{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:25:57Z","timestamp":1783650357411,"version":"3.55.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["SQ2018YFC100163"],"award-info":[{"award-number":["SQ2018YFC100163"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81571397"],"award-info":[{"award-number":["81571397"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771533"],"award-info":[{"award-number":["81771533"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>STUDY QUESTION<\/jats:title>\n                  <jats:p>Is there an association between peak serum estradiol (E2) level during controlled ovarian stimulation (COS) and neonatal birthweight in freeze-all cycles?<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>SUMMARY ANSWER<\/jats:title>\n                  <jats:p>Peak serum E2 level during ovarian stimulation is not associated with neonatal birthweight in freeze-all cycles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WHAT IS KNOWN ALREADY<\/jats:title>\n                  <jats:p>Supraphysiologic E2 levels during COS have been demonstrated to generate a suboptimal peri-implantation endometrial environment and thus lead to adverse neonatal outcomes in fresh embryo transfer cycles. Previous experimental studies also suggested a potential influence of superovulation on oocyte epigenetic programming, but whether it translates into altered phenotypes of fetal growth and development remains unclear in clinical practice. By segmenting the process of COS and embryo transfer, the freeze-all policy provides a novel model to investigate the sole impact of ovarian stimulation on oocytes after ruling out the effects of hyperestrogenic milieu on endometrium in fresh cycles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY DESIGN, SIZE, DURATION<\/jats:title>\n                  <jats:p>A retrospective cohort study of 8501 patients who underwent their first COS cycles with a freeze-all strategy and delivered live-born singletons in subsequent frozen-thawed embryo transfer cycles from January 2007 to December 2016 at a tertiary-care academic medical center.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PARTICIPANTS\/MATERIALS, SETTING, METHODS<\/jats:title>\n                  <jats:p>Patients were categorized into six groups according to E2 level on trigger day in regular increments of 1000\u00a0pg\/mL: &amp;lt;1000, 1000\u20131999, 2000\u20132999, 3000\u20133999, 4000\u20134999 and \u22655000\u00a0pg\/mL. Univariable and multivariable linear regression and logistic regression analysis were performed to assess the independent association between peak E2 level and measures of neonatal birthweight including absolute birthweight, Z-score, low birthweight (LBW) and small-for-gestational age (SGA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>MAIN RESULTS AND THE ROLE OF CHANCE<\/jats:title>\n                  <jats:p>The six groups did not differ significantly in birthweight, Z-score or the incidence of LBW and SGA. Compared with the E2 &amp;lt;1000\u00a0pg\/mL group, the adjusted mean difference (95% confidence interval [CI]) of stratified higher E2 groups was 17.2 (\u221231.0\u201365.5), 12.3 (\u221235.9\u201360.5), \u22124.1 (\u221251.9\u201343.7), \u22120.6 (\u221248.9\u201347.8) and \u22123.6 (\u221250.0\u201342.8) g for birthweight, and 0 (\u22120.11\u20130.10), 0.02 (\u22120.08\u20130.12), 0.04 (\u22120.06\u20130.14), \u22120.01 (\u22120.11\u20130.10) and \u22120.04 (\u22120.14\u20130.06) for Z-score, respectively. Regarding the outcomes of LBW and SGA, no increased risks were observed in each E2 category, with the adjusted odds ratio (95% CI) being 1.21 (0.68\u20132.16), 1.0 (0.58\u20131.90), 0.90 (0.50\u20131.63), 0.93 (0.51\u20131.69) and 1.08 (0.61\u20131.90) for LBW, and 0.97 (0.58\u20131.64), 1.06 (0.63\u20131.77), 0.77 (0.46\u20131.31), 0.71 (0.41\u20131.22) and 1.00 (0.60\u20131.65) for SGA, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>LIMITATIONS, REASONS FOR CAUTION<\/jats:title>\n                  <jats:p>The study was retrospective in design, and other unknown confounding factors may not be included for adjustment. Furthermore, the generalization of the study finding could be limited to some extent by the majority of double cleavage-stage embryo transfer and difference in birthweight reference percentiles between Chinese and other populations.