{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T19:29:43Z","timestamp":1790105383706,"version":"4.0.1"},"reference-count":436,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T00:00:00Z","timestamp":1774483200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"World Premier International Research Center Initiative"},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010848","name":"Gruber Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010848","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Science Foundation Graduate Research","award":["DGE-2139841"],"award-info":[{"award-number":["DGE-2139841"]}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R00HD104924"],"award-info":[{"award-number":["R00HD104924"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032455","name":"Male Contraceptive Initiative","doi-asserted-by":"crossref","award":["2024-303"],"award-info":[{"award-number":["2024-303"]}],"id":[{"id":"10.13039\/100032455","id-type":"DOI","asserted-by":"crossref"}]},{"name":"JSPS Grant-in-Aid for Scientific Research","award":["JP24K02033"],"award-info":[{"award-number":["JP24K02033"]}]},{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","award":["2024032851"],"award-info":[{"award-number":["2024032851"]}],"id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Research Encouragement"},{"DOI":"10.13039\/100007684","name":"Asahi Glass Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007684","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PRIMe Joint Research","award":["1301800004"],"award-info":[{"award-number":["1301800004"]}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"Abstract<\/jats:title>\n \n BACKGROUND<\/jats:title>\n Fertilization ensures the transmission of genetic material across generations through a series of precisely coordinated physiological and molecular events. To fertilize an oocyte, a spermatozoon must pass through the cumulus cell layer, penetrate the zona pellucida (ZP), and ultimately adhere to and fuse with the oolemma (the oocyte plasma membrane). Upon fusion, the oocyte initiates mechanisms to block additional sperm entry at both the ZP and oolemma. These processes are highly dynamic in space and time, posing substantial technical barriers to their mechanistic dissection. Nonetheless, recent in silico, in vitro, and in vivo studies have begun to elucidate how intricate networks of intracellular signaling cascades and extracellular protein\u2013protein interactions orchestrate successful fertilization in vertebrates. However, the extent to which these findings accurately reflect the biology of human sperm\u2013oocyte interactions remains obscure, owing to ethical constraints on human gamete experimentation and the limited availability of patients harboring pathogenic variants in fertilization-related genes.<\/jats:p>\n <\/jats:sec>\n \n OBJECTIVE AND RATIONALE<\/jats:title>\n This narrative review synthesizes current knowledge of the molecular determinants governing mammalian sperm\u2013oocyte interactions, summarizes relevant genetic anomalies identified in infertile patients, and discusses emerging experimental approaches for the direct investigation of human fertilization. We also explore how recent mechanistic insights and technological innovations may inform the diagnosis and treatment of fertilization disorders and guide the development of novel contraceptive strategies.<\/jats:p>\n <\/jats:sec>\n \n SEARCH METHODS<\/jats:title>\n We searched PubMed, Google Scholar, and Scopus to identify research and review articles published in English. Studies limited to non-mammalian species and non-peer-reviewed preprints were excluded. Searches used terms related to fertilization, sperm\u2013oocyte interactions, ZP, cumulus cells, polyspermy block, and human infertility, alone or in combination. Additional searches targeted key proteins and emerging technologies relevant to mammalian fertilization, clinical diagnostics, and contraceptive development.<\/jats:p>\n <\/jats:sec>\n \n OUTCOMES<\/jats:title>\n Our mechanistic understanding of mammalian gamete interactions has predominantly stemmed from in vitro and in vivo animal studies, which have revealed key molecular processes, such as sperm hyaluronidase-mediated cumulus matrix dispersal, translocation of sperm acrosomal membrane proteins to enable oolemma interaction, and ZP glycoprotein cleavage underlying the polyspermy block. While studies in model species remain indispensable, translating this knowledge to human biology requires meticulous validation. The integration of interdisciplinary approaches, such as humanized mouse models, artificial human oocytes, xenospecies fertilization assays, antibody inhibition studies, and high-throughput interactome screening, offers promising avenues to clarify interspecies discrepancies and generate insights more directly relevant to human gamete interactions.<\/jats:p>\n <\/jats:sec>\n \n WIDER IMPLICATIONS<\/jats:title>\n Advances in the mechanistic dissection of sperm\u2013oocyte interactions are anticipated to support the development of diagnostic tools and therapeutic interventions for infertility caused by defective fertilization. In parallel, these discoveries may enable the rational design of safe, reversible contraceptives that selectively block gamete interactions without compromising other physiological processes.<\/jats:p>\n <\/jats:sec>\n \n REGISTRATION NUMBER<\/jats:title>\n N\/A.<\/jats:p>\n <\/jats:sec>","DOI":"10.1093\/humupd\/dmag008","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T09:04:01Z","timestamp":1774515841000},"page":"409-439","source":"Crossref","is-referenced-by-count":6,"title":["Molecular interplay between sperm and oocyte: a narrative review"],"prefix":"10.1093","volume":"32","author":[{"given":"Hsin-Yi","family":"Chang","sequence":"first","affiliation":[{"name":"Graduate School of Medicine, The University of Osaka , Suita, Osaka,","place":["Japan"]},{"name":"Research Institute for Microbial Diseases, The University of Osaka , Suita, Osaka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taylor","family":"Gierke","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics and Biochemistry, Yale University , New Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3904-492X","authenticated-orcid":false,"given":"Shaogeng","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Molecular Biophysics and Biochemistry, Yale University , New Haven, CT,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0198-8906","authenticated-orcid":false,"given":"Yonggang","family":"Lu","sequence":"additional","affiliation":[{"name":"Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), The University of Osaka , Suita, Osaka,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,3,25]]},"reference":[{"key":"2026070101520834300_dmag008-B1","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0015-0282(16)57976-X","article-title":"Hyaluronidase activity in human semen: correlation with fertilization in vitro","volume":"64","author":"Abdul-Aziz","year":"1995","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B2","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B3","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1002\/j.1939-4640.1993.tb01667.x","article-title":"Analysis of the responses of human spermatozoa to A23187 employing a novel technique for assessing the acrosome reaction","volume":"14","author":"Aitken","year":"1993","journal-title":"J Androl"},{"key":"2026070101520834300_dmag008-B4","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/molehr\/gat067","article-title":"Sperm capacitation: a distant landscape glimpsed but unexplored","volume":"19","author":"Aitken","year":"2013","journal-title":"Mol Hum Reprod"},{"key":"2026070101520834300_dmag008-B5","doi-asserted-by":"crossref","first-page":"242","DOI":"10.4103\/jhrs.JHRS_97_17","article-title":"On the origins of the semen analysis: a close relationship with the history of the reproductive medicine","volume":"10","author":"Andrade-Rocha","year":"2017","journal-title":"J Hum Reprod Sci"},{"key":"2026070101520834300_dmag008-B6","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/j.1432-1033.1997.t01-1-00810.x","article-title":"In vitro mutagenesis of PH-20 hyaluronidase from human sperm","volume":"247","author":"Arming","year":"1997","journal-title":"Eur J Biochem"},{"key":"2026070101520834300_dmag008-B7","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1007\/s43032-019-00137-x","article-title":"Luteinizing hormone action in human oocyte maturation and quality: signaling pathways, regulation, and clinical impact","volume":"27","author":"Arroyo","year":"2020","journal-title":"Reprod Sci"},{"key":"2026070101520834300_dmag008-B8","doi-asserted-by":"crossref","first-page":"e3589","DOI":"10.1002\/jgm.3589","article-title":"Identification of novel homozygous missense and deletion mutations manifesting oligospermia infertility in Kashmiri population","volume":"26","author":"Aslam","year":"2024","journal-title":"J Gene Med"},{"key":"2026070101520834300_dmag008-B9","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1007\/s10815-010-9491-7","article-title":"Biomarkers of human oocyte developmental competence expressed in cumulus cells before ICSI: a preliminary study","volume":"28","author":"Assidi","year":"2011","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B10","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1071\/BI9510581","article-title":"Observations on the penetration of the sperm into the mammalian egg","volume":"4","author":"Austin","year":"1951","journal-title":"Aust J Sci Res B"},{"key":"2026070101520834300_dmag008-B11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/170326a0","article-title":"The \u2018capacitation\u2019 of the mammalian sperm","volume":"170","author":"Austin","year":"1952","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B12","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1038\/181851a0","article-title":"Capacitation of mammalian spermatozoa","volume":"181","author":"Austin","year":"1958","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B13","doi-asserted-by":"crossref","first-page":"336ra60","DOI":"10.1126\/scitranslmed.aad9946","article-title":"ZP2 peptide beads select human sperm in vitro, decoy mouse sperm in vivo, and provide reversible contraception","volume":"8","author":"Avella","year":"2016","journal-title":"Sci Transl Med"},{"key":"2026070101520834300_dmag008-B14","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1002\/(SICI)1098-2795(199607)44:3<370::AID-MRD11>3.0.CO;2-4","article-title":"Modifications of the lectin binding pattern in the rat zona pellucida after in vivo fertilization","volume":"44","author":"Avil\u00e9s","year":"1996","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B15","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nature18595","article-title":"Molecular architecture of the human sperm IZUMO1 and egg JUNO fertilization complex","volume":"534","author":"Aydin","year":"2016","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B16","doi-asserted-by":"crossref","first-page":"31845","DOI":"10.1016\/S0021-9258(18)31772-1","article-title":"Sperm from mice carrying a targeted mutation of the acrosin gene can penetrate the oocyte zona pellucida and effect fertilization","volume":"269","author":"Baba","year":"1994","journal-title":"J Biol Chem"},{"key":"2026070101520834300_dmag008-B17","doi-asserted-by":"crossref","first-page":"30310","DOI":"10.1074\/jbc.M204596200","article-title":"Mouse sperm lacking cell surface hyaluronidase PH-20 can pass through the layer of cumulus cells and fertilize the egg","volume":"277","author":"Baba","year":"2002","journal-title":"J Biol Chem"},{"key":"2026070101520834300_dmag008-B18","doi-asserted-by":"crossref","first-page":"e14004","DOI":"10.1111\/acel.14004","article-title":"Cumulus expansion is impaired with advanced reproductive age due to loss of matrix integrity and reduced hyaluronan","volume":"22","author":"Babayev","year":"2023","journal-title":"Aging Cell"},{"key":"2026070101520834300_dmag008-B19","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/s41598-018-37766-2","article-title":"Three-dimensional organization of transzonal projections and other cytoplasmic extensions in the mouse ovarian follicle","volume":"9","author":"Baena","year":"2019","journal-title":"Sci Rep"},{"key":"2026070101520834300_dmag008-B20","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1083\/jcb.201203062","article-title":"Human sperm bind to the N-terminal domain of ZP2 in humanized zonae pellucidae in transgenic mice","volume":"197","author":"Baibakov","year":"2012","journal-title":"J Cell Biol"},{"key":"2026070101520834300_dmag008-B21","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/mrd.1080390307","article-title":"Calcium influx into mouse spermatozoa activated by solubilized mouse zona pellucida, monitored with the calcium fluorescent indicator, fluo-3. inhibition of the influx by three inhibitors of the zona pellucida induced acrosome reaction: Tyrphostin A48, pertussis toxin, and 3-quinuclidinyl benzilate","volume":"39","author":"Bailey","year":"1994","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B22","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/s41467-023-36119-6","article-title":"On-demand male contraception via acute inhibition of soluble adenylyl cyclase","volume":"14","author":"Balbach","year":"2023","journal-title":"Nat Commun"},{"key":"2026070101520834300_dmag008-B23","doi-asserted-by":"crossref","first-page":"753","DOI":"10.3390\/genes13050753","article-title":"Hyaluronidase 6 does not affect cumulus\u2013oocyte complex dispersal and male mice fertility","volume":"13","author":"Bang","year":"2022","journal-title":"Genes (Basel)"},{"key":"2026070101520834300_dmag008-B24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1095\/biolreprod.108.074716","article-title":"Functional activity of human ZP3 primary sperm receptor resides toward its C-terminus","volume":"81","author":"Bansal","year":"2009","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B25","doi-asserted-by":"crossref","first-page":"5335","DOI":"10.1038\/s41598-020-62091-y","article-title":"Sperm SPACA6 protein is required for mammalian sperm-egg adhesion\/fusion","volume":"10","author":"Barbaux","year":"2020","journal-title":"Sci Rep"},{"key":"2026070101520834300_dmag008-B26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/978-1-4939-0659-8_7","volume-title":"Human Fertility: Methods and Protocols","author":"Barbieri","year":"2014"},{"key":"2026070101520834300_dmag008-B27","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1177\/1933719116678688","article-title":"Tetraspanins and mouse oocyte microvilli related to fertilizing ability","volume":"24","author":"Benammar","year":"2017","journal-title":"Reprod Sci"},{"key":"2026070101520834300_dmag008-B28","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1093\/oxfordjournals.humrep.a136116","article-title":"Fertilization and early embryology: does zona pellucida thickness influence the fertilization rate?","volume":"10","author":"Bertrand","year":"1995","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B29","doi-asserted-by":"crossref","first-page":"959586","DOI":"10.3389\/fviro.2022.959586","article-title":"Virus-host protein-protein interactions as molecular drug targets for arboviral infections","volume":"2","author":"Bhutkar","year":"2022","journal-title":"Front Virol"},{"key":"2026070101520834300_dmag008-B30","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/aja.2009.6","article-title":"NYD-SP27, a novel intrinsic decapacitation factor in sperm","volume":"11","author":"Bi","year":"2009","journal-title":"Asian J Androl"},{"key":"2026070101520834300_dmag008-B31","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1038\/nature13203","article-title":"Juno is the egg Izumo receptor and is essential for mammalian fertilization","volume":"508","author":"Bianchi","year":"2014","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B32","doi-asserted-by":"crossref","first-page":"eadk6352","DOI":"10.1126\/sciadv.adk6352","article-title":"No evidence for a direct extracellular interaction between human Fc receptor-like 3 (MAIA) and the sperm ligand IZUMO1","volume":"10","author":"Bianchi","year":"2024","journal-title":"Sci Adv"},{"key":"2026070101520834300_dmag008-B33","doi-asserted-by":"crossref","first-page":"20140101","DOI":"10.1098\/rstb.2014.0101","article-title":"Cross-species fertilization: the hamster egg receptor, Juno, binds the human sperm ligand, Izumo1","volume":"370","author":"Bianchi","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"key":"2026070101520834300_dmag008-B34","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1146\/annurev-genet-121415-121834","article-title":"Sperm meets egg: the genetics of mammalian fertilization","volume":"50","author":"Bianchi","year":"2016","journal-title":"Annu Rev Genet"},{"key":"2026070101520834300_dmag008-B35","doi-asserted-by":"crossref","first-page":"806982","DOI":"10.3389\/fcell.2021.806982","article-title":"The sperm protein Spaca6 is essential for fertilization in zebrafish","volume":"9","author":"Binner","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026070101520834300_dmag008-B36","doi-asserted-by":"crossref","first-page":"7952","DOI":"10.1038\/s41467-025-62427-0","article-title":"Multi-state catch bond formed in the