{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T08:21:03Z","timestamp":1765700463176,"version":"3.37.3"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T00:00:00Z","timestamp":1549929600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIH Men\u2019s Reproductive Health Research","award":["HD073917"],"award-info":[{"award-number":["HD073917"]}]},{"name":"Multidisciplinary K12 Urologic Research"},{"name":"Career Development Program","award":["P01HD36289"],"award-info":[{"award-number":["P01HD36289"]}]},{"name":"Eunice Kennedy Shriver National Institute for Child Health and Human Development","award":["U01DD000494"],"award-info":[{"award-number":["U01DD000494"]}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Title V Block Grant to the Texas Department of State Health Services"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Mentored Career Development Award","award":["K08DK115835-01"],"award-info":[{"award-number":["K08DK115835-01"]}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006280","name":"Urology Care Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006280","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,4,1]]},"DOI":"10.1093\/humrep\/dez005","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T23:30:42Z","timestamp":1548718242000},"page":"733-739","source":"Crossref","is-referenced-by-count":8,"title":["The risk of birth defects is not associated with semen parameters or mode of conception in offspring of men visiting a reproductive health clinic"],"prefix":"10.1093","volume":"34","author":[{"given":"Alexander W","family":"Pastuszak","sequence":"first","affiliation":[{"name":"Division of Urology, Department of Surgery, University of Utah School of Medicine, Salt Lake City, UT, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amin S","family":"Herati","sequence":"additional","affiliation":[{"name":"The James Buchanan Brady Urological Institute and Department of Urology, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5482-0141","authenticated-orcid":false,"given":"Michael L","family":"Eisenberg","sequence":"additional","affiliation":[{"name":"Department of Urology, Stanford University School of Medicine, Palo Alto, CA, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cenk","family":"Cengiz","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA"},{"name":"Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter H","family":"Langlois","sequence":"additional","affiliation":[{"name":"Texas Department of State Health Services, Birth Defects Epidemiology and Surveillance Branch, Austin, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taylor P","family":"Kohn","sequence":"additional","affiliation":[{"name":"Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dolores J","family":"Lamb","sequence":"additional","affiliation":[{"name":"Department of Urology, Weill Cornell Medical College, New York, NY, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Larry I","family":"Lipshultz","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX, USA"},{"name":"Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,2,12]]},"reference":[{"key":"key\n\t\t\t\t2019040113003861300_dez005C1","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/pd.4282","article-title":"Prenatal diagnosis of nonsyndromic congenital heart defects","volume":"34","author":"Ailes","year":"2014","journal-title":"Prenat Diagn"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C2","first-page":"1","article-title":"Update on overall prevalence of major birth defects\u2014Atlanta, Georgia, 1978\u20132005","volume":"57","author":"Centers for Disease Control and Prevention (CDC)","year":"2008","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C3","first-page":"1","article-title":"Fertility, family planning, and reproductive health of U.S. women: data from the 2002 National Survey of Family Growth","volume":"25","author":"Chandra","year":"2005","journal-title":"Vital Health Stat 23"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C4","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1093\/aje\/kwx169","article-title":"What does a single semen sample tell you? Implications for male factor infertility research","volume":"186","author":"Chiu","year":"2017","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C5","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1056\/NEJMoa1008095","article-title":"Reproductive technologies and the risk of birth defects","volume":"366","author":"Davies","year":"2012","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C6","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.eururo.2005.06.002","article-title":"EAU guidelines on male infertility","volume":"48","author":"Dohle","year":"2005","journal-title":"Eur Urol"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C7","doi-asserted-by":"crossref","first-page":"e12","DOI":"10.1016\/j.fertnstert.2013.06.025","article-title":"Increased cancer risk and azoospermia","volume":"100","author":"Eisenberg","year":"2013","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C8","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.fertnstert.2013.05.022","article-title":"Increased risk of cancer among azoospermic men","volume":"100","author":"Eisenberg","year":"2013","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C9","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1093\/humrep\/deu106","article-title":"Semen quality, infertility and mortality in the USA","volume":"29","author":"Eisenberg","year":"2014","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C10","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.fertnstert.2014.10.017","article-title":"Relationship between semen production and medical