R12","doi-asserted-by":"crossref","unstructured":"Higashiyama S, Lau K, Besner GE, Abraham JA and Klagsbrun M (1992) Structure of heparin-binding EGF-like growth factor. J Biol Chem267, 6205\u20136212.","DOI":"10.1016\/S0021-9258(18)42682-8"},{"key":"key\n\t\t\t\t20171010144108_R13","doi-asserted-by":"crossref","unstructured":"Higashiyama S, Abraham JA and Klagsbrun M (1993) Heparin-binding EGF-like growth factor stimulation of smooth muscle cell migration: development on interactions with cell surface heparin sulfate. J Cell Biol122, 933\u2013940.","DOI":"10.1083\/jcb.122.4.933"},{"key":"key\n\t\t\t\t20171010144108_R14","doi-asserted-by":"crossref","unstructured":"Horikawa M, Higashiyama S, Nomura S, Kitamura Y, Ishikawa M and Taniguchi N (1999) Upregulation of endogenous heparin-binding EGF-like growth factor and its role as a survival factor in skeletal myotubes. FEBS Lett459, 100\u2013104.","DOI":"10.1016\/S0014-5793(99)01213-2"},{"key":"key\n\t\t\t\t20171010144108_R15","doi-asserted-by":"crossref","unstructured":"Iwamoto R, Handa K and Mekada E (1999) Contact-dependent growth inhibition and apoptosis of epidermal growth factor (EGF) receptor-expressing cells by the membrane-anchored form of heparin-binding EGF-like growth factor. J Biol Chem274, 25906\u201325912.","DOI":"10.1074\/jbc.274.36.25906"},{"key":"key\n\t\t\t\t20171010144108_R16","doi-asserted-by":"crossref","unstructured":"Kelman Z (1997) PCNA: structure, functions and interactions. Oncogene14, 629\u2013640.","DOI":"10.1038\/sj.onc.1200886"},{"key":"key\n\t\t\t\t20171010144108_R17","unstructured":"Kennedy TG, Brown KD and Vaughan TJ (1993) Expression of the genes for the epidermal growth factor receptor and its ligands in porcine corpora lutea. Endocrinology132, 1857\u20131859."},{"key":"key\n\t\t\t\t20171010144108_R18","doi-asserted-by":"crossref","unstructured":"Klaus E, Subrolo P, Geneve A, Jilin S and Michael K (1997) Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation. EMBO J16, 1268\u20131278.","DOI":"10.1093\/emboj\/16.6.1268"},{"key":"key\n\t\t\t\t20171010144108_R19","doi-asserted-by":"crossref","unstructured":"Leone M, Cucuccio S, Venturini PL, Valenzano-Menada M, Messeni Leone M and De Cecco L (1991) Immunohistochemical localization of epidermal growth factor receptor in leiomyomas from women treated with Goserelin depot. Horm Metab Res23, 442\u2013445.","DOI":"10.1055\/s-2007-1003722"},{"key":"key\n\t\t\t\t20171010144108_R20","doi-asserted-by":"crossref","unstructured":"Mangrulkar RS, Ono M, Ishikawa M, Takashima S, Klagsbrun M and Nowak RA (1995) Isolation and characterization of heparin-binding growth factors in human leiomyomas and normal myometrium. Biol Reprod53, 636\u2013646.","DOI":"10.1095\/biolreprod53.3.636"},{"key":"key\n\t\t\t\t20171010144108_R21","doi-asserted-by":"crossref","unstructured":"Marikovsky M, Breuing K, Liu PY, Eriksson E, Higashiyama S, Farber P, Abraham J and Klagsbrun M (1993) Appearance of heparin-binding EGF-like growth factor in wound fluid as a response to injury. Proc Natl Acad Sci USA90, 3889\u20133893.","DOI":"10.1073\/pnas.90.9.3889"},{"key":"key\n\t\t\t\t20171010144108_R22","doi-asserted-by":"crossref","unstructured":"Maruo T, Ohara N, Wang J and Matsuo H (2004) Sex steroidal regulation of uterine leiomyoma growth and apoptosis. Hum Reprod Update10, 207\u2013220.","DOI":"10.1093\/humupd\/dmh019"},{"key":"key\n\t\t\t\t20171010144108_R23","doi-asserted-by":"crossref","unstructured":"McCormick