{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T01:34:11Z","timestamp":1792114451195,"version":"4.4.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","funder":[{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["#1002028"],"award-info":[{"award-number":["#1002028"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Victorian Government\u2019s Operational Infrastructure Support Program"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"DOI":"10.1093\/humrep\/dey029","type":"journal-article","created":{"date-parts":[[2018,1,31]],"date-time":"2018-01-31T13:56:12Z","timestamp":1517406972000},"page":"654-665","source":"Crossref","is-referenced-by-count":53,"title":["Obesity associated advanced glycation end products within the human uterine cavity adversely impact endometrial function and embryo implantation competence"],"prefix":"10.1093","volume":"33","author":[{"given":"Gabriella S","family":"Antoniotti","sequence":"first","affiliation":[{"name":"The Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria 3168, Australia"},{"name":"Department of Physiology, Scenic Boulevard, Monash University, Clayton, Victoria 3800, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melinda","family":"Coughlan","sequence":"additional","affiliation":[{"name":"Department of Diabetes, Central Clinical School, Monash University, The Alfred Centre, 99 Commercial Road, Melbourne, Victoria 3004, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lois A","family":"Salamonsen","sequence":"additional","affiliation":[{"name":"The Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria 3168, Australia"},{"name":"Department of Obstetrics and Gynaecology, School of Clinical Sciences at Monash Health, Monash University, Faculty of Medicine, Nursing and Health Sciences, 246 Clayton Road, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3300-8127","authenticated-orcid":false,"given":"Jemma","family":"Evans","sequence":"additional","affiliation":[{"name":"The Hudson Institute of Medical Research, 27-31 Wright Street, Clayton, Victoria 3168, Australia"},{"name":"Department of Molecular and Translational Science, Monash University, 27-31 Wright Street, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,20]]},"reference":[{"key":"key\n\t\t\t\t20180322084310_dey029C1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/abio.1995.1161","article-title":"A nondegradative route for the removal of endotoxin from exopolysaccharides","volume":"225","author":"Adam","year":"1995","journal-title":"Anal Biochem"},{"key":"key\n\t\t\t\t20180322084310_dey029C2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/aji.12462","article-title":"Differential receptor for advanced glycation end products expression in preeclamptic, intrauterine growth restricted, and gestational diabetic placentas","volume":"75","author":"Alexander","year":"2016","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t20180322084310_dey029C3","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.fertnstert.2013.06.001","article-title":"Obesity reduces uterine receptivity: clinical experience from 9,587 first cycles of ovum donation with normal weight donors","volume":"100","author":"Bellver","year":"2013","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180322084310_dey029C4","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1093\/humrep\/deu211","article-title":"Endometrial signals improve embryo outcome: functional role of vascular endothelial growth factor isoforms on embryo development and implantation in mice","volume":"29","author":"Binder","year":"2014","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180322084310_dey029C5","doi-asserted-by":"crossref","first-page":"e0163096","DOI":"10.1371\/journal.pone.0163096","article-title":"Placental growth factor is secreted by the human endometrium and has potential important functions during embryo development and implantation","volume":"11","author":"Binder","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180322084310_dey029C6","doi-asserted-by":"crossref","first-page":"5430","DOI":"10.1074\/jbc.272.9.5430","article-title":"In vitro kinetic studies of formation of antigenic advanced glycation end products (AGEs). Novel inhibition of post-Amadori glycation pathways","volume":"272","author":"Booth","year":"1997","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180322084310_dey029C7","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.fertnstert.2014.05.005","article-title":"Frequency of euploid miscarriage is increased in obese women with recurrent early pregnancy loss","volume":"102","author":"Boots","year":"2014","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180322084310_dey029C8","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1046\/j.1523-1755.2002.00207.x","article-title":"Pyridoxamine inhibits early renal disease and dyslipidemia in the streptozotocin-diabetic rat","volume":"61","author":"Degenhardt","year":"2002","journal-title":"Kidney Int"},{"key":"key\n\t\t\t\t20180322084310_dey029C9","doi-asserted-by":"crossref","first-page":"3082","DOI":"10.1093\/humrep\/dep303","article-title":"Determinants of pregnancy rate in the donor oocyte model: a multivariate analysis of 450 frozen-thawed embryo