Izumo1: Juno complex that initiates human fertilization","volume":"16","author":"Boult","year":"2025","journal-title":"Nat Commun"},{"key":"2026070101520834300_dmag008-B37","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ydbio.2006.07.014","article-title":"In the beginning\u2026 Animal fertilization and sea urchin development","volume":"300","author":"Briggs","year":"2006","journal-title":"Dev Biol"},{"key":"2026070101520834300_dmag008-B38","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1093\/molehr\/5.6.507","article-title":"Progesterone promotes the acrosome reaction in capacitated human spermatozoa as judged by flow cytometry and CD46 staining","volume":"5","author":"Bronson","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"2026070101520834300_dmag008-B39","doi-asserted-by":"crossref","first-page":"e202207147","DOI":"10.1083\/jcb.202207147","article-title":"A novel function for the sperm adhesion protein IZUMO1 in cell\u2013cell fusion","volume":"222","author":"Brukman","year":"2023","journal-title":"J Cell Biol"},{"key":"2026070101520834300_dmag008-B40","doi-asserted-by":"crossref","first-page":"e94228","DOI":"10.7554\/eLife.94228","article-title":"Sperm induction of somatic cell-cell fusion as a novel functional test","volume":"13","author":"Brukman","year":"2024","journal-title":"eLife"},{"key":"2026070101520834300_dmag008-B41","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1083\/jcb.201112094","article-title":"Ovastacin, a cortical granule protease, cleaves ZP2 in the zona pellucida to prevent polyspermy","volume":"197","author":"Burkart","year":"2012","journal-title":"J Cell Biol"},{"key":"2026070101520834300_dmag008-B42","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1101\/gr.7187808","article-title":"Large-scale screening for novel low-affinity extracellular protein interactions","volume":"18","author":"Bushell","year":"2008","journal-title":"Genome Res"},{"key":"2026070101520834300_dmag008-B43","first-page":"68","article-title":"A role for the chemokine receptor CCR6 in mammalian sperm motility and chemotaxis","volume":"229","author":"Caballero-Campo","year":"2014","journal-title":"J Cell Physiol"},{"key":"2026070101520834300_dmag008-B44","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/humrep\/15.suppl_1.28","article-title":"Effects of progesterone on sperm function: mechanisms of action","volume":"15","author":"Calogero","year":"2000","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B45","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41586-022-04654-9","article-title":"Design of protein-binding proteins from the target structure alone","volume":"605","author":"Cao","year":"2022","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B46","doi-asserted-by":"crossref","first-page":"e2025451118","DOI":"10.1073\/pnas.2025451118","article-title":"A membrane protein display platform for receptor interactome discovery","volume":"118","author":"Cao","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B47","doi-asserted-by":"crossref","first-page":"1407202","DOI":"10.3389\/fgene.2024.1407202","article-title":"ZP1-Y262C mutation causes abnormal zona pellucida formation and female infertility in humans","volume":"15","author":"Cao","year":"2024","journal-title":"Front Genet"},{"key":"2026070101520834300_dmag008-B48","doi-asserted-by":"crossref","first-page":"8557","DOI":"10.1111\/jcmm.15482","article-title":"Heterozygous mutations in ZP1 and ZP3 cause formation disorder of ZP and female infertility in human","volume":"24","author":"Cao","year":"2020","journal-title":"J Cell Mol Med"},{"key":"2026070101520834300_dmag008-B49","doi-asserted-by":"crossref","first-page":"hoae057","DOI":"10.1093\/hropen\/hoae057","article-title":"High rate of detected variants in male PLCZ1 and ACTL7A genes causing failed fertilization after ICSI","volume":"2024","author":"Cardona Barber\u00e1n","year":"2024","journal-title":"Hum Reprod Open"},{"key":"2026070101520834300_dmag008-B50","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/dbio.2002.0690","article-title":"Arylsulfatase A is present on the pig sperm surface and is involved in sperm-zona pellucida binding","volume":"247","author":"Carmona","year":"2002","journal-title":"Dev Biol"},{"key":"2026070101520834300_dmag008-B51","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1472-6483(10)60601-3","article-title":"Role of proteasomal activity in the induction of acrosomal exocytosis in human spermatozoa","volume":"16","author":"Chakravarty","year":"2008","journal-title":"Reprod Biomed Online"},{"key":"2026070101520834300_dmag008-B52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/mrd.20726","article-title":"Relevance of glycosylation of human zona pellucida glycoproteins for their binding to capacitated human spermatozoa and subsequent induction of acrosomal exocytosis","volume":"75","author":"Chakravarty","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B53","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1093\/molehr\/gah165","article-title":"Baculovirus-expressed recombinant human zona pellucida glycoprotein-B induces acrosomal exocytosis in capacitated spermatozoa in addition to zona pellucida glycoprotein-C","volume":"11","author":"Chakravarty","year":"2005","journal-title":"Mol Hum Reprod"},{"key":"2026070101520834300_dmag008-B54","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/168697b0","article-title":"Fertilizing capacity of spermatozoa deposited into the fallopian tubes","volume":"168","author":"Chang","year":"1951","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B55","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1038\/184466a0","article-title":"Fertilization of rabbit ova in vitro","volume":"184","author":"Chang","year":"1959","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B56","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1038\/s41467-021-21517-5","article-title":"Triptonide is a reversible non-hormonal male contraceptive agent in mice and non-human primates","volume":"12","author":"Chang","year":"2021","journal-title":"Nat Commun"},{"key":"2026070101520834300_dmag008-B57","doi-asserted-by":"crossref","first-page":"175","DOI":"10.4103\/aja202355","article-title":"Defects in phospholipase C zeta cause polyspermy and low fertilization after conventional IVF: not just ICSI failure","volume":"26","author":"Che","year":"2024","journal-title":"Asian J Androl"},{"key":"2026070101520834300_dmag008-B58","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/j.ajhg.2017.08.001","article-title":"A recurrent missense mutation in ZP3 causes empty follicle syndrome and female infertility","volume":"101","author":"Chen","year":"2017","journal-title":"Am J Hum Genet"},{"key":"2026070101520834300_dmag008-B59","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1126\/science.289.5479.625","article-title":"Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor","volume":"289","author":"Chen","year":"2000","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B60","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/s41594-022-00861-0","article-title":"In situ cryo-electron tomography reveals the asymmetric architecture of mammalian sperm axonemes","volume":"30","author":"Chen","year":"2023","journal-title":"Nat Struct Mol Biol"},{"key":"2026070101520834300_dmag008-B61","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1095\/biolreprod.105.048587","article-title":"Epididymal SPAM1 is a marker for sperm maturation in the mouse","volume":"74","author":"Chen","year":"2006","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B62","doi-asserted-by":"crossref","first-page":"6193","DOI":"10.1073\/pnas.95.11.6193","article-title":"Inactivation of the mouse sperm receptor, mZP3, by site-directed mutagenesis of individual serine residues located at the combining site for sperm","volume":"95","author":"Chen","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B63","doi-asserted-by":"crossref","first-page":"690070","DOI":"10.3389\/fgene.2021.690070","article-title":"Case report: a novel heterozygous ZP3 deletion associated with empty follicle syndrome and abnormal follicular development","volume":"12","author":"Chen","year":"2021","journal-title":"Front Genet"},{"key":"2026070101520834300_dmag008-B64","doi-asserted-by":"crossref","first-page":"eadg7492","DOI":"10.1126\/science.adg7492","article-title":"Accurate proteome-wide missense variant effect prediction with AlphaMissense","volume":"381","author":"Cheng","year":"2023","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B65","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0015-0282(98)00416-6","article-title":"Production of steroids from human cumulus cells treated with different concentrations of gonadotropins during culture in vitro","volume":"71","author":"Chian","year":"1999","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B66","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1095\/biolreprod.108.069344","article-title":"Effects of native human zona pellucida glycoproteins 3 and 4 on acrosome reaction and zona pellucida binding of human spermatozoa","volume":"79","author":"Chiu","year":"2008","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B67","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1093\/humrep\/den047","article-title":"Native human zona pellucida glycoproteins: purification and binding properties","volume":"23","author":"Chiu","year":"2008","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B68","doi-asserted-by":"crossref","first-page":"e3000007","DOI":"10.1371\/journal.pbio.3000007","article-title":"HAP2\/GCS1: mounting evidence of our true biological EVE?","volume":"16","author":"Clark","year":"2018","journal-title":"PLoS Biol"},{"key":"2026070101520834300_dmag008-B69","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.coemr.2021.03.015","article-title":"Mechanisms and function of germ line\u2013somatic communication during mammalian follicular growth","volume":"18","author":"Clarke","year":"2021","journal-title":"Curr Opin Endocr Metab Res"},{"key":"2026070101520834300_dmag008-B70","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1002\/mrd.23645","article-title":"Transzonal projections: essential structures mediating intercellular communication in the mammalian ovarian follicle","volume":"89","author":"Clarke","year":"2022","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B71","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1016\/j.cell.2017.10.033","article-title":"A method for the acute and rapid degradation of endogenous proteins","volume":"171","author":"Clift","year":"2017","journal-title":"Cell"},{"key":"2026070101520834300_dmag008-B72","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1038\/s41596-018-0028-3","article-title":"Acute and rapid degradation of endogenous proteins by Trim-Away","volume":"13","author":"Clift","year":"2018","journal-title":"Nat Protoc"},{"key":"2026070101520834300_dmag008-B73","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1439-0531.2012.02105.x","article-title":"An amazing 10 years: the discovery of egg and sperm in the 17th century","volume":"47","author":"Cobb","year":"2012","journal-title":"Reprod Domest Anim"},{"key":"2026070101520834300_dmag008-B74","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/978-3-319-30567-7_6","volume-title":"Sperm Acrosome Biogenesis and Function During Fertilization","author":"Cohen","year":"2016"},{"key":"2026070101520834300_dmag008-B75","doi-asserted-by":"crossref","first-page":"eabo6049","DOI":"10.1126\/sciadv.abo6049","article-title":"C11orf94\/Frey is a key regulator for male fertility by controlling Izumo1 complex assembly","volume":"8","author":"Contreras","year":"2022","journal-title":"Sci Adv"},{"key":"2026070101520834300_dmag008-B76","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1002\/(SICI)1098-2795(199610)45:2<212::AID-MRD14>3.0.CO;2-2","article-title":"Effect of cholesterol and other sterols on human sperm acrosomal responsiveness","volume":"45","author":"Cross","year":"1996","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B77","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ydbio.2008.03.015","article-title":"Impaired sperm fertilizing ability in mice lacking Cysteine-RIch Secretory Protein 1 (CRISP1)","volume":"320","author":"Da Ros","year":"2008","journal-title":"Dev Biol"},{"key":"2026070101520834300_dmag008-B78","first-page":"2201","article-title":"ZP1 mutations are associated with empty follicle syndrome: evidence for the existence of an intact oocyte and a zona pellucida in follicles up to the early antral stage. A case report","volume":"34","author":"Dai","year":"2019","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B79","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/s41436-018-0064-y","article-title":"ZP2 pathogenic variants cause in vitro fertilization failure and female infertility","volume":"21","author":"Dai","year":"2019","journal-title":"Genet Med"},{"key":"2026070101520834300_dmag008-B80","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1093\/nar\/gky971","article-title":"A combinatorial code for mRNA 3\u2032-UTR-mediated translational control in the mouse oocyte","volume":"47","author":"Dai","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2026070101520834300_dmag008-B81","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/j.1939-4640.2001.tb02228.x","article-title":"Semenogelin, the main protein of semen coagulum, inhibits human sperm capacitation by interfering with the superoxide anion generated during this process","volume":"22","author":"de Lamirande","year":"2001","journal-title":"J Androl"},{"key":"2026070101520834300_dmag008-B82","doi-asserted-by":"crossref","first-page":"e0135679","DOI":"10.1371\/journal.pone.0135679","article-title":"Cortical granule exocytosis is mediated by Alpha-SNAP and N-ethilmaleimide sensitive factor in mouse oocytes","volume":"10","author":"de Paola","year":"2015","journal-title":"PLoS One"},{"key":"2026070101520834300_dmag008-B83","doi-asserted-by":"crossref","first-page":"7066","DOI":"10.1016\/j.cell.2024.09.035","article-title":"A conserved fertilization complex bridges sperm and egg in vertebrates","volume":"187","author":"Deneke","year":"2024","journal-title":"Cell"},{"key":"2026070101520834300_dmag008-B84","doi-asserted-by":"crossref","first-page":"e2208993119","DOI":"10.1073\/pnas.2208993119","article-title":"Transmembrane proteins tetraspanin 4 and CD9 sense membrane curvature","volume":"119","author":"Dharan","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B85","doi-asserted-by":"crossref","first-page":"3821","DOI":"10.1074\/jbc.M115.680983","article-title":"Cyclic AMP-elevating agents promote cumulus cell survival and hyaluronan matrix stability, thereby prolonging the time of mouse oocyte fertilizability","volume":"291","author":"Di Giacomo","year":"2016","journal-title":"J Biol Chem"},{"key":"2026070101520834300_dmag008-B86","doi-asserted-by":"crossref","first-page":"249ra108","DOI":"10.1126\/scitranslmed.3009071","article-title":"Deficient human \u03b2-defensin 1 underlies male infertility associated with poor sperm motility and genital tract infection","volume":"6","author":"Diao","year":"2014","journal-title":"Sci Transl Med"},{"key":"2026070101520834300_dmag008-B87","doi-asserted-by":"crossref","first-page":"91445","DOI":"10.18632\/oncotarget.20651","article-title":"CCR6 is required for ligand-induced CatSper activation in human sperm","volume":"8","author":"Diao","year":"2017","journal-title":"Oncotarget"},{"key":"2026070101520834300_dmag008-B88","doi-asserted-by":"crossref","first-page":"e2426057122","DOI":"10.1073\/pnas.2426057122","article-title":"Structural basis of ZP2-targeted female nonhormonal contraception","volume":"122","author":"Dioguardi","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B89","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1093\/biolre\/ioaa072","article-title":"CCL20-CCR6 axis directs sperm\u2013oocyte interaction and its dysregulation correlates\/associates with male infertility","volume":"103","author":"Duan","year":"2020","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B90","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1038\/s44319-025-00670-8","article-title":"Roles of the zona pellucida in gamete fusion and of the perivitelline space in blocking polyspermy in mice","volume":"27","author":"Dubois","year":"2026","journal-title":"EMBO Rep"},{"key":"2026070101520834300_dmag008-B91","doi-asserted-by":"crossref","first-page":"24737","DOI":"10.1038\/srep24737","article-title":"The zinc spark is an inorganic signature of human egg activation","volume":"6","author":"Duncan","year":"2016","journal-title":"Sci Rep"},{"key":"2026070101520834300_dmag008-B92","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Dunham","year":"2012","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B93","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s10815-015-0496-0","article-title":"PLC\u03b6 disruption with complete fertilization failure in normozoospermia","volume":"32","author":"Durban","year":"2015","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B94","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1038\/221632a0","article-title":"Early stages of fertilization in vitro of human oocytes matured in vitro","volume":"221","author":"Edwards","year":"1969","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B95","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1038\/s42003-025-08358-4","article-title":"Sperm