{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T21:47:13Z","timestamp":1769636833298,"version":"3.49.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,8]]},"DOI":"10.1093\/humrep\/det240","type":"journal-article","created":{"date-parts":[[2013,6,6]],"date-time":"2013-06-06T03:45:29Z","timestamp":1370490329000},"page":"2118-2125","source":"Crossref","is-referenced-by-count":39,"title":["Misoprostol prior to inserting an intrauterine device in nulligravidas: a randomized clinical trial"],"prefix":"10.1093","volume":"28","author":[{"given":"Adriana","family":"Scavuzzi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex S.R.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aur\u00e9lio A.R.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melania M.R.","family":"Amorim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2013,6,5]]},"reference":[{"key":"key\n\t\t\t\t20170522104745_DET240C1","first-page":"CD007373","article-title":"Interventions for pain with intrauterine device insertion","author":"Allen","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20170522104745_DET240C2","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/01.AOG.0000291575.93944.1a","article-title":"ACOG Committee Opinion No. 392, December 2007. Intrauterine device and adolescents","volume":"110","author":"American College of Obstetricians and Gynecologists","year":"2007","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20170522104745_DET240C3","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00003081-200009000-00006","article-title":"Pharmacology of oxytocin and prostaglandins","volume":"43","author":"Arias","year":"2000","journal-title":"Clin Obstet Gynecol"},{"key":"key\n\t\t\t\t20170522104745_DET240C4","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/humrep\/deh005","article-title":"Effects of misoprostol on uterine contractility following different routes of administration","volume":"19","author":"Aronsson","year":"2004","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170522104745_DET240C5","doi-asserted-by":"crossref","first-page":"e11","DOI":"10.1016\/j.contraception.2011.05.012","article-title":"Ease of insertion and clinical performance of the levonorgestrel-releasing intrauterine system in nulligravidas","volume":"84","author":"Bahamondes","year":"2011","journal-title":"Contraception"},{"issue":"6 Suppl.","key":"key\n\t\t\t\t20170522104745_DET240C6","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.contraception.2006.12.024","article-title":"Worldwide use of intrauterine devices for contraception","volume":"75","author":"d'Arcangues","year":"2007","journal-title":"Contraception"},{"key":"key\n\t\t\t\t20170522104745_DET240C7","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/humrep\/deq348","article-title":"Vaginal misoprostol prior to insertion of an intrauterine device: an RCT","volume":"26","author":"Dijkhuizen","year":"2011","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170522104745_DET240C8","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.contraception.2011.01.016","article-title":"Effects of prophylactic misoprostol administration prior to intrauterine device insertion in nulliparous women","volume":"84","author":"Edelman","year":"2011","journal-title":"Contraception"},{"key":"key\n\t\t\t\t20170522104745_DET240C9","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1056\/NEJM199504133321502","article-title":"Induction of abortion with mifepristone (RU 486) and oral or vaginal misoprostol","volume":"332","author":"el-Refaey","year":"1995","journal-title":"N Engl J Med"},{"issue":"Suppl. 2","key":"key\n\t\t\t\t20170522104745_DET240C10","doi-asserted-by":"crossref","first-page":"S168","DOI":"10.1016\/j.ijgo.2007.09.005","article-title":"Cervical priming with misoprostol prior to transcervical procedures","volume":"99","author":"Fiala","year":"2007","journal-title":"Int J Gynecol Obstet"},{"key":"key\n\t\t\t\t20170522104745_DET240C11","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1111\/j.1552-6909.2009.01067.x","article-title":"A clinical review of the intrauterine device as an effective method of contraception","volume":"38","author":"Forthofer","year":"2009","journal-title":"J Obstet Gynecol Neonatal Nurs"},{"key":"key\n\t\t\t\t20170522104745_DET240C12","first-page":"CD001327","article-title":"Antibiotic prophylaxis for intrauterine contraceptive device insertion","author":"Grimes","year":"2001","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20170522104745_DET240C13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ajog.2003.08.025","article-title":"A randomized controlled comparison of sublingual and