{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T04:17:29Z","timestamp":1768450649385,"version":"3.49.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T00:00:00Z","timestamp":1575417600000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["140137\/2015-7"],"award-info":[{"award-number":["140137\/2015-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["309397\/2016-2"],"award-info":[{"award-number":["309397\/2016-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["471943\/2012-6"],"award-info":[{"award-number":["471943\/2012-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sao Paulo Research Foundation","award":["2011\/17614-6"],"award-info":[{"award-number":["2011\/17614-6"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>Compared to healthy women, is the profile of transcripts altered in the eutopic endometrium of infertile women with endometriosis during the implantation window (IW)?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>The eutopic endometrium of infertile women with endometriosis seems to be transcriptionally similar to the endometrium of infertile and fertile controls (FC) during the IW.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>Endometriosis is a disease related to infertility; nevertheless, little is known regarding the ethiopathogenic mechanisms underlying this association. Some studies evaluating the eutopic endometrium of endometriosis patients suggest there is an endometrial factor involved in the disease-related infertility. However, no study to date has evaluated the endometrial transcriptome (mRNA and miRNA) by next generation sequencing (NGS), comparing patients with endometriosis as the exclusive infertility factor (END) to infertile controls (IC; male and\/or tubal factor) and FC.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>From November 2011 to November 2015 we performed a case-control study, where 17 endometrial samples (six END, six IC, five FC) were collected during the IW.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>All endometrial samples had the RNA extracted. Two libraries were prepared for each one (mRNA and miRNA), which were sequenced, respectively, at HISEQ 2500 (RNA-Seq) and MiSeq System (miRNA-Seq), Illumina. The normalization and differential expression were conducted in statistical R environment using DESeq2 package. qPCR was used for data validation, which were analyzed by Kruskal\u2013Wallis test and Dunn posttest (P\u00a0&amp;lt;\u20090.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>RNA-Seq revealed no differentially expressed genes (DEG) among END, IC and FC groups. miRNA-Seq revealed three differentially expressed miRNAs (has-27a-5p, has-miR-150-5p, has-miR-504-5p) in END group compared to FC group. However, none of the miRNAs identified in the sequencing was validated by qPCR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>The main limitation of this study was the small sample size evaluated as a result of the restrictive eligibility criteria adopted, limiting the generalization of the results obtained here. On the other hand, strict eligibility criteria, which eliminated factors potentially related to impaired endometrial receptivity, were required to increase the study\u2019s internal validity.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>This study brings new perspectives on the mechanisms involved in endometriosis-related infertility. The present findings suggest the eutopic endometrium of infertile women with endometriosis, without considering the disease\u2019s stage, is transcriptionally similar to controls during the IW, possibly not affecting receptivity. Further studies are needed to evaluate endometrial alterations related to endometriosis\u2019 stages.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>This study received financial support from the Sao Paulo Research Foundation (FAPESP\u2014Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo; fellowship 2011\/17614\u20136, MGB) and from the National Council for Scientific and Technological Development (CNPq\u2014Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico; INCT\u2014National Institutes of Hormones and Woman\u2019s Health, grant 471\u2009943\/2012-6, 309\u2009397\/2016-2, PAN; fellowship 140\u2009137\/2015-7, MGB). The authors have no conflicts of interest.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>TRIAL REGISTRATION NUMBER<\/jats:title>\n                  <jats:p>N\/A.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/dez225","type":"journal-article","created":{"date-parts":[[2019,11,15]],"date-time":"2019-11-15T07:11:12Z","timestamp":1573801872000},"page":"2381-2390","source":"Crossref","is-referenced-by-count":29,"title":["Is the profile of transcripts altered in the eutopic endometrium of infertile women with endometriosis during the implantation window?"