{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:18:23Z","timestamp":1788995903486,"version":"build-2803163510"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1093\/humrep\/dez004","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T12:11:36Z","timestamp":1547122296000},"page":"770-779","source":"Crossref","is-referenced-by-count":25,"title":["Gonadoblastoma Y locus genes expressed in germ cells of individuals with dysgenetic gonads and a Y chromosome in their karyotypes include<i>DDX3Y<\/i>and<i>TSPY<\/i>"],"prefix":"10.1093","volume":"34","author":[{"given":"P H","family":"Vogt","sequence":"first","affiliation":[{"name":"Division of Reproduction Genetics, Department of Gynaecol. Endocrinology & Infertility Disorders, Women Hospital, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Besikoglu","sequence":"additional","affiliation":[{"name":"Division of Reproduction Genetics, Department of Gynaecol. Endocrinology & Infertility Disorders, Women Hospital, University of Heidelberg, Heidelberg, Germany"},{"name":"Novum, Center for Reproductive Medicine, Akazienallee 8, Essen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Bettendorf","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes, Children Hospital, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Frank-Herrmann","sequence":"additional","affiliation":[{"name":"Department of Gynaecol. Endocrinology & Infertility Disorders, Women Hospital, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Division of Reproduction Genetics, Department of Gynaecol. Endocrinology & Infertility Disorders, Women Hospital, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Bender","sequence":"additional","affiliation":[{"name":"Division of Reproduction Genetics, Department of Gynaecol. Endocrinology & Infertility Disorders, Women Hospital, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Knauer-Fischer","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes, Children Hospital, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Choukair","sequence":"additional","affiliation":[{"name":"Division of Paediatric Endocrinology and Diabetes, Children Hospital, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Sinn","sequence":"additional","affiliation":[{"name":"Division of Gynaecopathology, Department of Pathology, University Hospital Heidelberg, Im Neuenheimer Feld 224, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y-F C","family":"Lau","sequence":"additional","affiliation":[{"name":"Division of Cell & Developmental Genetics, Department of Medicine, VAMC 111C5, San Francisco, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P H","family":"Heidemann","sequence":"additional","affiliation":[{"name":"Children Hospital Augsburg I, Academic Hospital of University of Munich, Stenglinstra\u03b2e 2, Augsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Strowitzki","sequence":"additional","affiliation":[{"name":"Department of Gynaecol. Endocrinology & Infertility Disorders, Women Hospital, University of Heidelberg, Heidelberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"key\n\t\t\t\t2019040113000867000_dez004C1","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2605.2005.00569.x","article-title":"Dysfunction of the mitotic:meiotic switch as a potential cause of neoplastic conversion of primordial germ cells","volume":"29","author":"Adamah","year":"2006","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C2","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/1066896917744342","article-title":"Malignant mixed germ cell tumour overgrowing a gonadoblastoma in a female with a 46, XX karyotype: a case report","volume":"26","author":"Arafah","year":"2018","journal-title":"Int J Surg Pathol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C3","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/0888-7543(91)90107-P","article-title":"Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY","volume":"11","author":"Arnemann","year":"1991","journal-title":"Genomics"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C55","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2350\/10-12-0943-OA.1","article-title":"FOXL2 and SOX9 distinguish the lineage of the sex cord-stromal cells in gonadoblastomas","volume":"14","author":"Buell-Gutbrod","year":"2011","journal-title":"Pediatr Dev Pathol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C4","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2350\/11-01-0960-OA.1","article-title":"Undifferentiated gonadal tissue, Y chromosome instability, and tumours in XY gonadal dysgenesis","volume":"14","author":"Bergeron","year":"2011","journal-title":"Pediatr Dev Pathol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C5","doi-asserted-by":"crossref","first-page":"498.e1","DOI":"10.1016\/j.jpurol.2017.02.013","article-title":"Frequency of gonadal tumours in complete androgen insensitivity syndrome (CAIS): a retrospective case-series analysis","volume":"13","author":"Chaudhry","year":"2017","journal-title":"J Pediatr Urol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/path.2105","article-title":"OCT4: biological functions and clinical applications as a marker of germ cell neoplasia","volume":"211","author":"Cheng","year":"2007","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C7","first-page":"519","article-title":"Tumour risk and clinical follow-up in patients with disorders of sex development","volume":"9","author":"Cools","year":"2011","journal-title":"Pediatr Endocrinol Rev"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C8","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1159\/000477921","article-title":"Update on the pathophysiology and risk factors for the development of malignant testicular germ cell tumours in complete androgen insensitivity syndrome","volume":"11","author":"Cools","year":"2017","journal-title":"Sex Dev"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s12519-009-0020-7","article-title":"Disorders of sex development: update on the genetic background, terminology and risk for the development of germ cell tumours","volume":"5","author":"Cools","year":"2009","journal-title":"World J Pediatr"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C10","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1210\/jc.2005-2554","article-title":"Gonadoblastoma arising in undifferentiated gonadal tissue within dysgenetic