{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T12:41:41Z","timestamp":1793364101730,"version":"4.5.0"},"reference-count":204,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000066","name":"National Institute of Environmental Health Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000066","name":"NIEHS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000066","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 ES026578"],"award-info":[{"award-number":["R01 ES026578"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 ES026964"],"award-info":[{"award-number":["R01 ES026964"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 ES017885"],"award-info":[{"award-number":["P30 ES017885"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000125","name":"National Institute for Occupational Safety and Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["T42 OH008455"],"award-info":[{"award-number":["T42 OH008455"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>BACKGROUND<\/jats:title>\n                    <jats:p>Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are found widespread in drinking water, foods, food packaging materials and other consumer products. Several PFAS have been identified as endocrine-disrupting chemicals based on their ability to interfere with normal reproductive function and hormonal signalling. Experimental models and epidemiologic studies suggest that PFAS exposures target the ovary and represent major risks for women\u2019s health.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OBJECTIVE AND RATIONALE<\/jats:title>\n                    <jats:p>This review summarises human population and toxicological studies on the association between PFAS exposure and ovarian function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>SEARCH METHODS<\/jats:title>\n                    <jats:p>A comprehensive review was performed by searching PubMed. Search terms included an extensive list of PFAS and health terms ranging from general keywords (e.g. ovarian, reproductive, follicle, oocyte) to specific keywords (including menarche, menstrual cycle, menopause, primary ovarian insufficiency\/premature ovarian failure, steroid hormones), based on the authors\u2019 knowledge of the topic and key terms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>OUTCOMES<\/jats:title>\n                    <jats:p>Clinical evidence demonstrates the presence of PFAS in follicular fluid and their ability to pass through the blood\u2013follicle barrier. Although some studies found no evidence associating PFAS exposure with disruption in ovarian function, numerous epidemiologic studies, mostly with cross-sectional study designs, have identified associations of higher PFAS exposure with later menarche, irregular menstrual cycles, longer cycle length, earlier age of menopause and reduced levels of oestrogens and androgens. Adverse effects of PFAS on ovarian folliculogenesis and steroidogenesis have been confirmed in experimental models. Based on laboratory research findings, PFAS could diminish ovarian reserve and reduce endogenous hormone synthesis through activating peroxisome proliferator-activated receptors, disrupting gap junction intercellular communication between oocyte and granulosa cells, inducing thyroid hormone deficiency, antagonising ovarian enzyme activities involved in ovarian steroidogenesis or inhibiting kisspeptin signalling in the hypothalamus.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>WIDER IMPLICATIONS<\/jats:title>\n                    <jats:p>The published literature supports associations between PFAS exposure and adverse reproductive outcomes; however, the evidence remains insufficient to infer a causal relationship between PFAS exposure and ovarian disorders. Thus, more research is warranted. PFAS are of significant concern because these chemicals are ubiquitous and persistent in the environment and in humans. Moreover, susceptible groups, such as foetuses and pregnant women, may be exposed to harmful combinations of chemicals that include PFAS. However, the role environmental exposures play in reproductive disorders has received little attention by the medical community. To better understand the potential risk of PFAS on human ovarian function, additional experimental studies using PFAS doses equivalent to the exposure levels found in the general human population and mixtures of compounds are required. Prospective investigations in human populations are also warranted to ensure the temporality of PFAS exposure and health endpoints and to minimise the possibility of reverse causality.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/humupd\/dmaa018","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T08:08:42Z","timestamp":1585037322000},"page":"724-752","source":"Crossref","is-referenced-by-count":410,"title":["Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and their effects on the ovary"],"prefix":"10.1093","volume":"26","author":[{"given":"Ning","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siob\u00e1n D","family":"Harlow","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F","family":"Randolph Jr","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, School of Medicine, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Loch-Caruso","sequence":"additional","affiliation":[{"name":"Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9981-6250","authenticated-orcid":false,"given":"Sung Kyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA"},{"name":"Department of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, MI 48109, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,29]]},"reference":[{"key":"2020082914020828400_ref1","volume-title":"Toxicological profile for perfluoroalkyls","year":"2018"},{"key":"2020082914020828400_ref2","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1289\/ehp.0800026","article-title":"Differential regulation of dopamine transporter function and location by low concentrations of environmental estrogens and 17\u03b2-estradiol","volume":"117","author":"Alyea","year":"2009","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref3","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.chemosphere.2016.01.014","article-title":"Occurrence of select perfluoroalkyl substances at U.S. Air Force aqueous film-forming foam release sites other than fire-training areas: field-validation of critical fate and transport properties","volume":"150","author":"Anderson","year":"2016","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref4","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.chemosphere.2018.12.186","article-title":"The overlooked short- and ultrashort-chain poly- and perfluorinated substances: a review","volume":"220","author":"Ateia","year":"2019","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1097\/01.gme.0000218683.97338.ea","article-title":"Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis","volume":"13","author":"Atsma","year":"2006","journal-title":"Menopause"},{"key":"2020082914020828400_ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-1-4899-1202-2","volume-title":"Organofluorine Chemistry","author":"Banks","year":"1994"},{"key":"2020082914020828400_ref7","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1039\/b701417a","article-title":"Analysis of per- and polyfluorinated alkyl substances in air samples from Northwest Europe","volume":"9","author":"Barber","year":"2007","journal-title":"J Environ Monit"},{"key":"2020082914020828400_ref8","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1016\/j.fertnstert.2015.02.001","article-title":"Perfluoroalkyl substances and ovarian hormone concentrations in naturally cycling women","volume":"103","author":"Barrett","year":"2015","journal-title":"Fertil Steril"},{"key":"2020082914020828400_ref9","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1289\/ehp.1306615","article-title":"Perfluorooctanoic acid (PFOA) exposures and incident cancers among adults living near a chemical plant","volume":"121","author":"Barry","year":"2013","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref10","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1289\/ehp.0901252","article-title":"Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia","volume":"118","author":"Bartell","year":"2010","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref11","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1080\/02652030500183474","article-title":"Perfluorochemicals: potential sources of and