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4256-0228","authenticated-orcid":false,"given":"M G","family":"Da Broi","sequence":"first","affiliation":[{"name":"Division of Human Reproduction, Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Meola","sequence":"additional","affiliation":[{"name":"Division of Human Reproduction, Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J R","family":"Pla\u00e7a","sequence":"additional","affiliation":[{"name":"Center for Integrative Systems Biology\u2014CISBi, NAP\/USP, Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K C","family":"Peronni","sequence":"additional","affiliation":[{"name":"Center for Medical Genomics, Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto (HCFMRP)\/University of Sao Paulo (USP), Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"C V","family":"Rocha","sequence":"additional","affiliation":[{"name":"Division of Human Reproduction, Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"W A","family":"Silva","sequence":"additional","affiliation":[{"name":"Center for Integrative Systems Biology\u2014CISBi, NAP\/USP, Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil"},{"name":"Center for Medical Genomics, Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto (HCFMRP)\/University of Sao Paulo (USP), Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil"},{"name":"Department of Genetics, Ribeirao Preto Medical School, University of Sao Paulo, Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Ferriani","sequence":"additional","affiliation":[{"name":"Division of Human Reproduction, Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil"},{"name":"National Institute of Hormones and Woman\u2019s Health, National Council for Scientific and Technological Development (CNPq), Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P A","family":"Navarro","sequence":"additional","affiliation":[{"name":"Division of Human Reproduction, Department of Gynecology and Obstetrics, Ribeirao Preto Medical School, University of Sao Paulo, Avenida Bandeirantes, 3900, Ribeirao Preto, SP, 14049-900, Brazil"},{"name":"National Institute of Hormones and Woman\u2019s Health, National Council for Scientific and Technological Development (CNPq), Porto Alegre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"2019123012283723700_ref1","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1093\/molehr\/gah053","article-title":"Cyr61, a deregulated gene in endometriosis","volume":"10","author":"Absenger","year":"2004","journal-title":"Mol Hum Reprod"},{"key":"2019123012283723700_ref2","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1093\/humupd\/dmt048","article-title":"Guidelines for the design, analysis and interpretation of `omics\u2019 data: focus on human endometrium","volume":"20","author":"Altmae","year":"2014","journal-title":"Hum Reprod Update"},{"key":"2019123012283723700_ref3","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0015-0282(97)81391-X","article-title":"Revised American Society for Reproductive Medicine classification of endometriosis: 1996","volume":"67","author":"American Society for Reproductive Medicine","year":"1997","journal-title":"Fertil Steril"},{"key":"2019123012283723700_ref4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1093\/bioinformatics\/btu638","article-title":"HTSeq\u2014a Python framework to work with high-throughput sequencing data","volume":"31","author":"Anders","year":"2015","journal-title":"Bioinformatics"},{"key":"2019123012283723700_ref6","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1177\/1933719115585145","article-title":"Abundance and localization of progesterone receptor isoforms in endometrium in women with and without endometriosis and in peritoneal and ovarian endometriotic implants","volume":"22","author":"Bedaiwy","year":"2015","journal-title":"Reprod Sci"},{"key":"2019123012283723700_ref7","doi-asserted-by":"crossref","first-page":"196","DOI":"10.5935\/1518-0557.20170038","article-title":"Expression of PGR, HBEGF, ITGAV, ITGB3 and SPP1 genes in eutopic endometrium of infertile women with endometriosis during the implantation window: a pilot study","volume":"21","author":"Broi","year":"2017","journal-title":"JBRA Assist Reprod"},{"key":"2019123012283723700_ref8","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s10815-010-9436-1","article-title":"Endometriosis and infertility","volume":"27","author":"Bulletti","year":"2010","journal-title":"J Assist Reprod Genet"},{"key":"2019123012283723700_ref9","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","article-title":"Pathogenesis and pathophysiology of endometriosis","volume":"98","author":"Burney","year":"2012","journal-title":"Fertil Steril"},{"key":"2019123012283723700_ref10","doi-asserted-by":"crossref","first-page":"3814","DOI":"10.1210\/en.2006-1692","article-title":"Gene expression analysis of endometrium reveals progesterone resistance and candidate susceptibility genes in women with endometriosis","volume":"148","author":"Burney","year":"2007","journal-title":"Endocrinology"},{"key":"2019123012283723700_ref11","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1600-0897.2009.00692.x","article-title":"Endometrial