{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T02:59:01Z","timestamp":1790218741584,"version":"4.1.0"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2012,10]]},"DOI":"10.1093\/humrep\/des284","type":"journal-article","created":{"date-parts":[[2012,8,22]],"date-time":"2012-08-22T04:10:59Z","timestamp":1345608659000},"page":"2948-2954","source":"Crossref","is-referenced-by-count":15,"title":["Methylation profile of the promoters of Nanog and Oct4 in ICSI human embryos"],"prefix":"10.1093","volume":"27","author":[{"given":"M.","family":"Al-Khtib","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Blach\u00e8re","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.F.","family":"Gu\u00e9rin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Lef\u00e8vre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2012,8,21]]},"reference":[{"key":"key\n\t\t\t\t20170515120700_DES284C1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.ygeno.2007.12.004","article-title":"Transcriptional and epigenetic status of protamine 1 and 2 genes following round spermatids injection into mouse oocytes","volume":"91","author":"Borghol","year":"2008","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20170515120700_DES284C2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/molehr\/gah155","article-title":"Oct-4 mRNA and protein expression during human preimplantation development","volume":"11","author":"Cauffman","year":"2005","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170515120700_DES284C3","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/S0092-8674(03)00394-5","article-title":"Nanog: a new recruit to the embryonic stem cell orchestra","volume":"113","author":"Cavaleri","year":"2003","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170515120700_DES284C4","doi-asserted-by":"crossref","first-page":"7150","DOI":"10.1038\/sj.onc.1207930","article-title":"Self-renewal of teratocarcinoma and embryonic stem cells","volume":"23","author":"Chambers","year":"2004","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170515120700_DES284C5","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0092-8674(03)00392-1","article-title":"Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells","volume":"113","author":"Chambers","year":"2003","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170515120700_DES284C6","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.1074\/jbc.C400479200","article-title":"Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation","volume":"280","author":"Deb-Rinker","year":"2005","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170515120700_DES284C7","doi-asserted-by":"crossref","first-page":"e1000116","DOI":"10.1371\/journal.pgen.1000116","article-title":"Global mapping of DNA methylation in mouse promoters reveals epigenetic reprogramming of pluripotency genes","volume":"4","author":"Farthing","year":"2008","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20170515120700_DES284C8","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.stem.2007.12.011","article-title":"Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4\/Nanog, PcG complex, and histone H3 K4\/K27 trimethylation","volume":"2","author":"Fouse","year":"2008","journal-title":"Cell Stem Cell"},{"key":"key\n\t\t\t\t20170515120700_DES284C9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nature08162","article-title":"Distinctive chromatin in human sperm packages genes for embryo development","volume":"460","author":"Hammoud","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170515120700_DES284C10","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1136\/jmg.2008.057943","article-title":"Dynamic CpG methylation of the KCNQ1OT1 gene during maturation of human oocytes","volume":"45","author":"Khoueiry","year":"2008","journal-title":"J Med Genet"},{"key":"key\n\t\t\t\t20170515120700_DES284C11","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/1471-2199-10-88","article-title":"Promoter analysis of the rabbit POU5F1 gene and its expression in preimplantation stage embryos","volume":"10","author":"Kobolak","year":"2009","journal-title":"BMC Mol Biol"},{"key":"key\n\t\t\t\t20170515120700_DES284C12","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1673-8527(09)60047-3","article-title":"Methylation patterns in 5\u2032 terminal regions of pluripotency-related genes in bovine in vitro fertilized and cloned embryos","volume":"37","author":"Lan","year":"2010","journal-title":"J Genet Genomics"},{"key":"key\n\t\t\t\t20170515120700_DES284C13","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/35000656","article-title":"Demethylation of the zygotic paternal genome","volume":"403","author":"Mayer","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170515120700_DES284C14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0092-8674(03)00393-3","article-title":"The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells","volume":"113","author":"Mitsui","year":"2003","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170515120700_DES284C15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0092-8674(00)81769-9","article-title":"Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4","volume":"95","author":"Nichols","year":"1998","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170515120700_DES284C16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/74199","article-title":"Quantitative expression of Oct-3\/4 defines differentiation, dedifferentiation or self-renewal of ES cells","volume":"24","author":"Niwa","year":"2000","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170515120700_DES284C17","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0960-9822(00)00448-6","article-title":"Active demethylation of the paternal genome in the mouse zygote","volume":"10","author":"Oswald","year":"2000","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170515120700_DES284C18","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1016\/j.cub.2003.11.026","article-title":"Stella is a maternal effect gene required for normal early development in mice","volume":"13","author":"Payer","year":"2003","journal-title":"Curr Biol"},{"key":"key\n\t\t\t\t20170515120700_DES284C19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nature05918","article-title":"Stability and flexibility of epigenetic gene regulation in mammalian development","volume":"447","author":"Reik","year":"2007","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170515120700_DES284C20","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.1063443","article-title":"Epigenetic reprogramming in mammalian development","volume":"293","author":"Reik","year":"2001","journal-title":"Science"},{"key":"key\n\t\t\t\t20170515120700_DES284C21","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1006\/dbio.2001.0501","article-title":"Dynamic reprogramming of DNA methylation in the early mouse embryo","volume":"241","author":"Santos","year":"2002","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170515120700_DES284C22","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/ncb1176","article-title":"DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei","volume":"6","author":"Simonsson","year":"2004","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t20170515120700_DES284C23","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.cell.2007.02.010","article-title":"Genetic and epigenetic regulators of pluripotency","volume":"128","author":"Surani","year":"2007","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170515120700_DES284C24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ng1990","article-title":"Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome","volume":"39","author":"Weber","year":"2007","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170515120700_DES284C25","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/mrd.20411","article-title":"Gradual DNA demethylation of the Oct4 promoter in cloned mouse embryos","volume":"73","author":"Yamazaki","year":"2006","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170515120700_DES284C26","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.1002\/mrd.20867","article-title":"Isolation and characterization of embryonic stem-like cells derived from in vivo-produced cat blastocysts","volume":"75","author":"Yu","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20170515120700_DES284C27","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/j.placenta.2008.03.003","article-title":"Oct4 is epigenetically regulated by methylation in normal placenta and gestational trophoblastic disease","volume":"29","author":"Zhang","year":"2008","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170515120700_DES284C28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1083\/jcb.200801009","article-title":"A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A","volume":"184","author":"Zhang","year":"2009","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170515120700_DES284C29","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1471-213X-8-97","article-title":"Maternal Oct-4 is a potential key regulator of the developmental competence of mouse oocytes","volume":"8","author":"Zuccotti","year":"2008","journal-title":"BMC Dev Biol"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/27\/10\/2948\/17054598\/des284.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T01:26:01Z","timestamp":1562117161000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article-lookup\/doi\/10.1093\/humrep\/des284"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,21]]},"references-count":29,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2012,8,21]]},"published-print":{"date-parts":[[2012,10]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/des284","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published":{"date-parts":[[2012,8,21]]}}}