{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:20:44Z","timestamp":1767842444701,"version":"3.49.0"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,12,1]]},"DOI":"10.1093\/humrep\/dei248","type":"journal-article","created":{"date-parts":[[2005,8,26]],"date-time":"2005-08-26T20:14:10Z","timestamp":1125087250000},"page":"3500-3504","source":"Crossref","is-referenced-by-count":13,"title":["Enhancement of mouse sperm motility by the PI3-kinase inhibitor LY294002 does not result in toxic effects on preimplantation embryo development"],"prefix":"10.1093","volume":"20","author":[{"given":"Michaela","family":"Luconi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Torcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Domenico","family":"Grillo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Teresa","family":"Fiorenza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gianni","family":"Forti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Mangia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabetta","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2005,8,26]]},"reference":[{"key":"key\n\t\t\t\t20171012092945_ANDERSEN-ET-AL-2005","doi-asserted-by":"crossref","unstructured":"Andersen AN , Gianaroli L, Felberbaum R, de Mouzon J and Nygren KG; The European IVF-monitoring programme (EIM), European Society of Human Reproduction and Embryology (ESHRE). (2005) Assisted reproductive technology in Europe, 2001. Results generated from European registers by ESHRE. Hum Reprod20,1158\u20131176.","DOI":"10.1093\/humrep\/deh755"},{"key":"key\n\t\t\t\t20171012092945_BONDUELLE-ET-AL-2005","doi-asserted-by":"crossref","unstructured":"Bonduelle M , Wennerholm UB, Loft A, Tarlatzis BC, Peters C, Henriet S, Mau C, Victorin-Cederquist A, Van Steirteghem A, Balaska A et al. (2005) A multi-centre cohort study of the physical health of 5-year-old children conceived after intracytoplasmic sperm injection, in vitro fertilization and natural conception. Hum Reprod20,413\u2013419.","DOI":"10.1093\/humrep\/deh592"},{"key":"key\n\t\t\t\t20171012092945_BURDON-ET-AL-2002","doi-asserted-by":"crossref","unstructured":"Burdon T , Smith A and Savatier P (2002) Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol12,432\u2013438.","DOI":"10.1016\/S0962-8924(02)02352-8"},{"key":"key\n\t\t\t\t20171012092945_CARR-ET-AL-2001","doi-asserted-by":"crossref","unstructured":"Carr DW , Fujita A, Stentz CL, Liberty GA, Olson GE and Narumiya S (2001) Identification of sperm specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. J Biol Chem276,17332\u201317338.","DOI":"10.1074\/jbc.M011252200"},{"key":"key\n\t\t\t\t20171012092945_DUPLESSIS-ET-AL-2004","doi-asserted-by":"crossref","unstructured":"du Plessis SS , Franken DR, Baldi E and Luconi M (2004) Phosphatidylinositol 3-kinase inhibition enhances human sperm motility and sperm\u2013zona pellucida binding. Int J Androl27,19\u201326.","DOI":"10.1111\/j.1365-2605.2004.00440.x"},{"key":"key\n\t\t\t\t20171012092945_HOSHINO-ET-AL-2004","doi-asserted-by":"crossref","unstructured":"Hoshino Y , Yokoo M, Yoshida N, Sasada H, Matsumoto H and Sato E (2004) Phosphatidylinositol 3kinase and Akt participate in the FSH-induced meiotic maturation of mouse oocytes. Mol Reprod Dev69,77\u201386.","DOI":"10.1002\/mrd.20150"},{"key":"key\n\t\t\t\t20171012092945_LIGUORI-ET-AL-2005","doi-asserted-by":"crossref","unstructured":"Liguori L , de Lamirande E, Minelli A and Gagnon C (2005) Various protein kinases regulate human sperm acrosome reaction and the associated phosphorylation of Tyr residues and of the Thr-Glu-Tyr motif. Mol Hum Reprod11,211\u2013221.","DOI":"10.1093\/molehr\/gah154"},{"key":"key\n\t\t\t\t20171012092945_LUCONI-AND-BALDI-2003","unstructured":"Luconi M and Baldi E (2003) How do sperm swim? Molecular mechanisms underlying sperm motility. Cell Mol Biol (Noisy-le-grand)49,357\u2013369."