{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T17:34:05Z","timestamp":1783704845948,"version":"3.55.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,12,24]],"date-time":"2018-12-24T00:00:00Z","timestamp":1545609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"University of Ferrara, FAR"},{"name":"University Hospital of Ferrara\u2010University of Ferrara"},{"name":"Health Ministry, Finalized Research Young Investigators"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,3,1]]},"DOI":"10.1093\/humrep\/dey375","type":"journal-article","created":{"date-parts":[[2018,11,30]],"date-time":"2018-11-30T20:11:48Z","timestamp":1543608708000},"page":"433-440","source":"Crossref","is-referenced-by-count":17,"title":["Footprints of BK and JC polyomaviruses in specimens from females affected by spontaneous abortion"],"prefix":"10.1093","volume":"34","author":[{"given":"A","family":"Tagliapietra","sequence":"first","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine; Section of Pathology, Oncology and Experimental Biology; Laboratories of Cell Biology and Molecular Genetics, University of Ferrara, 64\/B, Fossato di Mortara Street, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J C","family":"Rotondo","sequence":"additional","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine; Section of Pathology, Oncology and Experimental Biology; Laboratories of Cell Biology and Molecular Genetics, University of Ferrara, 64\/B, Fossato di Mortara Street, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Bononi","sequence":"additional","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine; Section of Pathology, Oncology and Experimental Biology; Laboratories of Cell Biology and Molecular Genetics, University of Ferrara, 64\/B, Fossato di Mortara Street, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Mazzoni","sequence":"additional","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine; Section of Pathology, Oncology and Experimental Biology; Laboratories of Cell Biology and Molecular Genetics, University of Ferrara, 64\/B, Fossato di Mortara Street, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Magagnoli","sequence":"additional","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine; Section of Pathology, Oncology and Experimental Biology; Laboratories of Cell Biology and Molecular Genetics, University of Ferrara, 64\/B, Fossato di Mortara Street, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Maritati","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences; Section of Infectious Diseases and Dermatology; University of Ferrara, 8, Aldo Moro Street, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Contini","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences; Section of Infectious Diseases and Dermatology; University of Ferrara, 8, Aldo Moro Street, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Vesce","sequence":"additional","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine, Section of Obstetrics and Gynecology, University of Ferrara, 8, Aldo Moro Street, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Tognon","sequence":"additional","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine; Section of Pathology, Oncology and Experimental Biology; Laboratories of Cell Biology and Molecular Genetics, University of Ferrara, 64\/B, Fossato di Mortara Street, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Martini","sequence":"additional","affiliation":[{"name":"Department of Morphology, Surgery and Experimental Medicine; Section of Pathology, Oncology and Experimental Biology; Laboratories of Cell Biology and Molecular Genetics, University of Ferrara, 64\/B, Fossato di Mortara Street, Ferrara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,12,24]]},"reference":[{"key":"key\n\t\t\t\t2019022601311285900_dey375C1","first-page":"42","article-title":"Occurrence and significance of papovaviruses BK and JC in the urine","volume":"36","author":"Arthur","year":"1989","journal-title":"Prog Med Virol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C2","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1073\/pnas.84.8.2302","article-title":"Three clonal types of keratinocyte with different capacities for multiplication","volume":"84","author":"Barrandon","year":"1987","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C3","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/QCO.0b013e3282f3e6a5","article-title":"Emerging role of Chlamydia and Chlamydia-like organisms in adverse pregnancy outcomes","volume":"21","author":"Baud","year":"2008","journal-title":"Curr Opin Infect Dis"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C4","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1002\/jmv.21923","article-title":"BK virus sequences in specimens from aborted fetuses","volume":"82","author":"Boldorini","year":"2010","journal-title":"J Med Virol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C5","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1099\/vir.0.028571-0","article-title":"Serological evidence of vertical transmission of JC and BK polyomaviruses in humans","volume":"92","author":"Boldorini","year":"2011","journal-title":"J Gen Virol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C6","doi-asserted-by":"crossref","first-page":"5513","DOI":"10.1002\/jcp.26457","article-title":"Serum IgG antibodies from healthy subjects up to 100 years old react to JC polyomavirus","volume":"233","author":"Bononi","year":"2018","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C7","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1002\/(SICI)1099-1654(199712)7:4<219::AID-RMV205>3.0.CO;2-E","article-title":"The structure of the human placenta: implications for initiating and defending against virus infections","volume":"7","author":"Burton","year":"1997","journal-title":"Rev Med Virol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C8","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.4049\/jimmunol.1000289","article-title":"Viral infection of the placenta leads to fetal inflammation and sensitization to bacterial products predisposing to preterm labor","volume":"185","author":"Cardenas","year":"2010","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C9","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1097\/01.TP.0000136257.02830.29","article-title":"Hemorrhagic