migration from food packaging","volume":"22","author":"Begley","year":"2005","journal-title":"Food Addit Contam"},{"key":"2020082914020828400_ref12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.toxlet.2018.03.029","article-title":"Perfluoroalkylated substances (PFAS) affect neither estrogen and androgen receptor activity nor steroidogenesis in human cells in vitro","volume":"291","author":"Behr","year":"2018","journal-title":"Toxicol Lett"},{"key":"2020082914020828400_ref13","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1289\/ehp.0900699","article-title":"Exposure to a complex cocktail of environmental endocrine-disrupting compounds disturbs the kisspeptin\/GPR54 system in ovine hypothalamus and pituitary gland","volume":"117","author":"Bellingham","year":"2009","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref14","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1006\/taap.1995.1164","article-title":"Effects of ammonium perfluorooctanoate on Leydig-cell function: in vitro, in vivo, and ex vivo studies","volume":"134","author":"Biegel","year":"1995","journal-title":"Toxicol Appl Pharmacol"},{"key":"2020082914020828400_ref15","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1002\/mnfr.201200845","article-title":"Serum concentrations of perfluorinated alkyl acids and their associations with diet and personal characteristics among Swedish adults","volume":"57","author":"Bjermo","year":"2013","journal-title":"Mol Nutr Food Res"},{"key":"2020082914020828400_ref16","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1093\/toxsci\/kfp093","article-title":"Structure-activity relationships and human relevance for perfluoroalkyl acid\u2013induced transcriptional activation of peroxisome proliferation in liver cell cultures","volume":"111","author":"Bjork","year":"2009","journal-title":"Toxicol Sci"},{"key":"2020082914020828400_ref17","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.scitotenv.2018.10.245","article-title":"Per- and polyfluoroalkyl substances in source and treated drinking waters of the United States","volume":"653","author":"Boone","year":"2019","journal-title":"Sci Total Environ"},{"key":"2020082914020828400_ref18","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/s41370-018-0109-y","article-title":"Serum concentrations of PFASs and exposure-related behaviors in African American and non-Hispanic white women","volume":"29","author":"Boronow","year":"2019","journal-title":"J Expo Sci Environ Epidemiol"},{"key":"2020082914020828400_ref19","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1080\/02652030601013711","article-title":"Investigation into the migration potential of coating materials from cookware products","volume":"24","author":"Bradley","year":"2007","journal-title":"Food Addit Contam"},{"key":"2020082914020828400_ref20","doi-asserted-by":"crossref","first-page":"A6","DOI":"10.1289\/ehp.1510569","article-title":"What can epidemiological studies tell us about the impact of chemical mixtures on human health?","volume":"124","author":"Braun","year":"2016","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref21","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ijheh.2010.03.007","article-title":"Two-year follow-up biomonitoring pilot study of residents\u2019 and controls\u2019 PFC plasma levels after PFOA reduction in public water system in Arnsberg, Germany","volume":"213","author":"Brede","year":"2010","journal-title":"Int J Hyg Environ Health"},{"key":"2020082914020828400_ref22","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/ieam.258","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in the environment: terminology, classification, and origins","volume":"7","author":"Buck","year":"2011","journal-title":"Integr Environ Assess Manag"},{"key":"2020082914020828400_ref23","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/humupd\/dmm020","article-title":"A review of hormonal changes during the menopausal transition: focus on findings from the Melbourne Women\u2019s Midlife Health Project","volume":"13","author":"Burger","year":"2007","journal-title":"Hum Reprod Update"},{"key":"2020082914020828400_ref24","doi-asserted-by":"crossref","first-page":"1776","DOI":"10.1289\/ehp.9060","article-title":"The applicability of biomonitoring data for perfluorooctanesulfonate to the environmental public health continuum","volume":"114","author":"Butenhoff","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref25","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1289\/ehp.10598","article-title":"Polyfluoroalkyl chemicals in the U.S. population: data from the national health and nutrition examination survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000","volume":"115","author":"Calafat","year":"2007","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref26","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/humupd\/dmq061","article-title":"Environment and women\u2019s reproductive health","volume":"17","author":"Caserta","year":"2011","journal-title":"Hum Reprod Update"},{"key":"2020082914020828400_ref201","volume-title":"National Report on Human Exposure to Environmental Chemicals","year":"2019"},{"key":"2020082914020828400_ref27","volume-title":"Fourth Report on Human Exposure to Environmental Chemicals","year":"2009"},{"key":"2020082914020828400_ref28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.tox.2007.10.014","article-title":"Thyroid hormone status and pituitary function in adult rats given oral doses of perfluorooctanesulfonate (PFOS)","volume":"243","author":"Chang","year":"2008","journal-title":"Toxicology"},{"key":"2020082914020828400_ref29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.tiv.2017.09.030","article-title":"Endocrine disruptor effect of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) on porcine ovarian cell steroidogenesis","volume":"46","author":"Chaparro-Ortega","year":"2018","journal-title":"Toxicol Vitr"},{"key":"2020082914020828400_ref30","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1016\/j.jfda.2017.12.011","article-title":"Concentrations of perfluoroalkyl substances in foods and the dietary exposure among Taiwan general population and pregnant women","volume":"26","author":"Chen","year":"2018","journal-title":"J Food Drug Anal"},{"key":"2020082914020828400_ref31","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.reprotox.2017.02.010","article-title":"Maternal exposure to perfluorooctanoic acid inhibits luteal function via oxidative stress and apoptosis in pregnant mice","volume":"69","author":"Chen","year":"2017","journal-title":"Reprod Toxicol"},{"key":"2020082914020828400_ref32","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.envint.2010.08.007","article-title":"Exposure to polyfluoroalkyl chemicals during pregnancy is not associated with offspring age at menarche in a contemporary British cohort","volume":"37","author":"Christensen","year":"2011","journal-title":"Environ Int"},{"key":"2020082914020828400_ref33","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/ajpa.21188","article-title":"Reproductive ecology and the endometrium: physiology, variation, and new directions","volume":"140","author":"Clancy","year":"2009","journal-title":"Am J Phys Anthropol"},{"key":"2020082914020828400_ref34","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.reprotox.2018.07.087","article-title":"Impact of toxicant exposures on ovarian gap junctions","volume":"81","author":"Clark","year":"2018","journal-title":"Reprod Toxicol"},{"key":"2020082914020828400_ref35","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1093\/toxsci\/kfx285","article-title":"Pretty good or pretty bad? The ovary and chemicals in personal care products","volume":"162","author":"Craig","year":"2018","journal-title":"Toxicol Sci"},{"key":"2020082914020828400_ref36","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1289\/ehp.0900633","article-title":"Thyroid function and plasma concentrations of polyhalogenated compounds in Inuit adults","volume":"117","author":"Dallaire","year":"2009","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref37","article-title":"Risk assessment of fluorinated substances in cosmetic products","author":"Danish","year":"2018"},{"key":"2020082914020828400_ref38","first-page":"354","article-title":"Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat","volume":"137","author":"Dau\u00e7a","year":"2014","journal-title":"Endocrinology"},{"key":"2020082914020828400_ref39","first-page":"649","article-title":"Peroxisome