},{"key":"key\n\t\t\t\t20171012092945_LUCONI-ET-AL-2001","doi-asserted-by":"crossref","unstructured":"Luconi M , Marra F, Gandini L, Filimberti E, Lenzi A, Forti G and Baldi E (2001) Phosphatidylinositol 3-kinase inhibition enhances human sperm motility. Hum Reprod16,1931\u20131937.","DOI":"10.1093\/humrep\/16.9.1931"},{"key":"key\n\t\t\t\t20171012092945_LUCONI-ET-AL-2004","doi-asserted-by":"crossref","unstructured":"Luconi M , Carloni V, Marra F, Ferruzzi P, Forti G and Baldi E (2004) Increased phosphorylation of AKAP by inhibition of phosphatidylinositol 3-kinase enhances human sperm motility through tail recruitment of protein kinase A. J Cell Sci117,1235\u20131246.","DOI":"10.1242\/jcs.00931"},{"key":"key\n\t\t\t\t20171012092945_LUCONI-ET-AL-2005","doi-asserted-by":"crossref","unstructured":"Luconi M , Porazzi I, Ferruzzi P, Marchiani S, Forti G and Baldi E (2005) Tyrosine phosphorylation of the a kinase anchoring protein 3 (AKAP3) and soluble adenylate cyclase are involved in the increase of human sperm motility by bicarbonate. Biol Reprod72,22\u201332.","DOI":"10.1095\/biolreprod.104.032490"},{"key":"key\n\t\t\t\t20171012092945_NAGY-ET-AL-2003","unstructured":"Nagy A , Gertsenstein M, Vintersten K and Behringer R (eds) (2003) Manipulating the Mouse Embryo, 3rd edn, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY."},{"key":"key\n\t\t\t\t20171012092945_NAUC-ET-AL-2004","doi-asserted-by":"crossref","unstructured":"Nauc V , De Lamirande E, Leclerc P and Gagnon C (2004) Inhibitors of phosphoinositide 3-kinase, LY294002 and wortmannin, affect sperm capacitation and associated phosphorylation of proteins differently: Ca2+dependent divergences. J Androl25,573\u2013585.","DOI":"10.1002\/j.1939-4640.2004.tb02828.x"},{"key":"key\n\t\t\t\t20171012092945_QUILL-ET-AL-2003","doi-asserted-by":"crossref","unstructured":"Quill TA , Sugden SA, Rossi KL, Doolittle LK, Hammer RE and Garbers DL (2003) Hyperactivated sperm motility driven by CatSper2 is required for fertilization. Proc Natl Acad Sci USA100,14869\u201314874.","DOI":"10.1073\/pnas.2136654100"},{"key":"key\n\t\t\t\t20171012092945_QUINN-ET-AL-1985","doi-asserted-by":"crossref","unstructured":"Quinn P , Kerin JF and Warnes GM (1985) Improved pregnancy rate in human in vitro fertilization with the use of a medium based on the composition of human tubal fluid. Fertil Steril44,493\u2013498.","DOI":"10.1016\/S0015-0282(16)48918-1"},{"key":"key\n\t\t\t\t20171012092945_VIJAYARAGHAVAN-ET-AL-1999","doi-asserted-by":"crossref","unstructured":"Vijayaraghavan S , Liberty GA, Mohan J, Winfrey VP, Olson GE and Carr DW (1999) Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. Mol Endocrinol13,705\u2013717.","DOI":"10.1210\/mend.13.5.0278"},{"key":"key\n\t\t\t\t20171012092945_WHITTINGHAM-1971","unstructured":"Whittingham, DG (1971) Culture of mouse ova. J Reprod Fertil Suppl14,7\u201321."}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/20\/12\/3500\/9543362\/dei248.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,3,18]],"date-time":"2019-03-18T12:37:07Z","timestamp":1552912627000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humrep\/article\/20\/12\/3500\/2913744\/Enhancement-of-mouse-sperm-motility-by-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,8,26]]},"references-count":17,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2005,8,26]]},"published-print":{"date-parts":[[2005,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dei248","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published-other":{"date-parts":[[2005,12]]},"published":{"date-parts":[[2005,8,26]]}}}