{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T18:44:13Z","timestamp":1791053053342,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8,1]]},"DOI":"10.1093\/humrep\/dem117","type":"journal-article","created":{"date-parts":[[2007,6,12]],"date-time":"2007-06-12T02:32:13Z","timestamp":1181615533000},"page":"2084-2087","source":"Crossref","is-referenced-by-count":42,"title":["Unexplained infertility: does it really exist? Does it matter?"],"prefix":"10.1093","volume":"22","author":[{"given":"Charalambos","family":"Siristatidis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siladitya","family":"Bhattacharya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,6,11]]},"reference":[{"key":"key\n\t\t\t\t20171012170152_DEM117C1","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S0015-0282(16)58162-X","article-title":"The effect of endometriosis on implantation: results from the Yale University in vitro fertilization and embryo transfer program","volume":"65","author":"Arici","year":"1996","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012170152_DEM117C2","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/S0015-0282(02)03112-6","article-title":"Effect of endometriosis on in vitro fertilization","volume":"77","author":"Barnhart","year":"2002","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012170152_DEM117C3","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.fertnstert.2006.07.120","article-title":"A\u00a0randomised trial of expectant management, clomifene and intrauterine insemination (IUI) in the treatment of infertility","volume":"86","author":"Bhattacharya","year":"2006","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012170152_DEM117C4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1093\/humupd\/dml034","article-title":"A systematic review of tests predicting ovarian reserve and IVF outcome","volume":"12","author":"Broekmans","year":"2006","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171012170152_DEM117C5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1080\/003655101753352013","article-title":"The epidemiology and significance of autoimmune diseases in health care","volume":"235","author":"Cervera","year":"2001","journal-title":"Scand J Clin Lab Invest"},{"key":"key\n\t\t\t\t20171012170152_DEM117C6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0015-0282(16)57650-X","article-title":"The prognosis for live birth among untreated infertile couples","volume":"64","author":"Collins","year":"1995","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012170152_DEM117C7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1111\/j.1600-0897.1992.tb00740.x","article-title":"Evaluation of immunological infertility","volume":"27","author":"Coulam","year":"1992","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20171012170152_DEM117C8","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1093\/oxfordjournals.humrep.a138177","article-title":"Unexplained infertility (recommendations of ESHRE workshop)","volume":"8","author":"Crosignani","year":"1993","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012170152_DEM117C9","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0140-6736(02)09417-5","article-title":"Female subfertility","volume":"360","author":"Evers","year":"2002","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171012170152_DEM117C10","doi-asserted-by":"crossref","first-page":"2560","DOI":"10.1093\/oxfordjournals.humrep.a135745","article-title":"Autoimmune disorders: another possible cause for in-vitro fertilization and embryo transfer failure","volume":"10","author":"Geva","year":"1995","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012170152_DEM117C11","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1093\/humrep\/del135","article-title":"Unexplained infertility: does it really exist?","author":"Gleicher","year":"2006","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012170152_DEM117C12","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Guidice","year":"2004","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171012170152_DEM117C13","first-page":"CD000155","article-title":"Ovulation suppression for endometriosis","volume":"3","author":"Hughes","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20171012170152_DEM117C14","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1097\/00001703-200306000-00003","article-title":"Immune testing in fertility practice: truth or deception?","volume":"15","author":"Kallen","year":"2003","journal-title":"Curr Op Obst Gynecol"},{"key":"key\n\t\t\t\t20171012170152_DEM117C15","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1016\/S0015-0282(16)49891-2","article-title":"Sperm morphologic features as a prognostic factor in in vitro fertilization","volume":"46","author":"Kruger","year":"1986","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012170152_DEM117C16","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1056\/NEJM199707243370401","article-title":"Laparoscopic surgery in infertile women with minimal or mild endometriosis. Canadian Collaborative Group on Endometriosis","volume":"337","author":"Marcoux","year":"1997","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20171012170152_DEM117C17","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1034\/j.1600-0897.2001.d01-18.x","article-title":"Increased natural killer-cell activity is associated with infertile women","volume":"46","author":"Matsubayashi","year":"2001","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20171012170152_DEM117C18","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0165-0378(02)00014-1","article-title":"Basis, diagnosis and treatment of immunological infertility in men","volume":"57","author":"McLachlan","year":"2002","journal-title":"J Reprod Immunol"},{"key":"key\n\t\t\t\t20171012170152_DEM117C19","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1093\/humrep\/14.5.1237","article-title":"Comparison of hysterosalpingography and laparoscopy in predicting infertility outcome","volume":"14","author":"Mol","year":"1999","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012170152_DEM117C20","volume-title":"Fertility: Assessment and Treatment for People with Fertility Problems. Clinical Guideline","author":"NICE: National Collaborating Centre for Women's and Children's Health","year":"2004"},{"key":"key\n\t\t\t\t20171012170152_DEM117C21","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1056\/NEJM199306173282407","article-title":"Endometriosis","volume":"328","author":"Olive","year":"1993","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20171012170152_DEM117C22","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1093\/humrep\/14.5.1332","article-title":"Ablation