cystitis in children undergoing bone marrow transplantation: a putative role for simian virus 40","volume":"78","author":"Comar","year":"2004","journal-title":"Transplantation"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C10","doi-asserted-by":"crossref","first-page":"e42880","DOI":"10.1371\/journal.pone.0042880","article-title":"Association between the JC polyomavirus infection and male infertility","volume":"7","author":"Comar","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C11","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/jcp.26952","article-title":"Investigation on silent bacterial infections in specimens from pregnant women affected by spontaneous miscarriage","volume":"234","author":"Contini","year":"2018","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C12","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1093\/oxfordjournals.humrep.a137535","article-title":"Risk factors for spontaneous abortion: a case-control study in France","volume":"6","author":"Coste","year":"1991","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C13","first-page":"1","article-title":"Human papillomavirus in foetal and maternal tissues from miscarriage cases","volume":"8","author":"De Freitas","year":"2018","journal-title":"J Obstet Gynaecol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C14","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1093\/humrep\/17.6.1649","article-title":"Paternal age and maternal age are risk factors for miscarriage; results of a multicentre European study","volume":"17","author":"De la Rochebrochard","year":"2002","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C15","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1002\/ijc.2910610603","article-title":"High incidence of BK virus large-T-antigen-coding sequences in normal human tissues and tumors of different histotypes","volume":"61","author":"De Mattei","year":"1995","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C16","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1093\/infdis\/169.5.1175","article-title":"Polyomavirus latency and human tumors","volume":"169","author":"De Mattei","year":"1994","journal-title":"J Infect Dis"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C17","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1067\/mob.2000.105738","article-title":"Relationship of bacterial vaginosis and mycoplasmas to the risk of spontaneous abortion","volume":"183","author":"Donders","year":"2000","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C18","doi-asserted-by":"crossref","first-page":"6808","DOI":"10.1128\/JVI.74.15.6808-6820.2000","article-title":"Human cytomegalovirus infection of placental cytotrophoblasts in vitro and in utero: implications for transmission and pathogenesis","volume":"74","author":"Fisher","year":"2000","journal-title":"J Virol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C19","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/0042-6822(91)90069-N","article-title":"Amplification and sequencing of the control regions of BK and JC virus from human urine by polymerase chain reaction","volume":"180","author":"Flaegstad","year":"1991","journal-title":"Virology"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C20","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/humupd\/dmv041","article-title":"The role of infection in miscarriage","volume":"22","author":"Giakoumelou","year":"2016","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C21","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/med.20180","article-title":"Neurobiology, pharmacology, and medicinal chemistry of neuropeptide S and its receptor","volume":"3","author":"Guerrini","year":"2010","journal-title":"Med Res Rev"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2353\/jmoldx.2009.070140","article-title":"Detection of chromosome aneuploidies in chorionic villus samples by multiplex ligation-dependent probe amplification","volume":"11","author":"Kooper","year":"2009","journal-title":"J Mol Diagn"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C23","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1093\/humrep\/deh277","article-title":"Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study","volume":"19","author":"Lashen","year":"2004","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C24","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1095\/biolreprod54.3.682","article-title":"Transduction of human trophoblast cells by recombinant adenoviruses is differentiation dependent","volume":"54","author":"MacCalman","year":"1996","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C25","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/j.1471-0528.2006.01193.x","article-title":"Risk factors for first trimester miscarriage \u2013 results from a UK-population-based case-control study","volume":"114","author":"Maconochie","year":"2007","journal-title":"BJOG"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C26","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1081\/CNV-200032937","article-title":"Papilloma and polyoma DNA tumor virus sequences in female genital tumors","volume":"22","author":"Martini","year":"2004","journal-title":"Cancer Invest"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C27","doi-asserted-by":"crossref","first-page":"411","DOI":"10.3389\/fimmu.2017.00411","article-title":"Serum IgG antibodies from pregnant women reacting to mimotopes of simian virus 40 Large T antigen, the viral oncoprotein","volume":"8","author":"Mazzoni","year":"2017","journal-title":"Front Immunol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C28","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/neuonc\/not217","article-title":"Significant prevalence of antibodies reacting with simian virus 40 mimotopes in sera from patients affected by glioblastoma multiforme","volume":"16","author":"Mazzoni","year":"2014","journal-title":"Neuro Oncol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C29","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1002\/hed.23879","article-title":"Serologic investigation of undifferentiated nasopharyngeal carcinoma and simian virus 40 