{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T21:15:24Z","timestamp":1789852524087,"version":"4.0.1"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Human Reproduction"],"published-print":{"date-parts":[[2010,1,1]]},"DOI":"10.1093\/humrep\/dep347","type":"journal-article","created":{"date-parts":[[2009,10,14]],"date-time":"2009-10-14T20:36:18Z","timestamp":1255552578000},"page":"179-191","source":"Crossref","is-referenced-by-count":24,"title":["Cytogenetic analyses of human oocytes provide new data on non-disjunction mechanisms and the origin of trisomy 16"],"prefix":"10.1093","volume":"25","author":[{"given":"R.","family":"Garcia-Cruz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Casanovas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Brieno-Enriquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Robles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Roig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pujol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Cabero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Durban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Garcia Caldes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2009,10,14]]},"reference":[{"issue":"4","key":"1_9407964","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF00201839","volume":"86","author":"Angell","year":"1991","journal-title":"Human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6717","issn-type":"print"},{"issue":"3-4","key":"2_15819011","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1159\/000133977","volume":"69","author":"Angell","year":"1995","journal-title":"Cytogenetics and cell genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0171","issn-type":"print"},{"issue":"4","key":"3_5925085","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1093\/hmg\/7.4.661","volume":"7","author":"Bugge","year":"1998","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"16","key":"4_28922880","doi-asserted-by":"publisher","first-page":"2004","DOI":"10.1093\/hmg\/ddm148","volume":"16","year":"2007","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"4","key":"5_11350450","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/S0015-0282(01)01989-6","volume":"76","author":"Clyde","year":"2001","journal-title":"Fertility and sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"issue":"4","key":"6_17856153","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1016\/S0015-0282(03)01158-0","volume":"80","author":"Clyde","year":"2003","journal-title":"Fertility and sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"issue":"2","key":"7_21539608","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1093\/molehr\/gal007","volume":"12","year":"2006","journal-title":"Molecular Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/1360-9947","issn-type":"print"},{"issue":"1","key":"8_16262476","first-page":"176","volume":"59","author":"Dailey","year":"1996","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"4","key":"9_9198713","first-page":"656","volume":"47","author":"Eiben","year":"1990","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"2","key":"10_35503560","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/S1472-6483(10)60078-8","volume":"19","author":"Fragouli","year":"2009","journal-title":"Reproductive biomedicine online","ISSN":"https:\/\/id.crossref.org\/issn\/1472-6483","issn-type":"print"},{"key":"11_32374551","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1159\/000166638","volume":"5","author":"Garcia-Cruz","year":"2009","ISSN":"https:\/\/id.crossref.org\/issn\/1660-9263","issn-type":"print"},{"issue":"12","key":"12_18590373","doi-asserted-by":"publisher","first-page":"2859","DOI":"10.1093\/humrep\/deh515","volume":"19","year":"2004","journal-title":"Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/0268-1161","issn-type":"print"},{"issue":"9","key":"13_18414199","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1093\/humrep\/deh367","volume":"19","year":"2004","journal-title":"Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/0268-1161","issn-type":"print"},{"issue":"12","key":"14_20923892","doi-asserted-by":"publisher","first-page":"3395","DOI":"10.1093\/humrep\/dei252","volume":"20","year":"2005","journal-title":"Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/0268-1161","issn-type":"print"},{"issue":"1","key":"15_16848764","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s004390050459","volume":"100","author":"Guttenbach","year":"1997","journal-title":"Human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6717","issn-type":"print"},{"key":"16_35745301","first-page":"2242","volume":"143","year":"2007","journal-title":"American journal of medical genetics. Part A","ISSN":"https:\/\/id.crossref.org\/issn\/1552-4825","issn-type":"print"},{"key":"17_35745302","first-page":"2249","volume":"143","year":"2007","journal-title":"American journal of medical genetics. Part A","ISSN":"https:\/\/id.crossref.org\/issn\/1552-4825","issn-type":"print"},{"issue":"4","key":"18_11096175","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1038\/35066065","volume":"2","author":"Hassold","year":"2001","journal-title":"Nature reviews. Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1471-0056","issn-type":"print"},{"issue":"Pt 2","key":"19_8552179","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1469-1809.1980.tb00955.x","volume":"44","author":"Hassold","year":"1980","journal-title":"Annals of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4800","issn-type":"print"},{"issue":"4","key":"20_16041664","first-page":"867","volume":"57","author":"Hassold","year":"1995","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"R2","key":"21_29528530","doi-asserted-by":"publisher","first-page":"R203","DOI":"10.1093\/hmg\/ddm243","volume":"16","author":"Hassold","year":"2007","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"key":"22_34714251","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00412-002-0195-3","volume":"111","year":"2002","ISSN":"https:\/\/id.crossref.org\/issn\/1432-0886","issn-type":"print"},{"issue":"12","key":"23_19711210","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1038\/ng1672","volume":"37","author":"Hodges","year":"2005","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"1","key":"24_31993141","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1755-8166-1-21","volume":"1","author":"Hulten","year":"2008","ISSN":"https:\/\/id.crossref.org\/issn\/1755-8166","issn-type":"print"},{"issue":"5","key":"25_10128448","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1007\/BF00420934","volume":"90","author":"Kamiguchi","year":"1993","journal-title":"Human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6717","issn-type":"print"},{"issue":"2","key":"26_10387492","doi-asserted-by":"publisher","first-page":"395","DOI":"10.1086\/303009","volume":"67","author":"Kline","year":"2000","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"4","key":"27_16536825","doi-asserted-by":"publisher","first-page":"406","DOI":"10.1038\/ng1296-406","volume":"14","author":"Koehler","year":"1996","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"8","key":"28_29164483","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1038\/ng2065","volume":"39","author":"Kouznetsova","year":"2007","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"3-4","key":"29_19438700","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1159\/000086889","volume":"111","author":"Kuliev","year":"2005","journal-title":"Cytogenetic and genome research","ISSN":"https:\/\/id.crossref.org\/issn\/1424-8581","issn-type":"print"},{"issue":"4","key":"30_16536824","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1038\/ng1296-400","volume":"14","author":"Lamb","year":"1996","journal-title":"Nature genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1061-4036","issn-type":"print"},{"issue":"9","key":"31_5741376","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1093\/hmg\/6.9.1391","volume":"6","author":"Lamb","year":"1997","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"3-4","key":"32_19438707","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1159\/000086896","volume":"111","author":"Lamb","year":"2005","journal-title":"Cytogenetic and genome research","ISSN":"https:\/\/id.crossref.org\/issn\/1424-8581","issn-type":"print"},{"issue":"7","key":"33_35806643","doi-asserted-by":"publisher","first-page":"1611","DOI":"10.1083\/jcb.139.7.1611","volume":"139","year":"1997","journal-title":"The Journal of Cell Biology","ISSN":"https:\/\/id.crossref.org\/issn\/0021-9525","issn-type":"print"},{"issue":"8","key":"34_15689289","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1093\/hmg\/3.8.1365","volume":"3","author":"MacDonald","year":"1994","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"3-4","key":"35_6142826","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1159\/000015040","volume":"81","author":"M\u00a0\u00a0rquez","year":"1998","journal-title":"Cytogenetics and cell genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0301-0171","issn-type":"print"},{"issue":"10","key":"36_19451167","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1002\/pd.1156","volume":"25","author":"Montag","year":"2005","journal-title":"Prenatal diagnosis","ISSN":"https:\/\/id.crossref.org\/issn\/0197-3851","issn-type":"print"},{"issue":"Pt 3","key":"37_5276042","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1111\/j.1469-1809.1988.tb01100.x","volume":"52","author":"Morton","year":"1988","journal-title":"Annals of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0003-4800","issn-type":"print"},{"issue":"4","key":"38_15982757","doi-asserted-by":"publisher","first-page":"1014","DOI":"10.1093\/humrep\/","volume":"10","author":"Munne","year":"1995","journal-title":"Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/0268-1161","issn-type":"print"},{"issue":"3","key":"39_21854724","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/S1472-6483(10)61007-3","volume":"12","author":"Munne","year":"2006","journal-title":"Reproductive biomedicine online","ISSN":"https:\/\/id.crossref.org\/issn\/1472-6483","issn-type":"print"},{"issue":"2","key":"40_17467208","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1007\/s00439-003-0974-9","volume":"112","author":"Pellestor","year":"2003","journal-title":"Human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6717","issn-type":"print"},{"issue":"1","key":"41_18666852","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1093\/humupd\/dmh051","volume":"11","year":"2005","journal-title":"Human Reproduction Update","ISSN":"https:\/\/id.crossref.org\/issn\/1355-4786","issn-type":"print"},{"issue":"3-4","key":"42_19438702","doi-asserted-by":"publisher","first-page":"206","DOI":"10.1159\/000086891","volume":"111","author":"Pellestor","year":"2005","journal-title":"Cytogenetic and genome research","ISSN":"https:\/\/id.crossref.org\/issn\/1424-8581","issn-type":"print"},{"issue":"2","key":"43_21776851","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/j.ejmg.2005.08.001","volume":"49","author":"Pellestor","year":"2006","ISSN":"https:\/\/id.crossref.org\/issn\/1769-7212","issn-type":"print"},{"issue":"3","key":"44_8928234","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/BF00333536","volume":"62","author":"Polani","year":"1982","journal-title":"Human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0340-6717","issn-type":"print"},{"issue":"4","key":"45_17588774","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1038\/sj.ejhg.5200965","volume":"11","author":"Pujol","year":"2003","journal-title":"European