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>WIDER IMPLICATIONS OF THE FINDINGS<\/jats:title>\n                  <jats:p>Our observations suggest that the hyperestrogenic milieu during COS does not seem to pose adverse effects on neonatal birthweight after frozen-thawed embryo transfer, which provides reassuring information for high ovarian responders in freeze-all cycles concerning their offspring\u2019s health.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>STUDY FUNDING\/COMPETING INTEREST(S)<\/jats:title>\n                  <jats:p>This study was funded by the National Key Research and Development Program of China (SQ2018YFC100163) and National Natural Science Foundation of China (81571397, 81771533). The authors declare no conflict of interest.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/humrep\/dez262","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T07:13:43Z","timestamp":1574234023000},"page":"424-433","source":"Crossref","is-referenced-by-count":21,"title":["Association between peak serum estradiol level during controlled ovarian stimulation and neonatal birthweight in freeze-all cycles: a retrospective study of 8501 singleton live births"],"prefix":"10.1093","volume":"35","author":[{"given":"Jialyu","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuefeng","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaying","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7635-4401","authenticated-orcid":false,"given":"Qiuju","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyuan","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qifeng","family":"Lyu","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renfei","family":"Cai","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanping","family":"Kuang","sequence":"first","affiliation":[{"name":"Department of Assisted Reproduction, Shanghai Ninth People\u2019s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,20]]},"reference":[{"key":"2020022822594845100_ref1","first-page":"2014","article-title":"International Committee for Monitoring Assisted Reproductive Technologies (ICMART) World Report on ART, 2014 and The International Glossary on Infertility and Fertility Care, 2017","author":"Adamson","year":"2017","journal-title":"ICMART World Report"},{"key":"2020022822594845100_ref2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/uog.18942","article-title":"Influence of cryopreservation on perinatal outcome after blastocyst- vs cleavage-stage embryo transfer: systematic review and meta-analysis","volume":"51","author":"Alviggi","year":"2018","journal-title":"Ultrasound Obstet Gynecol"},{"key":"2020022822594845100_ref3","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1387\/ijdb.082619ea","article-title":"Unaltered imprinting establishment of key imprinted genes in mouse oocytes after in vitro follicle culture under variable follicle-stimulating hormone exposure","volume":"53","author":"Anckaert","year":"2009","journal-title":"Int J Dev Biol"},{"key":"2020022822594845100_ref4","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s10815-006-9101-x","article-title":"Cumulative exposure to high estradiol levels during the follicular phase of IVF cycles negatively affects implantation","volume":"24","author":"Arslan","year":"2007","journal-title":"J Assist Reprod Genet"},{"key":"2020022822594845100_ref5","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.fertnstert.2014.12.120","article-title":"Association of number of retrieved oocytes with live birth rate and birth weight: an analysis of 231,815 cycles of in vitro fertilization","volume":"103","author":"Baker","year":"2015","journal-title":"Fertil Steril"},{"key":"2020022822594845100_ref6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/humupd\/dmz001","article-title":"The health of children conceived by ART: \u2018the chicken or the egg?\u2019","volume":"25","author":"Berntsen","year":"2019","journal-title":"Hum Reprod Update"},{"key":"2020022822594845100_ref7","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1111\/1471-0528.15606","article-title":"Supraphysiological estradiol level in ovarian stimulation cycles affects the birthweight of neonates conceived through subsequent frozen-thawed cycles: a retrospective study","volume":"126","author":"Cai","year":"2019","journal-title":"BJOG"},{"key":"2020022822594845100_ref8","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1016\/j.fertnstert.2015.02.020","article-title":"Comparison of live-birth defects after luteal-phase ovarian stimulation vs. conventional ovarian stimulation for in vitro fertilization and vitrified embryo transfer cycles","volume":"103","author":"Chen","year":"2015","journal-title":"Fertil