{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T18:32:52Z","timestamp":1789410772964,"version":"build-2803163510"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,4]]},"DOI":"10.1093\/humrep\/dev027","type":"journal-article","created":{"date-parts":[[2015,3,5]],"date-time":"2015-03-05T01:33:20Z","timestamp":1425519200000},"page":"789-799","source":"Crossref","is-referenced-by-count":42,"title":["Trophoblast subtype-specific EGFR\/ERBB4 expression correlates with cell cycle progression and hyperplasia in complete hydatidiform moles"],"prefix":"10.1093","volume":"30","author":[{"given":"Valerie","family":"Fock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin","family":"Plessl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabine","family":"Dekan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie K.","family":"Milla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Haider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Fiala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Kn\u00f6fler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00fcrgen","family":"Pollheimer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,3]]},"reference":[{"key":"key\n\t\t\t\t20170518081045_DEV027C1","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00431-011-1526-2","article-title":"EGFR expression in acquired middle ear cholesteatoma in children and adults","volume":"171","author":"Alves","year":"2012","journal-title":"Eur J Pediatr"},{"key":"key\n\t\t\t\t20170518081045_DEV027C2","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/BF01214668","article-title":"Expression of epidermal growth factor receptor in gestational trophoblastic diseases","volume":"123","author":"Balaram","year":"1997","journal-title":"J Cancer Res Clin Oncol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C3","first-page":"185","article-title":"C-erbB-2 amplification and expression in gestational trophoblastic disease correlates with DNA content and karyotype","volume":"143","author":"Bauer","year":"1997","journal-title":"Gen Diagn Pathol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C4","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1210\/en.2008-0456","article-title":"Identification of novel trophoblast invasion-related genes: heme oxygenase-1 controls motility via peroxisome proliferator-activated receptor gamma","volume":"150","author":"Bilban","year":"2009","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170518081045_DEV027C5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.tree.2008.10.008","article-title":"Generalized linear mixed models: a practical guide for ecology and evolution","volume":"24","author":"Bolker","year":"2009","journal-title":"Trends Ecol Evol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1600-0897.1989.tb01009.x","article-title":"Expression of epidermal growth factor receptor and transferrin receptor by human trophoblast populations","volume":"21","author":"Bulmer","year":"1989","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C7","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S1097-2765(03)00350-2","article-title":"An open-and-shut case? Recent insights into the activation of EGF\/ErbB receptors","volume":"12","author":"Burgess","year":"2003","journal-title":"Mol Cell"},{"key":"key\n\t\t\t\t20170518081045_DEV027C8","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/nrm1962","article-title":"EGF-ERBB signalling: towards the systems level","volume":"7","author":"Citri","year":"2006","journal-title":"Nat Rev Mol Cell Biol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C9","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1074\/jbc.271.9.4813","article-title":"HER4-mediated biological and biochemical properties in NIH 3T3 cells. Evidence for HER1-HER4 heterodimers","volume":"271","author":"Cohen","year":"1996","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518081045_DEV027C10","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1172\/JCI115565","article-title":"Distribution patterns of extracellular matrix components and adhesion receptors are intricately modulated during first trimester cytotrophoblast differentiation along the invasive pathway, in vivo","volume":"89","author":"Damsky","year":"1992","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170518081045_DEV027C11","doi-asserted-by":"crossref","first-page":"26761","DOI":"10.1074\/jbc.272.42.26761","article-title":"A novel juxtamembrane domain isoform of HER4\/ErbB4. Isoform-specific tissue distribution and differential processing in response to phorbol ester","volume":"272","author":"Elenius","year":"1997","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518081045_DEV027C12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1006\/mcbr.1999.0157","article-title":"cbl-b inhibits EGF-receptor-induced apoptosis by enhancing ubiquitination and degradation of activated receptors","volume":"2","author":"Ettenberg","year":"1999","journal-title":"Mol Cell Biol Res Commun"},{"key":"key\n\t\t\t\t20170518081045_DEV027C13","doi-asserted-by":"crossref","first-page":"3734","DOI":"10.4049\/jimmunol.1300490","article-title":"Macrophage-derived IL-33 is a critical factor for placental growth","volume":"191","author":"Fock","year":"2013","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C14","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.4161\/cc.22529","article-title":"The mysterious human epidermal cell cycle, or an oncogene-induced differentiation checkpoint","volume":"11","author":"Gandarillas","year":"2012","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20170518081045_DEV027C15","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1101\/gad.11.21.2869","article-title":"c-Myc promotes differentiation of human epidermal stem cells","volume":"11","author":"Gandarillas","year":"1997","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170518081045_DEV027C16","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/0143-4004(92)90051-T","article-title":"Villous