proliferator-activated receptors: nuclear control of metabolism","volume":"20","author":"Desvergne","year":"1999","journal-title":"Endocr Rev"},{"key":"2020082914020828400_ref40","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.envres.2015.12.037","article-title":"Perfluorooctanoic acid exposure and natural menopause: a longitudinal study in a community cohort","volume":"146","author":"Dhingra","year":"2016","journal-title":"Environ Res"},{"key":"2020082914020828400_ref41","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1289\/EHP273","article-title":"A study of reverse causation: examining the associations of perfluorooctanoic acid serum levels with two outcomes","volume":"125","author":"Dhingra","year":"2017","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref42","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1210\/er.2009-0002","article-title":"Endocrine-disrupting chemicals: An Endocrine Society scientific statement","volume":"30","author":"Diamanti-Kandarakis","year":"2009","journal-title":"Endocr Rev"},{"key":"2020082914020828400_ref43","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1530\/eje.0.1340649","article-title":"Effect of hypothyroidism on ovarian follicular development, granulosa cell proliferation and peripheral hormone levels in the prepubertal rat","volume":"134","author":"Dijkstra","year":"1996","journal-title":"Eur J Endocrinol"},{"key":"2020082914020828400_ref44","doi-asserted-by":"crossref","first-page":"105381","DOI":"10.1016\/j.envint.2019.105381","article-title":"Longitudinal trends in perfluoroalkyl and polyfluoroalkyl substances among multiethnic midlife women from 1999 to 2011: the Study of Women\u2019s Health Across the Nation","volume":"135","author":"Ding","year":"2020","journal-title":"Environ Int"},{"key":"2020082914020828400_ref45","first-page":"1575","article-title":"Human dietary exposure to perfluoroalkyl substances in Catalonia","volume":"135","author":"Domingo","year":"2012","journal-title":"Spain Temporal trend Food Chem"},{"key":"2020082914020828400_ref46","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/acs.jafc.6b04683","article-title":"Per- and polyfluoroalkyl substances (PFASs) in food and human dietary intake: a review of the recent scientific literature","volume":"65","author":"Domingo","year":"2017","journal-title":"J Agric Food Chem"},{"key":"2020082914020828400_ref47","doi-asserted-by":"crossref","first-page":"108648","DOI":"10.1016\/j.envres.2019.108648","article-title":"Human exposure to per- and polyfluoroalkyl substances (PFAS) through drinking water: a review of the recent scientific literature","volume":"177","author":"Domingo","year":"2019","journal-title":"Environ Res"},{"key":"2020082914020828400_ref48","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.tiv.2016.05.011","article-title":"Effect of perfluorooctane sulfonate on viability, maturation and gap junctional intercellular communication of porcine oocytes in vitro","volume":"35","author":"Dom\u00ednguez","year":"2016","journal-title":"Toxicol Vitr"},{"key":"2020082914020828400_ref49","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/etc.2034","article-title":"Perfluorooctane sulfonate (PFOS) affects hormone receptor activity, steroidogenesis, and expression of endocrine-related genes in vitro and in vivo","volume":"32","author":"Du","year":"2013","journal-title":"Environ Toxicol Chem"},{"key":"2020082914020828400_ref50","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ecoenv.2018.10.025","article-title":"Neonatal and juvenile exposure to perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS): advance puberty onset and kisspeptin system disturbance in female rats","volume":"167","author":"Du","year":"2019","journal-title":"Ecotoxicol Environ Saf"},{"key":"2020082914020828400_ref51","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.chemosphere.2013.01.012","article-title":"Endocrine-related effects of perfluorooctanoic acid (PFOA) in zebrafish, H295R steroidogenesis and receptor reporter gene assays","volume":"91","author":"Du","year":"2013","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref52","article-title":"Report: up to 110 million Americans could have PFAS-contaminated drinking water","year":"2018"},{"key":"2020082914020828400_ref53","doi-asserted-by":"crossref","first-page":"7940","DOI":"10.1007\/s11356-013-1700-3","article-title":"Perfluoroalkyl substances (PFASs) in food and water from Faroe Islands","volume":"20","author":"Eriksson","year":"2013","journal-title":"Environ Sci Pollut Res"},{"key":"2020082914020828400_ref54","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.envpol.2016.09.036","article-title":"Temporal trends of PFSAs, PFCAs and selected precursors in Australian serum from 2002 to 2013","volume":"220","author":"Eriksson","year":"2017","journal-title":"Environ Pollut"},{"key":"2020082914020828400_ref54a","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1021\/jf0732408","article-title":"Human Exposure to Perfluorinated Chemicals through the Diet: Intake of Perfluorinated Compounds in Foods from the Catalan (Spain) Market","volume":"56","author":"Ericson","year":"2008","journal-title":"J Agric Food Chem"},{"key":"2020082914020828400_ref55","doi-asserted-by":"crossref","first-page":"1977","DOI":"10.1073\/pnas.1500247112","article-title":"Self-affirmation alters the brain\u2019s response to health messages and subsequent behavior change","volume":"112","author":"Falk","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020082914020828400_ref56","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1210\/en.2004-1046","article-title":"Activation of peroxisome proliferator-activated receptor-\u03b3 and retinoid X receptor inhibits aromatase transcription via nuclear factor-\u03baB","volume":"146","author":"Fan","year":"2005","journal-title":"Endocrinology"},{"key":"2020082914020828400_ref57","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s12020-013-0092-y","article-title":"Roles of thyroid hormones in follicular development in the ovary of neonatal and immature rats","volume":"46","author":"Fedail","year":"2014","journal-title":"Endocrine"},{"key":"2020082914020828400_ref58","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1093\/humrep\/den490","article-title":"Maternal levels of perfluorinated chemicals and subfecundity","volume":"24","author":"Fei","year":"2009","journal-title":"Hum Reprod"},{"key":"2020082914020828400_ref59","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1021\/jf500674j","article-title":"Root uptake and translocation of perfluorinated alkyl acids by three hydroponically grown crops","volume":"62","author":"Felizeter","year":"2014","journal-title":"J Agric Food Chem"},{"key":"2020082914020828400_ref60","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1093\/toxsci\/kfw219","article-title":"Exposure of pregnant mice to perfluorobutanesulfonate causes hypothyroxinemia and developmental abnormalities in female offspring","volume":"155","author":"Feng","year":"2017","journal-title":"Toxicol Sci"},{"key":"2020082914020828400_ref61","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1093\/toxsci\/kfv197","article-title":"Chronic exposure of female mice to an environmental level of perfluorooctane sulfonate suppresses estrogen synthesis through reduced histone H3K14 acetylation of the StAR promoter leading to deficits in follicular development and ovulation","volume":"148","author":"Feng","year":"2015","journal-title":"Toxicol Sci"},{"key":"2020082914020828400_ref61a","doi-asserted-by":"crossref","first-page":"7928","DOI":"10.1021\/es071244n","article-title":"Exposure of an adult population to perfluorinated substances using duplicate diet portions and biomonitoring data","volume":"41","author":"Fromme","year":"2007","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref62","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.chemosphere.2015.07.024","article-title":"Neutral polyfluorinated compounds in indoor air in Germany \u2013 the LUPE 4 study","volume":"139","author":"Fromme","year":"2015","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref63","first-page":"E520","article-title":"KiSS-1 in the mammalian ovary: distribution of kisspeptin in human and marmoset and alterations in KiSS-1 mRNA levels in a rat model of ovulatory dysfunction","volume":"296","author":"Gayt\u00e1n","year":"2009","journal-title":"Am J Physiol Metab"},{"key":"2020082914020828400_ref64","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.envpol.2014.12.022","article-title":"Perfluoroalkyl