{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:58:02Z","timestamp":1791201482942,"version":"4.2.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1093\/humrep\/dev022","type":"journal-article","created":{"date-parts":[[2015,2,12]],"date-time":"2015-02-12T23:43:35Z","timestamp":1423784615000},"page":"987-993","source":"Crossref","is-referenced-by-count":32,"title":["Replication and meta-analysis of previous genome-wide association studies confirm vezatin as the locus with the strongest evidence for association with endometriosis"],"prefix":"10.1093","volume":"30","author":[{"given":"Luca","family":"Pagliardini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Gentilini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Maria","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Candiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Vigan\u00f2","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Maria","family":"Di Blasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,2,11]]},"reference":[{"key":"key\n\t\t\t\t20170518081028_DEV022C1","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/jhg.2010.118","article-title":"Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population","volume":"55","author":"Adachi","year":"2010","journal-title":"J Hum Genet"},{"key":"key\n\t\t\t\t20170518081028_DEV022C2","doi-asserted-by":"crossref","first-page":"e58257","DOI":"10.1371\/journal.pone.0058257","article-title":"Genome-wide association study link novel loci to endometriosis","volume":"8","author":"Albertsen","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170518081028_DEV022C3","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0015-0282(97)81391-X","article-title":"Revised American Society for Reproductive Medicine classification of endometriosis: 1996","volume":"67","author":"American Society for Reproductive Medicine","year":"1997","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170518081028_DEV022C4","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1038\/nprot.2010.116","article-title":"Data quality control in genetic case-control association studies","volume":"5","author":"Anderson","year":"2010","journal-title":"Nat Protoc"},{"key":"key\n\t\t\t\t20170518081028_DEV022C5","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1093\/humrep\/del079","article-title":"Deeply infiltrating endometriosis: pathogenetic implications of the anatomical distribution","volume":"21","author":"Chapron","year":"2006","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170518081028_DEV022C6","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2307\/3001666","article-title":"The combination of estimates from different experiments","volume":"10","author":"Cochran","year":"1954","journal-title":"Biometrics"},{"key":"key\n\t\t\t\t20170518081028_DEV022C7","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0140-6736(10)60490-4","article-title":"Endometriosis and infertility: pathophysiology and management","volume":"376","author":"de Ziegler","year":"2010","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170518081028_DEV022C8","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/01.ogx.0000279293.60436.60","article-title":"Endometriosis and genetic polymorphisms","volume":"62","author":"Falconer","year":"2007","journal-title":"Obstet Gynecol Surv"},{"key":"key\n\t\t\t\t20170518081028_DEV022C9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1136\/bmj.39073.736829.BE","article-title":"Endometriosis","volume":"334","author":"Farquhar","year":"2007","journal-title":"Br Med J"},{"key":"key\n\t\t\t\t20170518081028_DEV022C10","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1093\/humupd\/dmi029","article-title":"Endometriosis and pelvic pain: epidemiological evidence of the relationship and implications","volume":"11","author":"Fauconnier","year":"2005","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20170518081028_DEV022C11","first-page":"461","article-title":"Nonmalignant epithelial cells, potentially invasive in human endometriosis, lack the tumor suppressor molecule E-cadherin","volume":"150","author":"Gaetje","year":"1997","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170518081028_DEV022C12","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.fertnstert.2008.10.014","article-title":"Endometrial stromal cells from women with endometriosis reveal peculiar migratory behavior in response to ovarian steroids","volume":"93","author":"Gentilini","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170518081028_DEV022C13","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1530\/REP-06-0271","article-title":"Vezatin, a ubiquitous protein of adherens cell-cell junctions, is exclusively expressed in germ cells in mouse testis","volume":"133","author":"Hyenne","year":"2007","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170518081028_DEV022C14","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1093\/molehr\/gal060","article-title":"Extracellular matrix of the human cyclic corpus luteum","volume":"12","author":"Irving-Rodgers","year":"2006","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170518081028_DEV022C15","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1172\/JCI115835","article-title":"Integrin adhesion molecules in the human endometrium. Correlation with the normal and abnormal menstrual cycle","volume":"90","author":"Lessey","year":"1992","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170518081028_DEV022C16","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1038\/nature08494","article-title":"Finding the missing heritability of complex diseases","volume":"461","author":"Manolio","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170518081028_DEV022C17","doi-asserted-by":"crossref","first-page":"e74409","DOI":"10.1371\/journal.pone.0074409","article-title":"VEZT, a novel putative tumor suppressor, suppresses the growth and tumorigenicity of gastric cancer","volume":"8","author":"Miao","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20170518081028_DEV022C18","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0015-0282(97)00191-X","article-title":"Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities","volume":"68","author":"Nisolle","year":"1997","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170518081028_DEV022C19","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/ng.2445","article-title":"Genome-wide association meta-analysis identifies new endometriosis risk loci","volume":"44","author":"Nyholt","year":"2012","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170518081028_DEV022C20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1136\/jmedgenet-2012-101257","article-title":"An Italian association study and meta-analysis with previous GWAS confirm WNT4, CDKN2BAS and FN1 as the first identified susceptibility loci for endometriosis","volume":"50","author":"Pagliardini","year":"2013","journal-title":"J