{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:07:47Z","timestamp":1775142467355,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,10,17]],"date-time":"2019-10-17T00:00:00Z","timestamp":1571270400000},"content-version":"vor","delay-in-days":16,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Shanghai Ninth People\u2019s Hospital Foundation of China","award":["JYLJ030"],"award-info":[{"award-number":["JYLJ030"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31770989"],"award-info":[{"award-number":["31770989"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Study question<\/jats:title>\n                  <jats:p>Is there any association between the number of oocytes retrieved and neonatal outcomes following IVF\/ICSI treatment for patients using a freeze-all strategy?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Summary answer<\/jats:title>\n                  <jats:p>There was no increased risk of adverse neonatal outcomes in cycles with high number of oocytes retrieved (\u2265 16) compared to those with 10\u201315 oocytes retrieved in freeze-all cycles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>What is known already<\/jats:title>\n                  <jats:p>Recent studies have found that there is an increased risk of preterm birth (PTB, &lt;37\u00a0weeks gestation) and low birth weight (LBW, &lt;2500\u00a0g) following IVF in women with a high number (&gt;20) of oocytes retrieved in fresh embryo transfer (ET) cycles. Other studies have found that there is an association between the number of oocytes retrieved and placenta praevia. However, the association between the number of oocytes retrieved and neonatal outcomes when using a freeze-all strategy is unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study design, size, duration<\/jats:title>\n                  <jats:p>This retrospective cohort study included 14\u2009170 women with singleton deliveries achieved by a freeze-all strategy performed between November 2006 and December 2017 in China. Only the first delivery from one episode of ovarian stimulation was included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants\/materials, setting, methods<\/jats:title>\n                  <jats:p>Only cycles using a freeze-all strategy performed during the study period and resulting in singleton live births were included. Patients were categorized into five groups according to the number of oocytes retrieved: 1\u20133, 4\u20139, 10\u201315, 16\u201320 or &gt;20 oocytes. In univariate and multivariate logistic regression analysis of the association between ovarian response and the outcomes of PTB, early PTB, LBW and other neonatal outcomes, the 10 to 15 oocyte category was used as a reference and other four groups were analysed as dummy variables. Multiple linear regression analysis was used to evaluate possible associations of birth weight z-scores and the number of oocytes retrieved (analysed as a continuous variable) with other confounding factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Main results and the role of chance<\/jats:title>\n                  <jats:p>After adjusted for confounding factors, no significant differences were observed in the risk of PTB (P\u00a0=\u20090.837), LBW (P\u00a0=\u20090.974), early PTB (P\u00a0=\u20090.341), very LBW (P\u00a0=\u20090.848), congenital malformation (P\u00a0=\u20090.916) and other adverse neonatal outcome among patients with different number of oocytes retrieved. There was a higher risk of early PTB among women with a poor ovarian response (1\u20133 oocytes) compared with women with a normal response (10\u201315 oocytes) (1.5% vs 0.8%), crude odds ratio (OR): 2.001, 95% CI: 1.159\u20133.465, P\u00a0=\u20090.013. However, the difference was not significant after adjusting for confounders, adjusted OR: 1.753, 95% CI: 0.997\u20133.081, P\u00a0=\u20090.051.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Limitations, reasons for caution<\/jats:title>\n                  <jats:p>Data on some known confounders such as smoking and medical history of gestational diabetes mellitus and preeclampsia were lacking. As with any retrospective study, unknown confounders may affect outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Wider implications of the findings<\/jats:title>\n                  <jats:p>In the freeze-all cycles, there was no association between number of oocytes retrieved and adverse neonatal outcomes. This is a reassuring finding for both clinicians and patients who are planning to use freeze-all cycles for a variety of indications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Study funding\/competing interest(S)<\/jats:title>\n                  <jats:p>Grants from the National Natural Science Foundation of China (NSFC) (31770989 to Y.W.) and the Shanghai Ninth People\u2019s Hospital Foundation of China (JYLJ030 to Y.W.). None of the authors have any conflicts of interest to declare.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/dez137","type":"journal-article","created":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T15:28:38Z","timestamp":1567610918000},"page":"1937-1947","source":"Crossref","is-referenced-by-count":14,"title":["Association between the number of oocytes retrieved and neonatal outcomes after freeze-all IVF cycles"],"prefix":"10.1093","volume":"34","author":[{"given":"Xiaoyan","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People\u2019s Hospital Affiliated with JiaoTong University School of Medicine, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People\u2019s Hospital Affiliated with JiaoTong University School of Medicine, Shanghai, 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