acids and their precursors in Swedish food: the relative importance of direct and indirect dietary exposure","volume":"198","author":"Gebbink","year":"2015","journal-title":"Environ Pollut"},{"key":"2020082914020828400_ref65","doi-asserted-by":"crossref","first-page":"9071","DOI":"10.1021\/es301168c","article-title":"Perfluorinated alkyl acids in blood serum from primiparous women in Sweden: serial sampling during pregnancy and nursing, and temporal trends 1996\u20132010","volume":"46","author":"Glynn","year":"2012","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref66","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.envint.2012.04.007","article-title":"Perfluoroalkyl substances in UK indoor and outdoor air: spatial and seasonal variation, and implications for human exposure","volume":"45","author":"Goosey","year":"2012","journal-title":"Environ Int"},{"key":"2020082914020828400_ref67","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.taap.2014.03.012","article-title":"Perfluorinated chemicals: differential toxicity, inhibition of aromatase activity and alteration of cellular lipids in human placental cells","volume":"277","author":"Gorrochategui","year":"2014","journal-title":"Toxicol Appl Pharmacol"},{"key":"2020082914020828400_ref68","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116057","article-title":"Persistent organic pollutants and early menopause in U.S. women","volume":"10","author":"Grindler","year":"2015","journal-title":"PLoS One"},{"key":"2020082914020828400_ref69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2018.11.005","article-title":"Perfluorononanoic acid (PFNA) alters lipid accumulation in bovine blastocysts after oocyte exposure during in vitro maturation","volume":"84","author":"Hallberg","year":"2019","journal-title":"Reprod Toxicol"},{"key":"2020082914020828400_ref70","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.toxlet.2008.07.002","article-title":"Uptake of perfluorooctanoate in freshly isolated hepatocytes from male and female rats","volume":"181","author":"Han","year":"2008","journal-title":"Toxicol Lett"},{"key":"2020082914020828400_ref71","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1021\/tx034005w","article-title":"Binding of perfluorooctanoic acid to rat and human plasma proteins","volume":"16","author":"Han","year":"2003","journal-title":"Chem Res Toxicol"},{"key":"2020082914020828400_ref72","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.envres.2004.12.003","article-title":"Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion","volume":"99","author":"Harada","year":"2005","journal-title":"Environ Res"},{"key":"2020082914020828400_ref73","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/humrep\/dey337","article-title":"Association of phthalates, parabens and phenols found in personal care products with pubertal timing in girls and boys","volume":"34","author":"Harley","year":"2019","journal-title":"Hum Reprod"},{"key":"2020082914020828400_ref74","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.envint.2011.01.011","article-title":"Characterisation of human exposure pathways to perfluorinated compounds - comparing exposure estimates with biomarkers of exposure","volume":"37","author":"Haug","year":"2011","journal-title":"Environ Int"},{"key":"2020082914020828400_ref75","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1021\/es103456h","article-title":"Investigation on per- and polyfluorinated compounds in paired samples of house dust and indoor air from Norwegian homes","volume":"45","author":"Haug","year":"2011","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref76","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1016\/j.chemosphere.2010.06.023","article-title":"Levels in food and beverages and daily intake of perfluorinated compounds in Norway","volume":"80","author":"Haug","year":"2010","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref77","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1016\/j.ijheh.2018.07.009","article-title":"Perfluorinated alkyl acids in the serum and follicular fluid of UK women with and without polycystic ovarian syndrome undergoing fertility treatment and associations with hormonal and metabolic parameters","volume":"221","author":"Heffernan","year":"2018","journal-title":"Int J Hyg Environ Health"},{"key":"2020082914020828400_ref78","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.jhazmat.2014.07.004","article-title":"Foodstuff analyses show that seafood and water are major perfluoroalkyl acids (PFAAs) sources to humans in Korea","volume":"279","author":"Heo","year":"2014","journal-title":"J Hazard Mater"},{"key":"2020082914020828400_ref79","doi-asserted-by":"crossref","first-page":"7930","DOI":"10.1007\/s11356-013-1777-8","article-title":"Perfluorinated alkylated substances in vegetables collected in four European countries; occurrence and human exposure estimations","volume":"20","author":"Herzke","year":"2013","journal-title":"Environ Sci Pollut Res"},{"key":"2020082914020828400_ref80","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1095\/biolreprod58.3.705","article-title":"The ovarian blood follicle barrier is both charge- and size-selective in mice","volume":"58","author":"Hess","year":"1998","journal-title":"Biol Reprod"},{"key":"2020082914020828400_ref81","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.chemosphere.2017.04.122","article-title":"Substitution of PFAS chemistry in outdoor apparel and the impact on repellency performance","volume":"181","author":"Hill","year":"2017","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref82","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0303-7207(94)90278-X","article-title":"Follicular oestrogen synthesis: the \u201ctwo-cell, two-gonadotrophin\u201d model revisited","volume":"100","author":"Hillier","year":"1994","journal-title":"Mol Cell Endocrinol"},{"key":"2020082914020828400_ref83","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archinte.159.10.1061","article-title":"Age at natural menopause and risk of cardiovascular disease","volume":"159","author":"Hu","year":"1999","journal-title":"Arch Intern Med"},{"key":"2020082914020828400_ref84","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3389\/fendo.2017.00365","article-title":"Kisspeptin\/kisspeptin receptor system in the ovary","volume":"8","author":"Hu","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2020082914020828400_ref85","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1021\/acs.estlett.6b00260","article-title":"Detection of poly- and perfluoroalkyl substances (PFASs) in U.S. drinking water linked to industrial sites, military fire training areas, and wastewater treatment plants","volume":"3","author":"Hu","year":"2016","journal-title":"Environ Sci Technol Lett"},{"key":"2020082914020828400_ref86","volume-title":"PFAS Fact Sheets","year":"2020"},{"key":"2020082914020828400_ref87","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/aje\/kwg066","article-title":"Age at natural menopause and all-cause mortality: a 37-year follow-up of 19,731 Norwegian women","volume":"157","author":"Jacobsen","year":"2003","journal-title":"Am J Epidemiol"},{"key":"2020082914020828400_ref88","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/j.1365-2605.2008.00870.x","article-title":"Emerging endocrine disrupters: perfluoroalkylated substances","volume":"31","author":"Jensen","year":"2008","journal-title":"Int J Androl"},{"key":"2020082914020828400_ref89","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.envint.2017.07.024","article-title":"Global distribution of perfluorochemicals (PFCs) in potential human exposure source\u2013a review","volume":"108","author":"Jian","year":"2017","journal-title":"Environ Int"},{"key":"2020082914020828400_ref90","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.chemosphere.2009.08.058","article-title":"PFOS and PFOA in environmental and tap water in China","volume":"77","author":"Jin","year":"2009","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref91","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1897\/02-553","article-title":"Binding of perfluorinated fatty acids to serum proteins","volume":"22","author":"Jones","year":"2003","journal-title":"Environ Toxicol Chem"},{"key":"2020082914020828400_ref92","doi-asserted-by":"crossref","first-page":"2413","DOI":"10.1007\/s00216-010-3944-9","article-title":"Emerging food contaminants: a review","volume":"398","author":"Kantiani","year":"2010","journal-title":"Anal