Steril"},{"key":"2020022822594845100_ref9","doi-asserted-by":"crossref","DOI":"10.1098\/rsbl.2017.0643","article-title":"Associations between imprinted gene expression in the placenta, human fetal growth and preeclampsia","volume":"13","author":"Christians","year":"2017","journal-title":"Biol Lett"},{"key":"2020022822594845100_ref10","doi-asserted-by":"crossref","first-page":"e601","DOI":"10.1016\/j.ajog.2016.06.035","article-title":"Maternal dietary intake during pregnancy and offspring body composition: the Healthy Start Study","volume":"215","author":"Crume","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"2020022822594845100_ref11","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1007\/BF01133388","article-title":"A formula for scoring human embryo growth rates in in vitro fertilization: its value in predicting pregnancy and in comparison with visual estimates of embryo quality","volume":"3","author":"Cummins","year":"1986","journal-title":"J In Vitro Fert Embryo Transf"},{"key":"2020022822594845100_ref12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104779","article-title":"Birth weight reference percentiles for Chinese","volume":"9","author":"Dai","year":"2014","journal-title":"PLoS One"},{"key":"2020022822594845100_ref13","first-page":"6975","article-title":"The cumulative effect of assisted reproduction procedures on placental development and epigenetic perturbations in a mouse model","volume":"24","author":"de Waal","year":"2015","journal-title":"Hum Mol Genet"},{"key":"2020022822594845100_ref14","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.fertnstert.2011.06.055","article-title":"Embryonic imprinting perturbations do not originate from superovulation-induced defects in DNA methylation acquisition","volume":"96","author":"Denomme","year":"2011","journal-title":"Fertil Steril"},{"key":"2020022822594845100_ref15","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.rbmo.2010.04.022","article-title":"High serum oestradiol concentrations in IVF cycles increase the risk of pregnancy complications related to abnormal placentation","volume":"21","author":"Farhi","year":"2010","journal-title":"Reprod Biomed Online"},{"key":"2020022822594845100_ref16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.mce.2014.03.003","article-title":"Modulation of imprinted gene expression following superovulation","volume":"388","author":"Fortier","year":"2014","journal-title":"Mol Cell Endocrinol"},{"key":"2020022822594845100_ref17","first-page":"378","volume-title":"Towards Reproductive Certainty: Infertility and Genetics Beyond","author":"Gardner","year":"1999"},{"key":"2020022822594845100_ref18","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1093\/humrep\/dep039","article-title":"Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients","volume":"24","author":"Haouzi","year":"2009","journal-title":"Hum Reprod"},{"key":"2020022822594845100_ref19","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1093\/humupd\/dmi022","article-title":"Assisted reproduction: the epigenetic perspective","volume":"11","author":"Horsthemke","year":"2005","journal-title":"Hum Reprod Update"},{"key":"2020022822594845100_ref20","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.fertnstert.2012.03.028","article-title":"Peak serum estradiol level during controlled ovarian hyperstimulation is associated with increased risk of small for gestational age and preeclampsia in singleton pregnancies after in vitro fertilization","volume":"97","author":"Imudia","year":"2012","journal-title":"Fertil Steril"},{"key":"2020022822594845100_ref21","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bpobgyn.2017.07.004","article-title":"Genetic and epigenetic risks of assisted reproduction","volume":"44","author":"Jiang","year":"2017","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"2020022822594845100_ref22","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1159\/000371628","article-title":"Gestational diabetes mellitus and macrosomia: a literature review","volume":"66","author":"Kc","year":"2015","journal-title":"Ann Nutr Metab"},{"key":"2020022822594845100_ref23","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1136\/jmg.2008.057943","article-title":"Dynamic CpG methylation of the KCNQ1OT1 gene during maturation of human oocytes","volume":"45","author":"Khoueiry","year":"2008","journal-title":"J Med Genet"},{"key":"2020022822594845100_ref24","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1093\/humrep\/dew156","article-title":"Influence of embryo culture medium (G5 and HTF) on pregnancy and perinatal outcome after IVF: a multicenter