osteopontin mRNA expression and plasma osteopontin levels are increased in patients with endometriosis","volume":"61","author":"Cho","year":"2009","journal-title":"Am J Reprod Immunol"},{"key":"2019123012283723700_ref12","volume-title":"Statistical Power Analysis for the Behavioral Sciences","author":"Cohen","year":"1988"},{"key":"2019123012283723700_ref13","first-page":"571","article-title":"Direct regulation of beta3-integrin subunit gene expression by HOXA10 in endometrial cells","volume":"16","author":"Daftary","year":"2002","journal-title":"Mol Endocrinol"},{"key":"2019123012283723700_ref14","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1387\/ijdb.130340pd","article-title":"Transcriptomics of the human endometrium","volume":"58","author":"Diaz-Gimeno","year":"2014","journal-title":"Int J Dev Biol"},{"key":"2019123012283723700_ref15","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1093\/humrep\/des127","article-title":"Combined mRNA microarray and proteomic analysis of eutopic endometrium of women with and without endometriosis","volume":"27","author":"Fassbender","year":"2012","journal-title":"Hum Reprod"},{"key":"2019123012283723700_ref16","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1177\/1933719117718276","article-title":"Dysregulation of GdA expression in endometrium of women with endometriosis: implication for endometrial receptivity","volume":"25","author":"Focarelli","year":"2018","journal-title":"Reprod Sci"},{"key":"2019123012283723700_ref17","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.fertnstert.2007.01.023","article-title":"A process designed to lead to international agreement on terminologies and definitions used to describe abnormalities of menstrual bleeding","volume":"87","author":"Fraser","year":"2007","journal-title":"Fertil Steril"},{"key":"2019123012283723700_ref18","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.rbmo.2015.07.014","article-title":"Is endometrial receptivity transcriptomics affected in women with endometriosis? A pilot study","volume":"31","author":"Garcia-Velasco","year":"2015","journal-title":"Reprod Biomed Online"},{"key":"2019123012283723700_ref19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1093\/humupd\/6.1.67","article-title":"Follicular hormonal environment and embryo quality in women with endometriosis","volume":"6","author":"Garrido","year":"2000","journal-title":"Hum Reprod Update"},{"key":"2019123012283723700_ref20","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1016\/S0140-6736(04)17403-5","article-title":"Endometriosis","volume":"364","author":"Giudice","year":"2004","journal-title":"Lancet"},{"key":"2019123012283723700_ref21","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/j.1749-6632.2002.tb02786.x","article-title":"The molecular basis for implantation failure in endometriosis: on the road to discovery","volume":"955","author":"Giudice","year":"2002","journal-title":"Ann N Y Acad Sci"},{"key":"2019123012283723700_ref22","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/S1472-6483(10)62026-3","article-title":"Role of oxidative stress in endometriosis","volume":"13","author":"Gupta","year":"2006","journal-title":"Reprod Biomed Online"},{"key":"2019123012283723700_ref23","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.fertnstert.2008.02.093","article-title":"Pathogenic mechanisms in endometriosis-associated infertility","volume":"90","author":"Gupta","year":"2008","journal-title":"Fertil Steril"},{"key":"2019123012283723700_ref24","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1177\/1933719116650758","article-title":"Global Transcriptome abnormalities of the Eutopic endometrium from women with Adenomyosis","volume":"23","author":"Herndon","year":"2016","journal-title":"Reprod Sci"},{"key":"2019123012283723700_ref25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1097\/GRF.0b013e3181db7d71","article-title":"Endometriosis and infertility","volume":"53","author":"Holoch","year":"2010","journal-title":"Clin Obstet Gynecol"},{"key":"2019123012283723700_ref26","doi-asserted-by":"crossref","first-page":"E2744","DOI":"10.1210\/jc.2014-2155","article-title":"Transcriptomic changes during the pre-receptive to receptive transition in human endometrium detected by RNA-Seq","volume":"99","author":"Hu","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2019123012283723700_ref27","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1210\/en.2003-0043","article-title":"Expression profiling of endometrium from women with endometriosis reveals candidate genes for disease-based implantation failure and infertility","volume":"144","author":"Kao","year":"2003","journal-title":"Endocrinology"},{"key":"2019123012283723700_ref28","doi-asserted-by":"crossref","first-page":"R36","DOI":"10.1186\/gb-2013-14-4-r36","article-title":"TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions","volume":"14","author":"Kim","year":"2013","journal-title":"Genome