gonads","volume":"91","author":"Cools","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C11","doi-asserted-by":"crossref","first-page":"5295","DOI":"10.1210\/jc.2005-0139","article-title":"Morphological and immunohistochemical differences between gonadal maturation delay and early germ cell neoplasia in patients with undervirilization syndromes","volume":"90","author":"Cools","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C12","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.1093\/hmg\/ddh240","article-title":"The AZFa gene DBY (DDX3Y) is widely transcribed but the protein is limited to the male germ cells by translation control","volume":"13","author":"Ditton","year":"2004","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1186\/1471-2350-14-115","article-title":"Screening of Y chromosome microdeletions in 46,XY partial gonadal dysgenesis and in patients with a 45,X\/46,XY karyotype or its variants","volume":"14","author":"Dos Santos","year":"2013","journal-title":"BMC Med Genet"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C14","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1093\/humrep\/des047","article-title":"AZFa protein DDX3Y is differentially expressed in human male germ cells during development and in testicular tumours: new evidence for phenotypic plasticity of germ cells","volume":"27","author":"Gueler","year":"2012","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C15","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/path.1890","article-title":"Testicular development in the complete androgen insensitivity syndrome","volume":"208","author":"Hannema","year":"2006","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mce.2008.02.028","article-title":"New insights into type II germ cell tumour pathogenesis based on studies of patients with various forms of disorders of sex development (DSD)","volume":"291","author":"Hersmus","year":"2008","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C17","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/(SICI)1096-9896(199912)189:4<623::AID-PATH475>3.0.CO;2-#","article-title":"Detection of TSPY protein in a unilateral microscopic gonadoblastoma of a Turner mosaic patient with a Y-derived marker chromosome","volume":"189","author":"Hildenbrand","year":"1999","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C18","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1016\/S0140-6736(12)60071-3","article-title":"Androgen insensitivity syndrome","volume":"380","author":"Hughes","year":"2012","journal-title":"Lancet"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jpurol.2006.03.004","article-title":"Lawson Wilkins Pediatric Endocrine Society\/European Society for Paediatric Endocrinology Consensus Group. Consensus statement on management of intersex disorders","volume":"2","author":"Hughes","year":"2006","journal-title":"J Pediatr Urol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C20","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/modpathol.2013.193","article-title":"Complete androgen insensitivity syndrome: factors influencing gonadal histology including germ cell pathology","volume":"27","author":"Kaprova-Pleskacova","year":"2014","journal-title":"Mod Pathol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C21","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/sj.embor.7400279","article-title":"Oct4 is required for primordial germ cell survival","volume":"5","author":"Kehler","year":"2004","journal-title":"EMBO Rep"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C22","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.humpath.2005.02.016","article-title":"Identification of germ cells at risk for neoplastic transformation in gonadoblastoma: an immunohistochemical study for OCT3\/4 and TSPY","volume":"36","author":"Kersemaekers","year":"2005","journal-title":"Hum Pathol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C23","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3390\/genes1020283","article-title":"Expression of the Y-encoded TSPY is associated with progression of prostate cancer","volume":"1","author":"Kido","year":"2010","journal-title":"Genes (Basel)"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C24","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1016\/j.humpath.2014.05.002","article-title":"The potential contributions of a Y-located protooncogene and its X homologue in sexual dimorphisms in hepatocellular carcinoma","volume":"45","author":"Kido","year":"2014","journal-title":"Hum Pathol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C25","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1086\/302353","article-title":"Gonadoblastoma, testicular and prostate cancers, and the TSPY gene","volume":"64","author":"Lau","year":"1999","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/bdrc.20144","article-title":"Gonadoblastoma locus and the TSPY gene on the human Y chromosome","volume":"87","author":"Lau","year":"2009","journal-title":"Birth Defects Res C Embryo Today"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C27","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3109\/19396368.2010.499157","article-title":"Role of the Y-located putative gonadoblastoma gene in human spermatogenesis","volume":"57","author":"Lau","year":"2011","journal-title":"Syst Biol Reprod Med"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.beem.2009.10.002","article-title":"Gonadal tumours and DSD","volume":"24","author":"Looijenga","year":"2010","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C29","first-page":"2244","article-title":"POU5F1 (OCT3\/4) identifies cells with pluripotent potential in human germ cell tumours","volume":"63","author":"Looijenga","year":"2003","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C30","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/1687-9856-2014-4","article-title":"State of the art review in gonadal dysgenesis: challenges in diagnosis and management","volume":"2014","author":"McCann-Crosby","year":"2014","journal-title":"Int J Pediatr Endocrinol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C31","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/molehr\/gag031","article-title":"Accelerated germ cell apoptosis in sex chromosome aneuploid fetal human gonads","volume":"9","author":"Modi","year":"2003","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C32","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1210\/jcem-59-4-785","article-title":"Morphometry