RCT","volume":"31","author":"Kleijkers","year":"2016","journal-title":"Hum Reprod"},{"key":"2020022822594845100_ref25","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/S0015-0282(02)03323-X","article-title":"Effect of ovarian stimulation with recombinant follicle-stimulating hormone, gonadotropin releasing hormone antagonists, and human chorionic gonadotropin on endometrial maturation on the day of oocyte pick-up","volume":"78","author":"Kolibianakis","year":"2002","journal-title":"Fertil Steril"},{"key":"2020022822594845100_ref26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.fertnstert.2015.03.022","article-title":"Medroxyprogesterone acetate is an effective oral alternative for preventing premature luteinizing hormone surges in women undergoing controlled ovarian hyperstimulation for in vitro fertilization","volume":"104","author":"Kuang","year":"2015","journal-title":"Fertil Steril"},{"key":"2020022822594845100_ref27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.rbmo.2017.04.010","article-title":"High oestradiol concentration after ovarian stimulation is associated with lower maternal serum beta-HCG concentration and neonatal birth weight","volume":"35","author":"Liu","year":"2017","journal-title":"Reprod Biomed Online"},{"key":"2020022822594845100_ref28","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1016\/j.fertnstert.2009.05.092","article-title":"Factors associated with ovarian hyperstimulation syndrome (OHSS) and its effect on assisted reproductive technology (ART) treatment and outcome","volume":"94","author":"Luke","year":"2010","journal-title":"Fertil Steril"},{"key":"2020022822594845100_ref29","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1093\/humrep\/dex277","article-title":"Vanishing twin syndrome among ART singletons and pregnancy outcomes","volume":"32","author":"Magnus","year":"2017","journal-title":"Hum Reprod"},{"key":"2020022822594845100_ref30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1093\/hmg\/ddp465","article-title":"Dual effects of superovulation: loss of maternal and paternal imprinted methylation in a dose-dependent manner","volume":"19","author":"Market-Velker","year":"2010","journal-title":"Hum Mol Genet"},{"key":"2020022822594845100_ref31","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1002\/mrd.22951","article-title":"The effects of superovulation and reproductive aging on the epigenome of the oocyte and embryo","volume":"85","author":"Marshall","year":"2018","journal-title":"Mol Reprod Dev"},{"key":"2020022822594845100_ref32","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1093\/humrep\/deh384","article-title":"Comparison of endometrial and subendometrial blood flow measured by three-dimensional power Doppler ultrasound between stimulated and natural cycles in the same patients","volume":"19","author":"Ng","year":"2004","journal-title":"Hum Reprod"},{"key":"2020022822594845100_ref33","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/icvts\/ivy102","article-title":"Statistical primer: how to deal with missing data in scientific research?","volume":"27","author":"Papageorgiou","year":"2018","journal-title":"Interact Cardiovasc Thorac Surg"},{"key":"2020022822594845100_ref34","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2147\/CLEP.S129785","article-title":"Missing data and multiple imputation in clinical epidemiological research","volume":"9","author":"Pedersen","year":"2017","journal-title":"Clin Epidemiol"},{"key":"2020022822594845100_ref35","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.1093\/humrep\/dex095","article-title":"Supraphysiologic estradiol is an independent predictor of low birth weight in full-term singletons born after fresh embryo transfer","volume":"32","author":"Pereira","year":"2017","journal-title":"Hum Reprod"},{"key":"2020022822594845100_ref36","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s10815-015-0434-1","article-title":"Impact of elevated peak serum estradiol levels during controlled ovarian hyperstimulation on the birth weight of term singletons from fresh IVF-ET cycles","volume":"32","author":"Pereira","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"2020022822594845100_ref37","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s00404-017-4291-2","article-title":"Worldwide prevalence of adverse pregnancy outcomes associated with in vitro fertilization\/intracytoplasmic sperm injection among multiple births: a systematic review and meta-analysis based on cohort studies","volume":"295","author":"Qin","year":"2017","journal-title":"Arch Gynecol