{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:41:37Z","timestamp":1790347297477,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"7","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"DOI":"10.1093\/humrep\/dey087","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T23:09:50Z","timestamp":1522105790000},"page":"1307-1315","source":"Crossref","is-referenced-by-count":35,"title":["Maternal polycystic ovarian syndrome and early offspring development"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1364-0915","authenticated-orcid":false,"given":"Griffith A","family":"Bell","sequence":"first","affiliation":[{"name":"Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeshwari","family":"Sundaram","sequence":"additional","affiliation":[{"name":"Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunni L","family":"Mumford","sequence":"additional","affiliation":[{"name":"Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyojun","family":"Park","sequence":"additional","affiliation":[{"name":"Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Mills","sequence":"additional","affiliation":[{"name":"Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin M","family":"Bell","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Services, University at Albany, State University of New York, 1 University Place, Rensselaer, NY, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Broadney","sequence":"additional","affiliation":[{"name":"Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwina H","family":"Yeung","sequence":"additional","affiliation":[{"name":"Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 6710B Rockledge Drive, Bethesda, MD, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,4,16]]},"reference":[{"key":"key\n\t\t\t\t20180620113740_dey087C1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1348\/000712608X311731","article-title":"Fetal testosterone and autistic traits","volume":"100","author":"Auyeung","year":"2009","journal-title":"Br J Psychol"},{"key":"key\n\t\t\t\t20180620113740_dey087C2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/2040-2392-1-11","article-title":"Foetal testosterone and autistic traits in 18 to 24-month-old children","volume":"1","author":"Auyeung","year":"2010","journal-title":"Mol Autism"},{"key":"key\n\t\t\t\t20180620113740_dey087C3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1005653411471","article-title":"The Autism-Spectrum Quotient (AQ): evidence from Asperger syndrome\/high-functioning autism, males and females, scientists and mathematicians","volume":"31","author":"Baron-Cohen","year":"2001","journal-title":"J Autism Dev Disord"},{"key":"key\n\t\t\t\t20180620113740_dey087C4","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3109\/01443615.2010.485254","article-title":"Umbilical vein testosterone in female infants born to mothers with polycystic ovary syndrome is elevated to male levels","volume":"30","author":"Barry","year":"2010","journal-title":"J Obstet Gynaecol"},{"key":"key\n\t\t\t\t20180620113740_dey087C5","author":"Berkman","year":"2015"},{"key":"key\n\t\t\t\t20180620113740_dey087C6","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1093\/humupd\/dml036","article-title":"A meta-analysis of pregnancy outcomes in women with polycystic ovary syndrome","volume":"12","author":"Boomsma","year":"2006","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20180620113740_dey087C7","volume-title":"Ages & Stages Questionnaires: A Parent-Completed, Child-Monitoring System","author":"Bricker","year":"1999"},{"key":"key\n\t\t\t\t20180620113740_dey087C8","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/ppe.12121","article-title":"Methodology for establishing a population-based birth cohort focusing on couple fertility and children\u2019s development, the upstate kids study","volume":"28","author":"Buck Louis","year":"2014","journal-title":"Paediatr Perinat Epidemiol"},{"key":"key\n\t\t\t\t20180620113740_dey087C9","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/humupd\/dmu022","article-title":"First-trimester exposure to metformin and risk of birth defects: a systematic review and meta-analysis","volume":"20","author":"Cassina","year":"2014","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20180620113740_dey087C10","doi-asserted-by":"crossref","first-page":"P1","DOI":"10.1530\/EJE-14-0253","article-title":"The polycystic ovary syndrome: a position statement from the european society of endocrinology","volume":"171","author":"Conway","year":"2014","journal-title":"Eur J Endocrinol"},{"key":"key\n\t\t\t\t20180620113740_dey087C11","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1097\/AOG.0000000000000852","article-title":"Implications of polycystic ovary syndrome for pregnancy and for the health of offspring","volume":"125","author":"Doherty","year":"2015","journal-title":"Obstet Gynecol"},{"key":"key\n\t\t\t\t20180620113740_dey087C12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.fertnstert.2011.10.022","article-title":"Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis","volume":"97","author":"Dokras","year":"2012","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180620113740_dey087C13","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1210\/er.2015-1018","article-title":"Scientific statement on the diagnostic criteria, epidemiology, pathophysiology, and molecular genetics of polycystic ovary syndrome","volume":"36","author":"Dumesic","year":"2015","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20180620113740_dey087C14","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.psyneuen.2015.06.017","article-title":"Congenital adrenal hyperplasia and risk for psychiatric disorders in girls and women born between 1915 and 2010: a total population study","volume":"60","author":"Engberg","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"key\n\t\t\t\t20180620113740_dey087C15","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.fertnstert.2011.09.024","article-title":"Consensus