Biol"},{"key":"2019123012283723700_ref29","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1095\/biolreprod.113.116590","article-title":"MicroRNA-31 is significantly elevated in both human endometrium and serum during the window of implantation: a potential biomarker for optimum receptivity","volume":"91","author":"Kresowik","year":"2014","journal-title":"Biol Reprod"},{"key":"2019123012283723700_ref30","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1186\/1477-7827-11-78","article-title":"MicroRNAs expression profiling of eutopic proliferative endometrium in women with ovarian endometriosis","volume":"11","author":"Laudanski","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"key":"2019123012283723700_ref31","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/760698","article-title":"Profiling of selected MicroRNAs in proliferative eutopic endometrium of women with ovarian endometriosis","volume":"2015","author":"Laudanski","year":"2015","journal-title":"Biomed Res Int"},{"key":"2019123012283723700_ref32","first-page":"643","article-title":"Aberrant integrin expression in the endometrium of women with endometriosis","volume":"79","author":"Lessey","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"2019123012283723700_ref33","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1093\/bioinformatics\/btp352","article-title":"The sequence alignment\/map format and SAMtools","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2019123012283723700_ref34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2019123012283723700_ref35","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1016\/j.fertnstert.2005.04.041","article-title":"DNA microarray analysis of gene expression in eutopic endometrium from patients with deep endometriosis using laser capture microdissection","volume":"84 Suppl 2","author":"Matsuzaki","year":"2005","journal-title":"Fertil Steril"},{"key":"2019123012283723700_ref36","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1093\/humupd\/dmr013","article-title":"Endometrial alterations in endometriosis: a systematic review of putative biomarkers","volume":"17","author":"May","year":"2011","journal-title":"Hum Reprod Update"},{"key":"2019123012283723700_ref37","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/humrep\/dem399","article-title":"Endometriosis and human infertility: a new investigation into the role of eutopic endometrium","volume":"23","author":"Minici","year":"2008","journal-title":"Hum Reprod"},{"key":"2019123012283723700_ref38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1093\/molehr\/gaq010","article-title":"Epigenetic regulation of endometrium during the menstrual cycle","volume":"16","author":"Munro","year":"2010","journal-title":"Mol Hum Reprod"},{"key":"2019123012283723700_ref39","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0002-9378(16)33500-1","article-title":"Dating the endometrial biopsy","volume":"122","author":"Noyes","year":"1975","journal-title":"Am J Obstet Gynecol"},{"key":"2019123012283723700_ref40","doi-asserted-by":"crossref","first-page":"S156","DOI":"10.1016\/j.fertnstert.2006.08.014","article-title":"Endometriosis and infertility","volume":"86","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2006","journal-title":"Fertil Steril"},{"key":"2019123012283723700_ref41","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.fertnstert.2012.05.031","article-title":"Endometriosis and infertility: a committee opinion","volume":"98","author":"Practice Committee of the American Society for Reproductive Medicine","year":"2012","journal-title":"Fertil Steril"},{"key":"2019123012283723700_ref42","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1586\/epr.09.83","article-title":"Bioinformatics for protein biomarker panel classification: what is needed to bring biomarker panels into in vitro diagnostics","volume":"6","author":"Robin","year":"2009","journal-title":"Expert Rev Proteomics"},{"key":"2019123012283723700_ref43","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1261\/rna.053959.115","article-title":"How many biological replicates are needed in an RNA-seq experiment and which differential expression tool should you use","volume":"22","author":"Schurch","year":"2016","journal-title":"RNA"},{"key":"2019123012283723700_ref44","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2478\/s11658-014-0207-3","article-title":"miR-375 induces human decidua basalis-derived stromal cells to become insulin-producing cells","volume":"19","author":"Shaer","year":"2014","journal-title":"Cell Mol Biol Lett"},{"key":"2019123012283723700_ref45","doi-asserted-by":"crossref","first-page":"2","DOI":"10.4103\/0974-1208.97777","article-title":"Understanding implantation window, a crucial phenomenon","volume":"5","author":"Sharma","year":"2012","journal-title":"J Hum Reprod Sci"},{"key":"2019123012283723700_ref46","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1093\/humrep\/den078","article-title":"Global gene analysis of late secretory phase, eutopic endometrium does not provide the