{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:44:11Z","timestamp":1791053051701,"version":"4.1.0"},"reference-count":48,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1093\/humrep\/del135","type":"journal-article","created":{"date-parts":[[2006,5,9]],"date-time":"2006-05-09T23:35:59Z","timestamp":1147217759000},"page":"1951-1955","source":"Crossref","is-referenced-by-count":69,"title":["Unexplained infertility: Does it really exist?"],"prefix":"10.1093","volume":"21","author":[{"given":"N.","family":"Gleicher","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Barad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,5,9]]},"reference":[{"key":"key\n\t\t\t\t20171012110857_b1","unstructured":"ASRM A Practice Committee report; A Committee Opinion: antiphospholipid antibodies do not affect IVF success 1999 Birmingham Alabama"},{"key":"key\n\t\t\t\t20171012110857_b2","article-title":"A Practice Committee Report; A Committee Opinion: optimal evaluation of the infertile female.","author":"ASRM","year":"2000"},{"key":"key\n\t\t\t\t20171012110857_b3","doi-asserted-by":"crossref","unstructured":"ASRM A Practice Committee Report; A Committee Opinion: aging and infertility in women Fertil Steril 2002 78 215 219","DOI":"10.1016\/S0015-0282(02)03212-0"},{"key":"key\n\t\t\t\t20171012110857_b4","doi-asserted-by":"crossref","unstructured":"ASRM A Practice Committee Report; A Committee Opinion: endometriosis infertility Fertil Steril 2004 81 1441 1446","DOI":"10.1016\/j.fertnstert.2004.01.019"},{"key":"key\n\t\t\t\t20171012110857_b5","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/S0015-0282(02)03227-2","article-title":"Women with regular menstrual cycles and a poor response to ovarian aging","volume":"78","author":"Beckens","year":"2002","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b6","first-page":"663","article-title":"The role of laparoscopy in the treatment of endometriosis","volume":"55","author":"Cook","year":"1995","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b7","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/oxfordjournals.humrep.a138177","article-title":"Unexplained infertility (recommendations of ESHRE workshop)","volume":"8","author":"Crosignani","year":"1993","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b8","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1016\/S0015-0282(02)02972-2","article-title":"A low number of retrieved oocytes at in vitro treatment is predictive of early menopause","volume":"77","author":"de Boer","year":"2002","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b9","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1093\/humrep\/deg278","article-title":"Increased risk of early menopausal transition and natural menopause after poor response at first IVF treatment","volume":"18","author":"de Boer","year":"2003","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b10","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1093\/oxfordjournals.humrep.a019484","article-title":"Guidelines: prevalence, diagnosis, treatment and management of infertility, 1996. Infertility revisited: the state of the art today and tomorrow","volume":"8","author":"The ESHRE Capri Workshop Group","year":"1996","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b11","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1093\/humrep\/15.3.723","article-title":"Optimal use of infertility diagnostic tests and treatments","volume":"15","author":"The ESHRE Capri Workshop Group","year":"2000","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(02)09417-5","article-title":"Female subfertility","volume":"360","author":"Evers","year":"2002","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171012110857_b13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0303-7207(99)00238-5","article-title":"Follicle dynamics during ovarian aging","volume":"163","author":"Faddy","year":"2000","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20171012110857_b14","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1093\/oxfordjournals.humrep.a137570","article-title":"Accelerated disappearance of ovarian follicles in mid-life: implications for forecasting menopause","volume":"7","author":"Faddy","year":"1992","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/S0015-0282(16)57007-1","article-title":"Subtle tubal abnormalities adversely affect gamete intrafallopian transfer outcome in women with endometriosis","volume":"62","author":"Fakih","year":"1994","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b16","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/S0015-0282(97)81351-9","article-title":"Autoimmunity and reproduction","volume":"67","author":"Geva","year":"1997","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b17","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0015-0282(97)81903-6","article-title":"Observer variability in the diagnosis and management of the hysterosalpingogram","volume":"67","author":"Glatstein","year":"1997","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b18","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1093\/rheumatology\/38.6.485","article-title":"Reproductive failure prior to the onset of clinical autoimmune disease (Editorial)","volume":"38","author":"Gleicher","year":"1999","journal-title":"Rheumatology"},{"key":"key\n\t\t\t\t20171012110857_b19","first-page":"65","article-title":"Ovarian aging: Is there a norm?","volume":"50","author":"Gleicher","year":"2005","journal-title":"Contemp Ob\/Gyn"},{"key":"key\n\t\t\t\t20171012110857_b20","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/0002-9378(89)90858-2","article-title":"Reproductive failure because of autoantibodies: unexplained infertility and pregnancy wastage","volume":"160","author":"Gleicher","year":"1989","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171012110857_b21","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1016\/S0015-0282(16)55558-7","article-title":"Standardization of hysterosalpingography and selective salpingography: a valuable adjunct to simple opacification studies","volume":"58","author":"Gleicher","year":"1992","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b22","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Guidice","year":"2004","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171012110857_b23","doi-asserted-by":"crossref","first-page":"2306","DOI":"10.1093\/oxfordjournals.humrep.a138442","article-title":"Infertility evaluation in infertile women: a model for answering the efficacy of infertility testing","volume":"9","author":"Guzick","year":"1994","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b24","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1016\/S0015-0282(16)57183-0","article-title":"Endometriosis impairs the efficacy of gamete intrafallopian transfer: results of a case-control study","volume":"62","author":"Guzick","year":"1994","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b25","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0015-0282(00)01531-4","article-title":"It\u2019s not what you don\u2019t know that makes you look like a fool. It\u2019s what you know that ain\u2019t