{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:41:18Z","timestamp":1791078078394,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,2]]},"DOI":"10.1093\/humrep\/del385","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T12:08:18Z","timestamp":1161086898000},"page":"356-361","source":"Crossref","is-referenced-by-count":19,"title":["Human oviductal epithelial cells express Toll-like receptor 3 and respond to double-stranded RNA: Fallopian tube-specific mucosal immunity against viral infection"],"prefix":"10.1093","volume":"22","author":[{"given":"K.","family":"Nasu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Yuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Nishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Narahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2006,10,16]]},"reference":[{"key":"key\n\t\t\t\t20171012133044_b1","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1074\/jbc.M411223200","article-title":"Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells","volume":"280","author":"Aksoy","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171012133044_b2","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-\u03baB by Toll-like receptor 3","volume":"413","author":"Alexopoulou","year":"2001","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171012133044_b3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0264-410X(03)00195-6","article-title":"Innate immunity and pathogen\u2013host interaction","volume":"S2","author":"Basset","year":"2003","journal-title":"Vaccine"},{"key":"key\n\t\t\t\t20171012133044_b4","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.molimm.2004.11.007","article-title":"The role of Toll-like receptors in the host response to viruses","volume":"42","author":"Bowie","year":"2005","journal-title":"Mol Immunol"},{"key":"key\n\t\t\t\t20171012133044_b5","first-page":"329","article-title":"Is there mucosal immune system associated with the mammalian oviduct?","volume":"31","author":"Cardenas","year":"1998","journal-title":"Biol Res"},{"key":"key\n\t\t\t\t20171012133044_b6","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1073\/pnas.94.7.3279","article-title":"A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis","volume":"94","author":"Der","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20171012133044_b7","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1126\/science.1093616","article-title":"Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA","volume":"303","author":"Diebold","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012133044_b8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S1074-7613(02)00390-4","article-title":"IRF3 mediates a TLR3\/TLR4-specific antiviral gene program","volume":"17","author":"Doyle","year":"2002","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20171012133044_b9","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1093\/humrep\/deh775","article-title":"Characterization of Toll-like receptors in the female reproductive tract in humans","volume":"20","author":"Fazeli","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012133044_b10","doi-asserted-by":"crossref","first-page":"2424","DOI":"10.4049\/jimmunol.168.5.2424","article-title":"Response to Neisseria gonorrhoeae by cervicovaginal epithelial cells occurs in the absence of Toll-like receptor 4-mediated signaling","volume":"168","author":"Fichorova","year":"2002","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20171012133044_b11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1186\/1465-9921-6-100","article-title":"Up-regulation of Toll-like receptors 2, 3 and 4 in allergic rhinitis","volume":"6","author":"Fransson","year":"2005","journal-title":"Respir Res"},{"key":"key\n\t\t\t\t20171012133044_b12","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/j.1365-2567.2005.02200.x","article-title":"Toll-like receptors-2, -3, and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria","volume":"115","author":"Furrie","year":"2005","journal-title":"Immunology"},{"key":"key\n\t\t\t\t20171012133044_b13","doi-asserted-by":"crossref","first-page":"5571","DOI":"10.1074\/jbc.M410592200","article-title":"Involvement of Toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus","volume":"280","author":"Guillot","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171012133044_b14","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1038\/35074106","article-title":"The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5","volume":"410","author":"Hayashi","year":"2001","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171012133044_b15","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1126\/science.1093620","article-title":"Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8","volume":"303","author":"Heil","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20171012133044_b16","first-page":"384","article-title":"Anatomic sites of upper genital tract infection","volume":"66","author":"Heinonen","year":"1985","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20171012133044_b17","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/35047123","article-title":"A Toll-like receptor recognizes bacterial DNA","volume":"408","author":"Hemmi","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171012133044_b18","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1600-0897.2006.00389.x","article-title":"Human oviductal stromal fibroblasts, but not oviductal epithelial cells, express toll-like receptor 4: the site-specific mucosal immunity of the human Fallopian tube against bacterial infection","volume":"56","author":"Itoh","year":"2006","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20171012133044_b19","first-page":"1097","article-title":"Hypoxia regulates vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts. Fertil Steril","volume":"85","author":"Itoh","year":"2006"},{"key":"key\n\t\t\t\t20171012133044_b20","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1006\/viro.1996.0259","article-title":"When