{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T11:08:08Z","timestamp":1791198488244,"version":"4.1.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"6","funder":[{"DOI":"10.13039\/501100007486","name":"Paris-Sud University","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007486","id-type":"DOI","asserted-by":"crossref"}]},{"name":"French Ministry of Health, Hospital Clinical Research Program on Rare Diseases"},{"name":"Assistance Publique H\u00f4pitaux de Paris, Programme Hospitalier de Recherche Clinique","award":["PHRC # P081212 HYPOPROTEO"],"award-info":[{"award-number":["PHRC # P081212 HYPOPROTEO"]}]},{"name":"Agence R\u00e9gionale de Sant\u00e9 Provence Alpes C\u00f4tes d'Azur"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Reprod."],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1093\/humrep\/dew073","type":"journal-article","created":{"date-parts":[[2016,4,19]],"date-time":"2016-04-19T20:59:17Z","timestamp":1461099557000},"page":"1363-1374","source":"Crossref","is-referenced-by-count":56,"title":["Prevalence of<i>KISS1 Receptor<\/i>mutations in a series of 603 patients with normosmic congenital hypogonadotrophic hypogonadism and characterization of novel mutations: a single-centre study"],"prefix":"10.1093","volume":"31","author":[{"given":"Bruno","family":"Francou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larbi","family":"Amazit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Cartes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Bouvattier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9rique","family":"Albarel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Maiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Chanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9verine","family":"Trabado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvie","family":"Brailly-Tabard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Brue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Guiochon-Mantel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Young","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9r\u00f4me","family":"Bouligand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,4,19]]},"reference":[{"key":"2016051808080051000_31.6.1363.1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2014-1304"},{"key":"2016051808080051000_31.6.1363.2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01695-06"},{"key":"2016051808080051000_31.6.1363.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.05.044"},{"key":"2016051808080051000_31.6.1363.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.08.044"},{"key":"2016051808080051000_31.6.1363.5","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nrendo.2015.112","article-title":"Expert consensus document: European Consensus Statement on congenital hypogonadotropic hypogonadism\u2013pathogenesis, diagnosis and treatment","volume":"11","author":"Boehm","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"2016051808080051000_31.6.1363.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0900136"},{"key":"2016051808080051000_31.6.1363.7","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.164"},{"key":"2016051808080051000_31.6.1363.8","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-12-0127"},{"key":"2016051808080051000_31.6.1363.9","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0083"},{"key":"2016051808080051000_31.6.1363.10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0053896"},{"key":"2016051808080051000_31.6.1363.11","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02235"},{"key":"2016051808080051000_31.6.1363.12","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0903449106"},{"key":"2016051808080051000_31.6.1363.13","doi-asserted-by":"publisher","DOI":"10.1210\/me.2012-1386"},{"key":"2016051808080051000_31.6.1363.14","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12618"},{"key":"2016051808080051000_31.6.1363.15","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199711273372205"},{"key":"2016051808080051000_31.6.1363.16","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1834399100"},{"key":"2016051808080051000_31.6.1363.17","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2748-07.2007"},{"key":"2016051808080051000_31.6.1363.18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0025614"},{"key":"2016051808080051000_31.6.1363.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2003.11.066"},{"key":"2016051808080051000_31.6.1363.20","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2320"},{"key":"2016051808080051000_31.6.1363.21","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1264"},{"key":"2016051808080051000_31.6.1363.22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0039450"},{"key":"2016051808080051000_31.6.1363.23","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02031"},{"key":"2016051808080051000_31.6.1363.24","doi-asserted-by":"publisher","DOI":"10.1038\/ng0198-14"},{"key":"2016051808080051000_31.6.1363.25","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0069616"},{"key":"2016051808080051000_31.6.1363.26","doi-asserted-by":"crossref","unstructured":"Min L , Nie M , Zhang A , Wen J , Noel SD , Lee V , Carroll RS , Kaiser UB . Computational analysis of missense variants of G protein-coupled receptors involved in the neuroendocrine regulation of reproduction. Neuroendocrinology 2015. doi:10.1159\/000435884 [Epub ahead of print].","DOI":"10.1159\/000435884"},{"key":"2016051808080051000_31.6.1363.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.04.008"},{"key":"2016051808080051000_31.6.1363.28","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2010-1676"},{"key":"2016051808080051000_31.6.1363.29","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.mce.2006.04.019","article-title":"Neuroendocrine, gonadal, placental, and obstetric phenotypes in patients with IHH and mutations in the G-protein coupled receptor, GPR54","volume":"254\u2013255","author":"Pallais","year":"2006","journal-title":"Mol Cell Endocrinol"},{"key":"2016051808080051000_31.6.1363.30","doi-asserted-by":"publisher","DOI":"10.1210\/me.2009-0013"},{"key":"2016051808080051000_31.6.1363.31","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2265.1999.00708.x"},{"key":"2016051808080051000_31.6.1363.32","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa066494"},{"key":"2016051808080051000_31.6.1363.33","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa035322"},{"key":"2016051808080051000_31.6.1363.34","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1418"},{"key":"2016051808080051000_31.6.1363.35","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1210\/jc.2013-2809","article-title":"Reversal and relapse of hypogonadotropic hypogonadism: resilience and fragility of the reproductive neuroendocrine system","volume":"99","author":"Sidhoum","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2016051808080051000_31.6.1363.36","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den247"},{"key":"2016051808080051000_31.6.1363.37","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1009622107"},{"key":"2016051808080051000_31.6.1363.38","doi-asserted-by":"publisher","DOI":"10.1530\/EJE-10-0012"},{"key":"2016051808080051000_31.6.1363.39","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038456"},{"key":"2016051808080051000_31.6.1363.40","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2147"},{"key":"2016051808080051000_31.6.1363.41","doi-asserted-by":"publisher","DOI":"10.1038\/ng.306"},{"key":"2016051808080051000_31.6.1363.42","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1111184"},{"key":"2016051808080051000_31.6.1363.43","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-27302012000900008"},{"key":"2016051808080051000_31.6.1363.44","doi-asserted-by":"crossref","first-page":"649698","DOI":"10.1155\/2015\/649698","article-title":"Novel FGFR1 and KISS1R mutations in Chinese Kallmann syndrome males with Cleft Lip\/Palate","volume":"2015","author":"Xu","year":"2015","journal-title":"Biomed Res Int"},{"key":"2016051808080051000_31.6.1363.45","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-1664"},{"key":"2016051808080051000_31.6.1363.46","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-2600"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/31\/6\/1363\/17373386\/dew073.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T17:35:02Z","timestamp":1567791302000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article-lookup\/doi\/10.1093\/humrep\/dew073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4,19]]},"references-count":46,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2016,5,18]]},"published-print":{"date-parts":[[2016,6]]}},"alternative-id":["10.1093\/humrep\/dew073"],"URL":"https:\/\/doi.org\/10.1093\/humrep\/dew073","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,4,19]]}}}