{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:40:23Z","timestamp":1784691623068,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"7","funder":[{"name":"InterReg ReproUnion","award":["NYPS 20200407"],"award-info":[{"award-number":["NYPS 20200407"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,7,1]]},"DOI":"10.1093\/humrep\/dex097","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T09:34:01Z","timestamp":1493026441000},"page":"1474-1481","source":"Crossref","is-referenced-by-count":80,"title":["Risk of diabetes according to male factor infertility: a register-based cohort study"],"prefix":"10.1093","volume":"32","author":[{"given":"Clara Helene","family":"Glazer","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, DK-2400 Copenhagen NV, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Peter","family":"Bonde","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, DK-2400 Copenhagen NV, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksander","family":"Giwercman","sequence":"additional","affiliation":[{"name":"Molecular Reproductive Medicine, Department of Translational Medicine, Lund University, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ditte","family":"Vassard","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section of Social Medicine, University of Copenhagen, DK-1014 Copenhagen K, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anja","family":"Pinborg","sequence":"additional","affiliation":[{"name":"Department of Obstetrics\/Gynaecology, Hvidovre Hospital, Copenhagen University Hospital, DK-2650 Hvidovre, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lone","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Public Health, Section of Social Medicine, University of Copenhagen, DK-1014 Copenhagen K, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira","family":"Vaclavik Br\u00e4uner","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Bispebjerg University Hospital, DK-2400 Copenhagen NV, Denmark"},{"name":"Research Center for Prevention and Health (RCPH), University of Copenhagen, DK-2600 Glostrup, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,9]]},"reference":[{"key":"key\n\t\t\t\t20180306203515_dex097C1","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2337\/dc12-2625","article-title":"Economic costs of diabetes in the U.S. in 2012","volume":"36","author":"American Diabetes Association","year":"2013","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20180306203515_dex097C2","first-page":"357","article-title":"The Danish in vitro fertilisation (IVF) register","volume":"46","author":"Andersen","year":"1999","journal-title":"Dan Med Bull"},{"key":"key\n\t\t\t\t20180306203515_dex097C3","doi-asserted-by":"crossref","first-page":"f3978","DOI":"10.1136\/bmj.f3978","article-title":"Fertility treatment and risk of childhood and adolescent mental disorders: register based cohort study","volume":"347","author":"Bay","year":"2013","journal-title":"BMJ"},{"key":"key\n\t\t\t\t20180306203515_dex097C4","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1001\/jama.2010.843","article-title":"Association between adiposity in midlife and older age and risk of diabetes in older adults","volume":"303","author":"Biggs","year":"2010","journal-title":"JAMA"},{"key":"key\n\t\t\t\t20180306203515_dex097C5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/1403494811399957","article-title":"Danish registers on aspects of reproduction","volume":"39","author":"Blenstrup","year":"2011","journal-title":"Scand J Public Health"},{"key":"key\n\t\t\t\t20180306203515_dex097C6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1177\/1403494811404278","article-title":"The National Diabetes Register","volume":"39","author":"Carstensen","year":"2011","journal-title":"Scand J Public Health"},{"key":"key\n\t\t\t\t20180306203515_dex097C7","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1007\/s00125-008-1156-z","article-title":"The Danish National Diabetes Register: trends in incidence, prevalence and mortality","volume":"51","author":"Carstensen","year":"2008","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t20180306203515_dex097C8","author":"Danish Fertility Society","year":"2015"},{"key":"key\n\t\t\t\t20180306203515_dex097C9","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/humrep\/deu106","article-title":"Semen quality, infertility and mortality in the USA","volume":"29","author":"Eisenberg","year":"2014","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180306203515_dex097C10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.fertnstert.2014.10.017","article-title":"Relationship between semen production and medical comorbidity","volume":"103","author":"Eisenberg","year":"2015","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180306203515_dex097C11","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/j.fertnstert.2015.11.011","article-title":"Increased risk of incident chronic medical conditions in infertile men: analysis of United States claims data","volume":"105","author":"Eisenberg","year":"2015","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180306203515_dex097C12","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/j.2047-2927.2013.00083.x","article-title":"Retrograde ejaculation and sexual dysfunction in men with diabetes mellitus: a prospective, controlled