D, Yu C, Hobbs C and Hall PA (1993) The relevance of antibody concentration to the immunohistological quantification of cell proliferation-associated antigens. Histopathology22, 543\u2013547.","DOI":"10.1111\/j.1365-2559.1993.tb00174.x"},{"key":"key\n\t\t\t\t20171010144108_R24","doi-asserted-by":"crossref","unstructured":"Michalsky MP, Kuhn A, Mehta V and Besner GE (2001) Heparin-binding EGF-like growth factor decreases apoptosis in intestinal epithelial cells in vitro. J Pediatr Surg36, 1130\u20131135.","DOI":"10.1053\/jpsu.2001.25730"},{"key":"key\n\t\t\t\t20171010144108_R25","doi-asserted-by":"crossref","unstructured":"Miyoshi E, Higashiyama S, Nakagawa T, Hayashi N and Taniguchi N (1997) Membrane-anchored heparin-binding epidermal growth factor-like growth factor acts as a tumor survival factor in a hepatoma cell line. J Biol Chem272, 14349\u201314355.","DOI":"10.1074\/jbc.272.22.14349"},{"key":"key\n\t\t\t\t20171010144108_R26","doi-asserted-by":"crossref","unstructured":"Nguyen H, Bride SH, Badawy A-B, Adam RM, Lin J, Orsola A, Guthrie PD, Freeman MR and Peters CA (2000) Heparin-binding EGF-like growth factor is up-regulated in the obstructed kidney in a cello- and region-specific manner and acts to inhibit apoptosis. Am J Pathol156, 889\u2013898.","DOI":"10.1016\/S0002-9440(10)64958-9"},{"key":"key\n\t\t\t\t20171010144108_R27","doi-asserted-by":"crossref","unstructured":"Noyes RW, Hertig AT and Rock J (1950) Dating the endometrial biopsy. Fertil Steril1, 3\u201325.","DOI":"10.1016\/S0015-0282(16)30062-0"},{"key":"key\n\t\t\t\t20171010144108_R28","unstructured":"Ono M, Raab G, Lau K, Abraham JA and Klagsbrun M (1994) Purification and characterization of transmembrane forms of heparin-binding EGF-like growth factor. J Biol Chem269, 31315\u201331321."},{"key":"key\n\t\t\t\t20171010144108_R29","doi-asserted-by":"crossref","unstructured":"Razandi M, Pedram A, Park ST and Levin ER (2002) Proximal events in signaling by plasma membrane estrogen receptors. J Biol Chem278, 2701\u20132712.","DOI":"10.1074\/jbc.M205692200"},{"key":"key\n\t\t\t\t20171010144108_R30","doi-asserted-by":"crossref","unstructured":"Reynolds CM, Eguchi S, Frank GD and Motley ED (2002) Signaling mechanisms of heparin-binding epidermal growth factor-like growth factor in vascular smooth muscle cells. Hypertension39, 525\u2013529.","DOI":"10.1161\/hy0202.103076"},{"key":"key\n\t\t\t\t20171010144108_R31","unstructured":"Riese DJ, II and Stein DF (1998) Specificity within the EGF family\/ErbB receptor family signaling network. BioEssays20, 41\u201348."},{"key":"key\n\t\t\t\t20171010144108_R32","doi-asserted-by":"crossref","unstructured":"Schluter C, Duchrow M, Wohlenberg C, Becker MH, Key G, Flad HD and Gerdes J (1993) The cell proliferation-associated antigen of antibody Ki-67: a very large, ubiquitous nuclear protein with numerous repeated elements, representing a new kind of cell cycle-maintaining proteins. J Cell Biol123, 513\u2013522.","DOI":"10.1083\/jcb.123.3.513"},{"key":"key\n\t\t\t\t20171010144108_R33","doi-asserted-by":"crossref","unstructured":"Shimomura Y, Matsuo H, Samoto T and Maruo T (1998) Up-regulation by progesterone of proliferating cell nuclear antigen and epidermal growth factor expression in human uterine leiomyoma. J Clin Endocrinol Metab83, 2192\u20132198.","DOI":"10.1210\/jc.83.6.2192"},{"key":"key\n\t\t\t\t20171010144108_R34","doi-asserted-by":"crossref","unstructured":"Takemura