navigation in humans: a concerted action of multiple means","volume":"8","author":"Eisenbach","year":"2025","journal-title":"Commun Biol"},{"key":"2026070101520834300_dmag008-B96","doi-asserted-by":"crossref","first-page":"e70010","DOI":"10.1002\/mrd.70010","article-title":"Putting nose into reproduction: influence of nasal and reproductive odourant signaling on male reproduction","volume":"92","author":"Elango","year":"2025","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B97","doi-asserted-by":"crossref","first-page":"RP93131","DOI":"10.7554\/eLife.93131","article-title":"Deep learning insights into the architecture of the mammalian egg-sperm fusion synapse","volume":"13","author":"Elofsson","year":"2024","journal-title":"Elife"},{"key":"2026070101520834300_dmag008-B98","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1111\/andr.13215","article-title":"Expression of membrane fusion proteins in spermatozoa and total fertilisation failure during in vitro fertilisation","volume":"10","author":"Enoiu","year":"2022","journal-title":"Andrology"},{"key":"2026070101520834300_dmag008-B99","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/mrd.23331","article-title":"Preventing polyspermy in mammalian eggs\u2014contributions of the membrane block and other mechanisms","volume":"87","author":"Evans","year":"2020","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B100","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/1477-7827-1-54","article-title":"SPAM1 (PH-20) protein and mRNA expression in the epididymides of humans and macaques: utilizing laser microdissection\/RT-PCR","volume":"1","author":"Evans","year":"2003","journal-title":"Reprod Biol Endocrinol"},{"key":"2026070101520834300_dmag008-B101","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/mrd.23320","article-title":"Mammalian egg coat modifications and the block to polyspermy","volume":"87","author":"Fahrenkamp","year":"2020","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B102","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.gim.2021.10.014","article-title":"Elucidating the clinical spectrum and molecular basis of HYAL2 deficiency","volume":"24","author":"Fasham","year":"2022","journal-title":"Genet Med"},{"key":"2026070101520834300_dmag008-B103","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/356159a0","article-title":"Hormonal stimulation of adenylyl cyclase through Gi-protein \u03b2\u03b3 subunits","volume":"356","author":"Federman","year":"1992","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B104","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/biolre\/iox065","article-title":"Subfertility in bulls carrying a nonsense mutation in transmembrane protein 95 is due to failure to interact with the oocyte vestments","volume":"97","author":"Fernandez-Fuertes","year":"2017","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B105","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s00441-012-1429-1","article-title":"MMP2 and acrosin are major proteinases associated with the inner acrosomal membrane and may cooperate in sperm penetration of the zona pellucida during fertilization","volume":"349","author":"Ferrer","year":"2012","journal-title":"Cell Tissue Res"},{"key":"2026070101520834300_dmag008-B106","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3390\/cells13141203","article-title":"Genetic deficiencies of hyaluronan degradation","volume":"13","author":"Fink","year":"2024","journal-title":"Cells"},{"key":"2026070101520834300_dmag008-B107","first-page":"73","article-title":"Characterization of the olfactory receptors expressed in human spermatozoa","volume":"2","author":"Flegel","year":"2015","journal-title":"Front Mol Biosci"},{"key":"2026070101520834300_dmag008-B108","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1016\/S0015-0282(16)57190-8","article-title":"Sperm-zona pellucida binding of human sperm is correlated with the immunocytochemical presence of proacrosin and acrosin in the sperm heads but not with the proteolytic activity of acrosin","volume":"62","author":"Francavilla","year":"1994","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B109","doi-asserted-by":"crossref","first-page":"1110681","DOI":"10.3389\/fcell.2023.1110681","article-title":"Juno and CD9 protein network organization in oolemma of mouse oocyte","volume":"11","author":"Frolikova","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"2026070101520834300_dmag008-B110","doi-asserted-by":"crossref","first-page":"e2108777118","DOI":"10.1073\/pnas.2108777118","article-title":"The conserved fertility factor SPACA4\/Bouncer has divergent modes of action in vertebrate fertilization","volume":"118","author":"Fujihara","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B111","doi-asserted-by":"crossref","first-page":"9393","DOI":"10.1073\/pnas.1917060117","article-title":"Spermatozoa lacking fertilization influencing membrane protein (FIMP) fail to fuse with oocytes in mice","volume":"117","author":"Fujihara","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B112","doi-asserted-by":"crossref","first-page":"18498","DOI":"10.1073\/pnas.1908736116","article-title":"Identification of multiple male reproductive tract-specific proteins that regulate sperm migration through the oviduct in mice","volume":"116","author":"Fujihara","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B113","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1126\/science.1059042","article-title":"Requirement of phospholipase C\u03b44 for the zona pellucida-induced acrosome reaction","volume":"292","author":"Fukami","year":"2001","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B114","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1083\/jcb.200210057","article-title":"Phospholipase C\u03b44 is required for Ca2+ mobilization essential for acrosome reaction in sperm","volume":"161","author":"Fukami","year":"2003","journal-title":"J Cell Biol"},{"key":"2026070101520834300_dmag008-B115","doi-asserted-by":"crossref","first-page":"2253","DOI":"10.1242\/dev.00422","article-title":"Impaired cumulus mucification and female sterility in tumor necrosis factor-induced protein-6 deficient mice","volume":"130","author":"Fu\u0308lo\u0308p","year":"2003","journal-title":"Development"},{"key":"2026070101520834300_dmag008-B116","doi-asserted-by":"crossref","first-page":"10522","DOI":"10.1038\/s41598-020-67468-7","article-title":"Rapid and sensitive large-scale screening of low affinity extracellular receptor protein interactions by using reaction induced inhibition of Gaussia luciferase","volume":"10","author":"Galaway","year":"2020","journal-title":"Sci Rep"},{"key":"2026070101520834300_dmag008-B117","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1093\/humrep\/deq105","article-title":"In humans, zona pellucida glycoprotein-1 binds to spermatozoa and induces acrosomal exocytosis","volume":"25","author":"Ganguly","year":"2010","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B118","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1007\/s43032-021-00691-3","article-title":"The differential metabolomes in cumulus and mural granulosa cells from human preovulatory follicles","volume":"29","author":"Gao","year":"2022","journal-title":"Reprod Sci"},{"key":"2026070101520834300_dmag008-B119","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1093\/humrep\/deae205","article-title":"CALR3 defects disrupt sperm-zona pellucida binding in humans: new insights into male factor fertilization failure and relevant clinical therapeutic approaches","volume":"39","author":"Gao","year":"2024","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B120","doi-asserted-by":"crossref","first-page":"e70000","DOI":"10.1002\/mrd.70000","article-title":"Novel genes of the male reproductive system: potential roles in male reproduction and as non-hormonal male contraceptive targets","volume":"91","author":"Garcia","year":"2024","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B121","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1530\/REP-06-0304","article-title":"Establishment of the mammalian membrane block to polyspermy: evidence for calcium-dependent and -independent regulation","volume":"133","author":"Gardner","year":"2007","journal-title":"Reproduction"},{"key":"2026070101520834300_dmag008-B122","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/molehr\/gat037","article-title":"Picomolar gradients of progesterone select functional human sperm even in subfertile samples","volume":"19","author":"Gatica","year":"2013","journal-title":"Mol Hum Reprod"},{"key":"2026070101520834300_dmag008-B123","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/bib\/bbr031","article-title":"When orthologs diverge between human and mouse","volume":"12","author":"Gharib","year":"2011","journal-title":"Brief Bioinform"},{"key":"2026070101520834300_dmag008-B124","doi-asserted-by":"crossref","first-page":"110954","DOI":"10.1016\/j.mce.2020.110954","article-title":"Getting to and away from the egg, an interplay between several sperm transport mechanisms and a complex oviduct physiology","volume":"518","author":"Giojalas","year":"2020","journal-title":"Mol Cell Endocrinol"},{"key":"2026070101520834300_dmag008-B125","doi-asserted-by":"crossref","first-page":"e240486","DOI":"10.1530\/REP-24-0486","article-title":"Acrosomal exocytosis is compromised in CATSPER1 KO mouse sperm","volume":"170","author":"Gomez-Olivieri","year":"2025","journal-title":"Reproduction"},{"key":"2026070101520834300_dmag008-B126","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1126\/science.7569899","article-title":"Activation of a G protein complex by aggregation of \u03b2-1,4-galactosyltransferase on the surface of sperm","volume":"269","author":"Gong","year":"1995","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B127","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1016\/j.fertnstert.2007.09.008","article-title":"Preliminary study on the role of the human IZUMO gene in oocyte\u2013spermatozoa fusion failure","volume":"90","author":"Granados-Gonzalez","year":"2008","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B128","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1530\/REP-07-0340","article-title":"Murine SPAM1 is secreted by the estrous uterus and oviduct in a form that can bind to sperm during capacitation: acquisition enhances hyaluronic acid-binding ability and cumulus dispersal efficiency","volume":"135","author":"Griffiths","year":"2008","journal-title":"Reproduction"},{"key":"2026070101520834300_dmag008-B129","doi-asserted-by":"crossref","first-page":"e2207605119","DOI":"10.1073\/pnas.2207605119","article-title":"SPACA9 is a lumenal protein of human ciliary singlet and doublet microtubules","volume":"119","author":"Gui","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B130","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1093\/humrep\/dex232","article-title":"Sperm chemorepulsion, a supplementary mechanism to regulate fertilization","volume":"32","author":"Guidobaldi","year":"2017","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B131","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1002\/mrd.22782","article-title":"An intact acrosome is required for the chemotactic response to progesterone in mouse spermatozoa","volume":"84","author":"Guidobaldi","year":"2017","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B132","doi-asserted-by":"crossref","first-page":"619868","DOI":"10.3389\/fcell.2021.619868","article-title":"Human zona pellucida glycoproteins: binding characteristics with human spermatozoa and induction of acrosome reaction","volume":"9","author":"Gupta","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026070101520834300_dmag008-B133","doi-asserted-by":"crossref","first-page":"e13535","DOI":"10.1111\/aji.13535","article-title":"Zona pellucida glycoproteins: relevance in fertility and development of contraceptive vaccines","volume":"89","author":"Gupta","year":"2023","journal-title":"Am J Reprod Immunol"},{"key":"2026070101520834300_dmag008-B134","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/aja.2010.72","article-title":"Acrosome reaction: relevance of zona pellucida glycoproteins","volume":"13","author":"Gupta","year":"2011","journal-title":"Asian J Androl"},{"key":"2026070101520834300_dmag008-B135","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.jri.2011.01.011","article-title":"Zona pellucida-based contraceptive vaccines for human and animal utility","volume":"88","author":"Gupta","year":"2011","journal-title":"J Reprod Immunol"},{"key":"2026070101520834300_dmag008-B136","doi-asserted-by":"crossref","first-page":"R100","DOI":"10.1016\/j.cub.2015.12.034","article-title":"Divergent evolution of vitamin B9 binding underlies Juno-mediated adhesion of mammalian gametes","volume":"26","author":"Han","year":"2016","journal-title":"Curr Biol"},{"key":"2026070101520834300_dmag008-B137","first-page":"27","article-title":"The vertebrate- and testis-specific transmembrane protein C11ORF94 plays a critical role in sperm-oocyte membrane binding","volume":"3","author":"Hao","year":"2022","journal-title":"Mol Med"},{"key":"2026070101520834300_dmag008-B138","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/cplu.201300008","article-title":"Sperm-activating odorous substances in human follicular fluid and vaginal secretion: identification by gas chromatography\u2013olfactometry and Ca2+ imaging","volume":"78","author":"Hartmann","year":"2013","journal-title":"Chempluschem"},{"key":"2026070101520834300_dmag008-B139","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.fertnstert.2006.11.086","article-title":"Positive expression of the immunoglobulin superfamily protein IZUMO on human sperm of severely infertile male patients","volume":"88","author":"Hayasaka","year":"2007","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B140","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1126\/science.1226889","article-title":"Offspring from oocytes derived from in vitro primordial germ cell-like cells in mice","volume":"338","author":"Hayashi","year":"2012","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B141","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/cge.14624","article-title":"A novel homozygous missense ZP1 variant result in human female empty follicle syndrome","volume":"107","author":"He","year":"2025","journal-title":"Clin Genet"},{"key":"2026070101520834300_dmag008-B142","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/nature20104","article-title":"Reconstitution in vitro of the entire cycle of the mouse female germ line","volume":"539","author":"Hikabe","year":"2016","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B143","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/S0015-0282(16)60499-5","article-title":"The measurement of hyaluronidase activity in human spermatozoa by substrate slide assay and its clinical application","volume":"51","author":"Hirayama","year":"1989","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B144","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1093\/biolre\/ioy045","article-title":"Sperm acrosome reaction: its site and role in fertilization","volume":"99","author":"Hirohashi","year":"2018","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B145","doi-asserted-by":"crossref","first-page":"2513","DOI":"10.1073\/pnas.1917595117","article-title":"Acrosin is essential for sperm penetration through the zona pellucida in hamsters","volume":"117","author":"Hirose","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B146","doi-asserted-by":"crossref","first-page":"16976","DOI":"10.1074\/jbc.M112470200","article-title":"A mouse serine protease TESP5 is selectively included into lipid rafts of sperm membrane presumably as a glycosylphosphatidylinositol-anchored protein","volume":"277","author":"Honda","year":"2002","journal-title":"J Biol Chem"},{"key":"2026070101520834300_dmag008-B147","doi-asserted-by":"crossref","first-page":"7991","DOI":"10.1128\/MCB.00904-06","article-title":"ZP2 and ZP3 traffic independently within oocytes prior to assembly into the extracellular zona pellucida","volume":"26","author":"Hoodbhoy","year":"2006","journal-title":"Mol Cell Biol"},{"key":"2026070101520834300_dmag008-B148","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.1007\/s43032-022-00958-3","article-title":"Novel heterozygous mutations in ZP2 cause abnormal zona pellucida and female infertility","volume":"29","author":"Hou","year":"2022","journal-title":"Reprod Sci"},{"key":"2026070101520834300_dmag008-B149","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/S0165-0378(01)00101-2","article-title":"Interactions between zona pellucida glycoproteins and sperm proacrosin\/acrosin during fertilization","volume":"53","author":"Howes","year":"2002","journal-title":"J Reprod Immunol"},{"key":"2026070101520834300_dmag008-B150","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1093\/humrep\/dead059","article-title":"ACROSIN deficiency causes total fertilization failure in humans by preventing the sperm from penetrating the zona pellucida","volume":"38","author":"Hua","year":"2023","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B151","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1056\/NEJMoa1308851","article-title":"Mutant ZP1 in familial