transfers","volume":"24","author":"Dessolle","year":"2009","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180322084310_dey029C10","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.fertnstert.2009.07.1005","article-title":"Surrogate obesity negatively impacts pregnancy rates in third-party reproduction","volume":"93","author":"DeUgarte","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180322084310_dey029C11","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.fertnstert.2012.09.046","article-title":"The accuracy and reproducibility of the endometrial receptivity array is superior to histology as a diagnostic method for endometrial receptivity","volume":"99","author":"Diaz-Gimeno","year":"2013","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180322084310_dey029C12","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1095\/biolreprod.113.108175","article-title":"Decidualized human endometrial stromal cells are sensors of hormone withdrawal in the menstrual inflammatory cascade","volume":"90","author":"Evans","year":"2014","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20180322084310_dey029C13","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1093\/humrep\/dev016","article-title":"Dynamic changes in hyperglycosylated human chorionic gonadotrophin throughout the first trimester of pregnancy and its role in early placentation","volume":"30","author":"Evans","year":"2015","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180322084310_dey029C14","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1007\/s001250051587","article-title":"Renoprotective effects of a novel inhibitor of advanced glycation","volume":"44","author":"Forbes","year":"2001","journal-title":"Diabetologia"},{"key":"key\n\t\t\t\t20180322084310_dey029C15","doi-asserted-by":"crossref","first-page":"240","DOI":"10.5935\/1518-0557.20160046","article-title":"Obesity and anovulatory infertility: a review","volume":"20","author":"Giviziez","year":"2016","journal-title":"JBRA Assist Reprod"},{"key":"key\n\t\t\t\t20180322084310_dey029C16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1095\/biolreprod.115.134890","article-title":"Human endometrial exosomes contain hormone-specific cargo modulating trophoblast adhesive capacity: insights into endometrial-embryo interactions","volume":"94","author":"Greening","year":"2016","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20180322084310_dey029C17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nri.2016.62","article-title":"The unfolded protein response in immunity and inflammation","volume":"16","author":"Grootjans","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20180322084310_dey029C18","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1177\/1933719113508815","article-title":"Trophoblast invasion and blood vessel remodeling are altered in a rat model of lifelong maternal obesity","volume":"21","author":"Hayes","year":"2014","journal-title":"Reprod Sci"},{"key":"key\n\t\t\t\t20180322084310_dey029C19","doi-asserted-by":"crossref","first-page":"783","DOI":"10.3109\/14767058.2012.760539","article-title":"Maternal obesity and its effect on placental cell turnover","volume":"26","author":"Higgins","year":"2013","journal-title":"J Matern Fetal Neonatal Med"},{"key":"key\n\t\t\t\t20180322084310_dey029C20","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1016\/j.placenta.2014.05.006","article-title":"Maternal prepregnancy obesity is associated with higher risk of placental pathological lesions","volume":"35","author":"Huang","year":"2014","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20180322084310_dey029C21","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1016\/j.placenta.2013.09.017","article-title":"Advanced glycation end products as an upstream molecule triggers ROS-induced sFlt-1 production in extravillous trophoblasts: a novel bridge between oxidative stress and preeclampsia","volume":"34","author":"Huang","year":"2013","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20180322084310_dey029C22","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1093\/nutrit\/nuv030","article-title":"Effect of diet-derived advanced glycation end products on inflammation","volume":"73","author":"Kellow","year":"2015","journal-title":"Nutr Rev"},{"key":"key\n\t\t\t\t20180322084310_dey029C23","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1093\/humrep\/dew156","article-title":"Influence of embryo culture medium (G5 and HTF) on pregnancy and perinatal outcome after IVF: a multicenter RCT","volume":"31","author":"Kleijkers","year":"2016","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180322084310_dey029C24","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1093\/humrep\/deh389","article-title":"Advanced glycation end products induce secretion of chemokines and apoptosis in human first trimester trophoblasts","volume":"19","author":"Konishi","year":"2004","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180322084310_dey029C25","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/1471-0528.13815","article-title":"Superfertility is more prevalent in obese women with recurrent early pregnancy miscarriage","volume":"123","author":"Ledger","year":"2016","journal-title":"BJOG"},{"key":"key\n\t\t\t\t20180322084310_dey029C26","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1479-828X.2011.01343.x","article-title":"Diet