{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T17:09:37Z","timestamp":1771002577350,"version":"3.50.1"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"8","funder":[{"name":"Bayer Pharma AG"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Hum. Reprod."],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1093\/humrep\/dew145","type":"journal-article","created":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T21:03:12Z","timestamp":1467925392000},"page":"1713-1722","source":"Crossref","is-referenced-by-count":27,"title":["Pharmacokinetics, pharmacodynamics, safety and tolerability of an intravaginal ring releasing anastrozole and levonorgestrel in healthy premenopausal women: a Phase 1 randomized controlled trial"],"prefix":"10.1093","volume":"31","author":[{"given":"M.-H.","family":"Schultze-Mosgau","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Waellnitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Nave","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Kraetzschmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Rautenberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Schmitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2016,6,19]]},"reference":[{"key":"2016080503423099000_31.8.1713.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.07.1136"},{"key":"2016080503423099000_31.8.1713.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2003.09.029"},{"key":"2016080503423099000_31.8.1713.3","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181e8b073"},{"key":"2016080503423099000_31.8.1713.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.02.012"},{"key":"2016080503423099000_31.8.1713.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.02.018"},{"key":"2016080503423099000_31.8.1713.6","unstructured":"Arimidex\u00ae Prescribing Information. AstraZeneca UK Limited. http:\/\/www.azpicentral.com\/arimidex\/arimidex.pdf (25 April 2016, date last accessed)."},{"key":"2016080503423099000_31.8.1713.7","first-page":"287","article-title":"Endometriosis and the estrogen threshold theory. Relation to surgical and medical treatment","volume":"43","author":"Barbieri","year":"1998","journal-title":"J Reprod Med"},{"issue":"(Suppl 1)","key":"2016080503423099000_31.8.1713.8","first-page":"i196","article-title":"A safety and efficacy study on long term treatment with letrozole after GnRH: a down-regulation in premenopausal patients with moderate and severe endometriosis","volume":"29","author":"Bartley","year":"2014","journal-title":"Hum Reprod"},{"key":"2016080503423099000_31.8.1713.9","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(85)90096-4"},{"key":"2016080503423099000_31.8.1713.10","doi-asserted-by":"crossref","unstructured":"Brown J , Pan A , Hart RJ . Gonadotrophin-releasing hormone analogues for pain associated with endometriosis. Cochrane Database Syst Rev 2010;12:CD008475.","DOI":"10.1002\/14651858.CD008475"},{"key":"2016080503423099000_31.8.1713.11","first-page":"CD002122","article-title":"Progestagens and anti-progestagens for pain associated with endometriosis","volume":"3","author":"Brown","year":"2012","journal-title":"Cochrane Database Syst Rev"},{"key":"2016080503423099000_31.8.1713.12","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0250035"},{"key":"2016080503423099000_31.8.1713.13","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/6.5.413"},{"key":"2016080503423099000_31.8.1713.14","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmi049"},{"key":"2016080503423099000_31.8.1713.15","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(87)90014-X"},{"key":"2016080503423099000_31.8.1713.16","doi-asserted-by":"crossref","unstructured":"Davis L , Kennedy SS , Moore J , Prentice A . Modern combined oral contraceptives for pain associated with endometriosis. Cochrane Database Syst Rev 2007;2:CD001019.","DOI":"10.1002\/14651858.CD001019.pub2"},{"key":"2016080503423099000_31.8.1713.17","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6690050"},{"key":"2016080503423099000_31.8.1713.18","doi-asserted-by":"publisher","DOI":"10.1054\/bjoc.2001.1925"},{"key":"2016080503423099000_31.8.1713.19","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det457"},{"key":"2016080503423099000_31.8.1713.20","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dep302"},{"key":"2016080503423099000_31.8.1713.21","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1996.531"},{"key":"2016080503423099000_31.8.1713.22","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1093\/ajhp\/55.5.445","article-title":"Anastrozole: a selective aromatase inhibitor for the treatment of breast cancer","volume":"55","author":"Higa","year":"1998","journal-title":"Am J Health Syst Pharm"},{"key":"2016080503423099000_31.8.1713.23","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(93)90025-3"},{"key":"2016080503423099000_31.8.1713.24","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-09-3024"},{"key":"2016080503423099000_31.8.1713.25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/j.1879-3479.1972.tb00857.x","article-title":"The cervical score A simple semiquantitative method for monitoring of the menstrual cycle","volume":"10","author":"Insler","year":"1972","journal-title":"Int J Gynaecol Obstet"},{"key":"2016080503423099000_31.8.1713.26","unstructured":"Jadelle\u00ae Prescribing information. \u201cNorplant\u00ae II\u201d levonorgestrel implants (Jadelle\u00ae). http:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2002\/20544se2-003_jadelle_lbl.pdf (25 April 2016, date last accessed)."},{"key":"2016080503423099000_31.8.1713.27","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200666170-00001"},{"key":"2016080503423099000_31.8.1713.28","unstructured":"Norgeston Summary of Product Characteristics. Bayer HealthCare. http:\/\/www.medicines.org.uk\/emc\/medicine\/1834 (25 April 2016, date last accessed)."},{"key":"2016080503423099000_31.8.1713.29","doi-asserted-by":"publisher","DOI":"10.1007\/BF00682745"},{"key":"2016080503423099000_31.8.1713.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.01.006"},{"key":"2016080503423099000_31.8.1713.31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2007.00722.x"},{"key":"2016080503423099000_31.8.1713.32","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.4.982"},{"key":"2016080503423099000_31.8.1713.33","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu315"},{"key":"2016080503423099000_31.8.1713.34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.64.081601.142703"},{"key":"2016080503423099000_31.8.1713.35","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh035"},{"key":"2016080503423099000_31.8.1713.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.04.059"},{"key":"2016080503423099000_31.8.1713.37","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)00193-3"},{"key":"2016080503423099000_31.8.1713.38","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200969060-00002"},{"key":"2016080503423099000_31.8.1713.39","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmq042"},{"key":"2016080503423099000_31.8.1713.40","doi-asserted-by":"publisher","DOI":"10.5414\/CPP48563"},{"key":"2016080503423099000_31.8.1713.41","doi-asserted-by":"publisher","DOI":"10.2165\/00002512-199813040-00008"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,9,10]],"date-time":"2019-09-10T17:42:59Z","timestamp":1568137379000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article-lookup\/doi\/10.1093\/humrep\/dew145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,19]]},"references-count":41,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2016,8,5]]},"published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1093\/humrep\/dew145"],"URL":"https:\/\/doi.org\/10.1093\/humrep\/dew145","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,19]]}}}