Obstet"},{"key":"2020022822594845100_ref38","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00404-016-4250-3","article-title":"Worldwide prevalence of adverse pregnancy outcomes among singleton pregnancies after in vitro fertilization\/intracytoplasmic sperm injection: a systematic review and meta-analysis","volume":"295","author":"Qin","year":"2017","journal-title":"Arch Gynecol Obstet"},{"key":"2020022822594845100_ref39","article-title":"Impact of sample size and variability on the power and type I error rates of equivalence tests: a simulation study","volume":"19","author":"Rusticus","year":"2014","journal-title":"Pract Assess Res Eval"},{"key":"2020022822594845100_ref40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/humrep\/del316","article-title":"Aberrant DNA methylation of imprinted loci in superovulated oocytes","volume":"22","author":"Sato","year":"2007","journal-title":"Hum Reprod"},{"key":"2020022822594845100_ref41","doi-asserted-by":"crossref","first-page":"2654","DOI":"10.1001\/jama.2015.17296","article-title":"Live-birth rate associated with repeat in vitro fertilization treatment cycles","volume":"314","author":"Smith","year":"2015","journal-title":"JAMA"},{"key":"2020022822594845100_ref42","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0140-6736(78)92957-4","article-title":"Birth after the reimplantation of a human embryo","volume":"2","author":"Steptoe","year":"1978","journal-title":"Lancet"},{"key":"2020022822594845100_ref43","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s40659-015-0059-y","article-title":"In vitro fertilization (IVF) in mammals: epigenetic and developmental alterations. Scientific and bioethical implications for IVF in humans","volume":"48","author":"Ventura-Junca","year":"2015","journal-title":"Biol Res"},{"key":"2020022822594845100_ref44","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1186\/s13063-018-2850-x","article-title":"Gonadotropin-releasing hormone antagonist versus progestin for the prevention of premature luteinising hormone surges in poor responders undergoing in vitro fertilisation treatment: study protocol for a randomised controlled trial","volume":"19","author":"Wang","year":"2018","journal-title":"Trials"},{"key":"2020022822594845100_ref45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1093\/aje\/155.3.203","article-title":"Impact of preeclampsia and gestational hypertension on birth weight by gestational age","volume":"155","author":"Xiong","year":"2002","journal-title":"Am J Epidemiol"},{"key":"2020022822594845100_ref46","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00404-015-3639-8","article-title":"Biochemical pregnancy and spontaneous abortion in first IVF cycles are negative predictors for subsequent cycles: an over 10,000 cases cohort study","volume":"292","author":"Yang","year":"2015","journal-title":"Arch Gynecol Obstet"},{"key":"2020022822594845100_ref47","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/84769","article-title":"Epigenetic change in IGF2R is associated with fetal overgrowth after sheep embryo culture","volume":"27","author":"Young","year":"2001","journal-title":"Nat Genet"},{"key":"2020022822594845100_ref48","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1093\/humrep\/deu346","article-title":"Does the type of culture medium used influence birthweight of children born after IVF?","volume":"30","author":"Zandstra","year":"2015","journal-title":"Hum Reprod"},{"key":"2020022822594845100_ref49","doi-asserted-by":"crossref","DOI":"10.1016\/j.rbmo.2019.04.015","article-title":"Supraphysiologic serum estradiol impacts oocytes and is negatively related to birth weight in full term singletons born after frozen embryo transfer: a retrospective cohort study","author":"Zhang","year":"2019","journal-title":"Reprod Biomed Online"}],"container-title":["Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/35\/2\/424\/32711115\/dez262.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/humrep\/article-pdf\/35\/2\/424\/32711115\/dez262.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T23:00:29Z","timestamp":1582930829000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humrep\/article\/35\/2\/424\/5678045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,2,20]]},"published-print":{"date-parts":[[2020,2,29]]}},"URL":"https:\/\/doi.org\/10.1093\/humrep\/dez262","relation":{},"ISSN":["0268-1161","1460-2350"],"issn-type":[{"value":"0268-1161","type":"print"},{"value":"1460-2350","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,2]]},"published":{"date-parts":[[2020,2]]}}}