basis for a minimally invasive test of endometriosis","volume":"23","author":"Sherwin","year":"2008","journal-title":"Hum Reprod"},{"key":"2019123012283723700_ref47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3892\/ijmm.2013.1536","article-title":"Downregulation of miR-183 inhibits apoptosis and enhances the invasive potential of endometrial stromal cells in endometriosis","volume":"33","author":"Shi","year":"2014","journal-title":"Int J Mol Med"},{"key":"2019123012283723700_ref48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1530\/JOE-10-0461","article-title":"Bridging endometrial receptivity and implantation: network of hormones, cytokines, and growth factors","volume":"210","author":"Singh","year":"2011","journal-title":"J Endocrinol"},{"key":"2019123012283723700_ref49","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1210\/en.2005-1076","article-title":"Molecular phenotyping of human endometrium distinguishes menstrual cycle phases and underlying biological processes in normo-ovulatory women","volume":"147","author":"Talbi","year":"2006","journal-title":"Endocrinology"},{"key":"2019123012283723700_ref50","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/humrep\/14.5.1328","article-title":"HOX gene expression is altered in the endometrium of women with endometriosis","volume":"14","author":"Taylor","year":"1999","journal-title":"Hum Reprod"},{"key":"2019123012283723700_ref51","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1093\/humupd\/dmp034","article-title":"The role of microRNAs in endometriosis and associated reproductive conditions","volume":"16","author":"Teague","year":"2010","journal-title":"Hum Reprod Update"},{"key":"2019123012283723700_ref52","doi-asserted-by":"crossref","first-page":"2558","DOI":"10.1016\/j.fertnstert.2010.03.006","article-title":"Prokineticin 1, homeobox A10, and progesterone receptor messenger ribonucleic acid expression in primary cultures of endometrial stromal cells isolated from endometrium of healthy women and from eutopic endometrium of women with endometriosis","volume":"94","author":"Tiberi","year":"2010","journal-title":"Fertil Steril"},{"key":"2019123012283723700_ref53","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1177\/1933719117734320","article-title":"Aberrant expression of lncRNA (HOXA11-AS1) and homeobox a (HOXA9, HOXA10, HOXA11, and HOXA13) genes in infertile women with endometriosis","volume":"25","author":"Wang","year":"2018","journal-title":"Reprod Sci"},{"key":"2019123012283723700_ref54","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1016\/j.fertnstert.2008.02.121","article-title":"Reduced expression of biomarkers associated with the implantation window in women with endometriosis","volume":"91","author":"Wei","year":"2009","journal-title":"Fertil Steril"},{"key":"2019123012283723700_ref55","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1056\/NEJM199906103402304","article-title":"Time of implantation of the conceptus and loss of pregnancy","volume":"340","author":"Wilcox","year":"1999","journal-title":"N Engl J Med"},{"issue":"7","key":"2019123012283723700_ref56","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1177\/1933719118799199","article-title":"Endometrial miR-543 is downregulated during the implantation window in women with endometriosis-related infertility","volume":"26","author":"Yang","year":"2018","journal-title":"Reprod Sci"},{"key":"2019123012283723700_ref57","article-title":"Microarray analysis of microRNA deregulation and angiogenesis-related proteins in endometriosis","volume":"15","author":"Yang","year":"2016","journal-title":"Genet Mol Res"},{"key":"2019123012283723700_ref58","doi-asserted-by":"crossref","first-page":"654","DOI":"10.3892\/br.2017.902","article-title":"Identification of global transcriptome abnormalities and potential biomarkers in eutopic endometria of women with endometriosis: a preliminary study","volume":"6","author":"Zhao","year":"2017","journal-title":"Biomed Rep"},{"key":"2019123012283723700_ref59","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1093\/humrep\/dew223","article-title":"miR-196a overexpression activates the MEK\/ERK signal and represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis","volume":"31","author":"Zhou","year":"2016","journal-title":"Hum Reprod"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/34\/12\/2381\/31642324\/dez225.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/34\/12\/2381\/31642324\/dez225.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,12,30]],"date-time":"2019-12-30T12:29:14Z","timestamp":1577708954000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/34\/12\/2381\/5651224"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,1]]},"references-count":58,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,12,4]]},"published-print":{"date-parts":[[2019,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dez225","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,12]]},"published":{"date-parts":[[2019,12,1]]}}}