infertility","volume":"370","author":"Huang","year":"2014","journal-title":"N Engl J Med"},{"key":"2026070101520834300_dmag008-B152","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1095\/biolreprod54.6.1343","article-title":"Structural relationship of sperm soluble hyaluronidase to the sperm membrane protein PH-201","volume":"54","author":"Hunnicutt","year":"1996","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B153","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1074\/jbc.M110.140152","article-title":"Calsperin is a testis-specific chaperone required for sperm fertility","volume":"286","author":"Ikawa","year":"2011","journal-title":"J Biol Chem"},{"key":"2026070101520834300_dmag008-B154","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/prot.26788","article-title":"Cryo-EM structure of human hyaluronidase PH-20","volume":"93","author":"Im","year":"2025","journal-title":"Proteins"},{"key":"2026070101520834300_dmag008-B155","doi-asserted-by":"crossref","first-page":"13821","DOI":"10.1038\/s41598-022-17776-x","article-title":"Efficient genome editing in wild strains of mice using the i-GONAD method","volume":"12","author":"Imai","year":"2022","journal-title":"Sci Rep"},{"key":"2026070101520834300_dmag008-B156","doi-asserted-by":"crossref","first-page":"e66313","DOI":"10.7554\/eLife.66313","article-title":"Evolutionarily conserved sperm factors, DCST1 and DCST2, are required for gamete fusion","volume":"10","author":"Inoue","year":"2021","journal-title":"Elife"},{"key":"2026070101520834300_dmag008-B157","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nature03362","article-title":"The immunoglobulin superfamily protein Izumo is required for sperm to fuse with eggs","volume":"434","author":"Inoue","year":"2005","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B158","doi-asserted-by":"crossref","first-page":"dev189985","DOI":"10.1242\/dev.189985","article-title":"Unveiling a novel function of CD9 in surface compartmentalization of oocytes","volume":"147","author":"Inoue","year":"2020","journal-title":"Development"},{"key":"2026070101520834300_dmag008-B159","doi-asserted-by":"crossref","first-page":"115463","DOI":"10.1016\/j.celrep.2025.115463","article-title":"Noncanonical phagocytosis-like SEAL establishes mammalian fertilization","volume":"44","author":"Inoue","year":"2025","journal-title":"Cell Rep"},{"key":"2026070101520834300_dmag008-B160","doi-asserted-by":"crossref","first-page":"4016","DOI":"10.1096\/fj.201701424R","article-title":"OC-STAMP promotes osteoclast fusion for pathogenic bone resorption in periodontitis via up-regulation of permissive fusogen CD9","volume":"32","author":"Ishii","year":"2018","journal-title":"FASEB J"},{"key":"2026070101520834300_dmag008-B161","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1038\/s42003-024-07305-z","article-title":"Age-associated aberrations of the cumulus-oocyte interaction and in the zona pellucida structure reduce fertility in female mice","volume":"7","author":"Ishikawa-Yamauchi","year":"2024","journal-title":"Commun Biol"},{"key":"2026070101520834300_dmag008-B162","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1093\/biolre\/iox066","article-title":"A delayed sperm penetration of cumulus layers by disruption of acrosin gene in rats","volume":"97","author":"Isotani","year":"2017","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B163","doi-asserted-by":"crossref","first-page":"626679","DOI":"10.3389\/fcell.2020.626679","article-title":"ZP4 is present in murine zona pellucida and is not responsible for the specific gamete interaction","volume":"8","author":"Izquierdo-Rico","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"2026070101520834300_dmag008-B164","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1146\/annurev-physiol-022516-034102","article-title":"Regulation of mammalian oocyte meiosis by intercellular communication within the ovarian follicle","volume":"79","author":"Jaffe","year":"2017","journal-title":"Annu Rev Physiol"},{"key":"2026070101520834300_dmag008-B165","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1093\/humrep\/dey340","article-title":"JUNO, the receptor of sperm IZUMO1, is expressed by the human oocyte and is essential for human fertilisation","volume":"34","author":"Jean","year":"2019","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B166","doi-asserted-by":"crossref","first-page":"5308","DOI":"10.1016\/j.cell.2023.10.003","article-title":"Mammalian oocytes store proteins for the early embryo on cytoplasmic lattices","volume":"186","author":"Jentoft","year":"2023","journal-title":"Cell"},{"key":"2026070101520834300_dmag008-B167","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1023\/A:1016674302652","article-title":"Andrology: follicular fluid enhances sperm attraction and its motility in human","volume":"18","author":"Jeon","year":"2001","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B168","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s10815-022-02466-4","article-title":"Novel mutations in ZP2 and ZP3 cause female infertility in three patients","volume":"39","author":"Jia","year":"2022","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B169","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1093\/humupd\/dmaa034","article-title":"Molecular genetics of infertility: loss-of-function mutations in humans and corresponding knockout\/mutated mice","volume":"27","author":"Jiao","year":"2021","journal-title":"Hum Reprod Update"},{"key":"2026070101520834300_dmag008-B170","doi-asserted-by":"crossref","first-page":"4892","DOI":"10.1073\/pnas.1018202108","article-title":"Most fertilizing mouse spermatozoa begin their acrosome reaction before contact with the zona pellucida during in vitro fertilization","volume":"108","author":"Jin","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B171","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/ncb802","article-title":"The ZP domain is a conserved module for polymerization of extracellular proteins","volume":"4","author":"Jovine","year":"2002","journal-title":"Nat Cell Biol"},{"key":"2026070101520834300_dmag008-B172","doi-asserted-by":"crossref","first-page":"e202503415","DOI":"10.26508\/lsa.202503415","article-title":"Characterisation of the manchette architecture and its role as transport scaffold using cryo-electron tomography","volume":"8","author":"Judernatz","year":"2025","journal-title":"Life Sci Alliance"},{"key":"2026070101520834300_dmag008-B173","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"Jumper","year":"2021","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B174","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1006\/dbio.2002.0694","article-title":"Infertility of CD9-deficient mouse eggs is reversed by mouse CD9, human CD9, or mouse CD81; polyadenylated mRNA injection developed for molecular analysis of sperm\u2013egg fusion","volume":"247","author":"Kaji","year":"2002","journal-title":"Dev Biol"},{"key":"2026070101520834300_dmag008-B175","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1038\/73502","article-title":"The gamete fusion process is defective in eggs of CD9-deficient mice","volume":"24","author":"Kaji","year":"2000","journal-title":"Nat Genet"},{"key":"2026070101520834300_dmag008-B176","doi-asserted-by":"crossref","first-page":"7383","DOI":"10.3390\/ijms26157383","article-title":"Artificial gametogenesis and in vitro spermatogenesis: emerging strategies for the treatment of male infertility","volume":"26","author":"Kaltsas","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026070101520834300_dmag008-B177","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/s41598-024-84965-1","article-title":"Development of the membrane ceiling method for in vitro spermatogenesis","volume":"15","author":"Kamoshita","year":"2025","journal-title":"Sci Rep"},{"key":"2026070101520834300_dmag008-B178","doi-asserted-by":"crossref","first-page":"e2417943122","DOI":"10.1073\/pnas.2417943122","article-title":"TEX38 localizes ZDHHC19 to the plasma membrane and regulates sperm head morphogenesis in mice","volume":"122","author":"Kaneda","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B179","doi-asserted-by":"crossref","first-page":"154","DOI":"10.5653\/cerm.2023.05981","article-title":"Ovastacin: an oolemma protein that cleaves the zona pellucida to prevent polyspermy","volume":"50","author":"Kang","year":"2023","journal-title":"Clin Exp Reprod Med"},{"key":"2026070101520834300_dmag008-B180","doi-asserted-by":"crossref","first-page":"12198","DOI":"10.1038\/ncomms12198","article-title":"Structural and functional insights into IZUMO1 recognition by JUNO in mammalian fertilization","volume":"7","author":"Kato","year":"2016","journal-title":"Nat Commun"},{"key":"2026070101520834300_dmag008-B181","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/360686a0","article-title":"Subunits \u03b2\u03b3 of heterotrimeric G protein activate \u03b22 isoform of phospholipase C","volume":"360","author":"Katz","year":"1992","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B182","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/0165-0378(89)90007-7","article-title":"Flow cytometric analysis of mouse sperm using monoclonal anti-sperm antibody OBF13","volume":"16","author":"Kawai","year":"1989","journal-title":"J Reprod Immunol"},{"key":"2026070101520834300_dmag008-B183","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1210\/en.2012-1059","article-title":"EGF-like factors induce expansion of the cumulus cell-oocyte complexes by activating calpain-mediated cell movement","volume":"153","author":"Kawashima","year":"2012","journal-title":"Endocrinology"},{"key":"2026070101520834300_dmag008-B184","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1095\/biolreprod66.6.1585","article-title":"Characterization of zona pellucida glycoprotein 3 (ZP3) and ZP2 binding sites on acrosome-intact mouse sperm","volume":"66","author":"Kerr","year":"2002","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B185","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0165-0378(98)00039-4","article-title":"Molecular basis of sperm\u2013egg interaction and the prospects for immunocontraception","volume":"40","author":"Kerr","year":"1998","journal-title":"J Reprod Immunol"},{"key":"2026070101520834300_dmag008-B186","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1677\/joe.0.1700565","article-title":"Granulosa cells of the cumulus oophorus are different from mural granulosa cells in their response to gonadotrophins and IGF-I","volume":"170","author":"Khamsi","year":"2001","journal-title":"J Endocrinol"},{"key":"2026070101520834300_dmag008-B187","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1002\/j.1939-4640.2000.tb02124.x","article-title":"Cholesterol inhibitory effects on human sperm-induced acrosome reaction","volume":"21","author":"Khorasani","year":"2000","journal-title":"J Androl"},{"key":"2026070101520834300_dmag008-B188","doi-asserted-by":"crossref","first-page":"18028","DOI":"10.1073\/pnas.0506825102","article-title":"Identification of a hyaluronidase, Hyal5, involved in penetration of mouse sperm through cumulus mass","volume":"102","author":"Kim","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B189","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.3390\/biom10111525","article-title":"Hyaluronan: metabolism and function","volume":"10","author":"Kobayashi","year":"2020","journal-title":"Biomolecules"},{"key":"2026070101520834300_dmag008-B190","doi-asserted-by":"crossref","first-page":"1256549","DOI":"10.3389\/fgene.2023.1256549","article-title":"Case report: a novel homozygous variant in ZP3 is associated with human empty follicle syndrome","volume":"14","author":"Kong","year":"2023","journal-title":"Front Genet"},{"key":"2026070101520834300_dmag008-B191","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1093\/molehr\/gax040","article-title":"Intracellular activation of ovastacin mediates pre-fertilization hardening of the zona pellucida","volume":"23","author":"K\u00f6rschgen","year":"2017","journal-title":"Mol Hum Reprod"},{"key":"2026070101520834300_dmag008-B192","doi-asserted-by":"crossref","first-page":"10408","DOI":"10.1074\/jbc.M313801200","article-title":"Recombinant phospholipase C\u03b6 has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs","volume":"279","author":"Kouchi","year":"2004","journal-title":"J Biol Chem"},{"key":"2026070101520834300_dmag008-B193","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ydbio.2005.07.020","article-title":"The spe-42 gene is required for sperm\u2013egg interactions during C. elegans fertilization and encodes a sperm-specific transmembrane protein","volume":"286","author":"Kroft","year":"2005","journal-title":"Dev Biol"},{"key":"2026070101520834300_dmag008-B194","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1126\/science.adl2688","article-title":"Reversible male contraception by targeted inhibition of serine\/threonine kinase 33","volume":"384","author":"Ku","year":"2024","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B195","doi-asserted-by":"crossref","first-page":"e48904","DOI":"10.7554\/eLife.48904","article-title":"ZP4 confers structural properties to the zona pellucida essential for embryo development","volume":"8","author":"Lamas-Toranzo","year":"2019","journal-title":"eLife"},{"key":"2026070101520834300_dmag008-B196","doi-asserted-by":"crossref","first-page":"e53913","DOI":"10.7554\/eLife.53913","article-title":"TMEM95 is a sperm membrane protein essential for mammalian fertilization","volume":"9","author":"Lamas-Toranzo","year":"2020","journal-title":"Elife"},{"key":"2026070101520834300_dmag008-B197","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1126\/science.287.5451.319","article-title":"Severely reduced female fertility in CD9-deficient mice","volume":"287","author":"Le Naour","year":"2000","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B198","doi-asserted-by":"crossref","first-page":"1135973","DOI":"10.3389\/fendo.2023.1135973","article-title":"The role of spermatozoa-zona pellucida interaction in selecting fertilization-competent spermatozoa in humans","volume":"14","author":"Leung","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026070101520834300_dmag008-B199","doi-asserted-by":"crossref","first-page":"hoaf024","DOI":"10.1093\/hropen\/hoaf024","article-title":"Automatic identification of human spermatozoa with zona pellucida-binding capability using deep learning","volume":"2025","author":"Leung","year":"2025","journal-title":"Hum Reprod Open"},{"key":"2026070101520834300_dmag008-B200","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nrm3531","article-title":"The road to maturation: somatic cell interaction and self-organization of the mammalian oocyte","volume":"14","author":"Li","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026070101520834300_dmag008-B201","doi-asserted-by":"crossref","first-page":"100825","DOI":"10.1016\/j.xcrm.2022.100825","article-title":"Defensin 19\/119 mediates sperm chemotaxis and is associated with idiopathic infertility","volume":"3","author":"Li","year":"2022","journal-title":"Cell Rep Med"},{"key":"2026070101520834300_dmag008-B202","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1038\/s41586-021-03742-6","article-title":"Structure of a mammalian sperm cation channel complex","volume":"595","author":"Lin","year":"2021","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B203","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1530\/REP-07-0375","article-title":"SPINKL, a Kazal-type serine protease inhibitor-like protein purified from mouse seminal vesicle fluid, is able to inhibit sperm capacitation","volume":"136","author":"Lin","year":"2008","journal-title":"Reproduction"},{"key":"2026070101520834300_dmag008-B204","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00441-023-03826-x","article-title":"Low acrosin activity is associated with decreased Spam1\/acrosin expression and GSH deficiency-caused premature acrosome release of human sperm cells","volume":"394","author":"Lin","year":"2023","journal-title":"Cell Tissue Res"},{"key":"2026070101520834300_dmag008-B205","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1083\/jcb.125.5.1157","article-title":"A hyaluronidase activity of the sperm plasma membrane protein PH-20 enables sperm to penetrate the cumulus cell layer surrounding the egg","volume":"125","author":"Lin","year":"1994","journal-title":"J Cell Biol"},{"key":"2026070101520834300_dmag008-B206","first-page":"21","article-title":"Zona pellucida genes and proteins and human fertility","volume":"13","author":"Litscher","year":"2020","journal-title":"Trends Dev Biol"},{"key":"2026070101520834300_dmag008-B207","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1146\/annurev-biochem-011520-105310","article-title":"Zona pellucida proteins, fibrils, and matrix","volume":"89","author":"Litscher","year":"2020","journal-title":"Annu Rev Biochem"},{"key":"2026070101520834300_dmag008-B208","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1095\/biolreprod48.2.340","article-title":"Inhibition of acrosin activity with a trypsin inhibitor blocks human sperm penetration of the zona pellucida","volume":"48","author":"Liu","year":"1993","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B209","doi-asserted-by":"crossref","first-page":"5431","DOI":"10.1073\/pnas.93.11.5431","article-title":"Targeted disruption