{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T22:10:36Z","timestamp":1793052636083,"version":"4.5.0"},"reference-count":465,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,3,7]],"date-time":"2023-03-07T00:00:00Z","timestamp":1678147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Regional Government of Catalonia","award":["2017-SGR-1229"],"award-info":[{"award-number":["2017-SGR-1229"]}]},{"DOI":"10.13039\/501100003741","name":"Catalan Institution for Research and Advanced Studies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003741","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>It has long been thought that the factors affecting embryo and foetal development were exclusively maternally derived; hence, if issues regarding fertility and embryo development were to arise, the blame has traditionally been placed solely on the mother. An escalating interest in how paternal factors influence embryo development, however, has begun to prove otherwise. Evidence suggests that both seminal plasma (SP) and sperm contribute multiple factors that shape embryogenesis. This review thus focuses on the role that semen has in driving early embryonic development, and describes how paternal factors, such as SP, sperm centriole, sperm proteins, sperm RNA, sperm DNA, and its integrity, together with epigenetics, may influence the female reproductive tract and post-fertilization events. The important contributions of paternal factors to embryo development highlight the imperative need for further research in this area, which is sure to bring forth breakthroughs leading to improvements in infertility diagnosis and ART as well as reducing the risk of miscarriage.<\/jats:p><\/jats:sec><jats:sec><jats:title>OBJECTIVE AND RATIONALE<\/jats:title><jats:p>This review provides a comprehensive overview of the role of human semen in development of the early embryo, with the aim of providing a better understanding of the influence of SP and sperm on early embryonic divisions, gene and protein expression, miscarriage, and congenital diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>SEARCH METHODS<\/jats:title><jats:p>PubMed searches were performed using the terms \u2018sperm structure\u2019, \u2018capacitation\u2019, \u2018acrosome reaction\u2019, \u2018fertilization\u2019, \u2018oocyte activation\u2019, \u2018PLC\u03b6\u2019, \u2018PAWP\u2019, \u2018sperm-borne oocyte activation factor\u2019, \u2018oocyte activation deficiency\u2019, \u2018sperm centriole\u2019, \u2018sperm transport\u2019, \u2018sperm mitochondria\u2019, \u2018seminal plasma\u2019, \u2018sperm epigenetics\u2019, \u2018sperm histone modifications\u2019, \u2018sperm DNA methylation\u2019, \u2018sperm-derived transcripts\u2019, \u2018sperm-derived proteins\u2019, \u2018sperm DNA fragmentation\u2019, \u2018sperm mRNA\u2019, \u2018sperm miRNAs\u2019, \u2018sperm piRNAs\u2019, and \u2018sperm-derived aneuploidy\u2019. The reviewed articles were restricted to those published in English between 1980 and 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>OUTCOMES<\/jats:title><jats:p>The data suggest that male-derived factors contribute much more than just the male haploid genome to the early embryo. Evidence indicates that semen contributes multiple factors that help shape the fate of embryogenesis. These male-derived factors include contributions from SP, the paternal centriole, RNA and proteins, and DNA integrity. In addition, epigenetic changes have an impact on the female reproductive tract, fertilization, and early stages of embryo development. For example, recent proteomic and transcriptomic studies have identified several sperm-borne markers that play important roles in oocyte fertilization and embryogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>WIDER IMPLICATIONS<\/jats:title><jats:p>This review highlights that several male-derived factors are required to work in tandem with female counterparts to allow for correct fertilization and development of the early embryo. A deeper understanding of the contributions of paternal factors that are shuttled over from the sperm cell to the embryo can shed light on how to improve ART from an andrological perspective. Further studies may aid in preventing the passing on of genetic and epigenetic abnormalities of paternal origin, thus decreasing the incidence of male factor infertility. In addition, understanding the exact mechanisms of paternal contribution may assist reproductive scientists and IVF clinicians in determining new causes of recurrent early miscarriage or fertilization failure.<\/jats:p><\/jats:sec>","DOI":"10.1093\/humupd\/dmad006","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:19:46Z","timestamp":1678234786000},"page":"395-433","source":"Crossref","is-referenced-by-count":136,"title":["Contribution of semen to early embryo development: fertilization and beyond"],"prefix":"10.1093","volume":"29","author":[{"given":"Montserrat","family":"Vallet-Buisan","sequence":"first","affiliation":[{"name":"Nuffield Department of Women\u2019s and Reproductive Health, Level 3, Women\u2019s Centre, John Radcliffe Hospital, University of Oxford , Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajwa","family":"Mecca","sequence":"additional","affiliation":[{"name":"Nuffield Department of Women\u2019s 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