of lesions or no treatment in minimal\u2013mild endometriosis in infertile women: a randomized trial. Gruppo Italiano per lo Studio dell'Endometriosi","volume":"14","author":"Parazzini","year":"1999","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012170152_DEM117C23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0015-0282(98)00204-0","article-title":"The follicular and endocrine environment in women with endometriosis: local and systemic cytokine production","volume":"70","author":"Pellicer","year":"1998","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012170152_DEM117C24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1600-0897.1996.tb00503.x","article-title":"Laboratory evaluation of women experiencing reproductive failure","volume":"35","author":"Roussev","year":"1996","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20171012170152_DEM117C25","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0015-0282(00)01533-8","article-title":"Deja vu all over again","volume":"74","author":"Scott","year":"2000","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012170152_DEM117C26","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1600-0897.2006.00428.x","article-title":"Association of unexplained infertility with gonadotropin and ovarian antibodies","volume":"56","author":"Shatavi","year":"2006","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20171012170152_DEM117C27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1600-0897.2006.00434.x","article-title":"Autoantibodies and prediction of reproductive failure","volume":"56","author":"Shoenfeld","year":"2006","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20171012170152_DEM117C28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1001\/jama.290.13.1767","article-title":"Diagnosis and management of female infertility","volume":"290","author":"Smith","year":"2003","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20171012170152_DEM117C29","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/humupd\/5.1.40","article-title":"Endometriosis and unexplained recurrent spontaneous abortion: pathological states resulting from aberrant modulation of natural killer cell function?","volume":"5","author":"Somigliana","year":"1999","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171012170152_DEM117C30","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1016\/S0015-0282(00)01622-8","article-title":"Treatment of repeated unexplained in vitro fertilization failure with intravenous immunoglobulin: a randomized, placebo-controlled Canadian trial","volume":"74","author":"Stephenson","year":"2000","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012170152_DEM117C31","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/S0140-6736(06)69042-9","article-title":"Collaborative Effort on the Clinical Evaluation in Reproductive Medicine. Intrauterine insemination with controlled ovarian hyperstimulation versus expectant management for couples with unexplained subfertility and an intermediate prognosis: a randomised clinical trial","volume":"368","author":"Steures","year":"2006","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171012170152_DEM117C32","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0015-0282(02)04686-1","article-title":"Accuracy of diagnostic laparoscopy in the infertility work-up before intrauterine insemination","volume":"79","author":"Tanahatoe","year":"2003","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012170152_DEM117C33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/humupd\/dmg007","article-title":"Clinical management of low ovarian response to stimulation for IVF: a systematic review","volume":"9","author":"Tarlatzis","year":"2003","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171012170152_DEM117C34","volume-title":"Unexplained Infertility","author":"Taylor","year":"1992"},{"key":"key\n\t\t\t\t20171012170152_DEM117C35","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1016\/S0140-6736(96)05291-9","article-title":"Factors that affect outcome of in-vitro fertilisation treatment","volume":"348","author":"Templeton","year":"1996","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20171012170152_DEM117C36","doi-asserted-by":"crossref","first-page":"1272","DOI":"10.1093\/humrep\/deh774","article-title":"Simple enumerations of peripheral blood natural killer (CD56 + NK) cells, B\u00a0cells and T cells have no predictive value in IVF treatment outcome","volume":"20","author":"Thum","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171012170152_DEM117C37","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/S0015-0282(16)49888-2","article-title":"Comparative trial of tubal insufflation, hysterosalpingography, and laparoscopy with dye hydrotubation for assessment of tubal patency","volume":"46","author":"World Health Organization","year":"1986","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171012170152_DEM117C38","first-page":"3","volume-title":"Collection and Examination of Human Semen. WHO Laboratory Manual for the Examination of Human Semen and Sperm\u2013Cervical Mucus Interaction","author":"World Health Organization","year":"1992","edition":"3rd edn"},{"key":"key\n\t\t\t\t20171012170152_DEM117C39","first-page":"CD003678","article-title":"Pre and post operative medical therapy for endometriosis surgery","volume":"3","author":"Yap","year":"2004","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20171012170152_DEM117C40","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00006254-199902000-00022","article-title":"The management of unexplained infertility","volume":"54","author":"Zayed","year":"1999","journal-title":"Obstet Gynecol Surv"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/22\/8\/2084\/1804878\/dem117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T01:27:01Z","timestamp":1556501221000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humrep\/article\/22\/8\/2084\/643021\/Unexplained-infertility-does-it-really-exist-Does"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,11]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2007,6,11]]},"published-print":{"date-parts":[[2007,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dem117","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published-other":{"date-parts":[[2007,8]]},"published":{"date-parts":[[2007,6,11]]}}}