of the mZP3 gene results in production of eggs lacking a zona pellucida and infertility in female mice","volume":"93","author":"Liu","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B210","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1007\/s10815-020-01855-x","article-title":"Novel biallelic loss-of-function variants in ZP1 identified in an infertile female with empty follicle syndrome","volume":"37","author":"Liu","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B211","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.ajhg.2021.01.002","article-title":"Deleterious variants in X-linked CFAP47 induce asthenoteratozoospermia and primary male infertility","volume":"108","author":"Liu","year":"2021","journal-title":"Am J Hum Genet"},{"key":"2026070101520834300_dmag008-B212","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s13048-025-01706-2","article-title":"A novel mutation in ZP3 causes human ovulatory dysfunction and oocyte maturation arrest","volume":"18","author":"Liu","year":"2025","journal-title":"J Ovarian Res"},{"key":"2026070101520834300_dmag008-B213","doi-asserted-by":"crossref","first-page":"107828","DOI":"10.1016\/j.isci.2023.107828","article-title":"A heterozygous ZP2 mutation causes zona pellucida defects and female infertility in mouse and human","volume":"26","author":"Liu","year":"2023","journal-title":"iScience"},{"key":"2026070101520834300_dmag008-B214","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1274\/jmor.26.2","article-title":"History of the egg in embryology","volume":"26","author":"Lopata","year":"2009","journal-title":"J Mamm Ova Res"},{"key":"2026070101520834300_dmag008-B215","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1007\/s00335-013-9491-x","article-title":"A transgenic insertion on mouse chromosome 17 inactivates a novel immunoglobulin superfamily gene potentially involved in sperm-egg fusion","volume":"25","author":"Lorenzetti","year":"2014","journal-title":"Mamm Genome"},{"key":"2026070101520834300_dmag008-B216","doi-asserted-by":"crossref","first-page":"e2425952122","DOI":"10.1073\/pnas.2425952122","article-title":"Allosteric inhibition of the IZUMO1-JUNO fertilization complex by the naturally occurring antisperm antibody OBF13","volume":"122","author":"Lu","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B217","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1095\/biolreprod.110.085100","article-title":"SERPINE2, a serine protease inhibitor extensively expressed in adult male mouse reproductive tissues, may serve as a murine sperm decapacitation factor","volume":"84","author":"Lu","year":"2011","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B218","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1093\/biolre\/ioz103","article-title":"CRISPR\/Cas9-mediated genome editing reveals 30 testis-enriched genes dispensable for male fertility in mice","volume":"101","author":"Lu","year":"2019","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B219","doi-asserted-by":"crossref","first-page":"e2207263120","DOI":"10.1073\/pnas.2207263120","article-title":"1700029I15Rik orchestrates the biosynthesis of acrosomal membrane proteins required for sperm-egg interaction","volume":"120","author":"Lu","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B220","doi-asserted-by":"crossref","first-page":"4121","DOI":"10.1242\/dev.124.20.4121","article-title":"Sperm from \u03b21,4-galactosyltransferase-null mice are refractory to ZP3-induced acrosome reactions and penetrate the zona pellucida poorly","volume":"124","author":"Lu","year":"1997","journal-title":"Development"},{"key":"2026070101520834300_dmag008-B221","doi-asserted-by":"crossref","first-page":"2853","DOI":"10.1007\/s10815-020-01926-z","article-title":"Novel mutations in ZP1 and ZP2 cause primary infertility due to empty follicle syndrome and abnormal zona pellucida","volume":"37","author":"Luo","year":"2020","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B222","doi-asserted-by":"crossref","first-page":"e2212338120","DOI":"10.1073\/pnas.2212338120","article-title":"A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function","volume":"120","author":"Lyon","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B223","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/s00439-021-02388-8","article-title":"ASTL is mutated in female infertility","volume":"141","author":"Maddirevula","year":"2022","journal-title":"Hum Genet"},{"key":"2026070101520834300_dmag008-B224","doi-asserted-by":"crossref","first-page":"1510","DOI":"10.3390\/ijms25031510","article-title":"In vitro growth of human follicles: current and future perspectives","volume":"25","author":"Malo","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026070101520834300_dmag008-B225","doi-asserted-by":"crossref","first-page":"102280","DOI":"10.1016\/j.omtn.2024.102280","article-title":"Emerging trends in virus and virus-like particle gene therapy delivery to the brain","volume":"35","author":"Mandalawatta","year":"2024","journal-title":"Mol Ther Nucleic Acids"},{"key":"2026070101520834300_dmag008-B226","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/s43856-025-00752-7","article-title":"Targeting the retinoid signaling pathway with YCT-529 for effective and reversible oral contraception in mice and primates","volume":"5","author":"Mannowetz","year":"2025","journal-title":"Commun Med (Lond)"},{"key":"2026070101520834300_dmag008-B227","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0002-9378(88)80068-1","article-title":"The sperm penetration assay: can it discriminate between fertile and infertile men?","volume":"159","author":"Mao","year":"1988","journal-title":"Am J Obstet Gynecol"},{"key":"2026070101520834300_dmag008-B228","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s10815-023-02984-9","article-title":"Biomarkers assessing the role of cumulus cells on IVF outcomes: a systematic review","volume":"41","author":"Massoud","year":"2024","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B229","doi-asserted-by":"crossref","first-page":"12105","DOI":"10.1038\/s41598-023-39304-1","article-title":"Generation of rat offspring using spermatids produced through in vitro spermatogenesis","volume":"13","author":"Matsumura","year":"2023","journal-title":"Sci Rep"},{"key":"2026070101520834300_dmag008-B230","doi-asserted-by":"crossref","first-page":"810118","DOI":"10.3389\/fcell.2021.810118","article-title":"Sperm IZUMO1 is required for binding preceding fusion with oolemma in mice and rats","volume":"9","author":"Matsumura","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026070101520834300_dmag008-B231","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1530\/ror.0.0030023","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases in ovarian function","volume":"3","author":"McIntush","year":"1998","journal-title":"Rev Reprod"},{"key":"2026070101520834300_dmag008-B232","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/nature04396","article-title":"Membrane curvature and mechanisms of dynamic cell membrane remodelling","volume":"438","author":"McMahon","year":"2005","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B233","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1083\/jcb.123.6.1431","article-title":"Egg cortical granule N-acetylglucosaminidase is required for the mouse zona block to polyspermy","volume":"123","author":"Miller","year":"1993","journal-title":"J Cell Biol"},{"key":"2026070101520834300_dmag008-B234","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1126\/science.aad6887","article-title":"Unconventional endocannabinoid signaling governs sperm activation via the sex hormone progesterone","volume":"352","author":"Miller","year":"2016","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B235","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2164\/jandrol.106.000356","article-title":"Hyalp1 in murine sperm function: evidence for unique and overlapping functions with other reproductive hyaluronidases","volume":"28","author":"Miller","year":"2007","journal-title":"J Androl"},{"key":"2026070101520834300_dmag008-B236","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1126\/science.287.5451.321","article-title":"Requirement of CD9 on the egg plasma membrane for fertilization","volume":"287","author":"Miyado","year":"2000","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B237","doi-asserted-by":"crossref","first-page":"12921","DOI":"10.1073\/pnas.0710608105","article-title":"The fusing ability of sperm is bestowed by CD9-containing vesicles released from eggs in mice","volume":"105","author":"Miyado","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B238","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1002\/jbmr.1575","article-title":"Osteoclast stimulatory transmembrane protein and dendritic cell-specific transmembrane protein cooperatively modulate cell\u2013cell fusion to form osteoclasts and foreign body giant cells","volume":"27","author":"Miyamoto","year":"2012","journal-title":"J Bone Miner Res"},{"key":"2026070101520834300_dmag008-B239","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nature07599","article-title":"Crystal structure of the ZP-N domain of ZP3 reveals the core fold of animal egg coats","volume":"456","author":"Monn\u00e9","year":"2008","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B240","doi-asserted-by":"crossref","first-page":"153, 1","DOI":"10.1095\/biolreprod.111.096156","article-title":"Characterization and significance of adhesion and junction-related proteins in mouse ovarian follicles","volume":"86","author":"Mora","year":"2012","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B241","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1093\/humrep\/deae154","article-title":"Granulosa cell metabolism at ovulation correlates with oocyte competence and is disrupted by obesity and aging","volume":"39","author":"Morimoto","year":"2024","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B242","doi-asserted-by":"crossref","first-page":"eade7607","DOI":"10.1126\/sciadv.ade7607","article-title":"Testis-enriched ferlin, FER1L5, is required for Ca2+-activated acrosome reaction and male fertility","volume":"9","author":"Morohoshi","year":"2023","journal-title":"Sci Adv"},{"key":"2026070101520834300_dmag008-B243","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.cell.2016.01.012","article-title":"Engineering customized cell sensing and response behaviors using synthetic notch receptors","volume":"164","author":"Morsut","year":"2016","journal-title":"Cell"},{"key":"2026070101520834300_dmag008-B244","doi-asserted-by":"crossref","first-page":"103325","DOI":"10.1016\/j.jri.2021.103325","article-title":"Evaluation of multi-epitope recombinant protein as a candidate for a contraceptive vaccine","volume":"145","author":"Mortazavi","year":"2021","journal-title":"J Reprod Immunol"},{"key":"2026070101520834300_dmag008-B245","doi-asserted-by":"crossref","first-page":"e1006470","DOI":"10.1371\/journal.pgen.1006470","article-title":"Mutations in HYAL2, encoding hyaluronidase 2, cause a syndrome of orofacial clefting and cor triatriatum sinister in humans and mice","volume":"13","author":"Muggenthaler","year":"2017","journal-title":"PLoS Genet"},{"key":"2026070101520834300_dmag008-B246","doi-asserted-by":"crossref","first-page":"RP86845","DOI":"10.7554\/eLife.86845","article-title":"Lack of CCDC146, a ubiquitous centriole and microtubule-associated protein, leads to non-syndromic male infertility in human and mouse","volume":"12","author":"Muro\u0148ov\u00e1","year":"2024","journal-title":"eLife"},{"key":"2026070101520834300_dmag008-B247","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/ijms23010054","article-title":"Cumulus extracellular matrix is an important part of oocyte microenvironment in ovarian follicles: its remodeling and proteolytic degradation","volume":"23","author":"Nagyov\u00e1","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026070101520834300_dmag008-B248","doi-asserted-by":"crossref","first-page":"381","DOI":"10.2164\/jandrol.106.001289","article-title":"Acrosome reaction induced by recombinant human zona pellucida 3 peptides rhuZP3a22\u223c176 and rhuZP3b177\u223c348 and their mechanism","volume":"28","author":"Ni","year":"2007","journal-title":"J Androl"},{"key":"2026070101520834300_dmag008-B249","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.fertnstert.2014.05.004","article-title":"Sperm involved in recurrent partial hydatidiform moles cannot induce the normal pattern of calcium oscillations","volume":"102","author":"Nikiforaki","year":"2014","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B250","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1038\/s41467-019-10931-5","article-title":"Molecular basis of egg coat cross-linking sheds light on ZP1-associated female infertility","volume":"10","author":"Nishimura","year":"2019","journal-title":"Nat Commun"},{"key":"2026070101520834300_dmag008-B251","doi-asserted-by":"crossref","first-page":"R661","DOI":"10.1016\/j.cub.2016.06.028","article-title":"The structure of sperm Izumo1 reveals unexpected similarities with Plasmodium invasion proteins","volume":"26","author":"Nishimura","year":"2016","journal-title":"Curr Biol"},{"key":"2026070101520834300_dmag008-B252","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1016\/j.cell.2024.02.013","article-title":"ZP2 cleavage blocks polyspermy by modulating the architecture of the egg coat","volume":"187","author":"Nishio","year":"2024","journal-title":"Cell"},{"key":"2026070101520834300_dmag008-B253","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1095\/biolreprod.105.044644","article-title":"The identification of mouse sperm-surface-associated proteins and characterization of their ability to act as decapacitation factors","volume":"74","author":"Nixon","year":"2006","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B254","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/s42003-022-03289-w","article-title":"Sperm membrane proteins DCST1 and DCST2 are required for sperm-egg interaction in mice and fish","volume":"5","author":"Noda","year":"2022","journal-title":"Commun Biol"},{"key":"2026070101520834300_dmag008-B255","doi-asserted-by":"crossref","first-page":"11493","DOI":"10.1073\/pnas.1922650117","article-title":"Sperm proteins SOF1, TMEM95, and SPACA6 are required for sperm-oocyte fusion in mice","volume":"117","author":"Noda","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B256","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.fertnstert.2012.08.035","article-title":"Phospholipase C\u03b6 rescues failed oocyte activation in a prototype of male factor infertility","volume":"99","author":"Nomikos","year":"2013","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B257","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/andr.13110","article-title":"Evaluation of the novel vaginal contraceptive agent PPCM in preclinical studies using sperm hyaluronan binding and acrosome status assays","volume":"10","author":"North","year":"2022","journal-title":"Andrology"},{"key":"2026070101520834300_dmag008-B258","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1038\/s41598-018-19497-6","article-title":"Sperm-borne phospholipase C zeta-1 ensures monospermic fertilization in mice","volume":"8","author":"Nozawa","year":"2018","journal-title":"Sci Rep"},{"key":"2026070101520834300_dmag008-B259","doi-asserted-by":"crossref","first-page":"e0195953","DOI":"10.1371\/journal.pone.0195953","article-title":"Inhibition of sperm motility in male macaques with EP055, a potential non-hormonal male contraceptive","volume":"13","author":"O\u2019Rand","year":"2018","journal-title":"PLoS One"},{"key":"2026070101520834300_dmag008-B260","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1242\/bio.20121420","article-title":"CD81 and CD9 work independently as extracellular components upon fusion of sperm and oocyte","volume":"1","author":"Ohnami","year":"2012","journal-title":"Biol Open"},{"key":"2026070101520834300_dmag008-B261","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1093\/molehr\/5.1.22","article-title":"Expression of CD44 in human cumulus and mural granulosa cells of individual patients in in-vitro fertilization programmes","volume":"5","author":"Ohta","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"2026070101520834300_dmag008-B262","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1038\/nature18596","article-title":"Structure of IZUMO1\u2013JUNO reveals sperm\u2013oocyte recognition during mammalian fertilization","volume":"534","author":"Ohto","year":"2016","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B263","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0165-0378(87)90014-3","article-title":"Capacitation-related changes in antigen distribution on mouse sperm heads and its relation to fertilization rate in vitro","volume":"11","author":"Okabe","year":"1987","journal-title":"J Reprod Immunol"},{"key":"2026070101520834300_dmag008-B264","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/0165-0378(86)90026-4","article-title":"Inconsistent reactivity of an anti-sperm monoclonal antibody and its relationship to sperm capacitation","volume":"9","author":"Okabe","year":"1986","journal-title":"J Reprod Immunol"},{"key":"2026070101520834300_dmag008-B265","doi-asserted-by":"crossref","first-page":"382","DOI":"10.3390\/genes11040382","article-title":"Homozygous