comorbidity","volume":"103","author":"Eisenberg","year":"2015","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C11","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.juro.2014.11.080","article-title":"Increased risk of cancer in infertile men: analysis of US claims data","volume":"193","author":"Eisenberg","year":"2015","journal-title":"J Urol"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C12","doi-asserted-by":"crossref","first-page":"141","DOI":"10.6061\/clinics\/2013(Sup01)16","article-title":"Reproductive outcomes, including neonatal data, following sperm injection in men with obstructive and nonobstructive azoospermia: case series and systematic review","volume":"68","author":"Esteves","year":"2013","journal-title":"Clinics (Sao Paulo)"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C13","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/humrep\/des377","article-title":"Neonatal outcome and congenital malformations in children born after ICSI with testicular or epididymal sperm: a controlled national cohort study","volume":"28","author":"Fedder","year":"2013","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C14","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1056\/NEJMoa003005","article-title":"Sperm morphology, motility, and concentration in fertile and infertile men","volume":"345","author":"Guzick","year":"2001","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C15","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/humrep\/deh593","article-title":"Assisted reproductive technologies and the risk of birth defects\u2014a systematic review","volume":"20","author":"Hansen","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C16","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1001\/jamapediatrics.2013.4858","article-title":"Genetic epidemiology and nonsyndromic structural birth defects: from candidate genes to epigenetics","volume":"168","author":"Hobbs","year":"2014","journal-title":"JAMA Pediatr"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C17","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/nrurol.2010.230","article-title":"Contemporary concepts in the evaluation and management of male infertility","volume":"8","author":"Hwang","year":"2011","journal-title":"Nat Rev Urol"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C18","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1111\/j.1749-6632.2010.05917.x","article-title":"Mendelian genetics of male infertility","volume":"1214","author":"Hwang","year":"2010","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C19","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1136\/bmj.321.7264.789","article-title":"Risk of testicular cancer in men with abnormal semen characteristics: cohort study","volume":"321","author":"Jacobsen","year":"2000","journal-title":"Br Med J"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C20","doi-asserted-by":"crossref","first-page":"e1001356","DOI":"10.1371\/journal.pmed.1001356","article-title":"National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys","volume":"9","author":"Mascarenhas","year":"2012","journal-title":"PLoS Med"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C21","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1038\/nm.f.1895","article-title":"The biology of infertility: research advances and clinical challenges","volume":"14","author":"Matzuk","year":"2008","journal-title":"Nat Med"},{"volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","year":"2010","author":"Organization WH","key":"key\n\t\t\t\t2019040113003861300_dez005C22"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C23","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1097\/01.ju.0000177491.98461.aa","article-title":"Increased incidence of testicular cancer in men presenting with infertility and abnormal semen analysis","volume":"174","author":"Raman","year":"2005","journal-title":"J Urol"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C24","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.fertnstert.2014.12.113","article-title":"Congenital anomalies in offspring of subfertile couples: a registry-based study in the northern Netherlands","volume":"103","author":"Seggers","year":"2015","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C25","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1093\/oxfordjournals.humrep.a137433","article-title":"Incidence and main causes of infertility in a resident population (1,850,000) of three French regions (1988\u20131989)","volume":"6","author":"Thonneau","year":"1991","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C26","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.fertnstert.2012.02.053","article-title":"Birth defects in children conceived by in vitro fertilization and intracytoplasmic sperm injection: a meta-analysis","volume":"97","author":"Wen","year":"2012","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2019040113003861300_dez005C27","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1136\/bmj.38919.495718.AE","article-title":"Infertility, infertility treatment, and congenital malformations: Danish national birth cohort","volume":"333","author":"Zhu","year":"2006","journal-title":"Br Med J"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/34\/4\/733\/28257632\/dez005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T13:01:33Z","timestamp":1554123693000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/34\/4\/733\/5316204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,12]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,2,12]]},"published-print":{"date-parts":[[2019,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dez005","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"type":"print","value":"0268-1161"},{"type":"electronic","value":"1460-2350"}],"subject":[],"published-other":{"date-parts":[[2019,4]]},"published":{"date-parts":[[2019,2,12]]}}}