T, Kondo S, Homma T, Sakai M and Marris RC (1997) The membrane-bound form of heparin-binding epidermal growth factor-like growth factor promotes survival of cultured renal epithelial cells. J Biol Chem272, 31036\u201331042.","DOI":"10.1074\/jbc.272.49.31036"},{"key":"key\n\t\t\t\t20171010144108_R35","doi-asserted-by":"crossref","unstructured":"Tazuke SI and Giudice LC (1996) Growth factors and cytokines in endometrium, embryonic development, and maternal embryonic interactions. Semin Reprod Endocrinol14, 231\u2013245.","DOI":"10.1055\/s-2007-1016333"},{"key":"key\n\t\t\t\t20171010144108_R36","doi-asserted-by":"crossref","unstructured":"Thompson SA, Higashiyama S, Wood K, Pollitt NS, Damm D, McEnroe G, Garrick B, Ashton N, Lau K, Hancock N, Klagsbrun M and Abraham JA (1994) Characterization of sequences within heparin-binding EGF-like growth factor that mediate interaction with heparin. J Biol Chem269, 2541\u20132549.","DOI":"10.1016\/S0021-9258(17)41979-X"},{"key":"key\n\t\t\t\t20171010144108_R37","unstructured":"Wang X-N, Das SK, Damm D, Klagsbrun M, Abraham JA and Dey SK (1994) Differential regulation of heparin-binding epidermal growth factor-like growth factor in the adult ovariectomized mouse uterus by progesterone and estrogen. Endocrinology135, 1264\u20131271."},{"key":"key\n\t\t\t\t20171010144108_R38","doi-asserted-by":"crossref","unstructured":"Yeh J, Rein M and Nowak R (1991) Presence of messenger ribonucleic acid for epidermal growth factor (EGF) and EGF receptor demonstrable in monolayer cell cultures of myometria and leiomyomata. Fertil Steril56, 997\u20131000.","DOI":"10.1016\/S0015-0282(16)54681-0"},{"key":"key\n\t\t\t\t20171010144108_R39","doi-asserted-by":"crossref","unstructured":"Zhang Z, Funk C, Roy D, Glasser S and Mulholland J (1994) Heparin-binding epidermal growth factor-like growth factor is differentially regulated by progesterone and estrogen in rat uterine epithelial and stromal cells. Endocrinology134, 1089\u20131094.","DOI":"10.1210\/endo.134.3.8119147"},{"key":"key\n\t\t\t\t20171010144108_R40","doi-asserted-by":"crossref","unstructured":"Zhang Z, Jane L, Stanley G, Peter D and Joy M (1998) Mediators of estradiol-stimulated mitosis in the rat uterine luminal epithelium. Endocrinology139, 961\u2013966.","DOI":"10.1210\/endo.139.3.5794"},{"key":"key\n\t\t\t\t20171010144108_R41","doi-asserted-by":"crossref","unstructured":"Zushi S, Shimomura Y, Kiyohara T, Miyazaki Y, Tsutsui S, Sugimachi M, Higashimoto Y, Kanayama S and Matsuzawa Y (1997) Role of heparin-binding EGF-related peptides in proliferation and apoptosis of activated ras-stimulated intestinal epithelial cells. Int J Cancer73, 917\u2013923.","DOI":"10.1002\/(SICI)1097-0215(19971210)73:6<917::AID-IJC26>3.0.CO;2-#"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/20\/6\/1456\/2245097\/deh842.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T16:35:16Z","timestamp":1683045316000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humrep\/article\/20\/6\/1456\/748922\/Comparative-effects-of-heparinbinding-epidermal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,6,1]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2005,6]]},"published-print":{"date-parts":[[2005,6,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/deh842","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,6]]},"published":{"date-parts":[[2005,6,1]]}}}