{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T23:51:03Z","timestamp":1791417063598,"version":"4.3.3"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,7,1]]},"DOI":"10.1093\/humrep\/dey118","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T07:08:31Z","timestamp":1526281711000},"page":"1322-1330","source":"Crossref","is-referenced-by-count":96,"title":["ICSI does not increase the cumulative live birth rate in non-male factor infertility"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7622-150X","authenticated-orcid":false,"given":"Z","family":"Li","sequence":"first","affiliation":[{"name":"Sydney Medical School, The University of Sydney, Sydney NSW, Australia"},{"name":"Australian Centre for Public and Population Health Research, Faculty of Health, University of Technology Sydney, Sydney NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3656-4284","authenticated-orcid":false,"given":"A Y","family":"Wang","sequence":"additional","affiliation":[{"name":"Australian Centre for Public and Population Health Research, Faculty of Health, University of Technology Sydney, Sydney NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bowman","sequence":"additional","affiliation":[{"name":"Sydney Medical School, The University of Sydney, Sydney NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5988-5865","authenticated-orcid":false,"given":"K","family":"Hammarberg","sequence":"additional","affiliation":[{"name":"Victorian Assisted Reproductive Treatment Authority, Melbourne Vic, Australia"},{"name":"School of Public Health and Preventive Medicine, Monash University, Melbourne Vic, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3685-3553","authenticated-orcid":false,"given":"C","family":"Farquhar","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Johnson","sequence":"additional","affiliation":[{"name":"Victorian Assisted Reproductive Treatment Authority, Melbourne Vic, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N","family":"Safi","sequence":"additional","affiliation":[{"name":"Australian Centre for Public and Population Health Research, Faculty of Health, University of Technology Sydney, Sydney NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"Sullivan","sequence":"additional","affiliation":[{"name":"Australian Centre for Public and Population Health Research, Faculty of Health, University of Technology Sydney, Sydney NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"key":"key\n\t\t\t\t20180620113750_dey118C1","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/humrep\/deg159","article-title":"The use of ICSI for all cases of in-vitro conception","volume":"18","author":"Abu-Hassan","year":"2003","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113750_dey118C2","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.fertnstert.2012.08.026","article-title":"Intracytoplasmic sperm injection (ICSI) for non-male factor infertility: a committee opinion","volume":"98","author":"ASRM","year":"2012","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180620113750_dey118C3","volume-title":"Medicare Benefits Schedule Book","author":"Australian Government Department of Health","year":"2018"},{"key":"key\n\t\t\t\t20180620113750_dey118C4","doi-asserted-by":"crossref","first-page":"2075","DOI":"10.1016\/S0140-6736(00)05179-5","article-title":"Conventional in-vitro fertilisation versus intracytoplasmic sperm injection for the treatment of non-male-factor infertility: a randomised controlled trial","volume":"357","author":"Bhattacharya","year":"2001","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180620113750_dey118C5","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/humrep\/17.3.671","article-title":"Neonatal data on a cohort of 2889 infants born after ICSI (1991\u20131999) and of 2995 infants born after IVF (1983\u20131999)","volume":"17","author":"Bonduelle","year":"2002","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113750_dey118C6","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jama.2014.17985","article-title":"Trends in use of and reproductive outcomes associated with intracytoplasmic sperm injection","volume":"313","author":"Boulet","year":"2015","journal-title":"J Am Med Assoc"},{"key":"key\n\t\t\t\t20180620113750_dey118C7","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1093\/humrep\/dew151","article-title":"Assisted reproductive technology in Europe, 2012: results generated from European registers by ESHRE","volume":"31","author":"Calhaz-Jorge","year":"2016","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113750_dey118C8","first-page":"CD000360","article-title":"Assisted reproductive technologies for male subfertility","volume":"2","author":"Cissen","year":"2016","journal-title":"Cochrane Database Syst Rev"},{"key":"key\n\t\t\t\t20180620113750_dey118C9","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1056\/NEJMoa1008095","article-title":"Reproductive technologies and the risk of birth defects","volume":"366","author":"Davies","year":"2012","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180620113750_dey118C10","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1023\/A:1013171505702","article-title":"A prospective study on oocyte survival rate after ICSI: influence of injection technique and morphological features","volume":"18","author":"Ebner","year":"2001","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t20180620113750_dey118C11","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s10815-005-9008-y","article-title":"A prospective randomized trial of conventional in vitro fertilization versus intracytoplasmic sperm injection in unexplained infertility","volume":"23","author":"Foong","year":"2006","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t20180620113750_dey118C12","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1093\/humrep\/dew247","article-title":"Use of ICSI in IVF cycles in women with tubal ligation does not improve pregnancy or live birth rates","volume":"31","author":"Grimstad","year":"2016","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113750_dey118C13","author":"Harris","year":"2016"},{"key":"key\n\t\t\t\t20180620113750_dey118C14","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.fertnstert.2013.04.038","article-title":"Does intracytoplasmic sperm injection improve the fertilization rate and decrease the total fertilization failure rate in couples with well-defined unexplained infertility? A systematic review and meta-analysis","volume":"100","author":"Johnson","year":"2013","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180620113750_dey118C15","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1093\/humrep\/deu338","article-title":"Association of assisted reproductive technology (ART) treatment and parental infertility diagnosis with autism in ART-conceived children","volume":"30","author":"Kissin","year":"2015","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113750_dey118C16","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s10815-013-0151-6","article-title":"Cumulative live-birth rate in women with polycystic ovary syndrome or isolated polycystic ovaries undergoing in-vitro fertilisation