Bioanal Chem"},{"key":"2020082914020828400_ref93","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.envint.2016.05.031","article-title":"Perfluorinated alkyl substances (PFASs) in household dust in Central Europe and North America","volume":"94","author":"Kar\u00e1skov\u00e1","year":"2016","journal-title":"Environ Int"},{"key":"2020082914020828400_ref94","volume-title":"Fluorinated Surfactants and Repellents","author":"Kissa","year":"2011"},{"key":"2020082914020828400_ref95","doi-asserted-by":"crossref","first-page":"8031","DOI":"10.1007\/s11356-013-1753-3","article-title":"Perfluorinated compounds affect the function of sex hormone receptors","volume":"20","author":"Kjeldsen","year":"2013","journal-title":"Environ Sci Pollut Res"},{"key":"2020082914020828400_ref96","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/aje\/155.4.339","article-title":"Endogenous estrogen exposure and cardiovascular mortality risk in postmenopausal women","volume":"155","author":"de Kleijn","year":"2002","journal-title":"Am J Epidemiol"},{"key":"2020082914020828400_ref97","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1210\/jc.2010-2401","article-title":"Implications of early menopause in women exposed to perfluorocarbons","volume":"96","author":"Knox","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"2020082914020828400_ref98","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1477-7827-3-41","article-title":"Peroxisome proliferator-activated receptors (PPARs) and ovarian function \u2013 implications for regulating steroidogenesis, differentiation, and tissue remodeling","volume":"3","author":"Komar","year":"2005","journal-title":"Reprod Biol Endocrinol"},{"key":"2020082914020828400_ref99","doi-asserted-by":"crossref","first-page":"4831","DOI":"10.1210\/endo.142.11.8429","article-title":"Expression and localization of PPARs in the rat ovary during follicular development and the periovulatory period","volume":"142","author":"Komar","year":"2001","journal-title":"Endocrinology"},{"key":"2020082914020828400_ref100","doi-asserted-by":"crossref","first-page":"14546","DOI":"10.1007\/s11356-015-4202-7","article-title":"Perfluoroalkyl and polyfluoroalkyl substances in consumer products","volume":"22","author":"Kotthoff","year":"2015","journal-title":"Environ Sci Pollut Res"},{"key":"2020082914020828400_ref101","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.1093\/humrep\/det382","article-title":"Long-term effects of prenatal exposure to perfluoroalkyl substances on female reproduction","volume":"28","author":"Kristensen","year":"2013","journal-title":"Hum Reprod"},{"key":"2020082914020828400_ref102","doi-asserted-by":"crossref","first-page":"983","DOI":"10.2105\/AJPH.83.7.983","article-title":"Early menopause, number of reproductive years, and bone mineral density in postmenopausal women","volume":"83","author":"Kritz-Silverstein","year":"1993","journal-title":"Am J Public Health"},{"key":"2020082914020828400_ref103","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1039\/b507731c","article-title":"Occurrence of perfluorosulfonates and other perfluorochemicals in dust from selected homes in the city of Ottawa, Canada","volume":"7","author":"Kubwabo","year":"2005","journal-title":"J Environ Monit"},{"key":"2020082914020828400_ref104","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0009-2797(02)00006-6","article-title":"Sex hormone-regulated renal transport of perfluorooctanoic acid","volume":"139","author":"Kudo","year":"2002","journal-title":"Chem Biol Interact"},{"key":"2020082914020828400_ref105","doi-asserted-by":"crossref","first-page":"8075","DOI":"10.1021\/es102384z","article-title":"Polyfluorinated compounds in residential and nonresidential indoor air","volume":"44","author":"Langer","year":"2010","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref106","first-page":"382","article-title":"Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse","volume":"74","author":"Lau","year":"2003","journal-title":"II: Postnatal Evaluation Toxicol Sci"},{"key":"2020082914020828400_ref107","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1016\/j.ijheh.2017.06.005","article-title":"Serum concentrations of per- and poly-fluoroalkyl substances and factors associated with exposure in the general adult population in South Korea","volume":"220","author":"Lee","year":"2017","journal-title":"Int J Hyg Environ Health"},{"key":"2020082914020828400_ref108","doi-asserted-by":"crossref","first-page":"6098","DOI":"10.3390\/ijerph120606098","article-title":"Serum biomarkers of exposure to perfluoroalkyl substances in relation to serum testosterone and measures of thyroid function among adults and adolescents from NHANES 2011-2012","volume":"12","author":"Lewis","year":"2015","journal-title":"Int J Environ Res Public Health"},{"key":"2020082914020828400_ref109","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1136\/oemed-2017-104651","article-title":"Half-lives of PFOS, PFHxS and PFOA after end of exposure to contaminated drinking water","volume":"75","author":"Li","year":"2018","journal-title":"Occup Environ Med"},{"key":"2020082914020828400_ref110","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.aquatox.2007.09.009","article-title":"Evaluation of estrogenic activities and mechanism of action of perfluorinated chemicals determined by vitellogenin induction in primary cultured tilapia hepatocytes","volume":"85","author":"Liu","year":"2007","journal-title":"Aquat Toxicol"},{"key":"2020082914020828400_ref111","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1002\/tox.22661","article-title":"Perfluorooctanoic acid disrupts gap junction intercellular communication and induces reactive oxygen species formation and apoptosis in mouse ovaries","volume":"34","author":"L\u00f3pez-Arellano","year":"2019","journal-title":"Environ Toxicol"},{"key":"2020082914020828400_ref112","doi-asserted-by":"crossref","first-page":"8160","DOI":"10.1021\/es1038694","article-title":"Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with age of puberty among children living near a chemical plant","volume":"45","author":"Lopez-Espinosa","year":"2011","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref113","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1289\/ehp.1509869","article-title":"Perfluoroalkyl substances, sex hormones, and insulin-like growth factor-1 at 6-9 years of age: a cross-sectional analysis within the C8 health project","volume":"124","author":"Lopez-Espinosa","year":"2016","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref114","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.chemosphere.2014.07.093","article-title":"The effect of ongoing blood loss on human serum concentrations of perfluorinated acids","volume":"118","author":"Lorber","year":"2015","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref115","doi-asserted-by":"crossref","first-page":"8006","DOI":"10.1021\/es103718h","article-title":"Simple intake and pharmacokinetic modeling to characterize exposure of Americans to perfluoroctanoic acid, PFOA","volume":"45","author":"Lorber","year":"2011","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref116","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/EDE.0000000000000552","article-title":"Perfluoroalkyl chemicals, menstrual cycle length, and fecundity","volume":"28","author":"Lum","year":"2017","journal-title":"Epidemiology"},{"key":"2020082914020828400_ref117","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1093\/humrep\/det390","article-title":"Menstrual cycle characteristics in fertile women from Greenland, Poland and Ukraine exposed to perfluorinated chemicals: a cross-sectional study","volume":"29","author":"Lyngs\u00f8","year":"2014","journal-title":"Hum Reprod"},{"key":"2020082914020828400_ref118","doi-asserted-by":"crossref","first-page":"4824","DOI":"10.1021\/es900637a","article-title":"Perfluorinated compounds in tap water from China and several other countries","volume":"43","author":"Mak","year":"2009","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref119","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1289\/ehp.8149","article-title":"Estrogen-like properties of fluorotelomer alcohols as revealed by MCF-7 breast cancer cell proliferation","volume":"114","author":"Maras","year":"2006","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref120","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1177\/0960327114565492","article-title":"Mechanistic approach for the toxic