journal of human genetics : EJHG","ISSN":"https:\/\/id.crossref.org\/issn\/1018-4813","issn-type":"print"},{"issue":"3","key":"46_17808795","doi-asserted-by":"publisher","first-page":"656","DOI":"10.1016\/S0015-0282(03)00787-8","volume":"80","author":"Reis Soares","year":"2003","journal-title":"Fertility and sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"issue":"1","key":"47_13928418","first-page":"68","volume":"39","author":"Risch","year":"1986","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"6","key":"48_6001233","doi-asserted-by":"publisher","first-page":"1011","DOI":"10.1093\/hmg\/7.6.1011","volume":"7","author":"Robinson","year":"1998","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"6","key":"49_34998426","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/S1472-6483(10)60027-2","volume":"18","author":"Robles","year":"2009","journal-title":"Reproductive biomedicine online","ISSN":"https:\/\/id.crossref.org\/issn\/1472-6483","issn-type":"print"},{"key":"50_36181356","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1534\/genetics.106.058933","volume":"174","year":"2006","ISSN":"https:\/\/id.crossref.org\/issn\/1943-2631","issn-type":"print"},{"issue":"5","key":"51_18864606","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1530\/rep.1.00568","volume":"129","author":"Roig","year":"2005","journal-title":"Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/1470-1626","issn-type":"print"},{"issue":"11","key":"52_22602779","doi-asserted-by":"publisher","first-page":"2739","DOI":"10.1093\/humrep\/del122","volume":"21","year":"2006","journal-title":"Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/0268-1161","issn-type":"print"},{"issue":"6","key":"53_17069687","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1093\/molehr\/8.6.580","volume":"8","author":"Sandalinas","year":"2002","journal-title":"Molecular Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/1360-9947","issn-type":"print"},{"issue":"8","key":"54_6083143","doi-asserted-by":"publisher","first-page":"1221","DOI":"10.1093\/hmg\/7.8.1221","volume":"7","author":"Savage","year":"1998","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"5","key":"55_28525205","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.fertnstert.2006.08.108","volume":"87","author":"Sher","year":"2007","journal-title":"Fertility and sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"issue":"9","key":"56_15743649","doi-asserted-by":"publisher","first-page":"1529","DOI":"10.1093\/hmg\/3.9.1529","volume":"3","author":"Sherman","year":"1994","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"1","key":"57_11018084","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1093\/molehr\/7.1.49","volume":"7","author":"Steuerwald","year":"2001","journal-title":"Molecular Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/1360-9947","issn-type":"print"},{"issue":"15","key":"58_22329311","doi-asserted-by":"publisher","first-page":"2376","DOI":"10.1093\/hmg\/ddl162","volume":"15","year":"2006","journal-title":"Human Molecular Genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0964-6906","issn-type":"print"},{"issue":"6","key":"59_17036428","doi-asserted-by":"publisher","first-page":"1469","DOI":"10.1086\/340734","volume":"70","author":"Tease","year":"2002","journal-title":"American journal of human genetics","ISSN":"https:\/\/id.crossref.org\/issn\/0002-9297","issn-type":"print"},{"issue":"4","key":"60_10803636","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1023\/A:1020304621338","volume":"16","author":"Verlinsky","year":"1999","journal-title":"Journal of assisted reproduction and genetics","ISSN":"https:\/\/id.crossref.org\/issn\/1058-0468","issn-type":"print"},{"key":"61_28808793","doi-asserted-by":"crossref","first-page":"S47","DOI":"10.1016\/S0303-7207(01)00565-2","volume":"183","year":"2001","journal-title":"Molecular and cellular endocrinology","ISSN":"https:\/\/id.crossref.org\/issn\/0303-7207","issn-type":"print"},{"issue":"6","key":"62_28818324","doi-asserted-by":"publisher","first-page":"1333","DOI":"10.1016\/j.fertnstert.2006.11.042","volume":"87","author":"Vialard","year":"2007","journal-title":"Fertility and sterility","ISSN":"https:\/\/id.crossref.org\/issn\/0015-0282","issn-type":"print"},{"issue":"1-2","key":"63_30536676","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.mrgentox.2007.10.015","volume":"651","author":"Vogt","year":"2008","journal-title":"Mutation Research","ISSN":"https:\/\/id.crossref.org\/issn\/0027-5107","issn-type":"print"},{"issue":"1","key":"64_5928166","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1093\/humrep\/13.1.154","volume":"13","author":"Volarcik","year":"1998","journal-title":"Human Reproduction","ISSN":"https:\/\/id.crossref.org\/issn\/0268-1161","issn-type":"print"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/25\/1\/179\/2045800\/dep347.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T21:31:58Z","timestamp":1550957518000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article-lookup\/doi\/10.1093\/humrep\/dep347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,10,14]]},"references-count":64,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2009,12,16]]},"published-print":{"date-parts":[[2010,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dep347","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10,14]]}}}