study","volume":"1","author":"Fedder","year":"2013","journal-title":"Andrology"},{"key":"key\n\t\t\t\t20180306203515_dex097C13","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1093\/humrep\/det278","article-title":"Assisted reproductive technology in Europe, 2009: results generated from European registers by ESHRE","volume":"28","author":"Ferraretti","year":"2013","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180306203515_dex097C14","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.2337\/diacare.26.8.2335","article-title":"Prevalences of diabetes and impaired glucose regulation in a Danish population: the Inter99 study","volume":"26","author":"Glumer","year":"2003","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20180306203515_dex097C15","first-page":"46","article-title":"Men with subnormal sperm counts live shorter lives","volume":"53","author":"Groos","year":"2006","journal-title":"Soc Biol"},{"key":"key\n\t\t\t\t20180306203515_dex097C16","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.2337\/diacare.21.7.1138","article-title":"Mortality in adults with and without diabetes in a national cohort of the U.S. population, 1971\u20131993","volume":"21","author":"Gu","year":"1998","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20180306203515_dex097C17","doi-asserted-by":"crossref","first-page":"C3","DOI":"10.2337\/diacare.21.3.C3","article-title":"Epidemiology of type 2 diabetes: risk factors","volume":"21","author":"Haffner","year":"1998","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20180306203515_dex097C18","doi-asserted-by":"crossref","first-page":"3180","DOI":"10.1210\/jc.2016-1778","article-title":"Low testosterone: a risk marker rather than a risk factor for Type 2 diabetes","volume":"101","author":"Holmboe","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20180306203515_dex097C19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.urology.2011.09.021","article-title":"Men who seek infertility care may not represent the general U.S. population: data from the National Survey of Family Growth","volume":"79","author":"Hotaling","year":"2012","journal-title":"Urology"},{"key":"key\n\t\t\t\t20180306203515_dex097C20","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/nrurol.2009.179","article-title":"Male infertility: a risk factor for testicular cancer","volume":"6","author":"Hotaling","year":"2009","journal-title":"Nat Rev Urol"},{"key":"key\n\t\t\t\t20180306203515_dex097C21","doi-asserted-by":"crossref","first-page":"147","DOI":"10.2174\/1573399810666140606111745","article-title":"Diabetes mellitus induced impairment of male reproductive functions: a review","volume":"10","author":"Jangir","year":"2014","journal-title":"Curr Diabetes Rev"},{"key":"key\n\t\t\t\t20180306203515_dex097C22","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/aje\/kwp168","article-title":"Good semen quality and life expectancy: a cohort study of 43,277 men","volume":"170","author":"Jensen","year":"2009","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t20180306203515_dex097C23","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2164\/jandrol.107.003731","article-title":"The metabolic syndrome and male infertility","volume":"29","author":"Kasturi","year":"2008","journal-title":"J Androl"},{"key":"key\n\t\t\t\t20180306203515_dex097C24","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1530\/JOE-12-0455","article-title":"Testosterone: a metabolic hormone in health and disease","volume":"217","author":"Kelly","year":"2013","journal-title":"J Endocrinol"},{"key":"key\n\t\t\t\t20180306203515_dex097C25","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1111\/obr.12282","article-title":"Testosterone and obesity","volume":"16","author":"Kelly","year":"2015","journal-title":"Obes Rev"},{"key":"key\n\t\t\t\t20180306203515_dex097C26","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0015-0282(00)01679-4","article-title":"Effects of male age on semen quality and fertility: a review of the literature","volume":"75","author":"Kidd","year":"2001","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180306203515_dex097C27","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1177\/1403494810394717","article-title":"The Danish National Prescription Registry","volume":"39","author":"Kildemoes","year":"2011","journal-title":"Scand J Public Health"},{"key":"key\n\t\t\t\t20180306203515_dex097C28","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.beem.2010.08.006","article-title":"Male infertility: pathogenesis and clinical diagnosis","volume":"25","author":"Krausz","year":"2011","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20180306203515_dex097C29","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1210\/jc.2007-1792","article-title":"Low serum testosterone and mortality in older men","volume":"93","author":"Laughlin","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20180306203515_dex097C30","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.2337\/dc09-1788","article-title":"Association of testosterone and sex hormone-binding globulin with metabolic syndrome and insulin resistance in men","volume":"33","author":"Li","year":"2010","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20180306203515_dex097C31","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.2337\/diacare.27.5.1036","article-title":"Testosterone and sex hormone-binding globulin predict the metabolic syndrome and diabetes in middle-aged men","volume":"27","author":"Laaksonen","year":"2004","journal-title":"Diabetes Care"},{"key":"key\n\t\t\t\t20180306203515_dex097C32","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1016\/j.socscimed.2009.08.043","article-title":"Can patient self-management explain the health gradient? Goldman and Smith's \u2018Can patient self-management help explain the SES health gradient?