splice site mutation in ZP1 causes familial oocyte maturation defect","volume":"11","author":"Okutman","year":"2020","journal-title":"Genes (Basel)"},{"key":"2026070101520834300_dmag008-B266","doi-asserted-by":"crossref","first-page":"e2406407121","DOI":"10.1073\/pnas.2406407121","article-title":"AlphaFold-multimer accurately captures interactions and dynamics of intrinsically disordered protein regions","volume":"121","author":"Omidi","year":"2024","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B267","doi-asserted-by":"crossref","first-page":"2339","DOI":"10.1093\/humrep\/den265","article-title":"The sperm chemoattractant secreted from human cumulus cells is progesterone","volume":"23","author":"Oren-Benaroya","year":"2008","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B268","doi-asserted-by":"crossref","first-page":"3079","DOI":"10.1007\/s00405-013-2441-0","article-title":"Human olfactory sensitivity for bourgeonal and male infertility: a preliminary investigation","volume":"270","author":"Ottaviano","year":"2013","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"2026070101520834300_dmag008-B269","doi-asserted-by":"crossref","first-page":"22198","DOI":"10.1038\/s41598-022-26501-7","article-title":"Proximity-dependent biotin labeling in testicular germ cells identified TESMIN-associated proteins","volume":"12","author":"Oura","year":"2022","journal-title":"Sci Rep"},{"key":"2026070101520834300_dmag008-B270","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1095\/biolreprod52.1.105","article-title":"Location of the PH-20 protein on acrosome-intact and acrosome-reacted spermatozoa of cynomolgus macaques","volume":"52","author":"Overstreet","year":"1995","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B271","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1126\/science.1207438","article-title":"Human sperm binding is mediated by the Sialyl-Lewisx oligosaccharide on the zona pellucida","volume":"333","author":"Pang","year":"2011","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B272","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1096\/fj.201900889RRR","article-title":"SPAM1\/HYAL5 double deficiency in male mice leads to severe male subfertility caused by a cumulus-oocyte complex penetration defect","volume":"33","author":"Park","year":"2019","journal-title":"FASEB J"},{"key":"2026070101520834300_dmag008-B273","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.3390\/ijms25021344","article-title":"Phospholipase C Zeta in human spermatozoa: a systematic review on current development and clinical application","volume":"25","author":"Parrella","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026070101520834300_dmag008-B274","first-page":"175","article-title":"Evaluation of zona pellucida antigens as potential candidates for immunocontraception","volume":"50","author":"Paterson","year":"1996","journal-title":"J Reprod Fertil Suppl"},{"key":"2026070101520834300_dmag008-B275","doi-asserted-by":"crossref","first-page":"e1004044","DOI":"10.1371\/journal.pgen.1004044","article-title":"A nonsense mutation in TMEM95 encoding a nondescript transmembrane protein causes idiopathic male subfertility in cattle","volume":"10","author":"Pausch","year":"2014","journal-title":"PLoS Genet"},{"key":"2026070101520834300_dmag008-B276","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s10815-022-02670-2","article-title":"Mutations in PLCZ1 induce male infertility associated with polyspermy and fertilization failure","volume":"40","author":"Peng","year":"2023","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B277","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/471313a","article-title":"Progesterone\u2019s gateway into sperm","volume":"471","author":"Publicover","year":"2011","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B278","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejogrb.2022.12.011","article-title":"A ZP1 gene mutation in a patient with empty follicle syndrome: a case report and literature review","volume":"280","author":"Pujalte","year":"2023","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2026070101520834300_dmag008-B279","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1039\/C6IB00212A","article-title":"Zinc sparks induce physiochemical changes in the egg zona pellucida that prevent polyspermy","volume":"9","author":"Que","year":"2017","journal-title":"Integr Biol (Camb)"},{"key":"2026070101520834300_dmag008-B280","doi-asserted-by":"crossref","first-page":"110951","DOI":"10.1016\/j.mce.2020.110951","article-title":"CatSper: the complex main gate of calcium entry in mammalian spermatozoa","volume":"518","author":"Rahban","year":"2020","journal-title":"Mol Cell Endocrinol"},{"key":"2026070101520834300_dmag008-B281","doi-asserted-by":"crossref","first-page":"2840","DOI":"10.1073\/pnas.88.7.2840","article-title":"Sperm attraction to a follicular factor(s) correlates with human egg fertilizability","volume":"88","author":"Ralt","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B282","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1242\/dev.122.9.2903","article-title":"Mice homozygous for an insertional mutation in the Zp3 gene lack a zona pellucida and are infertile","volume":"122","author":"Rankin","year":"1996","journal-title":"Development"},{"key":"2026070101520834300_dmag008-B283","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1242\/dev.128.7.1119","article-title":"Defective zonae pellucidae in Zp2-null mice disrupt folliculogenesis, fertility and development","volume":"128","author":"Rankin","year":"2001","journal-title":"Development"},{"key":"2026070101520834300_dmag008-B284","doi-asserted-by":"crossref","first-page":"3847","DOI":"10.1242\/dev.126.17.3847","article-title":"Abnormal zonae pellucidae in mice lacking ZP1 result in early embryonic loss","volume":"126","author":"Rankin","year":"1999","journal-title":"Development"},{"key":"2026070101520834300_dmag008-B285","first-page":"494","article-title":"Egg CD9 protein tides correlated with sperm oscillations tune the gamete fusion ability in mammal","volume":"10","author":"Ravaux","year":"2018","journal-title":"J Mol Cell Biol"},{"key":"2026070101520834300_dmag008-B286","doi-asserted-by":"crossref","first-page":"e50851","DOI":"10.1371\/journal.pone.0050851","article-title":"The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition","volume":"7","author":"Redgrove","year":"2012","journal-title":"PLoS One"},{"key":"2026070101520834300_dmag008-B287","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1002\/mrd.21217","article-title":"Acidic hyaluronidase activity is present in mouse sperm and is reduced in the absence of SPAM1: evidence for a role for hyaluronidase 3 in mouse and human sperm","volume":"77","author":"Reese","year":"2010","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B288","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1042\/BJ20060598","article-title":"Mouse testicular hyaluronidase-like proteins SPAM1 and HYAL5 but not HYALP1 degrade hyaluronan","volume":"401","author":"Reitinger","year":"2007","journal-title":"Biochem J"},{"key":"2026070101520834300_dmag008-B289","doi-asserted-by":"crossref","first-page":"3144","DOI":"10.1111\/bph.14355","article-title":"A novel cross-species inhibitor to study the function of CatSper Ca2+ channels in sperm","volume":"175","author":"Rennhack","year":"2018","journal-title":"Br J Pharmacol"},{"key":"2026070101520834300_dmag008-B290","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1016\/j.cell.2018.02.054","article-title":"Common features of enveloped viruses and implications for immunogen design for next-generation vaccines","volume":"172","author":"Rey","year":"2018","journal-title":"Cell"},{"key":"2026070101520834300_dmag008-B291","doi-asserted-by":"crossref","first-page":"4456","DOI":"10.1038\/s41467-019-12406-z","article-title":"Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization","volume":"10","author":"Rival","year":"2019","journal-title":"Nat Commun"},{"key":"2026070101520834300_dmag008-B292","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1095\/biolreprod.102.013771","article-title":"Inhibition of capacitation-associated tyrosine phosphorylation signaling in rat sperm by epididymal protein Crisp-1","volume":"69","author":"Roberts","year":"2003","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B293","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0015-0282(16)48608-5","article-title":"The sperm penetration assay: its usefulness reevaluated","volume":"43","author":"Rogers","year":"1985","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B294","doi-asserted-by":"crossref","first-page":"jcs218958","DOI":"10.1242\/jcs.218958","article-title":"Super-resolution imaging of live sperm reveals dynamic changes of the actin cytoskeleton during acrosomal exocytosis","volume":"131","author":"Romarowski","year":"2018","journal-title":"J Cell Sci"},{"key":"2026070101520834300_dmag008-B295","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.ydbio.2005.11.031","article-title":"Reduced fertility of female mice lacking CD81","volume":"290","author":"Rubinstein","year":"2006","journal-title":"Dev Biol"},{"key":"2026070101520834300_dmag008-B296","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ydbio.2006.12.041","article-title":"Oocyte CD9 is enriched on the microvillar membrane and required for normal microvillar shape and distribution","volume":"304","author":"Runge","year":"2007","journal-title":"Dev Biol"},{"key":"2026070101520834300_dmag008-B297","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1210\/en.2002-220434","article-title":"Hormone-regulated expression and localization of versican in the rodent ovary","volume":"144","author":"Russell","year":"2003","journal-title":"Endocrinology"},{"key":"2026070101520834300_dmag008-B298","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/1471-0528.18094","article-title":"Association of zona pellucida gene variants with female infertility: a retrospective genetic analysis","volume":"132","author":"Sa","year":"2025","journal-title":"BJOG"},{"key":"2026070101520834300_dmag008-B299","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1002\/j.1939-4640.1997.tb01895.x","article-title":"The PH-20 protein in human spermatozoa","volume":"18","author":"Sabeur","year":"1997","journal-title":"J Androl"},{"key":"2026070101520834300_dmag008-B300","doi-asserted-by":"crossref","first-page":"eaaz6830","DOI":"10.1126\/science.aaz6830","article-title":"Mammalian in vitro gametogenesis","volume":"374","author":"Saitou","year":"2021","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B301","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1186\/s12958-015-0094-0","article-title":"Human sperm degradation of zona pellucida proteins contributes to fertilization","volume":"13","author":"Sald\u00edvar-Hern\u00e1ndez","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"2026070101520834300_dmag008-B302","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/humupd\/5.4.293","article-title":"Hyaluronan and proteoglycans in ovarian follicles","volume":"5","author":"Salustri","year":"1999","journal-title":"Hum Reprod Update"},{"key":"2026070101520834300_dmag008-B303","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1242\/dev.01056","article-title":"PTX3 plays a key role in the organization of the cumulus oophorus extracellular matrix and in in vivo fertilization","volume":"131","author":"Salustri","year":"2004","journal-title":"Development"},{"key":"2026070101520834300_dmag008-B304","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1095\/biolreprod.114.119768","article-title":"Acrosome reaction and Ca2+ imaging in single human spermatozoa: new regulatory roles of [Ca2+]i","volume":"91","author":"S\u00e1nchez-C\u00e1rdenas","year":"2014","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B305","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/mrd.1120150208","article-title":"Sperm-oocyte membrane fusion in the human during monospermic fertilization","volume":"15","author":"Sathananthan","year":"1986","journal-title":"Gamete Res"},{"key":"2026070101520834300_dmag008-B306","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature09850","article-title":"In vitro production of functional sperm in cultured neonatal mouse testes","volume":"471","author":"Sato","year":"2011","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B307","first-page":"4985","article-title":"Visualization of the moment of mouse sperm\u2013egg fusion and dynamic localization of IZUMO1","volume":"125","author":"Satouh","year":"2012","journal-title":"J Cell Sci"},{"key":"2026070101520834300_dmag008-B308","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1093\/biolre\/ioae116","article-title":"Improved low-invasive mRNA electroporation method into immature mouse oocytes visualizes protein dynamics during development","volume":"111","author":"Satouh","year":"2024","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B309","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1242\/dev.129.15.3533","article-title":"PLC\u03b6: a sperm-specific trigger of Ca2+ oscillations in eggs and embryo development","volume":"129","author":"Saunders","year":"2002","journal-title":"Development"},{"key":"2026070101520834300_dmag008-B310","first-page":"227","article-title":"Hyaluronidase activity in split human semen","volume":"31","author":"Savion","year":"1986","journal-title":"Int J Fertil"},{"key":"2026070101520834300_dmag008-B311","doi-asserted-by":"crossref","first-page":"3008","DOI":"10.1073\/pnas.95.6.3008","article-title":"A new prostaglandin E receptor mediates calcium influx and acrosome reaction in human spermatozoa","volume":"95","author":"Schaefer","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B312","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1093\/molehr\/8.8.722","article-title":"Zona pellucida-induced acrosome reaction in human sperm: dependency on activation of pertussis toxin-sensitive Gi protein and extracellular calcium, and priming effect of progesterone and follicular fluid","volume":"8","author":"Schuffner","year":"2002","journal-title":"Mol Hum Reprod"},{"key":"2026070101520834300_dmag008-B313","first-page":"23","volume-title":"Mouse Models of Innate Immunity: Methods and Protocols","author":"Scott","year":"2019"},{"key":"2026070101520834300_dmag008-B314","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1530\/jrf.0.1050085","article-title":"Plasma membrane block to polyspermy in human oocytes and preimplantation embryos","volume":"105","author":"Sengoku","year":"1995","journal-title":"J Reprod Fertil"},{"key":"2026070101520834300_dmag008-B315","doi-asserted-by":"crossref","first-page":"411","DOI":"10.4103\/aja202176","article-title":"Sperm hyaluronidase is critical to mammals\u2019 fertilization for its ability to disperse cumulus\u2013oocyte complex layer","volume":"24","author":"Seol","year":"2022","journal-title":"Asian J Androl"},{"key":"2026070101520834300_dmag008-B316","first-page":"480","article-title":"The incidence of polyspermy during in vitro fertilisation. A study at the H. F. Verwoerd Hospital, Pretoria","volume":"72","author":"Sevenster","year":"1987","journal-title":"S Afr Med J"},{"key":"2026070101520834300_dmag008-B317","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1146\/annurev-virology-100520-011851","article-title":"Systems biology of virus-host protein interactions: from hypothesis generation to mechanisms of replication and pathogenesis","volume":"9","author":"Shah","year":"2022","journal-title":"Annu Rev Virol"},{"key":"2026070101520834300_dmag008-B318","doi-asserted-by":"crossref","first-page":"e2501302122","DOI":"10.1073\/pnas.2501302122","article-title":"ELAPOR1 is a copper-dependent tethering factor driving proacrosomal vesicle fusion during acrosome biogenesis","volume":"122","author":"Shao","year":"2025","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B319","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/humrep\/deac026","article-title":"Identification of a heterozygous variant of ZP2 as a novel cause of empty follicle syndrome in humans and mice","volume":"37","author":"Shen","year":"2022","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B320","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1242\/dev.128.5.645","article-title":"Cell surface \u03b21,4-galactosyltransferase-I activates G protein-dependent exocytotic signaling","volume":"128","author":"Shi","year":"2001","journal-title":"Development"},{"key":"2026070101520834300_dmag008-B321","doi-asserted-by":"crossref","first-page":"e2018355118","DOI":"10.1073\/pnas.2018355118","article-title":"ARMC12 regulates spatiotemporal mitochondrial dynamics during spermiogenesis and is required for male fertility","volume":"118","author":"Shimada","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B322","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1093\/molehr\/4.6.555","article-title":"Prostaglandins induce calcium influx in human spermatozoa","volume":"4","author":"Shimizu","year":"1998","journal-title":"Mol Hum Reprod"},{"key":"2026070101520834300_dmag008-B323","doi-asserted-by":"crossref","first-page":"e12564","DOI":"10.1002\/rmb2.12564","article-title":"Analysis of cell\u2013cell interaction between mural granulosa cells and cumulus granulosa cells during ovulation using single-cell RNA sequencing data of