on women\u2019s health aspects of polycystic ovary syndrome (PCOS): the Amsterdam ESHRE\/ASRM-sponsored 3rd PCOS consensus workshop group","volume":"97","author":"Fauser","year":"2012","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180620113740_dey087C16","doi-asserted-by":"crossref","first-page":"833","DOI":"10.3109\/09513590.2015.1041906","article-title":"Efficacy of metformin on pregnancy complications in women with polycystic ovary syndrome: a meta-analysis","volume":"31","author":"Feng","year":"2015","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20180620113740_dey087C17","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1111\/j.1365-2214.2009.01041.x","article-title":"Concurrent validity of the parent-completed ages and stages questionnaires, 2nd ed. with the Bayley scales of infant development ii in a low-risk sample","volume":"36","author":"Gollenberg","year":"2010","journal-title":"Child Care Health Dev"},{"key":"key\n\t\t\t\t20180620113740_dey087C18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1542\/peds.2012-0765","article-title":"Effectiveness of developmental screening in an urban setting","volume":"131","author":"Guevara","year":"2013","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20180620113740_dey087C19","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.yfrne.2011.02.006","article-title":"Prenatal endocrine influences on sexual orientation and on sexually differentiated childhood behavior","volume":"32","author":"Hines","year":"2011","journal-title":"Front Neuroendocrinol"},{"key":"key\n\t\t\t\t20180620113740_dey087C20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.2217\/WHE.09.39","article-title":"Polycystic ovary syndrome, obesity and reproductive implications","volume":"5","author":"Hirschberg","year":"2009","journal-title":"Womens Health (Lond)"},{"key":"key\n\t\t\t\t20180620113740_dey087C21","doi-asserted-by":"crossref","first-page":"14348","DOI":"10.1073\/pnas.1507514112","article-title":"Maternal testosterone exposure increases anxiety-like behavior and impacts the limbic system in the offspring","volume":"112","author":"Hu","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180620113740_dey087C22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1055\/s-0035-1571195","article-title":"Polycystic ovary syndrome, obesity, and pregnancy","volume":"34","author":"Joham","year":"2016","journal-title":"Semin Reprod Med"},{"key":"key\n\t\t\t\t20180620113740_dey087C23","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/cch.12314","article-title":"Validity of the ages and stages questionnaire to detect risk of developmental coordination disorder in preschoolers","volume":"42","author":"King-Dowling","year":"2016","journal-title":"Child Care Health Dev"},{"key":"key\n\t\t\t\t20180620113740_dey087C24","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1038\/mp.2015.183","article-title":"Maternal polycystic ovary syndrome and the risk of autism spectrum disorders in the offspring: a population-based nationwide study in Sweden","volume":"21","author":"Kosidou","year":"2015","journal-title":"Mol Psychiatry"},{"key":"key\n\t\t\t\t20180620113740_dey087C25","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.biopsych.2016.09.022","article-title":"Maternal polycystic ovary syndrome and risk for attention-deficit\/hyperactivity disorder in the offspring","volume":"82","author":"Kosidou","year":"2017","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20180620113740_dey087C26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.4103\/0974-1208.101012","article-title":"Effects of metformin use in pregnant patients with polycystic ovary syndrome","volume":"5","author":"Kumar","year":"2012","journal-title":"J Hum Reprod Sci"},{"key":"key\n\t\t\t\t20180620113740_dey087C27","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1477-7827-12-98","article-title":"Metformin induces a prompt decrease in LH-stimulated testosterone response in women with PCOS independent of its insulin-sensitizing effects","volume":"12","author":"Kurzthaler","year":"2014","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t20180620113740_dey087C28","doi-asserted-by":"crossref","first-page":"14956","DOI":"10.1073\/pnas.95.25.14956","article-title":"Evidence for a genetic basis for hyperandrogenemia in polycystic ovary syndrome","volume":"95","author":"Legro","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180620113740_dey087C29","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1097\/DBP.0b013e31822552e9","article-title":"Comparison of the asq and peds in screening for developmental delay in children presenting for primary care","volume":"32","author":"Limbos","year":"2011","journal-title":"J Dev Behav Pediatr"},{"key":"key\n\t\t\t\t20180620113740_dey087C30","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.biopsych.2012.05.027","article-title":"Fetal programming effects of testosterone on the reward system and behavioral approach tendencies in humans","volume":"72","author":"Lombardo","year":"2012","journal-title":"Biol Psychiatry"},{"key":"key\n\t\t\t\t20180620113740_dey087C31","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ejogrb.2012.10.015","article-title":"Placental steroidogenesis in pregnant women with polycystic ovary syndrome","volume":"166","author":"Maliqueo","year":"2013","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"key\n\t\t\t\t20180620113740_dey087C32","doi-asserted-by":"crossref","first-page":"S16","DOI":"10.1016\/j.metabol.2008.07.010","article-title":"Prenatal exposure to sex steroid hormones and behavioral\/cognitive outcomes","volume":"57","author":"Manson","year":"2008","journal-title":"Metabolism"},{"key":"key\n\t\t\t\t20180620113740_dey087C33","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nn.2834","article-title":"Reframing sexual differentiation of the