and IVF pilot study: short-term weight loss improves pregnancy rates in overweight\/obese women undertaking IVF","volume":"51","author":"Moran","year":"2011","journal-title":"Aust N Z J Obstet Gynaecol"},{"key":"key\n\t\t\t\t20180322084310_dey029C27","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1016\/j.fertnstert.2003.11.030","article-title":"A critical analysis of the accuracy, reproducibility, and clinical utility of histologic endometrial dating in fertile women","volume":"81","author":"Murray","year":"2004","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180322084310_dey029C28","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.fertnstert.2015.11.008","article-title":"Pregnancy outcomes decline with increasing body mass index: analysis of 239,127 fresh autologous in vitro fertilization cycles from the 2008\u20132010 Society for Assisted Reproductive Technology registry","volume":"105","author":"Provost","year":"2016","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180322084310_dey029C29","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1093\/humrep\/dew048","article-title":"Diet-induced obesity impairs endometrial stromal cell decidualization: a potential role for impaired autophagy","volume":"31","author":"Rhee","year":"2016","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180322084310_dey029C30","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jri.2013.06.002","article-title":"A review of the mechanism for poor placentation in early-onset preeclampsia: the role of autophagy in trophoblast invasion and vascular remodeling","volume":"101\u2013102","author":"Saito","year":"2014","journal-title":"J Reprod Immunol"},{"key":"key\n\t\t\t\t20180322084310_dey029C31","doi-asserted-by":"crossref","first-page":"e10287","DOI":"10.1371\/journal.pone.0010287","article-title":"Natural selection of human embryos: impaired decidualization of endometrium disables embryo-maternal interactions and causes recurrent pregnancy loss","volume":"5","author":"Salker","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180322084310_dey029C32","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1093\/molehr\/gal019","article-title":"Possible involvement of crosstalk cell-adhesion mechanism by endometrial CD26\/dipeptidyl peptidase IV and embryonal fibronectin in human blastocyst implantation","volume":"12","author":"Shimomura","year":"2006","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20180322084310_dey029C33","doi-asserted-by":"crossref","first-page":"3142","DOI":"10.3390\/biom5043142","article-title":"Immune mechanisms linking obesity and preeclampsia","volume":"5","author":"Spradley","year":"2015","journal-title":"Biomolecules"},{"key":"key\n\t\t\t\t20180322084310_dey029C34","doi-asserted-by":"crossref","first-page":"4390","DOI":"10.1091\/mbc.E11-06-0510","article-title":"The eIF2 kinase PERK and the integrated stress response facilitate activation of ATF6 during endoplasmic reticulum stress","volume":"22","author":"Teske","year":"2011","journal-title":"Mol Biol Cell"},{"key":"key\n\t\t\t\t20180322084310_dey029C35","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/humrep\/dem371","article-title":"Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women","volume":"23","author":"van der Steeg","year":"2008","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180322084310_dey029C36","doi-asserted-by":"crossref","first-page":"e41424","DOI":"10.1371\/journal.pone.0041424","article-title":"Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos","volume":"7","author":"Weimar","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180322084310_dey029C37","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1210\/en.2016-1877","article-title":"The endometrial polarity paradox: differential regulation of polarity within secretory-phase human endometrium","volume":"159","author":"Whitby","year":"2018","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20180322084310_dey029C38","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1056\/NEJM199906103402304","article-title":"Time of implantation of the conceptus and loss of pregnancy","volume":"340","author":"Wilcox","year":"1999","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180322084310_dey029C39","author":"World Health Organization","year":"2016"},{"key":"key\n\t\t\t\t20180322084310_dey029C40","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1242\/dev.122846","article-title":"Human stem cells from single blastomeres reveal pathways of embryonic or trophoblast fate specification","volume":"142","author":"Zdravkovic","year":"2015","journal-title":"Development"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/33\/4\/654\/24456934\/dey029.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,22]],"date-time":"2018-03-22T08:55:59Z","timestamp":1521708959000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/33\/4\/654\/4879245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,20]]},"references-count":40,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,2,20]]},"published-print":{"date-parts":[[2018,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dey029","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,4]]},"published":{"date-parts":[[2018,2,20]]}}}