treatment","volume":"31","author":"Li","year":"2014","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t20180620113750_dey118C17","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1056\/NEJMoa1110238","article-title":"Cumulative birth rates with linked assisted reproductive technology cycles","volume":"366","author":"Luke","year":"2012","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180620113750_dey118C18","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1007\/s10815-011-9614-9","article-title":"Should ICSI be recommended routinely in patients with four or fewer oocytes retrieved?","volume":"28","author":"Luna","year":"2011","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t20180620113750_dey118C19","first-page":"2703","article-title":"Cumulative live birth rate: time for a consensus?","volume":"30","author":"Maheshwari","year":"2015","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113750_dey118C20","volume-title":"Introducing Survival and Event History Analysis","author":"Mills","year":"2010"},{"key":"key\n\t\t\t\t20180620113750_dey118C21","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/1477-7827-11-84","article-title":"Obstetric and perinatal outcomes in IVF versus ICSI-conceived pregnancies at a tertiary care center\u2014a pilot study","volume":"11","author":"Nouri","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"key":"key\n\t\t\t\t20180620113750_dey118C22","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1093\/humupd\/dmn032","article-title":"Trends in the use of intracytoplasmatic sperm injection marked variability between countries","volume":"14","author":"Nyboe Andersen","year":"2008","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20180620113750_dey118C23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0140-6736(92)92425-F","article-title":"Pregnancies after intracytoplasmic injection of single spermatozoon into an oocyte","volume":"340","author":"Palermo","year":"1992","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180620113750_dey118C24","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humupd\/dms044","article-title":"Why do singletons conceived after assisted reproduction technology have adverse perinatal outcome? Systematic review and meta-analysis","volume":"19","author":"Pinborg","year":"2013","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20180620113750_dey118C25","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2013"},{"key":"key\n\t\t\t\t20180620113750_dey118C26","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.fertnstert.2005.12.017","article-title":"Oocyte degeneration after intracytoplasmic sperm injection: a multivariate analysis to assess its importance as a laboratory or clinical marker","volume":"85","author":"Rosen","year":"2006","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180620113750_dey118C27","first-page":"194","article-title":"The ICSI procedure from past to future: a systematic review of the more controversial aspects","volume":"22","author":"Rubino","year":"2016","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20180620113750_dey118C28","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1001\/jama.2013.7222","article-title":"Autism and mental retardation among offspring born after in vitro fertilization","volume":"310","author":"Sandin","year":"2013","journal-title":"J Am Med Assoc"},{"key":"key\n\t\t\t\t20180620113750_dey118C29","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/and.12291","article-title":"Comparison of conventional in vitro fertilisation and intracytoplasmic sperm injection outcomes in patients with moderate oligoasthenozoospermia","volume":"47","author":"Shuai","year":"2015","journal-title":"Andrologia"},{"key":"key\n\t\t\t\t20180620113750_dey118C30","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1001\/jama.2015.17296","article-title":"Live-birth rate associated with repeat in vitro fertilization treatment cycles","volume":"314","author":"Smith","year":"2015","journal-title":"J Am Med Assoc"},{"key":"key\n\t\t\t\t20180620113750_dey118C31","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.fertnstert.2009.05.052","article-title":"Calculating cumulative live-birth rates from linked cycles of assisted reproductive technology (ART): data from the Massachusetts SART CORS","volume":"94","author":"Stern","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180620113750_dey118C32","first-page":"119","article-title":"The role of intracytoplasmic sperm injection in non-male factor infertility in advanced maternal age","volume":"32","author":"Tannus","year":"2017","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113750_dey118C33","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1093\/humrep\/des400","article-title":"The risk for four specific congenital heart defects associated with assisted reproductive techniques: a population-based evaluation","volume":"28","author":"Tararbit","year":"2013","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113750_dey118C34","first-page":"556","article-title":"Cumulative live birth rates after one ART cycle including all subsequent frozen-thaw cycles in 1050 women: secondary outcome of an RCT comparing GnRH-antagonist and GnRH-agonist protocols","volume":"32","author":"Toftager","year":"2017","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113750_dey118C35","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1038\/aja.2011.65","article-title":"Male factor infertility and ART","volume":"14","author":"Tournaye","year":"2012","journal-title":"Asian J Androl"},{"key":"key\n\t\t\t\t20180620113750_dey118C36","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/S0140-6736(01)06679-X","article-title":"Conventional insemination versus intracytoplasmic sperm injection","volume":"358","author":"Tucker","year":"2001","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180620113750_dey118C37","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/humrep\/deh061","article-title":"ICSI versus conventional techniques for oocyte insemination during IVF in patients with non-male factor subfertility: a Cochrane review","volume":"19","author":"van Rumste","year":"2004","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180620113750_dey118C38","author":"VARTA","year":"2015"},{"key":"key\n\t\t\t\t20180620113750_dey118C39","volume-title":"Assisted Reproductive Technology in Australia and New Zealand 2005","author":"Wang","year":"2007"},{"key":"key\n\t\t\t\t20180620113750_dey118C40","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.fertnstert.2012.02.053","article-title":"Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis","volume":"97","author":"Wen","year":"2012","journal-title":"Fertil Steril"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/33\/7\/1322\/25071010\/dey118.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T20:41:50Z","timestamp":1571344910000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/33\/7\/1322\/5036092"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,6,12]]},"references-count":40,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,6,12]]},"published-print":{"date-parts":[[2018,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dey118","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,7]]},"published":{"date-parts":[[2018,6,12]]}}}