{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:37:26Z","timestamp":1792442246213,"version":"4.5.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,12,1]]},"DOI":"10.1093\/humrep\/dex317","type":"journal-article","created":{"date-parts":[[2017,10,3]],"date-time":"2017-10-03T07:10:08Z","timestamp":1507014608000},"page":"2443-2455","source":"Crossref","is-referenced-by-count":56,"title":["Alterations in the sperm histone-retained epigenome are associated with unexplained male factor infertility and poor blastocyst development in donor oocyte IVF cycles"],"prefix":"10.1093","volume":"32","author":[{"given":"Michelle M","family":"Denomme","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Blair R","family":"McCallie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C","family":"Parks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William B","family":"Schoolcraft","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandy G","family":"Katz-Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,10,26]]},"reference":[{"key":"key\n\t\t\t\t20171121073606_ctw010C1","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1095\/biolreprod.106.056499","article-title":"A restricted role for sperm-borne microRNAs in mammalian fertilization","volume":"75","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20171121073606_ctw010C2","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.fertnstert.2015.08.019","article-title":"Aberrant sperm DNA methylation predicts male fertility status and embryo quality","volume":"104","year":"2015","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171121073606_ctw010C3","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/humrep\/deh684","article-title":"Influence of global sperm DNA methylation on IVF results","volume":"20","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171121073606_ctw010C4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1093\/molehr\/gap090","article-title":"The human sperm epigenome and its potential role in embryonic development","volume":"16","year":"2010","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20171121073606_ctw010C5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/humupd\/dmp048","article-title":"World Health Organization reference values for human semen characteristics","volume":"16","year":"2010","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20171121073606_ctw010C6","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.fertnstert.2015.05.003","article-title":"Spermatozoa micro ribonucleic acid-34c level is correlated with intracytoplasmic sperm injection outcomes","volume":"104","year":"2015","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171121073606_ctw010C7","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s10815-012-9715-0","article-title":"Epigenetics and its role in male infertility","volume":"29","year":"2012","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t20171121073606_ctw010C8","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0968-4328(95)00007-0","article-title":"The nuclear status of human sperm cells","volume":"26","year":"1995","journal-title":"Micron"},{"key":"key\n\t\t\t\t20171121073606_ctw010C9","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1111\/andr.12170","article-title":"Intra- and inter-individual differences in human sperm DNA methylation","volume":"4","year":"2016","journal-title":"Andrology"},{"key":"key\n\t\t\t\t20171121073606_ctw010C10","first-page":"378","volume-title":"Toward Reproductive Certainty: Fertility and Genetics Beyond 1999","year":"1999"},{"key":"key\n\t\t\t\t20171121073606_ctw010C11","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1126\/science.3576213","article-title":"Sequence-specific packaging of DNA in human sperm chromatin","volume":"236","year":"1987","journal-title":"Science"},{"key":"key\n\t\t\t\t20171121073606_ctw010C12","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/01.XHA.0000397686.82729.09","article-title":"Unexplained male infertility: potential causes and management","volume":"1","year":"2011","journal-title":"Hum Androl"},{"key":"key\n\t\t\t\t20171121073606_ctw010C13","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1590\/S1677-55382012000500002","article-title":"Unexplained male infertility: diagnosis and management","volume":"38","year":"2012","journal-title":"Int Braz J Urol"},{"key":"key\n\t\t\t\t20171121073606_ctw010C14","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1101\/gad.261925.115","article-title":"Transcription and imprinting dynamics in developing postnatal male germline stem cells","volume":"29","year":"2015","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20171121073606_ctw010C15","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1093\/humrep\/der192","article-title":"Genome-wide analysis identifies changes in histone retention and epigenetic modifications at developmental and imprinted gene loci in the sperm of infertile men","volume":"26","year":"2011","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171121073606_ctw010C16","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1038\/nature08162","article-title":"Distinctive chromatin in human sperm packages genes for embryo development","volume":"460","year":"2009","journal-title":"Nature"},{"key":"key\n\t\t\t\t20171121073606_ctw010C17","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.fertnstert.2009.09.010","article-title":"Alterations in sperm DNA methylation patterns at imprinted loci in two classes of infertility","volume":"94","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171121073606_ctw010C18","doi-asserted-by":"crossref","first-page":"e1289","DOI":"10.1371\/journal.pone.0001289","article-title":"Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm","volume":"2","year":"2007","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20171121073606_ctw010C19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/nar\/gkn923","article-title":"Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists","volume":"37","year":"2009","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20171121073606_ctw010C20","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/nprot.2008.211","article-title":"Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources","volume":"4","year":"2009","journal-title":"Nat Protoc"},{"key":"key\n\t\t\t\t20171121073606_ctw010C21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1093\/humrep\/13.suppl_1.33","article-title":"Epidemiology and aetiology of male