mouse ovary","volume":"23","author":"Shirafuta","year":"2024","journal-title":"Reprod Med Biol"},{"key":"2026070101520834300_dmag008-B324","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1007\/s11538-018-0478-3","article-title":"A model for the acrosome reaction in mammalian sperm","volume":"80","author":"Simons","year":"2018","journal-title":"Bull Math Biol"},{"key":"2026070101520834300_dmag008-B325","doi-asserted-by":"crossref","first-page":"338a","DOI":"10.1016\/j.bpj.2011.11.1851","article-title":"Calcium channel CatSper is a non-genomic progesterone receptor of human sperm","volume":"102","author":"Smith","year":"2012","journal-title":"Biophys J"},{"key":"2026070101520834300_dmag008-B326","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1126\/science.1080376","article-title":"Identification of a testicular odorant receptor mediating human sperm chemotaxis","volume":"299","author":"Spehr","year":"2003","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B327","doi-asserted-by":"crossref","first-page":"40194","DOI":"10.1074\/jbc.M403913200","article-title":"Particulate adenylate cyclase plays a key role in human sperm olfactory receptor-mediated chemotaxis","volume":"279","author":"Spehr","year":"2004","journal-title":"J Biol Chem"},{"key":"2026070101520834300_dmag008-B328","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1242\/jcs.109.7.1947","article-title":"Calcium mobilization and influx during sperm exocytosis","volume":"109","author":"Spungin","year":"1996","journal-title":"J Cell Sci"},{"key":"2026070101520834300_dmag008-B329","doi-asserted-by":"crossref","first-page":"824629","DOI":"10.3389\/fcell.2022.824629","article-title":"In silico docking analysis for blocking JUNO-IZUMO1 interaction identifies two small molecules that block in vitro fertilization","volume":"10","author":"Stepanenko","year":"2022","journal-title":"Front Cell Dev Biol"},{"key":"2026070101520834300_dmag008-B330","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/S0140-6736(78)92957-4","article-title":"Birth after the reimplantation of a human embryo","volume":"2","author":"Steptoe","year":"1978","journal-title":"Lancet"},{"key":"2026070101520834300_dmag008-B331","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1186\/s12967-024-05948-4","article-title":"Disruption of gamete fusion alters the sperm-egg ratio at gamete interaction","volume":"22","author":"Stickler","year":"2024","journal-title":"J Transl Med"},{"key":"2026070101520834300_dmag008-B332","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1093\/humupd\/dmn029","article-title":"Control of hyperactivation in sperm","volume":"14","author":"Suarez","year":"2008","journal-title":"Hum Reprod Update"},{"key":"2026070101520834300_dmag008-B333","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/humupd\/dmi047","article-title":"Sperm transport in the female reproductive tract","volume":"12","author":"Suarez","year":"2006","journal-title":"Hum Reprod Update"},{"key":"2026070101520834300_dmag008-B334","first-page":"227","article-title":"Microfluidic devices for the study of sperm migration","volume":"23","author":"Suarez","year":"2017","journal-title":"Mol Hum Reprod"},{"key":"2026070101520834300_dmag008-B335","doi-asserted-by":"crossref","first-page":"e12538","DOI":"10.1002\/rmb2.12538","article-title":"Paracrine regulation of granulosa cell development in the antral follicles in mammals","volume":"22","author":"Sugiura","year":"2023","journal-title":"Reprod Med Biol"},{"key":"2026070101520834300_dmag008-B336","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1093\/humrep\/deh657","article-title":"Human sperm chemotaxis: both the oocyte and its surrounding cumulus cells secrete sperm chemoattractants","volume":"20","author":"Sun","year":"2005","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B337","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1002\/humu.23864","article-title":"Compound heterozygous ZP1 mutations cause empty follicle syndrome in infertile sisters","volume":"40","author":"Sun","year":"2019","journal-title":"Hum Mutat"},{"key":"2026070101520834300_dmag008-B338","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1095\/biolreprod60.4.900","article-title":"A contraceptive peptide vaccine targeting sulfated glycoprotein ZP2 of the mouse zona pellucida1","volume":"60","author":"Sun","year":"1999","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B339","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/j.rbmo.2023.01.010","article-title":"Novel variants in ZP1, ZP2 and ZP3 associated with empty follicle syndrome and abnormal zona pellucida","volume":"46","author":"Sun","year":"2023","journal-title":"Reprod Biomed Online"},{"key":"2026070101520834300_dmag008-B340","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1007\/s10815-021-02107-2","article-title":"A novel homozygous variant in ZP2 causes abnormal zona pellucida formation and female infertility","volume":"38","author":"Sun","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B341","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1091\/mbc.12.4.809","article-title":"Sequence-specific interaction between the disintegrin domain of mouse ADAM 3 and murine eggs: role of \u03b21 integrin-associated proteins CD9, CD81, and CD98","volume":"12","author":"Takahashi","year":"2001","journal-title":"Mol Biol Cell"},{"key":"2026070101520834300_dmag008-B342","first-page":"59","article-title":"Mutation analysis of the JUNO gene in female infertility of unknown etiology","volume":"2","author":"Takaiso","year":"2016","journal-title":"Fujita Med J"},{"key":"2026070101520834300_dmag008-B343","doi-asserted-by":"crossref","first-page":"14539","DOI":"10.1073\/pnas.0805699105","article-title":"Timely interaction between prostaglandin and chemokine signaling is a prerequisite for successful fertilization","volume":"105","author":"Tamba","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B344","doi-asserted-by":"crossref","first-page":"e2207805119","DOI":"10.1073\/pnas.2207805119","article-title":"Human sperm TMEM95 binds eggs and facilitates membrane fusion","volume":"119","author":"Tang","year":"2022","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B345","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1095\/biolreprod67.1.212","article-title":"Role of sperm surface arylsulfatase A in mouse sperm-zona pellucida binding","volume":"67","author":"Tantibhedhyangkul","year":"2002","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B346","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/S1472-6483(10)60341-0","article-title":"Natural history of the mammalian oocyte","volume":"15","author":"Telfer","year":"2007","journal-title":"Reprod Biomed Online"},{"key":"2026070101520834300_dmag008-B347","doi-asserted-by":"crossref","first-page":"12726","DOI":"10.3390\/ijms232112726","article-title":"Short-chain fatty acids modulate sperm migration through olfactory receptor 51E2 activity","volume":"23","author":"Teveroni","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026070101520834300_dmag008-B348","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.fertnstert.2006.02.080","article-title":"Progesterone at the picomolar range is a chemoattractant for mammalian spermatozoa","volume":"86","author":"Teves","year":"2006","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B349","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1007\/s000180050108","article-title":"Trefoil peptides: from structure to function","volume":"53","author":"Thim","year":"1997","journal-title":"Cell Mol Life Sci"},{"key":"2026070101520834300_dmag008-B350","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1038\/s41556-024-01524-6","article-title":"Ex vivo imaging reveals the spatiotemporal control of ovulation","volume":"26","author":"Thomas","year":"2024","journal-title":"Nat Cell Biol"},{"key":"2026070101520834300_dmag008-B351","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S0015-0282(16)40271-2","article-title":"Fertilization of mouse ova in vitro: an electron microscopic study","volume":"25","author":"Thompson","year":"1974","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B352","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.devcel.2018.07.020","article-title":"Glycan-independent gamete recognition triggers egg zinc sparks and ZP2 cleavage to prevent polyspermy","volume":"46","author":"Tokuhiro","year":"2018","journal-title":"Dev Cell"},{"key":"2026070101520834300_dmag008-B353","doi-asserted-by":"crossref","first-page":"3850","DOI":"10.1073\/pnas.1117963109","article-title":"Protein disulfide isomerase homolog PDILT is required for quality control of sperm membrane protein ADAM3 and male fertility","volume":"109","author":"Tokuhiro","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B354","doi-asserted-by":"crossref","first-page":"389","DOI":"10.4103\/aja202376","article-title":"Novel PLCZ1 mutation caused polyspermy during in vitro fertilization","volume":"26","author":"Tong","year":"2024","journal-title":"Asian J Androl"},{"key":"2026070101520834300_dmag008-B355","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/0014-5793(87)80546-X","article-title":"Acrosin shows zona and fucose binding, novel properties for a serine proteinase","volume":"226","author":"T\u00f6pfer-Petersen","year":"1987","journal-title":"FEBS Lett"},{"key":"2026070101520834300_dmag008-B356","doi-asserted-by":"crossref","first-page":"6296","DOI":"10.1073\/pnas.96.11.6296","article-title":"Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX","volume":"96","author":"Triggs-Raine","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B357","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1095\/biolreprod61.6.1649","article-title":"Expression of recombinant human zona pellucida protein 2 and its binding capacity to spermatozoa","volume":"61","author":"Tsubamoto","year":"1999","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B358","doi-asserted-by":"crossref","first-page":"133","DOI":"10.3390\/cells10010133","article-title":"Ligands and receptors involved in the sperm-zona pellucida interactions in mammals","volume":"10","author":"Tumova","year":"2021","journal-title":"Cells"},{"key":"2026070101520834300_dmag008-B359","doi-asserted-by":"crossref","first-page":"2292","DOI":"10.3390\/cells10092292","article-title":"The function of cumulus cells in oocyte growth and maturation and in subsequent ovulation and fertilization","volume":"10","author":"Turathum","year":"2021","journal-title":"Cells"},{"key":"2026070101520834300_dmag008-B360","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0303-7207(94)90238-0","article-title":"Progesterone initiation of the human sperm acrosome reaction: the obligatory increase in intracellular calcium is independent of the chloride requirement","volume":"101","author":"Turner","year":"1994","journal-title":"Mol Cell Endocrinol"},{"key":"2026070101520834300_dmag008-B361","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1074\/mcp.M500279-MCP200","article-title":"A Human Protein Atlas for normal and cancer tissues based on antibody proteomics","volume":"4","author":"Uhl\u00e9n","year":"2005","journal-title":"Mol Cell Proteomics"},{"key":"2026070101520834300_dmag008-B362","doi-asserted-by":"crossref","first-page":"1260419","DOI":"10.1126\/science.1260419","article-title":"Tissue-based map of the human proteome","volume":"347","author":"Uhl\u00e9n","year":"2015","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B363","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/S0015-0282(16)55568-X","article-title":"Direct effects of progesterone and antiprogesterone on human sperm hyperactivated motility and acrosome reaction","volume":"58","author":"Uhler","year":"1992","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B364","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1038\/s41467-020-15459-7","article-title":"Structural insights into tetraspanin CD9 function","volume":"11","author":"Umeda","year":"2020","journal-title":"Nat Commun"},{"key":"2026070101520834300_dmag008-B365","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/mrd.23665","article-title":"Optical coherence tomography for dynamic investigation of mammalian reproductive processes","volume":"90","author":"Umezu","year":"2023","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B366","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1038\/s42003-022-03883-y","article-title":"SPACA6 ectodomain structure reveals a conserved superfamily of gamete fusion-associated proteins","volume":"5","author":"Vance","year":"2022","journal-title":"Commun Biol"},{"key":"2026070101520834300_dmag008-B367","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/humrep\/des368","article-title":"Diagnostic and prognostic value of calcium oscillatory pattern analysis for patients with ICSI fertilization failure","volume":"28","author":"Vanden Meerschaut","year":"2013","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B368","first-page":"59","article-title":"An overview of the proacrosin\/acrosin system in human spermatozoa","volume":"56","author":"Vazquez-Levin","year":"2007","journal-title":"Treb Soc Catalana Biol"},{"key":"2026070101520834300_dmag008-B369","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1016\/j.fertnstert.2009.08.040","article-title":"Anti-human proacrosin antibody inhibits the zona pellucida (ZP)-induced acrosome reaction of ZP-bound spermatozoa","volume":"93","author":"Veaute","year":"2010","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B370","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/BF00283043","article-title":"Hydatidiform mole: genetic origin in polyploid conceptuses","volume":"76","author":"Vejerslev","year":"1987","journal-title":"Hum Genet"},{"key":"2026070101520834300_dmag008-B371","doi-asserted-by":"crossref","first-page":"2174","DOI":"10.1007\/s43032-024-01558-z","article-title":"Artificial gametes and human reproduction in the 21st century: an ethical analysis","volume":"31","author":"Villalba","year":"2024","journal-title":"Reprod Sci"},{"key":"2026070101520834300_dmag008-B372","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1016\/S0015-0282(16)57982-5","article-title":"Progesterone induces human sperm chemotaxis","volume":"64","author":"Villanueva-D\u00edaz","year":"1995","journal-title":"Fertil Steril"},{"key":"2026070101520834300_dmag008-B373","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1242\/dev.121.4.1139","article-title":"Capacitation of mouse spermatozoa: II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway","volume":"121","author":"Visconti","year":"1995","journal-title":"Development"},{"key":"2026070101520834300_dmag008-B374","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1006\/dbio.1999.9428","article-title":"Cholesterol efflux-mediated signal transduction in mammalian sperm: cholesterol release signals an increase in protein tyrosine phosphorylation during mouse sperm capacitation","volume":"214","author":"Visconti","year":"1999","journal-title":"Dev Biol"},{"key":"2026070101520834300_dmag008-B375","doi-asserted-by":"crossref","first-page":"eabn0047","DOI":"10.1126\/sciadv.abn0047","article-title":"MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization","volume":"8","author":"Vondrakova","year":"2022","journal-title":"Sci Adv"},{"key":"2026070101520834300_dmag008-B376","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1083\/jcb.130.4.857","article-title":"Inositol 1,4,5-trisphosphate receptors selectively localized to the acrosomes of mammalian sperm","volume":"130","author":"Walensky","year":"1995","journal-title":"J Cell Biol"},{"key":"2026070101520834300_dmag008-B377","doi-asserted-by":"crossref","first-page":"103614","DOI":"10.1016\/j.semcdb.2025.103614","article-title":"The role of granulosa cells in oocyte development and aging: mechanisms and therapeutic opportunities","volume":"171","author":"Wang","year":"2025","journal-title":"Semin Cell Dev Biol"},{"key":"2026070101520834300_dmag008-B378","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41392-024-01780-w","article-title":"Adeno-associated virus as a delivery vector for gene therapy of human diseases","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"2026070101520834300_dmag008-B379","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/biolre\/ioab048","article-title":"Sperm-oocyte signaling: the role of IZUMO1R and CD9 in PTK2B activation and actin remodeling at the sperm binding site","volume":"104","author":"Wang","year":"2021","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B380","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1038\/s43587-024-00697-x","article-title":"Rejuvenation of aged oocyte through exposure to young follicular microenvironment","volume":"4","author":"Wang","year":"2024","journal-title":"Nat Aging"},{"key":"2026070101520834300_dmag008-B381","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/s13048-025-01674-7","article-title":"A compound heterozygous mutation in ZP1 and two novel heterozygous cis mutations in ZP3 causes infertility in women presenting with empty follicle syndrome","volume":"18","author":"Wang","year":"2025","journal-title":"J Ovarian Res"},{"key":"2026070101520834300_dmag008-B382","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1080\/gye.15.4.286.292","article-title":"Effects of follicular fluid and steroid hormones on chemotaxis and motility of human spermatozoa