two strands are better than one: the mediators and modulators of the cellular responses to double-stranded RNA","volume":"219","author":"Jacobs","year":"1996","journal-title":"Virology"},{"key":"key\n\t\t\t\t20171012133044_b21","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1016\/j.humimm.2004.12.003","article-title":"Human endometrial epithelial cells cyclically express Toll-like receptor 3 (TLR3) and exhibit TLR3-dependent responses to dsRNA","volume":"66","author":"Jorgenson","year":"2005","journal-title":"Hum Immunol"},{"key":"key\n\t\t\t\t20171012133044_b22","doi-asserted-by":"crossref","first-page":"12542","DOI":"10.1074\/jbc.M310175200","article-title":"mRNA is an endogenous ligand for Toll-like receptor 3","volume":"279","author":"Kariko","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171012133044_b23","first-page":"121","article-title":"TLR2: cellular sensor for microbial and endogenous molecular patterns","volume":"270","author":"Kirschning","year":"2002","journal-title":"Curr Top Microbiol Immunol"},{"key":"key\n\t\t\t\t20171012133044_b24","doi-asserted-by":"crossref","first-page":"33419","DOI":"10.1074\/jbc.274.47.33419","article-title":"Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products","volume":"274","author":"Lien","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20171012133044_b25","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0006-291X(02)00380-7","article-title":"Establishment of a monoclonal antibody against human toll-like receptor 3 that blocks double-stranded RNA-mediated signaling","volume":"293","author":"Matsumoto","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20171012133044_b26","doi-asserted-by":"crossref","first-page":"4304","DOI":"10.4049\/jimmunol.171.8.4304","article-title":"Toll\/IL-1 receptor domain-containing adapter inducing IFN-\u03b2 (TRIF) associates with TNF receptor-associated factor 6 and TANK-binding kinase 1, and activates two distinct transcription factors, NF-\u03baB and IFN-regulatory factor-3, in the Toll-like receptor signaling","volume":"171","author":"Sato","year":"2003","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20171012133044_b27","doi-asserted-by":"crossref","first-page":"992","DOI":"10.4049\/jimmunol.174.2.992","article-title":"Innate immunity in the human female reproductive tract: antiviral response of uterine epithelia cells to the TLR3 agonist poly(I:C)","volume":"174","author":"Schaefer","year":"2005","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20171012133044_b28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cytogfr.2005.01.006","article-title":"Transcriptional signaling by double-stranded RNA: role of TLR3","volume":"16","author":"Sen","year":"2005","journal-title":"Cytokine Growth Factor Rev"},{"key":"key\n\t\t\t\t20171012133044_b29","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1165\/rcmb.2003-0388OC","article-title":"Activation of airway epithelial cells by Toll-like receptor agonists","volume":"31","author":"Sha","year":"2004","journal-title":"Am J Respir Cell Mol Biol"},{"key":"key\n\t\t\t\t20171012133044_b30","doi-asserted-by":"crossref","first-page":"518","DOI":"10.2337\/diab.43.4.518","article-title":"Poly I:C induction of alpha-interferon in the diabetes-prone BB and normal Wistar rats. Dose\u2013response relationships","volume":"43","author":"Sobel","year":"1994","journal-title":"Diabetes"},{"key":"key\n\t\t\t\t20171012133044_b31","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","article-title":"Differential roles of TLR2 and TLR4 in recognition of Gram-negative and Gram-positive bacterial cell wall components","volume":"11","author":"Takeuchi","year":"1999","journal-title":"Immunity"},{"key":"key\n\t\t\t\t20171012133044_b32","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1146\/annurev.immunol.19.1.623","article-title":"IRF family of transcription factors as regulators of host defense","volume":"19","author":"Taniguchi","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"key\n\t\t\t\t20171012133044_b33","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.bbrc.2005.07.105","article-title":"dsRNA-mediated innate immunity of epidermal keratinocytes","volume":"335","author":"Tohyama","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20171012133044_b34","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.bbrc.2005.02.196","article-title":"Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines","volume":"331","author":"Ueta","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20171012133044_b35","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/nm1140","article-title":"Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis","volume":"10","author":"Wang","year":"2004","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20171012133044_b36","doi-asserted-by":"crossref","first-page":"6668","DOI":"10.4049\/jimmunol.169.12.6668","article-title":"Cutting edge: a novel Toll\/IL-1 receptor domain-containing adapter that preferentially activates the IFN-\u03b2 promoter in the Toll-like receptor signaling","volume":"169","author":"Yamamoto","year":"2002","journal-title":"J Immunol"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/22\/2\/356\/9682616\/del385.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,10,12]],"date-time":"2017-10-12T17:52:04Z","timestamp":1507830724000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humrep\/article\/22\/2\/356\/2939156\/Human-oviductal-epithelial-cells-express-Tolllike"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,10,16]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2006,10,16]]},"published-print":{"date-parts":[[2007,2]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/del385","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published-other":{"date-parts":[[2007,2]]},"published":{"date-parts":[[2006,10,16]]}}}