infertility","volume":"13","year":"1998","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171121073606_ctw010C22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/ng1089","article-title":"Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals","volume":"33","year":"2003","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20171121073606_ctw010C23","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1111\/andr.12231","article-title":"Teratozoospermia and asthenozoospermia are associated with specific epigenetic signatures","volume":"4","year":"2016","journal-title":"Andrology"},{"key":"key\n\t\t\t\t20171121073606_ctw010C24","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.fertnstert.2015.09.013","article-title":"Decreased fecundity and sperm DNA methylation patterns","volume":"105","year":"2016","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171121073606_ctw010C25","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/molehr\/gau115","article-title":"Intra-sample heterogeneity of sperm DNA methylation","volume":"21","year":"2015","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20171121073606_ctw010C26","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1530\/REP-11-0450","article-title":"The sperm epigenome and potential implications for the developing embryo","volume":"143","year":"2012","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20171121073606_ctw010C27","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrg1654","article-title":"Paternal contribution: new insights and future challenges","volume":"6","year":"2005","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20171121073606_ctw010C28","doi-asserted-by":"crossref","first-page":"1648","DOI":"10.4161\/15592294.2014.988063","article-title":"Epigenetic heterogeneity of developmentally important genes in human sperm: implications for assisted reproduction outcome","volume":"9","year":"2014","journal-title":"Epigenetics"},{"key":"key\n\t\t\t\t20171121073606_ctw010C29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.6061\/clinics\/2013(Sup01)02","article-title":"Novel insights into the genetic and epigenetic paternal contribution to the human embryo","volume":"68","year":"2013","journal-title":"Clinics (Sao Paulo)"},{"key":"key\n\t\t\t\t20171121073606_ctw010C30","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1093\/hmg\/ddu540","article-title":"Epigenetic germline mosaicism in infertile men","volume":"24","year":"2015","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20171121073606_ctw010C31","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13148-016-0256-8","article-title":"DNA methylation: conducting the orchestra from exposure to phenotype?","volume":"8","year":"2016","journal-title":"Clin Epigenetics"},{"key":"key\n\t\t\t\t20171121073606_ctw010C32","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1530\/REP-09-0281","article-title":"Paternal DNA packaging in spermatozoa: more than the sum of its parts? DNA, histones, protamines and epigenetics","volume":"139","year":"2010","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20171121073606_ctw010C33","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0015-0282(16)46750-6","article-title":"Unexplained infertility","volume":"39","year":"1983","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171121073606_ctw010C34","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1743-1050-5-2","article-title":"Paternal effects on early embryogenesis","volume":"5","year":"2008","journal-title":"J Exp Clin Assist Reprod"},{"key":"key\n\t\t\t\t20171121073606_ctw010C35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0079-6603(08)60839-9","article-title":"Vertebrate protamine genes and the histone-to-protamine replacement reaction","volume":"40","year":"1991","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"key":"key\n\t\t\t\t20171121073606_ctw010C36","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1016\/j.fertnstert.2010.08.009","article-title":"Blastocyst gene expression correlates with implantation potential","volume":"95","year":"2011","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20171121073606_ctw010C37","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S0006-291X(89)80208-6","article-title":"Presence of RNA in the sperm nucleus","volume":"158","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20171121073606_ctw010C38","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","year":"2002","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20171121073606_ctw010C39","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1503\/cmaj.050774","article-title":"Epigenetics and human disease: translating basic biology into clinical applications","volume":"174","year":"2006","journal-title":"CMAJ"},{"key":"key\n\t\t\t\t20171121073606_ctw010C40","doi-asserted-by":"crossref","first-page":"4104","DOI":"10.1093\/nar\/gkt132","article-title":"Stability, delivery and functions of human sperm RNAs at fertilization","volume":"41","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20171121073606_ctw010C41","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/ng.864","article-title":"Dynamic CpG island methylation landscape in oocytes and preimplantation embryos","volume":"43","year":"2011","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20171121073606_ctw010C42","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1093\/humrep\/dev053","article-title":"Aberrant DNA methylation patterns of spermatozoa in men with unexplained infertility","volume":"30","year":"2015","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20171121073606_ctw010C43","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1095\/biolreprod.107.067033","article-title":"Birth of mice after intracytoplasmic injection of single purified sperm nuclei and detection of messenger RNAs and MicroRNAs in the sperm nuclei","volume":"78","year":"2008","journal-title":"Biol Reprod"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/32\/12\/2443\/21903632\/dex317.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T01:49:53Z","timestamp":1570153793000},"score":1,"resource":{"primary":{"URL":"http:\/\/academic.oup.com\/humrep\/article\/32\/12\/2443\/4565816"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,26]]},"references-count":43,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2017,10,26]]},"published-print":{"date-parts":[[2017,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dex317","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,12]]},"published":{"date-parts":[[2017,10,26]]}}}