and histology of gonads from twelve children and adolescents with the androgen insensitivity (testicular feminization) syndrome","volume":"59","author":"Mueller","year":"1984","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C33","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1210\/jc.2013-3690","article-title":"Disorders of sex development (DSDs): an update","volume":"99","author":"Ostrer","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C34","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1242\/dev.101.Supplement.151","article-title":"Hypothesis: a Y-chromosomal gene causes gonadoblastoma in dysgenetic gonads","volume":"101","author":"Page","year":"1987","journal-title":"Development"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C35","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1093\/humrep\/deh265","article-title":"Developmental expression of POU5F1 (OCT-3\/4) in normal and dysgenetic human gonads","volume":"19","author":"Rajpert-De Meyts","year":"2004","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C36","doi-asserted-by":"crossref","first-page":"15041","DOI":"10.1038\/srep15041","article-title":"DDX3Y gene rescue of a Y chromosome AZFa deletion restores germ cell formation and transcriptional programs","volume":"5","author":"Ramathal","year":"2015","journal-title":"Sci Rep"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C37","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00004347-199104000-00002","article-title":"The androgen insensitivity syndrome (testicular feminization): a clinicopathologic study of 43 cases","volume":"10","author":"Rutgers","year":"1991","journal-title":"Int J Gynecol Pathol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C38","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1093\/hmg\/5.11.1801","article-title":"Testis-specific protein, Y-encoded (TSPY) expression in testicular tissues","volume":"5","author":"Schnieders","year":"1996","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C39","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1095\/biolreprod.107.067025","article-title":"TSPY expression is variably altered in transgenic mice with testicular feminization","volume":"79","author":"Schubert","year":"2008","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C40","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/humrep\/der018","article-title":"Variable expression of the Fragile X Mental Retardation 1 (FMR1) gene in patients with premature ovarian failure syndrome is not dependent on number of (CGG)n triplets in exon 1","volume":"26","author":"Schuettler","year":"2011","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C41","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/1097-0142(195305)6:3<455::AID-CNCR2820060303>3.0.CO;2-U","article-title":"Gonadoblastoma: a gonadal tumour reletade to the dysgereminoma (seminoma) and capable of sex-hormone production","volume":"6","author":"Scully","year":"1953","journal-title":"Cancer"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C42","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1002\/1097-0142(197006)25:6<1340::AID-CNCR2820250612>3.0.CO;2-N","article-title":"Gonadoblastoma. A review of 74 cases","volume":"25","author":"Scully","year":"1970","journal-title":"Cancer"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C43","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.yexcr.2004.07.005","article-title":"Human DDX3Y, the Y-encoded isoform of RNA helicase DDX3, rescues a hamster temperature-sensitive ET24 mutant cell line with a DDX3X mutation","volume":"300","author":"Sekiguchi","year":"2004","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C44","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/nature01722","article-title":"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes","volume":"423","author":"Skaletsky","year":"2003","journal-title":"Nature"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C45","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1016\/j.bbrc.2018.07.145","article-title":"OCT4 directly regulates stemness and extracellular matrix-related genes in human germ cell tumours","volume":"503","author":"Song","year":"2018","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C46","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mce.2018.04.004","article-title":"A brief history of sex determination","volume":"468","author":"St\u00e9vant","year":"2018","journal-title":"Mol Cell Endocrinol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C47","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1053\/j.semdp.2014.07.001","article-title":"Gonadoblastoma and selected other aspects of gonadal pathology in young patients with disorders of sex development","volume":"31","author":"Ulbright","year":"2014","journal-title":"Semin Diagn Pathol"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C48","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0165-4608(87)90180-4","article-title":"Abnormal sexual differentiation and neoplasia","volume":"25","author":"Verp","year":"1987","journal-title":"Cancer Genet Cytogenet"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C49","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.beem.2009.10.004","article-title":"Surgical options in disorders of sex development (dsd) with ambiguous genitalia","volume":"24","author":"Vidal","year":"2010","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C50","first-page":"187","volume-title":"Spermatogenesis and Spermiogenesis: in: \u2018Meth Mol Biol\u2019","author":"Vogt","year":"2012"},{"key":"key\n\t\t\t\t2019040113000867000_dez004C51","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1142\/9789812770431_0005","volume-title":"The Y Chromosome and Male Germ Cell Biology in Health and Diseases","author":"Vogt","year":"2007"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/34\/4\/770\/28257586\/dez004.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T01:40:54Z","timestamp":1662774054000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/34\/4\/770\/5316209"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,12]]},"references-count":52,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,2,12]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dez004","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2019,2,12]]}}}