Med Genet"},{"key":"key\n\t\t\t\t20170518081028_DEV022C21","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/ng.731","article-title":"Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis","volume":"43","author":"Painter","year":"2011","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170518081028_DEV022C22","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/9781444398519.ch6","article-title":"Understanding the pathogenesis of endometriosis: Gene Mapping Studies","volume-title":"Endometriosis Science and Practice","author":"Painter","year":"2012"},{"key":"key\n\t\t\t\t20170518081028_DEV022C23","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.fertnstert.2012.06.056","article-title":"The expression of estrogen receptors as well as GREB1, c-MYC, and cyclin D1, estrogen-regulated genes implicated in proliferation, is increased in peritoneal endometriosis","volume":"98","author":"Pellegrini","year":"2012","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170518081028_DEV022C24","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1093\/humupd\/dmu015","article-title":"Genetic variants underlying risk of endometriosis: insights from meta-analysis of eight genome-wide association and replication datasets","volume":"20","author":"Rahmioglu","year":"2014","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20170518081028_DEV022C25","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.fertnstert.2014.02.040","article-title":"The WNT\/beta-catenin signaling pathway and expression of survival promoting genes in luteinized granulosa cells: endometriosis as a paradigm for a dysregulated apoptosis pathway","volume":"101","author":"Sanchez","year":"2014","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170518081028_DEV022C26","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/0002-9378(80)90917-5","article-title":"Heritable aspects of endometriosis. I. Genetic studies","volume":"137","author":"Simpson","year":"1980","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170518081028_DEV022C27","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/S1357-4310(99)01497-5","article-title":"The putative role of cell adhesion molecules in endometriosis: can we learn from tumour metastasis?","volume":"5","author":"Starzinski-Powitz","year":"1999","journal-title":"Mol Med Today"},{"key":"key\n\t\t\t\t20170518081028_DEV022C28","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1093\/humupd\/dmq050","article-title":"Chronic pelvic pain and endometriosis: translational evidence of the relationship and implications","volume":"17","author":"Stratton","year":"2011","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20170518081028_DEV022C29","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/humrep\/des457","article-title":"Replication of endometriosis-associated single-nucleotide polymorphisms from genome-wide association studies in a Caucasian population","volume":"28","author":"Sundqvist","year":"2013","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170518081028_DEV022C30","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0015-0282(98)00540-8","article-title":"Genetic influences on endometriosis in an Australian twin sample","volume":"71","author":"Treloar","year":"1999","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170518081028_DEV022C31","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1038\/ng.612","article-title":"A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese","volume":"42","author":"Uno","year":"2010","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170518081028_DEV022C32","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/humrep\/del339","article-title":"Association between endometriosis stage, lesion type, patient characteristics and severity of pelvic pain symptoms: a multivariate analysis of over 1000 patients","volume":"22","author":"Vercellini","year":"2007","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170518081028_DEV022C33","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1471-0528.2008.02055.x","article-title":"\u2018Blood On The Tracks\u2019 from corpora lutea to endometriomas","volume":"116","author":"Vercellini","year":"2009","journal-title":"BJOG"},{"key":"key\n\t\t\t\t20170518081028_DEV022C34","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/nrendo.2013.255","article-title":"Endometriosis: pathogenesis and treatment","volume":"10","author":"Vercellini","year":"2014","journal-title":"Nat Rev Endocrinol"},{"key":"key\n\t\t\t\t20170518081028_DEV022C35","doi-asserted-by":"crossref","first-page":"3247","DOI":"10.2741\/2308","article-title":"Genetics of endometriosis: current status and prospects","volume":"12","author":"Vigano","year":"2007","journal-title":"Front Biosci"},{"key":"key\n\t\t\t\t20170518081028_DEV022C36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/228402650900100102","article-title":"Back to the original question in endometriosis: implantation or metaplasia?","volume":"1","author":"Vigano","year":"2009","journal-title":"J Endometr"},{"key":"key\n\t\t\t\t20170518081028_DEV022C37","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1093\/humupd\/dms001","article-title":"Principles of phenomics in endometriosis","volume":"18","author":"Vigano","year":"2012","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20170518081028_DEV022C38","doi-asserted-by":"crossref","first-page":"62","DOI":"10.5301\/je.5000156","article-title":"Unravelling the ovarian endometrioma pathogenesis: \u201cThe long and winding road\u201d across the various theories","volume":"5","author":"Vigan\u00f2","year":"2013","journal-title":"J Endometr"},{"key":"key\n\t\t\t\t20170518081028_DEV022C39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.ajhg.2011.11.029","article-title":"Five years of GWAS discovery","volume":"90","author":"Visscher","year":"2012","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20170518081028_DEV022C40","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1093\/bioinformatics\/btq340","article-title":"METAL: fast and efficient meta-analysis of genomewide association scans","volume":"26","author":"Willer","year":"2010","journal-title":"Bioinformatics"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/30\/4\/987\/17189324\/dev022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,8,20]],"date-time":"2019-08-20T18:26:37Z","timestamp":1566325597000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article-lookup\/doi\/10.1093\/humrep\/dev022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,2,11]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,2,11]]},"published-print":{"date-parts":[[2015,4]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dev022","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725354604.793504257","asserted-by":"object"}]},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published":{"date-parts":[[2015,2,11]]}}}