effects of perfluorooctanoic acid on isolated rat liver and brain mitochondria","volume":"34","author":"Mashayekhi","year":"2015","journal-title":"Hum Exp Toxicol"},{"key":"2020082914020828400_ref121","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.scitotenv.2017.06.137","article-title":"Associations between perfluorinated alkyl acids in blood and ovarian follicular fluid and ovarian function in women undergoing assisted reproductive treatment","volume":"605\u2013606","author":"McCoy","year":"2017","journal-title":"Sci Total Environ"},{"key":"2020082914020828400_ref122","first-page":"279","article-title":"Estrogen actions in the central nervous system","volume":"20","author":"McEwen","year":"1999","journal-title":"Endocr Rev"},{"key":"2020082914020828400_ref123","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1093\/aje\/kwi324","article-title":"Age at natural menopause and cause-specific mortality","volume":"162","author":"Mondul","year":"2005","journal-title":"Am J Epidemiol"},{"key":"2020082914020828400_ref124","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.envres.2008.06.001","article-title":"Serum levels of perfluoroalkyl compounds in human maternal and umbilical cord blood samples","volume":"108","author":"Monroy","year":"2008","journal-title":"Environ Res"},{"key":"2020082914020828400_ref125","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1093\/aje\/155.7.672","article-title":"Recall of early menstrual history and menarcheal body size: after 30 years, how well do women remember?","volume":"155","author":"Must","year":"2002","journal-title":"Am J Epidemiol"},{"key":"2020082914020828400_ref126","doi-asserted-by":"crossref","first-page":"7496","DOI":"10.1021\/jf104943p","article-title":"Levels of perfluorinated compounds in food and dietary intake of PFOS and PFOA in the Netherlands","volume":"59","author":"Noorlander","year":"2011","journal-title":"J Agric Food Chem"},{"key":"2020082914020828400_ref127","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/S0140-6736(07)61345-2","article-title":"Polycystic ovary syndrome","volume":"370","author":"Norman","year":"2007","journal-title":"Lancet (London, England)"},{"key":"2020082914020828400_ref128","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1289\/ehp.10009","article-title":"Half-life of serum elimination of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers","volume":"115","author":"Olsen","year":"2007","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref129","doi-asserted-by":"crossref","first-page":"6330","DOI":"10.1021\/es300604p","article-title":"Temporal trends of perfluoroalkyl concentrations in American Red Cross adult blood donors, 2000\u20132010","volume":"46","author":"Olsen","year":"2012","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref130","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1097\/01.ede.0000165392.35273.d4","article-title":"Age at menopause, cause-specific mortality and total life expectancy","volume":"16","author":"Ossewaarde","year":"2005","journal-title":"Epidemiology"},{"key":"2020082914020828400_ref130a","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/j.chemosphere.2009.02.053","article-title":"Estimated dietary exposure to fluorinated compounds from traditional foods among Inuit in Nunavut, Canada","volume":"75","author":"Ostertag","year":"2009","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref131","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1056\/NEJMcp1109290","article-title":"Delayed puberty","volume":"366","author":"Palmert","year":"2012","journal-title":"N Engl J Med"},{"key":"2020082914020828400_ref132","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1136\/jech.50.5.519","article-title":"Menopause, menstrual and reproductive history, and bone density in northern Italy","volume":"50","author":"Parazzini","year":"1996","journal-title":"J Epidemiol Community Health"},{"key":"2020082914020828400_ref133","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.envres.2019.05.028","article-title":"Determinants of per- and polyfluoroalkyl substances (PFAS) in midlife women: evidence of racial\/ethnic and geographic differences in PFAS exposure","volume":"175","author":"Park","year":"2019","journal-title":"Environ Res"},{"key":"2020082914020828400_ref134","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/j.envint.2013.06.004","article-title":"Accumulation of perfluoroalkyl substances in human tissues","volume":"59","author":"P\u00e9rez","year":"2013","journal-title":"Environ Int"},{"key":"2020082914020828400_ref135","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.scitotenv.2014.07.028","article-title":"Perfluoroalkyl acid contamination of follicular fluid and its consequence for in vitro oocyte developmental competence","volume":"496","author":"Petro","year":"2014","journal-title":"Sci Total Environ"},{"key":"2020082914020828400_ref136","doi-asserted-by":"crossref","first-page":"8248","DOI":"10.1021\/es0713678","article-title":"Semivolatile fluorinated organic compounds in Asian and Western U.S. air masses","volume":"41","author":"Piekarz","year":"2007","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref137","doi-asserted-by":"crossref","first-page":"4547","DOI":"10.1021\/es900301s","article-title":"Occurrence and potential significance of perfluorooctanoic acid (PFOA) detected in New Jersey public drinking water systems","volume":"43","author":"Post","year":"2009","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref138","doi-asserted-by":"crossref","first-page":"692067","DOI":"10.1155\/2014\/692067","article-title":"A role of lipid metabolism during cumulus-oocyte complex maturation: impact of lipid modulators to improve embryo production","volume":"2014","author":"Prates","year":"2014","journal-title":"Mediators Inflamm"},{"key":"2020082914020828400_ref139","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.chemosphere.2009.07.079","article-title":"Specific profiles of perfluorinated compounds in surface and drinking waters and accumulation in mussels, fish, and dolphins from southeastern Brazil","volume":"77","author":"Quinete","year":"2009","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref140","doi-asserted-by":"crossref","first-page":"9089","DOI":"10.1021\/es9024707","article-title":"Occurrence of perfluoroalkyl carboxylates and sulfonates in drinking water utilities and related waters from the United States","volume":"43","author":"Qui\u00f1ones","year":"2009","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref141","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.theriogenology.2014.02.016","article-title":"Rosiglitazone stimulates peroxisome proliferator-activated receptor gamma expression and directly affects in vitro steroidogenesis in porcine ovarian follicles","volume":"82","author":"Rak-Mardy\u0142a","year":"2014","journal-title":"Theriogenology"},{"key":"2020082914020828400_ref142","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.toxrep.2015.11.004","article-title":"Hypercholesterolemia with consumption of PFOA-laced Western diets is dependent on strain and sex of mice","volume":"3","author":"Rebholz","year":"2016","journal-title":"Toxicol Reports"},{"key":"2020082914020828400_ref142a","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.marpolbul.2013.09.014","article-title":"Perfluorinated compounds: Levels, trophic web enrichments and human dietary intakes in transitional water ecosystems","volume":"76","author":"Renzi","year":"2013","journal-title":"Mar Pollut Bull"},{"key":"2020082914020828400_ref143","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.peptides.2008.08.009","article-title":"Kisspeptins and the control of gonadotropin secretion in male and female rodents","volume":"30","author":"Roa","year":"2009","journal-title":"Peptides"},{"key":"2020082914020828400_ref144","first-page":"39","article-title":"Long-term effects of bilateral oophorectomy on brain aging: unanswered questions from the Mayo Clinic Cohort Study of Oophorectomy and Aging","volume":"5","author":"Rocca","year":"2009","journal-title":"Women\u2019s Heal"},{"key":"2020082914020828400_ref145","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.envint.2016.11.030","article-title":"Quantitative bias analysis for epidemiological associations of perfluoroalkyl substance serum concentrations and early onset of menopause","volume":"99","author":"Ruark","year":"2017","journal-title":"Environ Int"},{"key":"2020082914020828400_ref146","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1021\/acs.estlett.6b00435","article-title":"Fluorinated