infection","volume":"38","author":"Mazzoni","year":"2016","journal-title":"Head Neck"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C30","doi-asserted-by":"crossref","first-page":"e110923","DOI":"10.1371\/journal.pone.0110923","article-title":"Significant low prevalence of antibodies reacting with simian virus 40 mimotopes in serum samples from patients affected by inflammatory neurologic diseases, including multiple sclerosis","volume":"9","author":"Mazzoni","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C31","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3389\/fonc.2017.00294","article-title":"Detection of Merkel cell polyomavirus DNA in serum samples of healthy blood donors","volume":"7","author":"Mazzoni","year":"2017","journal-title":"Front Oncol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C32","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/j.1600-0897.2010.00836.x","article-title":"The immune system in pregnancy: a unique complexity","volume":"63","author":"Mor","year":"2010","journal-title":"Am J Reprod Immunol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C33","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1182\/blood-2010-09-310557","article-title":"Merkel cell polyomavirus DNA sequences in the buffy coats of healthy blood donors","volume":"117","author":"Pancaldi","year":"2011","journal-title":"Blood"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C34","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fimmu.2017.00236","article-title":"Specific IgG antibodies react to mimotopes of BK polyomavirus, a small DNA tumor virus, in healthy adult sera","volume":"8","author":"Pietrobon","year":"2017","journal-title":"Front Immunol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C35","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/(SICI)1096-9071(199812)56:4<372::AID-JMV14>3.0.CO;2-4","article-title":"Transplacental transmission of human polyomavirus BK","volume":"56","author":"Pietropaolo","year":"1998","journal-title":"J Med Virol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C36","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/S0140-6736(06)69204-0","article-title":"Recurrent miscarriage","volume":"368","author":"Rai","year":"2006","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C37","doi-asserted-by":"crossref","first-page":"3929","DOI":"10.1158\/1078-0432.CCR-16-2899","article-title":"Merkel cell carcinomas arising in autoimmune disease affected patients treated with biologic drugs, including anti-TNF","volume":"23","author":"Rotondo","year":"2017","journal-title":"Clin Cancer Res"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C38","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1001\/jamadermatol.2016.1336","article-title":"Hypermethylation-induced inactivation of the IRF6 gene as a possible early event in progression of vulvar squamous cell carcinoma associated with lichen sclerosus","volume":"152","author":"Rotondo","year":"2016","journal-title":"JAMA Dermatol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C39","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1001\/jamadermatol.2018.1373","article-title":"Association of retinoic acid receptor \u03b2 gene with onset and progression of lichen sclerosus-associated vulvar squamous cell carcinoma","volume":"154","author":"Rotondo","year":"2018","journal-title":"JAMA Dermatol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C40","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1002\/jcp.24808","article-title":"Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes","volume":"230","author":"Rotondo","year":"2015","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C41","doi-asserted-by":"crossref","first-page":"3632","DOI":"10.1093\/humrep\/des319","article-title":"Methylenetetrahydrofolate reductase gene promoter hypermethylation in semen samples of infertile couples correlates with recurrent spontaneous abortion","volume":"27","author":"Rotondo","year":"2012","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C42","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1002\/jcp.25686","article-title":"Tracing males from different continents by genotyping JC polyomavirus in DNA from semen samples","volume":"232","author":"Rotondo","year":"2017","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C43","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1002\/etc.4029","article-title":"Environmental doses of perfluorooctanoic acid change the expression of genes in target tissues of common carp","volume":"37","author":"Rotondo","year":"2018","journal-title":"Environ Toxicol Chem"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C44","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nri803","article-title":"Effects of cigarette smoke on the immune system","volume":"2","author":"Sopori","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C45","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.ajog.2006.05.049","article-title":"Placental inflammation and viral infection are implicated in second trimester pregnancy loss","volume":"195","author":"Srinivas","year":"2006","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C46","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.2174\/092986710793176302","article-title":"Genetic factors as a cause of miscarriage","volume":"17","author":"Suzumori","year":"2010","journal-title":"Curr Med Chem"},{"key":"key\n\t\t\t\t2019022601311285900_dey375C47","doi-asserted-by":"crossref","first-page":"2618","DOI":"10.1002\/cncr.29404","article-title":"Immunologic evidence of a strong association between non-Hodgkin lymphoma and simian virus 40","volume":"121","author":"Tognon","year":"2015","journal-title":"Cancer"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/34\/3\/433\/27979209\/dey375.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T06:36:55Z","timestamp":1551163015000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/34\/3\/433\/5259177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,12,24]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,12,24]]},"published-print":{"date-parts":[[2019,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dey375","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,3]]},"published":{"date-parts":[[2018,12,24]]}}}