culture of first trimester human placenta\u2013model to study extravillous trophoblast (EVT) differentiation","volume":"13","author":"Genbacev","year":"1992","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170518081045_DEV027C17","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1093\/emboj\/16.7.1647","article-title":"ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling","volume":"16","author":"Graus-Porta","year":"1997","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170518081045_DEV027C18","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/00000372-200104000-00002","article-title":"Proliferation and differentiation of the keratinocytes in hyperplastic epidermis overlying dermatofibroma: immunohistochemical characterization","volume":"23","author":"Han","year":"2001","journal-title":"Am J Dermatopathol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C19","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1038\/embor.2012.162","article-title":"Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a\/125b and DNA methylation","volume":"13","author":"He","year":"2012","journal-title":"EMBO Rep"},{"key":"key\n\t\t\t\t20170518081045_DEV027C20","doi-asserted-by":"crossref","first-page":"8933","DOI":"10.1073\/pnas.1537685100","article-title":"The ErbB2\/ErbB3 heterodimer functions as an oncogenic unit: ErbB2 requires ErbB3 to drive breast tumor cell proliferation","volume":"100","author":"Holbro","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170518081045_DEV027C21","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1038\/ncb2158","article-title":"Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation","volume":"13","author":"Hsu","year":"2011","journal-title":"Nat Cell Biol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C22","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1242\/jcs.116277","article-title":"Nuclear ErbB4 signaling through H3K9me3 is antagonized by EGFR-activated c-Src","volume":"126","author":"Ishibashi","year":"2013","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20170518081045_DEV027C23","first-page":"177","article-title":"Expression of epidermal growth factor and its receptor in gestational trophoblastic diseases","volume":"4","author":"John","year":"1997","journal-title":"Oncol Rep"},{"key":"key\n\t\t\t\t20170518081045_DEV027C24","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/1043-4666(94)90068-X","article-title":"Reciprocal expression of epidermal growth factor receptor (EGF-R) and c-erbB2 by non-invasive and invasive human trophoblast populations","volume":"6","author":"Jokhi","year":"1994","journal-title":"Cytokine"},{"key":"key\n\t\t\t\t20170518081045_DEV027C25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1046\/j.1365-2559.2003.01667.x","article-title":"p57kip2 is useful in the classification and differential diagnosis of complete and partial hydatidiform moles","volume":"43","author":"Jun","year":"2003","journal-title":"Histopathology"},{"key":"key\n\t\t\t\t20170518081045_DEV027C26","first-page":"5346","article-title":"Identification of patients with transitional cell carcinoma of the bladder overexpressing ErbB2, ErbB3, or specific ErbB4 isoforms: real-time reverse transcription-PCR analysis in estimation of ErbB receptor status from cancer patients","volume":"9","author":"Junttila","year":"2003","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t20170518081045_DEV027C27","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1158\/0008-5472.CAN-04-3150","article-title":"Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells","volume":"65","author":"Junttila","year":"2005","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170518081045_DEV027C28","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ccr.2009.03.020","article-title":"Ligand-independent HER2\/HER3\/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941","volume":"15","author":"Junttila","year":"2009","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20170518081045_DEV027C29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.102.014977","article-title":"Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia","volume":"69","author":"Kaufmann","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170518081045_DEV027C30","doi-asserted-by":"crossref","first-page":"33334","DOI":"10.1074\/jbc.M305597200","article-title":"WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus","volume":"278","author":"Komuro","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518081045_DEV027C31","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1126\/science.2326636","article-title":"A class I antigen, HLA-G, expressed in human trophoblasts","volume":"248","author":"Kovats","year":"1990","journal-title":"Science"},{"key":"key\n\t\t\t\t20170518081045_DEV027C32","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1210\/en.2004-1550","article-title":"Stimulation of human trophoblast invasion by placental growth hormone","volume":"146","author":"Lacroix","year":"2005","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170518081045_DEV027C33","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1074\/jbc.M112.339820","article-title":"Met kinase-dependent loss of the E3 ligase Cbl in gastric cancer","volume":"287","author":"Lai","year":"2012","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518081045_DEV027C34","doi-asserted-by":"crossref","first-page":"e1004451","DOI":"10.1371\/journal.pgen.1004451","article-title":"The epidermal growth factor receptor critically regulates endometrial function during early pregnancy","volume":"10","author":"Large","year":"2014","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20170518081045_DEV027C35","doi-asserted-by":"crossref","first-page":"4935","DOI":"10.1128\/MCB.01705-08","article-title":"ErbB4 