compounds in U.S. fast food packaging","volume":"4","author":"Schaider","year":"2017","journal-title":"Environ Sci Technol Lett"},{"key":"2020082914020828400_ref148","doi-asserted-by":"crossref","first-page":"2960","DOI":"10.1093\/humrep\/del257","article-title":"Peptide and protein profiles in serum and follicular fluid of women undergoing IVF","volume":"21","author":"Schweigert","year":"2006","journal-title":"Hum Reprod"},{"key":"2020082914020828400_ref149","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.reprotox.2009.02.008","article-title":"The effect of perfluorododecanonic acid on endocrine status, sex hormones and expression of steroidogenic genes in pubertal female rats","volume":"27","author":"Shi","year":"2009","journal-title":"Reprod Toxicol"},{"key":"2020082914020828400_ref150","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.maturitas.2009.08.003","article-title":"Premature menopause or early menopause: Long-term health consequences","volume":"65","author":"Shuster","year":"2010","journal-title":"Maturitas"},{"key":"2020082914020828400_ref151","doi-asserted-by":"crossref","DOI":"10.1021\/es062377w","article-title":"Quantitation of gas-phase perfluoroalkyl surfactants and fluorotelomer alcohols released from nonstick cookware and microwave popcorn bags","author":"Sinclair","year":"2007"},{"key":"2020082914020828400_ref152","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.annepidem.2006.05.005","article-title":"Validity of self-reported menstrual cycle length","volume":"17","author":"Small","year":"2007","journal-title":"Ann Epidemiol"},{"key":"2020082914020828400_ref153","doi-asserted-by":"crossref","first-page":"5361","DOI":"10.1021\/es8006244","article-title":"Use of newborn screening program blood spots for exposure assessment: declining levels of perfluorinated compounds in New York state infants","volume":"42","author":"Spliethoff","year":"2008","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref154","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1021\/es7032058","article-title":"Perfluorinated compounds in house dust from Ohio and North Carolina, USA","volume":"42","author":"Strynar","year":"2008","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref155","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1016\/j.chemosphere.2008.05.034","article-title":"Perfluorooctanesulfonate and perfluorooctanoate in raw and treated tap water from Osaka, Japan","volume":"72","author":"Takagi","year":"2008","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref156","first-page":"E380","article-title":"Blockage of gonadotropin-induced first ovulation caused by thyroidectomy and its possible mechanisms in rats","volume":"275","author":"Tamura","year":"1998","journal-title":"Am J Physiol Metab"},{"key":"2020082914020828400_ref157","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1289\/ehp.1306707","article-title":"Polyfluoroalkyl chemicals and menopause among women 20-65 years of age (NHANES)","volume":"122","author":"Taylor","year":"2014","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref158","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1093\/toxsci\/kfg121","article-title":"Exposure to perfluorooctane sulfonate during pregnancy in rat and mouse. I: Maternal and prenatal evaluations","volume":"74","author":"Thibodeaux","year":"2003","journal-title":"Toxicol Sci"},{"key":"2020082914020828400_ref159","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.chemosphere.2011.04.017","article-title":"Concentrations of PFOS, PFOA and other perfluorinated alkyl acids in Australian drinking water","volume":"83","author":"Thompson","year":"2011","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref160","doi-asserted-by":"crossref","first-page":"3203","DOI":"10.1021\/jf0634045","article-title":"Dietary exposure of Canadians to perfluorinated carboxylates and perfluorooctane sulfonate via consumption of meat, fish, fast foods, and food items prepared in their packaging","volume":"55","author":"Tittlemier","year":"2007","journal-title":"J Agric Food Chem"},{"key":"2020082914020828400_ref161","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1007\/s11356-010-0439-3","article-title":"Polyfluorinated surfactants (PFS) in paper and board coatings for food packaging","volume":"18","author":"Trier","year":"2011","journal-title":"Environ Sci Pollut Res"},{"key":"2020082914020828400_ref162","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1539-6924.2008.01017.x","article-title":"Estimating consumer exposure to PFOS and PFOA","volume":"28","author":"Trudel","year":"2008","journal-title":"Risk Anal"},{"key":"2020082914020828400_ref163","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.ijheh.2015.03.008","article-title":"Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults","volume":"218","author":"Tsai","year":"2015","journal-title":"Int J Hyg Environ Health"},{"key":"2020082914020828400_ref164","article-title":"Health effects support document for perfluorooctane sulfonate (PFOS)","year":"2016"},{"key":"2020082914020828400_ref165","article-title":"Health effects support document for perfluorooctanoic acid (PFOA)","year":"2016"},{"key":"2020082914020828400_ref166","article-title":"Fact sheet: toxicity assessments for GenX chemicals and PFBS","year":"2018"},{"key":"2020082914020828400_ref167","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/s12940-017-0242-4","article-title":"Environmental pollutants, a possible etiology for premature ovarian insufficiency: a narrative review of animal and human data","volume":"16","author":"Vabre","year":"2017","journal-title":"Environ Health"},{"key":"2020082914020828400_ref189","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/S0140-6736(96)90075-6","article-title":"Age at menopause as a risk factor for cardiovascular mortality","volume":"347","author":"van der Schouw","year":"1996","journal-title":"Lancet (London, England)"},{"key":"2020082914020828400_ref168","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/gme.0b013e3180f6108c","article-title":"Decreased androgen concentrations and diminished general and sexual well-being in women with premature ovarian failure","volume":"15","author":"Van Der Stege","year":"2008","journal-title":"Menopause"},{"key":"2020082914020828400_ref169","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.envint.2012.08.016","article-title":"Dietary exposure to perfluoroalkyl acids for the Swedish population in 1999, 2005 and 2010","volume":"49","author":"Vestergren","year":"2012","journal-title":"Environ Int"},{"key":"2020082914020828400_ref170","doi-asserted-by":"crossref","first-page":"5565","DOI":"10.1021\/es900228k","article-title":"Tracking the pathways of human exposure to perfluorocarboxylates","volume":"43","author":"Vestergren","year":"2009","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref171","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1289\/ehp.1205829","article-title":"Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: a geographic analysis","volume":"121","author":"Vieira","year":"2013","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref172","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0015-0282(16)56941-6","article-title":"Thyroid hormone receptor messenger ribonucleic acid in human granulosa and ovarian stromal cells","volume":"62","author":"Wakim","year":"1994","journal-title":"Fertil Steril"},{"key":"2020082914020828400_ref173","first-page":"1092","article-title":"PFOS-induced hepatic steatosis, the mechanistic actions on \u03b2-oxidation and lipid transport","volume":"2012","author":"Wan","year":"1820","journal-title":"Biochim Biophys Acta - Gen Subj"},{"key":"2020082914020828400_ref174","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1021\/tx5004563","article-title":"Perfluorooctyl iodide stimulates steroidogenesis in H295R cells via a cyclic adenosine monophosphate signaling pathway","volume":"28","author":"Wang","year":"2015","journal-title":"Chem Res Toxicol"},{"key":"2020082914020828400_ref175","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1289\/ehp.1103773","article-title":"The in vitro estrogenic activities of polyfluorinated iodine alkanes","volume":"120","author":"Wang","year":"2012","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref176","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.envpol.2019.01.039","article-title":"Perfluoroalkyl substances exposure and risk of polycystic