brain","volume":"14","author":"McCarthy","year":"2011","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180620113740_dey087C34","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1093\/humupd\/dmv029","article-title":"Pregnancy complications in women with polycystic ovary syndrome","volume":"21","author":"Palomba","year":"2015","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20180620113740_dey087C35","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1016\/j.fertnstert.2009.10.043","article-title":"Pregnancy in women with polycystic ovary syndrome: the effect of different phenotypes and features on obstetric and neonatal outcomes","volume":"94","author":"Palomba","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180620113740_dey087C36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1210\/er.2008-0030","article-title":"Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: a comprehensive review","volume":"30","author":"Palomba","year":"2009","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20180620113740_dey087C37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/humrep\/dev284","article-title":"Pregnancy complications in women with polycystic ovary syndrome: importance of diagnostic criteria or of phenotypic features?","volume":"31","author":"Palomba","year":"2016","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113740_dey087C38","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1365-2265.2012.04443.x","article-title":"Pervasive developmental disorders in children of hyperandrogenic women with polycystic ovary syndrome: a longitudinal case-control study","volume":"77","author":"Palomba","year":"2012","journal-title":"Clin Endocrinol (Oxf)"},{"key":"key\n\t\t\t\t20180620113740_dey087C39","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S0140-6736(88)91612-1","article-title":"Polycystic ovaries\u2014a common finding in normal women","volume":"1","author":"Polson","year":"1988","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180620113740_dey087C40","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.mce.2015.11.030","article-title":"Effect of maternal PCOS and PCOS-like phenotype on the offspring\u2019s health","volume":"435","author":"Puttabyatappa","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t20180620113740_dey087C41","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1056\/NEJMoa0707193","article-title":"Metformin versus insulin for the treatment of gestational diabetes","volume":"358","author":"Rowan","year":"2008","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180620113740_dey087C42","doi-asserted-by":"crossref","first-page":"e1468","DOI":"10.1542\/peds.2012-3313","article-title":"Validity of the ages and stages questionnaires in term and preterm infants","volume":"131","author":"Schonhaut","year":"2013","journal-title":"Pediatrics"},{"key":"key\n\t\t\t\t20180620113740_dey087C43","doi-asserted-by":"crossref","first-page":"2573","DOI":"10.1093\/humrep\/17.10.2573","article-title":"Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization","volume":"17","author":"Sir-Petermann","year":"2002","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113740_dey087C44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2147\/CLEP.S37559","article-title":"Epidemiology, diagnosis, and management of polycystic ovary syndrome","volume":"6","author":"Sirmans","year":"2013","journal-title":"Clin Epidemiol"},{"key":"key\n\t\t\t\t20180620113740_dey087C45","volume-title":"ASQ-3 User\u2019s Guide","author":"Squires","year":"2009"},{"key":"key\n\t\t\t\t20180620113740_dey087C46","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/jpepsy\/22.3.313","article-title":"Revision of a parent-completed development screening tool: ages and stages questionnaires","volume":"22","author":"Squires","year":"1997","journal-title":"J Pediatr Psychol"},{"key":"key\n\t\t\t\t20180620113740_dey087C47","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1056\/NEJMoa1509819","article-title":"Metformin versus placebo in obese pregnant women without diabetes mellitus","volume":"374","author":"Syngelaki","year":"2016","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180620113740_dey087C48","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.acap.2014.08.002","article-title":"Concurrent validity of the ages and stages questionnaires and bayley developmental scales in a general population sample","volume":"15","author":"Veldhuizen","year":"2015","journal-title":"Acad Pediatr"},{"key":"key\n\t\t\t\t20180620113740_dey087C49","doi-asserted-by":"crossref","first-page":"2100","DOI":"10.1210\/jc.2005-1494","article-title":"Heritability of polycystic ovary syndrome in a Dutch twin-family study","volume":"91","author":"Vink","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20180620113740_dey087C50","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1001\/jamapediatrics.2015.4164","article-title":"Examining infertility treatment and early childhood development in the upstate kids study","volume":"170","author":"Yeung","year":"2016","journal-title":"JAMA Pediatr"},{"key":"key\n\t\t\t\t20180620113740_dey087C51","doi-asserted-by":"crossref","first-page":"e4526","DOI":"10.1097\/MD.0000000000004526","article-title":"Effects of metformin on pregnancy outcomes in women with polycystic ovary syndrome: a meta-analysis","volume":"95","author":"Zeng","year":"2016","journal-title":"Medicine (Baltimore)"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/33\/7\/1307\/25071008\/dey087.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T09:22:25Z","timestamp":1570958545000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/33\/7\/1307\/4969924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,4,16]]},"references-count":51,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,4,16]]},"published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dey087","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7]]},"published":{"date-parts":[[2018,4,16]]}}}