in vitro","volume":"15","author":"Wang","year":"2001","journal-title":"Gynecol Endocrinol"},{"key":"2026070101520834300_dmag008-B383","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1007\/s10815-021-02136-x","article-title":"A novel homozygous nonsense mutation in zona pellucida 1 (ZP1) causes human female empty follicle syndrome","volume":"38","author":"Wang","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B384","doi-asserted-by":"crossref","first-page":"700396","DOI":"10.3389\/fcell.2021.700396","article-title":"Identification of sialyl-Lewis(x)-interacting protein on human spermatozoa","volume":"9","author":"Wang","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026070101520834300_dmag008-B385","doi-asserted-by":"crossref","first-page":"14061","DOI":"10.1016\/S0021-9258(19)49678-6","article-title":"Activation of a Gi protein in mouse sperm membranes by solubilized proteins of the zona pellucida, the egg\u2019s extracellular matrix","volume":"267","author":"Ward","year":"1992","journal-title":"J Biol Chem"},{"key":"2026070101520834300_dmag008-B386","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1159\/000078193","article-title":"Mouse zona pellucida genes and glycoproteins","volume":"105","author":"Wassarman","year":"2004","journal-title":"Cytogenet Genome Res"},{"key":"2026070101520834300_dmag008-B387","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.3390\/genes12081266","article-title":"Zona pellucida genes and proteins: essential players in mammalian oogenesis and fertility","volume":"12","author":"Wassarman","year":"2021","journal-title":"Genes (Basel)"},{"key":"2026070101520834300_dmag008-B388","doi-asserted-by":"crossref","first-page":"e76106","DOI":"10.7554\/eLife.76106","article-title":"Female fertility and the zona pellucida","volume":"11","author":"Wassarman","year":"2022","journal-title":"eLife"},{"key":"2026070101520834300_dmag008-B389","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1136\/jclinpath-2020-207170","article-title":"Mutations in ZP4 are associated with abnormal zona pellucida and female infertility","volume":"75","author":"Wei","year":"2022","journal-title":"J Clin Pathol"},{"key":"2026070101520834300_dmag008-B390","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/andr.12638","article-title":"Relevance of CRISP proteins for epididymal physiology, fertilization, and fertility","volume":"7","author":"Weigel Mu\u00f1oz","year":"2019","journal-title":"Andrology"},{"key":"2026070101520834300_dmag008-B391","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/biolre\/ioaa087","article-title":"Development of multipurpose technologies products for pregnancy and STI prevention: update on polyphenylene carboxymethylene MPT gel development","volume":"103","author":"Weitzel","year":"2020","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B392","volume-title":"WHO Laboratory Manual for the Examination and Processing of Human Semen","author":"WHO","year":"2021"},{"key":"2026070101520834300_dmag008-B393","doi-asserted-by":"crossref","first-page":"4871","DOI":"10.1242\/dev.02671","article-title":"Sperm plasma membrane breakdown during Drosophila fertilization requires Sneaky, an acrosomal membrane protein","volume":"133","author":"Wilson","year":"2006","journal-title":"Development"},{"key":"2026070101520834300_dmag008-B394","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1002\/mrd.22992","article-title":"The Caenorhabditis elegans spe-49 gene is required for fertilization and encodes a sperm-specific transmembrane protein homologous to SPE-42","volume":"85","author":"Wilson","year":"2018","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B395","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1471-213X-11-10","article-title":"Fertilization in C. elegans requires an intact C-terminal RING finger in sperm protein SPE-42","volume":"11","author":"Wilson","year":"2011","journal-title":"BMC Dev Biol"},{"key":"2026070101520834300_dmag008-B396","doi-asserted-by":"crossref","first-page":"e0128275","DOI":"10.1371\/journal.pone.0128275","article-title":"Studies of OC-STAMP in osteoclast fusion: a new knockout mouse model, rescue of cell fusion, and transmembrane topology","volume":"10","author":"Witwicka","year":"2015","journal-title":"PLoS One"},{"key":"2026070101520834300_dmag008-B397","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/jcp.21113","article-title":"Sperm surface arylsulfatase A can disperse the cumulus matrix of cumulus oocyte complexes","volume":"213","author":"Wu","year":"2007","journal-title":"J Cell Physiol"},{"key":"2026070101520834300_dmag008-B398","doi-asserted-by":"crossref","first-page":"147745","DOI":"10.1016\/j.gene.2023.147745","article-title":"Novel biallelic ASTL variants are associated with polyspermy and female infertility: a successful live birth following ICSI treatment","volume":"887","author":"Wu","year":"2023","journal-title":"Gene"},{"key":"2026070101520834300_dmag008-B399","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/cge.13921","article-title":"Novel mutations in ZP1: expanding the mutational spectrum associated with empty follicle syndrome in infertile women","volume":"99","author":"Wu","year":"2021","journal-title":"Clin Genet"},{"key":"2026070101520834300_dmag008-B400","doi-asserted-by":"crossref","first-page":"1087612","DOI":"10.3389\/fcell.2023.1087612","article-title":"Intercellular communication in the cumulus-oocyte complex during folliculogenesis: a review","volume":"11","author":"Xie","year":"2023","journal-title":"Front Cell Dev Biol"},{"key":"2026070101520834300_dmag008-B401","doi-asserted-by":"crossref","first-page":"e1269","DOI":"10.1002\/mgg3.1269","article-title":"A novel homozygous nonsense ZP1 variant causes human female infertility associated with empty follicle syndrome (EFS)","volume":"8","author":"Xu","year":"2020","journal-title":"Mol Genet Genomic Med"},{"key":"2026070101520834300_dmag008-B402","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1095\/biolreprod.108.074021","article-title":"Disruption of ADAM3 impairs the migration of sperm into oviduct in mouse","volume":"81","author":"Yamaguchi","year":"2009","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B403","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s12610-017-0059-6","article-title":"Relationship between Semenogelins bound to human sperm and other semen parameters and pregnancy outcomes","volume":"27","author":"Yamasaki","year":"2017","journal-title":"Basic Clin Androl"},{"key":"2026070101520834300_dmag008-B404","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/200281b0","article-title":"Fertilization of hamster eggs in vitro","volume":"200","author":"Yanagimachi","year":"1963","journal-title":"Nature"},{"key":"2026070101520834300_dmag008-B405","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1002\/aja.1001280404","article-title":"Electron microscope studies of sperm incorporation into the golden hamster egg","volume":"128","author":"Yanagimachi","year":"1970","journal-title":"Am J Anat"},{"key":"2026070101520834300_dmag008-B406","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1007\/s43032-024-01729-y","article-title":"A compound heterozygous pathogenic variant in ZP2 gene causes female infertility","volume":"32","author":"Yang","year":"2025","journal-title":"Reprod Sci"},{"key":"2026070101520834300_dmag008-B407","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1126\/science.adm8485","article-title":"Engineering synthetic phosphorylation signaling networks in human cells","volume":"387","author":"Yang","year":"2025","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B408","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1530\/REP-10-0241","article-title":"Human ZP4 is not sufficient for taxon-specific sperm recognition of the zona pellucida in transgenic mice","volume":"141","author":"Yauger","year":"2011","journal-title":"Reproduction"},{"key":"2026070101520834300_dmag008-B409","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.24272\/j.issn.2095-8137.2024.019","article-title":"Homozygous CCDC146 mutation causes oligoasthenoteratozoospermia in humans and mice","volume":"45","author":"Ye","year":"2024","journal-title":"Zool Res"},{"key":"2026070101520834300_dmag008-B410","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1093\/humrep\/des092","article-title":"Recombinant human phospholipase C zeta 1 induces intracellular calcium oscillations and oocyte activation in mouse and human oocytes","volume":"27","author":"Yoon","year":"2012","journal-title":"Hum Reprod"},{"key":"2026070101520834300_dmag008-B411","doi-asserted-by":"crossref","first-page":"eabe0237","DOI":"10.1126\/science.abe0237","article-title":"Generation of ovarian follicles from mouse pluripotent stem cells","volume":"373","author":"Yoshino","year":"2021","journal-title":"Science"},{"key":"2026070101520834300_dmag008-B412","doi-asserted-by":"crossref","first-page":"623","DOI":"10.4103\/1008-682X.153851","article-title":"Advantages of using the CRISPR\/Cas9 system of genome editing to investigate male reproductive mechanisms using mouse models","volume":"17","author":"Young","year":"2015","journal-title":"Asian J Androl"},{"key":"2026070101520834300_dmag008-B413","doi-asserted-by":"crossref","first-page":"e2021102118","DOI":"10.1073\/pnas.2021102118","article-title":"Discovery and characterization of bromodomain 2-specific inhibitors of BRDT","volume":"118","author":"Yu","year":"2021","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026070101520834300_dmag008-B414","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/s10815-017-1101-5","article-title":"Mutational analysis of IZUMO1R in women with fertilization failure and polyspermy after in vitro fertilization","volume":"35","author":"Yu","year":"2018","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B415","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13048-019-0495-3","article-title":"HAS2-AS1 is a novel LH\/hCG target gene regulating HAS2 expression and enhancing cumulus cells migration","volume":"12","author":"Yung","year":"2019","journal-title":"J Ovarian Res"},{"key":"2026070101520834300_dmag008-B416","doi-asserted-by":"crossref","first-page":"575126","DOI":"10.3389\/fcell.2020.575126","article-title":"Male decapacitation factor SPINK3 blocks membrane hyperpolarization and calcium entry in mouse sperm","volume":"8","author":"Zalazar","year":"2020","journal-title":"Front Cell Dev Biol"},{"key":"2026070101520834300_dmag008-B417","doi-asserted-by":"crossref","first-page":"2326","DOI":"10.1093\/hmg\/ddad070","article-title":"Bi-allelic variants in ASTL cause abnormal fertilization or oocyte maturation defects","volume":"32","author":"Zeng","year":"2023","journal-title":"Hum Mol Genet"},{"key":"2026070101520834300_dmag008-B418","doi-asserted-by":"crossref","first-page":"1169378","DOI":"10.3389\/fendo.2023.1169378","article-title":"Identification of zona pellucida defects revealed a novel loss-of-function mutation in ZP2 in humans and rats","volume":"14","author":"Zeng","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026070101520834300_dmag008-B419","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1093\/biolre\/ioab047","article-title":"Zp4 is completely dispensable for fertility in female rats","volume":"104","author":"Zeng","year":"2021","journal-title":"Biol Reprod"},{"key":"2026070101520834300_dmag008-B420","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3390\/ani9070444","article-title":"Detection of bovine TMEM95 p.Cys161X mutation in 13 chinese indigenous cattle breeds","volume":"9","author":"Zhang","year":"2019","journal-title":"Animals"},{"key":"2026070101520834300_dmag008-B421","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/mrd.20360","article-title":"Sperm dysfunction in the Rb(6.16)- and Rb(6.15)-bearing mice revisited: involvement of Hyalp1 and Hyal5","volume":"72","author":"Zhang","year":"2005","journal-title":"Mol Reprod Dev"},{"key":"2026070101520834300_dmag008-B422","doi-asserted-by":"crossref","first-page":"eabn0968","DOI":"10.1126\/sciadv.abn0968","article-title":"Loss-of-function mutations in CEP78 cause male infertility in humans and mice","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci Adv"},{"key":"2026070101520834300_dmag008-B423","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10815-020-01995-0","article-title":"A novel mutation in ZP3 causes empty follicle syndrome and abnormal zona pellucida formation","volume":"38","author":"Zhang","year":"2021","journal-title":"J Assist Reprod Genet"},{"key":"2026070101520834300_dmag008-B424","doi-asserted-by":"crossref","first-page":"3439","DOI":"10.1038\/s41467-022-31050-8","article-title":"3D structure and in situ arrangements of CatSper channel in the sperm flagellum","volume":"13","author":"Zhao","year":"2022","journal-title":"Nat Commun"},{"key":"2026070101520834300_dmag008-B425","doi-asserted-by":"crossref","first-page":"103993","DOI":"10.1016\/j.rbmo.2024.103993","article-title":"Acrosin activity negatively influences the cumulative live birth rate in patients undergoing IVF treatment","volume":"49","author":"Zhao","year":"2024","journal-title":"Reprod Biomed Online"},{"key":"2026070101520834300_dmag008-B426","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1016\/j.cell.2023.05.009","article-title":"Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility","volume":"186","author":"Zhou","year":"2023","journal-title":"Cell"},{"key":"2026070101520834300_dmag008-B427","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00439-019-01990-1","article-title":"Novel mutations in ZP1, ZP2, and ZP3 cause female infertility due to abnormal zona pellucida formation","volume":"138","author":"Zhou","year":"2019","journal-title":"Hum Genet"},{"key":"2026070101520834300_dmag008-B428","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1007\/s43032-024-01732-3","article-title":"Novel loss-of-function variants of ZP3 associated with premature ovarian insufficiency","volume":"31","author":"Zhou","year":"2024","journal-title":"Reprod Sci"},{"key":"2026070101520834300_dmag008-B429","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41422-025-01135-2","article-title":"In situ structure of the mouse sperm central apparatus reveals mechanistic insights into asthenozoospermia","volume":"35","author":"Zhu","year":"2025","journal-title":"Cell Res"},{"key":"2026070101520834300_dmag008-B430","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1038\/s41467-019-09716-7","article-title":"Humanising the mouse genome piece by piece","volume":"10","author":"Zhu","year":"2019","journal-title":"Nat Commun"},{"key":"2026070101520834300_dmag008-B431","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1247\/csf.26.189","article-title":"Cumulus oophorus extracellular matrix: its construction and regulation","volume":"26","author":"Zhuo","year":"2001","journal-title":"Cell Struct Funct"},{"key":"2026070101520834300_dmag008-B432","doi-asserted-by":"crossref","first-page":"7693","DOI":"10.1074\/jbc.C000899200","article-title":"Defect in SHAP-hyaluronan complex causes severe female infertility: a study by inactivation of the Bikunin gene in mice","volume":"276","author":"Zhuo","year":"2001","journal-title":"J Biol Chem"},{"key":"2026070101520834300_dmag008-B433","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.cell.2016.09.056","article-title":"Crystal structure of a full-length human tetraspanin reveals a cholesterol-binding pocket","volume":"167","author":"Zimmerman","year":"2016","journal-title":"Cell"},{"key":"2026070101520834300_dmag008-B434","doi-asserted-by":"crossref","first-page":"e17256","DOI":"10.1371\/journal.pone.0017256","article-title":"Sperm proteasomes degrade sperm receptor on the egg zona pellucida during mammalian fertilization","volume":"6","author":"Zimmerman","year":"2011","journal-title":"PLoS One"},{"key":"2026070101520834300_dmag008-B435","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1007\/s43032-022-01024-8","article-title":"A novel homozygous nonsense mutation in ZP1 causes female infertility due to empty follicle syndrome","volume":"29","author":"Zou","year":"2022","journal-title":"Reprod Sci"},{"key":"2026070101520834300_dmag008-B436","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1017\/S0967199409990189","article-title":"Decrease in CD9 content and reorganization of microvilli may contribute to the oolemma block to sperm penetration during fertilization of mouse oocyte","volume":"18","author":"\u017by\u0142kiewicz","year":"2010","journal-title":"Zygote"}],"container-title":["Human Reproduction Update"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/humupd\/article-pdf\/32\/4\/409\/67511818\/dmag008.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/humupd\/article-pdf\/32\/4\/409\/67511818\/dmag008.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:01:05Z","timestamp":1782914465000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/humupd\/article\/32\/4\/409\/8540561"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,25]]},"references-count":436,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2026,3,25]]},"published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/humupd\/dmag008","relation":{},"ISSN":["1355-4786","1460-2369"],"issn-type":[{"value":"1355-4786","type":"print"},{"value":"1460-2369","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,7]]},"published":{"date-parts":[[2026,3,25]]}}}