\u2019 (2002) revisited","volume":"70","author":"Maitra","year":"2010","journal-title":"Soc Sci Med"},{"key":"key\n\t\t\t\t20180306203515_dex097C33","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/nm.f.1895","article-title":"The biology of infertility: research advances and clinical challenges","volume":"14","author":"Matzuk","year":"2008","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180306203515_dex097C34","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.urology.2003.09.015","article-title":"Impact of infertility on quality of life, marital adjustment, and sexual function","volume":"63","author":"Monga","year":"2004","journal-title":"Urology"},{"key":"key\n\t\t\t\t20180306203515_dex097C35","author":"Nordkap","year":"2016"},{"key":"key\n\t\t\t\t20180306203515_dex097C36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1177\/1403494810387965","article-title":"The Danish Civil Registration System","volume":"39","author":"Pedersen","year":"2011","journal-title":"Scand J Public Health"},{"key":"key\n\t\t\t\t20180306203515_dex097C37","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/nrendo.2013.122","article-title":"Testosterone and insulin resistance in the metabolic syndrome and T2DM in men","volume":"9","author":"Rao","year":"2013","journal-title":"Nat Rev Endocrinol"},{"key":"key\n\t\t\t\t20180306203515_dex097C38","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1097\/01.ede.0000165391.65690.e1","article-title":"Has human fertility declined over time? Why we may never know","volume":"16","author":"Sallmen","year":"2005","journal-title":"Epidemiology"},{"key":"key\n\t\t\t\t20180306203515_dex097C39","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.eururo.2009.03.001","article-title":"Are infertile men less healthy than fertile men? Results of a prospective case-control survey","volume":"56","author":"Salonia","year":"2009","journal-title":"Eur Urol"},{"key":"key\n\t\t\t\t20180306203515_dex097C40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12958-015-0028-x","article-title":"Effects of increased paternal age on sperm quality, reproductive outcome and associated epigenetic risks to offspring","volume":"13","author":"Sharma","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t20180306203515_dex097C41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s12958-015-0029-9","article-title":"Infertility etiologies are genetically and clinically linked with other diseases in single meta-diseases","volume":"13","author":"Tarin","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t20180306203515_dex097C42","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1002\/sim.2098","article-title":"Choice of time-scale in Cox's model analysis of epidemiologic cohort data: a simulation study","volume":"23","author":"Thiebaut","year":"2004","journal-title":"Stat Med"},{"key":"key\n\t\t\t\t20180306203515_dex097C43","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.fertnstert.2015.04.020","article-title":"Infertility as a proxy of general male health: results of a cross-sectional survey","volume":"104","author":"Ventimiglia","year":"2015","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180306203515_dex097C44","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/MOU.0000000000000259","article-title":"Comorbidities and male infertility: a worrisome picture","volume":"26","author":"Ventimiglia","year":"2016","journal-title":"Curr Opin Urol"},{"key":"key\n\t\t\t\t20180306203515_dex097C45","first-page":"2140","article-title":"Increased risk of high-grade prostate cancer among infertile men","volume":"116","author":"Walsh","year":"2010","journal-title":"Cancer"},{"key":"key\n\t\t\t\t20180306203515_dex097C46","doi-asserted-by":"crossref","first-page":"816","DOI":"10.2105\/AJPH.82.6.816","article-title":"Socioeconomic status and health: how education, income, and occupation contribute to risk factors for cardiovascular disease","volume":"82","author":"Winkleby","year":"1992","journal-title":"Am J Public Health"},{"key":"key\n\t\t\t\t20180306203515_dex097C47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1136\/postgradmedj-2015-133281","article-title":"Pathophysiology of type 1 and type 2 diabetes mellitus: a 90-year perspective","volume":"92","author":"Zaccardi","year":"2016","journal-title":"Postgrad Med J"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/32\/7\/1474\/24265467\/dex097.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T20:35:42Z","timestamp":1520368542000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/32\/7\/1474\/3807183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,9]]},"references-count":47,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2017,5,9]]},"published-print":{"date-parts":[[2017,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dex097","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,7]]},"published":{"date-parts":[[2017,5,9]]}}}