ovarian syndrome related infertility in Chinese women","volume":"247","author":"Wang","year":"2019","journal-title":"Environ Pollut"},{"key":"2020082914020828400_ref177","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1093\/toxsci\/kfy167","article-title":"Impact of perfluorooctane sulfonate on reproductive ability of female mice through suppression of estrogen receptor \u03b1-activated kisspeptin neurons","volume":"165","author":"Wang","year":"2018","journal-title":"Toxicol Sci"},{"key":"2020082914020828400_ref178","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.envint.2018.09.035","article-title":"Associations of cumulative exposure to heavy metal mixtures with obesity and its comorbidities among U.S. adults in NHANES 2003\u20132014","volume":"121","author":"Wang","year":"2018","journal-title":"Environ Int"},{"key":"2020082914020828400_ref179","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.119.013571","article-title":"Does information on blood heavy metals improve cardiovascular mortality prediction?","volume":"8","author":"Wang","year":"2019","journal-title":"J Am Heart Assoc"},{"key":"2020082914020828400_ref180","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1289\/ehp.1306925","article-title":"Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan Maternal and Infant Cohort Study","volume":"122","author":"Wang","year":"2014","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref181","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.chemosphere.2014.10.014","article-title":"Perfluoroalkylated substances (PFAS) affect oxidative stress biomarkers in vitro","volume":"129","author":"Wiels\u00f8e","year":"2015","journal-title":"Chemosphere"},{"key":"2020082914020828400_ref182","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijheh.2010.05.004","article-title":"Occurrence of perfluorinated compounds (PFCs) in drinking water of North Rhine-Westphalia, Germany and new approach to assess drinking water contamination by shorter-chained C4\u2013C7 PFCs","volume":"213","author":"Wilhelm","year":"2010","journal-title":"Int J Hyg Environ Health"},{"key":"2020082914020828400_ref183","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1021\/es500796y","article-title":"Enhanced elimination of perfluorooctane sulfonic acid by menstruating women: evidence from population-based pharmacokinetic modeling","volume":"48","author":"Wong","year":"2014","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref184","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1021\/es500796y","article-title":"Enhanced elimination of perfluorooctane sulfonic acid by menstruating women: evidence from population-based pharmacokinetic modeling","volume":"48","author":"Wong","year":"2014","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref185","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.envint.2017.06.007","article-title":"Per- and polyfluoroalkyl substances in human serum and urine samples from a residentially exposed community","volume":"106","author":"Worley","year":"2017","journal-title":"Environ Int"},{"key":"2020082914020828400_ref186","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.envint.2015.05.006","article-title":"Can the observed association between serum perfluoroalkyl substances and delayed menarche be explained on the basis of puberty-related changes in physiology and pharmacokinetics?","volume":"82","author":"Wu","year":"2015","journal-title":"Environ Int"},{"key":"2020082914020828400_ref187","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.watres.2014.09.052","article-title":"Perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) in soils and groundwater of a U.S. metropolitan area: migration and implications for human exposure","volume":"72","author":"Xiao","year":"2015","journal-title":"Water Res"},{"key":"2020082914020828400_ref188","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.reprotox.2017.02.010","article-title":"Maternal exposure to perfluorooctanoic acid inhibits luteal function via oxidative stress and apoptosis in pregnant mice","volume":"69","author":"Xie","year":"2017","journal-title":"Reprod Toxicol"},{"key":"2020082914020828400_ref190","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tox.2014.10.008","article-title":"Comparative in vivo and in vitro analysis of possible estrogenic effects of perfluorooctanoic acid","volume":"326","author":"Yao","year":"2014","journal-title":"Toxicology"},{"key":"2020082914020828400_ref191","doi-asserted-by":"crossref","first-page":"3156","DOI":"10.1021\/acs.est.7b04971","article-title":"Per- and polyfluoroalkyl substances (PFASs) in indoor air and dust from homes and various microenvironments in China: implications for human exposure","volume":"52","author":"Yao","year":"2018","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref192","doi-asserted-by":"crossref","first-page":"3865","DOI":"10.1021\/es303716k","article-title":"Part I. a temporal study of PFCAs and their precursors in human plasma from two German cities 1982\u20132009","volume":"47","author":"Yeung","year":"2013","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref193","doi-asserted-by":"crossref","first-page":"3875","DOI":"10.1021\/es4004153","article-title":"Part II. A temporal study of PFOS and its precursors in human plasma from two German cities in 1982\u20132009","volume":"47","author":"Yeung","year":"2013","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref194","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-0773.1990.tb00700.x","article-title":"Tissue distribution and elimination of perfluorodecanoic acid in the rat after single intraperitoneal administration","volume":"66","author":"Ylinen","year":"1990","journal-title":"Pharmacol Toxicol"},{"key":"2020082914020828400_ref195","doi-asserted-by":"crossref","first-page":"2543","DOI":"10.1210\/jc.2017-02783","article-title":"Association of perfluoroalkyl and polyfluoroalkyl substances with premature ovarian insufficiency in Chinese women","volume":"103","author":"Zhang","year":"2018","journal-title":"J Clin Endocrinol Metab"},{"key":"2020082914020828400_ref196","doi-asserted-by":"crossref","first-page":"3572","DOI":"10.1021\/es1000159","article-title":"Perfluorochemicals in meat, eggs and indoor dust in China: assessment of sources and pathways of human exposure to perfluorochemicals","volume":"44","author":"Zhang","year":"2010","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref197","doi-asserted-by":"crossref","first-page":"10619","DOI":"10.1021\/es401905e","article-title":"Biomonitoring of perfluoroalkyl acids in human urine and estimates of biological half-life","volume":"47","author":"Zhang","year":"2013","journal-title":"Environ Sci Technol"},{"key":"2020082914020828400_ref198","doi-asserted-by":"crossref","DOI":"10.1289\/EHP1203","article-title":"Shanghai Birth Cohort Study. Plasma perfluoroalkyl and polyfluoroalkyl substances concentration and menstrual cycle characteristics in preconception women","volume":"125","author":"Zhou","year":"2017","journal-title":"Environ Health Perspect"},{"key":"2020082914020828400_ref199","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.envint.2016.05.018","article-title":"Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: by sex status","volume":"94","author":"Zhou","year":"2016","journal-title":"Environ Int"},{"key":"2020082914020828400_ref200","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-3177","article-title":"Adult consequences of self-limited delayed puberty","volume":"139","author":"Zhu","year":"2017","journal-title":"Pediatrics"}],"container-title":["Human Reproduction Update"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/humupd\/article-pdf\/26\/5\/724\/33697868\/dmaa018.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/humupd\/article-pdf\/26\/5\/724\/33697868\/dmaa018.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,31]],"date-time":"2020-08-31T13:24:06Z","timestamp":1598880246000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humupd\/article\/26\/5\/724\/5848465"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,29]]},"references-count":204,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,5,29]]},"published-print":{"date-parts":[[2020,9,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humupd\/dmaa018","relation":{},"ISSN":["1355-4786","1460-2369"],"issn-type":[{"value":"1355-4786","type":"print"},{"value":"1460-2369","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,9]]},"published":{"date-parts":[[2020,5,29]]}}}