so","volume":"74","author":"Hill","year":"2000","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b26","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/S0015-0282(00)01529-6","article-title":"Antiphospholipid antibodies in patients undergoing IVF: the data do not support testing","volume":"74","author":"Hornstein","year":"2000","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b27","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/S0015-0282(16)57591-8","article-title":"The limited value of hysterosalpingography in answering tubal status and fertility potential","volume":"63","author":"Karande","year":"1995","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b28","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1016\/S0015-0282(16)57962-X","article-title":"Elevated tubal perfusion pressures during selective salpingography are highly suggestive of tubal endometriosis","author":"Karande","year":"1995","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b29","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1093\/humupd\/2.5.429","article-title":"The assessment of tubal functional status by tubal perfusion pressure measurements","volume":"2","author":"Karande","year":"1996","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b30","first-page":"2702","article-title":"Is mild endometriosis as disease? Is mild endometriosis a condition occurring intermittently in all women?","volume":"9","author":"Koniwckx","year":"1994","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b31","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1093\/humrep\/10.1.8","article-title":"Is mild endometriosis a disease? Why do women develop endometriosis and why is it diagnosed?","volume":"10","author":"Moen","year":"1995","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b32","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1093\/oxfordjournals.humrep.a019356","article-title":"Reproducibility of the interpretation of hysterosalpingography in the diagnosis of tubal pathology","volume":"11","author":"Mol","year":"1996","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b33","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/humrep\/14.5.1237","article-title":"Comparison of hysterosalpingography and laparoscopy in predicting infertility outcome","volume":"14","author":"Mol","year":"1999","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b34","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1002\/art.1780360103","article-title":"Fecundity before disease onset in women with rheumatoid arthritis","volume":"36","author":"Nelson","year":"1993","journal-title":"Arthritis Rheum"},{"key":"key\n\t\t\t\t20171012110857_b35","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/humrep\/deg245","article-title":"Early ovarian aging: a hypothesis. Detection and clinical relevance","volume":"18","author":"Nikolaou","year":"2003","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b36","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ejogrb.2003.09.024","article-title":"Early ovarian aging","volume":"113","author":"Nikolaou","year":"2004","journal-title":"Eur J Obstet Gynecol"},{"key":"key\n\t\t\t\t20171012110857_b37","doi-asserted-by":"crossref","first-page":"1106","DOI":"10.1093\/humrep\/17.4.1106","article-title":"Is there a link between an extremely poor response to ovarian hyperstimulation and early ovarian failure?","volume":"17","author":"Nikolaou","year":"2002","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b38","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1056\/NEJM199306173282407","article-title":"Endometriosis","volume":"328","author":"Olive","year":"1993","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20171012110857_b39","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/S0015-0282(16)56158-5","article-title":"The predictive value of hysterosalpingography for tubal and peritoneal factors","volume":"60","author":"Opsahl","year":"1993","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b40","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1093\/humrep\/deg049","article-title":"The potential value of tubal perfusion pressure measured during selective salpingography in predicting fertility","volume":"18","author":"Papaioannou","year":"2003","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012110857_b41","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0015-0282(00)01533-8","article-title":"D\u00e9j\u00e0 vu all over again","volume":"74","author":"Scott","year":"2000","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b42","first-page":"441","article-title":"Increased incidence of spontaneous abortion and infertility in women with scleroderma before disease onset: a controlled study","volume":"47","author":"Sicman","year":"1998","journal-title":"Ann Rheum Dis"},{"key":"key\n\t\t\t\t20171012110857_b43","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1001\/jama.290.13.1767","article-title":"Diagnosis and management of female infertility","volume":"290","author":"Smith","year":"2003","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20171012110857_b44","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0015-0282(16)57781-4","article-title":"The accuracy of hysterosalpingography in the diagnosis of tubal pathology: a meta analysis","volume":"64","author":"Swant","year":"1995","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b45","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0015-0282(02)04686-1","article-title":"Accuracy of diagnostic laparoscopy in the infertility wash-ups before intrauterine insemination","volume":"79","author":"Tanahatoe","year":"2003","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b46","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0303-7207(98)00171-3","article-title":"Development of endocrine aspects of normal ovarian aging","volume":"145","author":"te Velde","year":"1998","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20171012110857_b47","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0015-0282(97)81482-3","article-title":"Age at natural menopause in a population-based screening cohort: the role of menarche","volume":"68","author":"van Noord","year":"1997","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012110857_b48","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0015-0282(99)00382-9","article-title":"A randomized, prospective, controlled study of laparoscopic dye studies and selective salpingography on diagnostic tests of fallopian tube patency","volume":"72","author":"Woolcott","year":"1999","journal-title":"Fertil Steril"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/21\/8\/1951\/9680676\/del135.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T15:09:33Z","timestamp":1555600173000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humrep\/article\/21\/8\/1951\/2938641\/Unexplained-infertility-Does-it-really-exist"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,9]]},"references-count":48,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2006,5,9]]},"published-print":{"date-parts":[[2006,8]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/del135","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published-other":{"date-parts":[[2006,8]]},"published":{"date-parts":[[2006,5,9]]}}}