vaginal administration of misoprostol for cervical priming before first-trimester surgical abortion","volume":"190","author":"Hamoda","year":"2004","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170522104745_DET240C14","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.contraception.2010.01.020","article-title":"Double-blind, randomized, placebo-controlled study on the effect of misoprostol on ease of consecutive insertion of the levonorgestrel-releasing intrauterine system","volume":"81","author":"Heikinheimo","year":"2010","journal-title":"Contraception"},{"key":"key\n\t\t\t\t20170522104745_DET240C15","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1056\/NEJMoa010438","article-title":"Use of copper intrauterine devices and the risk of tubal infertility among nulligravid women","volume":"345","author":"Hubacher","year":"2001","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20170522104745_DET240C16","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ijgo.2005.01.036","article-title":"Cervical softening with vaginal misoprostol before intrauterine device insertion","volume":"89","author":"Li","year":"2005","journal-title":"Int J Gynaecol Obstet"},{"key":"key\n\t\t\t\t20170522104745_DET240C17","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.jmwh.2006.06.008","article-title":"The intrauterine device: rethinking old paradigms","volume":"51","author":"Morgan","year":"2006","journal-title":"J Midwifery Womens Health"},{"key":"key\n\t\t\t\t20170522104745_DET240C18","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1093\/humrep\/dem244","article-title":"Cervical priming with sublingual misoprostol prior to insertion of an intrauterine device in nulliparous women: a randomized controlled trial","volume":"22","author":"S\u00e4\u00e4v","year":"2007","journal-title":"Hum Reprod"},{"issue":"2 Suppl.","key":"key\n\t\t\t\t20170522104745_DET240C19","doi-asserted-by":"crossref","first-page":"S330","DOI":"10.1016\/S0020-7292(09)61202-9","article-title":"Misoprostol prior to insertion of intrauterine device in nulligravida: a randomized controlled trial","volume":"107","author":"Scavuzzi","year":"2009","journal-title":"A pilot study. Int J Gynaecol Obstet"},{"key":"key\n\t\t\t\t20170522104745_DET240C20","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.contraception.2010.04.043","article-title":"Prophylactic misoprostol prior to IUD insertion in nulliparous women","volume":"82","author":"Schaefer","year":"2010","journal-title":"Contraception"},{"key":"key\n\t\t\t\t20170522104745_DET240C21","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.contraception.2008.01.001","article-title":"Pelvic inflammatory disease attributable to the IUD: modeling risk in West Africa","volume":"77","author":"Stanback","year":"2008","journal-title":"Contraception"},{"key":"key\n\t\t\t\t20170522104745_DET240C22","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1093\/humrep\/17.2.332","article-title":"Pharmacokinetics of different routes of administration of misoprostol","volume":"17","author":"Tang","year":"2002","journal-title":"Hum Reprod"},{"issue":"Suppl. 2","key":"key\n\t\t\t\t20170522104745_DET240C23","doi-asserted-by":"crossref","first-page":"S160","DOI":"10.1016\/j.ijgo.2007.09.004","article-title":"Misoprostol: pharmacokinetic profiles, effects on the uterus and side-effects","volume":"99","author":"Tang","year":"2007","journal-title":"Int J Gynaecol Obstet"},{"key":"key\n\t\t\t\t20170522104745_DET240C24","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.contraception.2011.03.011","article-title":"A survey of provider experience with misoprostol to facilitate intrauterine device insertion in nulliparous women","volume":"84","author":"Ward","year":"2011","journal-title":"Contraception"},{"key":"key\n\t\t\t\t20170522104745_DET240C25","first-page":"17","volume-title":"Improving Access to Quality Care in Family Planning: Medical Eligibility Criteria for Initiating and Continuing Use of Contraceptive Methods","author":"World Health Organization (WHO)","year":"2004","edition":"3rd edn"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/28\/8\/2118\/17371317\/det240.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T02:58:03Z","timestamp":1503457083000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article-lookup\/doi\/10.1093\/humrep\/det240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,5]]},"references-count":25,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2013,6,5]]},"published-print":{"date-parts":[[2013,8]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/det240","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6,5]]}}}