splice variants Cyt1 and Cyt2 differ by 16 amino acids and exert opposing effects on the mammary epithelium in vivo","volume":"29","author":"Muraoka-Cook","year":"2009","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C36","doi-asserted-by":"crossref","first-page":"3159","DOI":"10.1093\/emboj\/19.13.3159","article-title":"The ErbB signaling network: receptor heterodimerization in development and cancer","volume":"19","author":"Olayioye","year":"2000","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170518081045_DEV027C37","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.1128\/MCB.01809-07","article-title":"A tale of two Cbls: interplay of c-Cbl and Cbl-b in epidermal growth factor receptor downregulation","volume":"28","author":"Pennock","year":"2008","journal-title":"Mol Cell Biol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C38","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00403-003-0391-x","article-title":"Proliferation-differentiation relationships in the expression of heparin-binding epidermal growth factor-related factors and erbB receptors by normal and psoriatic human keratinocytes","volume":"295","author":"Piepkorn","year":"2003","journal-title":"Arch Dermatol Res"},{"issue":"Suppl A","key":"key\n\t\t\t\t20170518081045_DEV027C39","doi-asserted-by":"crossref","first-page":"S21","DOI":"10.1016\/j.placenta.2004.11.013","article-title":"Signalling pathways regulating the invasive differentiation of human trophoblasts: a review","volume":"26","author":"Pollheimer","year":"2005","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170518081045_DEV027C40","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.2353\/ajpath.2006.050686","article-title":"Activation of the canonical wingless\/T-cell factor signaling pathway promotes invasive differentiation of human trophoblast","volume":"168","author":"Pollheimer","year":"2006","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C41","doi-asserted-by":"crossref","first-page":"10379","DOI":"10.1074\/jbc.275.14.10379","article-title":"Tumor necrosis factor-alpha-converting enzyme is required for cleavage of erbB4\/HER4","volume":"275","author":"Rio","year":"2000","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170518081045_DEV027C42","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"key\n\t\t\t\t20170518081045_DEV027C43","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/S0140-6736(10)60280-2","article-title":"Gestational trophoblastic disease","volume":"376","author":"Seckl","year":"2010","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170518081045_DEV027C44","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/S1470-2045(07)70204-8","article-title":"Gestational trophoblastic neoplasia\u2014pathogenesis and potential therapeutic targets","volume":"8","author":"Shih Ie","year":"2007","journal-title":"Lancet Oncol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C45","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1038\/labinvest.3780334","article-title":"Characterization of human villous and extravillous trophoblasts isolated from first trimester placenta","volume":"81","author":"Tarrade","year":"2001","journal-title":"Lab Invest"},{"key":"key\n\t\t\t\t20170518081045_DEV027C46","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/j.1600-0625.2009.01028.x","article-title":"Epidermal growth factor receptor gene numerical aberrations are frequent events in actinic keratoses and invasive cutaneous squamous cell carcinomas","volume":"19","author":"Toll","year":"2010","journal-title":"Exp Dermatol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C47","doi-asserted-by":"crossref","first-page":"e556","DOI":"10.1038\/cddis.2013.79","article-title":"Functional cooperation of miR-125a, miR-125b, and miR-205 in entinostat-induced downregulation of erbB2\/erbB3 and apoptosis in breast cancer cells","volume":"4","author":"Wang","year":"2013","journal-title":"Cell Death Dis"},{"key":"key\n\t\t\t\t20170518081045_DEV027C48","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1083\/jcb.200403155","article-title":"The ERBB4\/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone","volume":"167","author":"Williams","year":"2004","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20170518081045_DEV027C49","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1095\/biolreprod.109.083246","article-title":"HER1 signaling mediates extravillous trophoblast differentiation in humans","volume":"83","author":"Wright","year":"2010","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170518081045_DEV027C50","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/1476-4598-13-220","article-title":"miR-143 and miR-145 synergistically regulate ERBB3 to suppress cell proliferation and invasion in breast cancer","volume":"13","author":"Yan","year":"2014","journal-title":"Mol Cancer"},{"key":"key\n\t\t\t\t20170518081045_DEV027C51","doi-asserted-by":"crossref","first-page":"e15701","DOI":"10.1371\/journal.pone.0015701","article-title":"A mitosis block links active cell cycle with human epidermal differentiation and results in endoreplication","volume":"5","author":"Zanet","year":"2010","journal-title":"PLoS One"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/30\/4\/789\/17189393\/dev027.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T08:09:27Z","timestamp":1503475767000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article-lookup\/doi\/10.1093\/humrep\/dev027"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,3]]},"references-count":51,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,3,3]]},"published-print":{"date-parts":[[2015,4]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dev027","relation":{},"ISSN":["1460-2350","0268-1161"],"issn-type":[{"value":"1460-2350","type":"electronic"},{"value":"0268-1161","type":"print"}],"subject":[],"published":{"date-parts":[[2015,3,3]]}}}